Peripheral blood RNAseq links neutrophilic inflammation to clinical glioma metastasis | BMC Medicine

The paper presented by Zhang et al. [6] provides a more sensitive CTC measurement than the conventional CellSearch method. Their method, which is based on human telomerase reverse transcriptase (hTERT) detection, revealed new mechanisms between CTCs and innate immunity, especially pathways of neutrophil activation and neutrophil extracellular traps in gliomas. The hTRET detection method is a cell-surface marker-independent technology. It uses telomerase-specific, replication-selective oncolytic herpes simplex virus-1 to target telomerase reverse transcriptase-positive cancer cells and label them with green fluorescent protein, enabling identification of viable CTCs from a broad spectrum of malignancies [7]. Using this method, Zhang et al. found that postoperative CTCs are a poor prognosis factor, while preoperative CTCs are not, which refines our former understanding of glioma CTCs [6].

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