Polygenetic risk score construction in UKBB

Polygenetic risk score construction in UKBB

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Hi, all. I am learning to construct a polygenetic score in UKBB using published GWAS summary statistics. So I was trying to apply for certain SNPs in the AMS. When applying for SNPs one by one, I was asked to enter SNP (Affy) IDs. However, I came into the situation that most SNP rs ids unmatched in UKBB when using the searching function in UKBB websites (only 40 out of 400 matched). When I used the annotation file named “Axiom_UKB_WCSG.na34.annot” and “Axiom_UKBiLEVE.na34.annot”, It’s the same. Does anyone know how it is going on? Any could anyone tell me which file shall I use to match SNP ids? When the chromosome: position was present instead of rs ids, can I also match the information as well?


PRS


UKBB

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