KEGG ENZYME: 4.1.1.65

Entry
EC 4.1.1.65                 Enzyme                                 
Name

phosphatidylserine decarboxylase;
PS decarboxylase;
phosphatidyl-L-serine carboxy-lyase

Class

Lyases;
Carbon-carbon lyases;
Carboxy-lyases

Sysname

phosphatidyl-L-serine carboxy-lyase (phosphatidylethanolamine-forming)

Reaction(IUBMB)
phosphatidyl-L-serine = phosphatidylethanolamine + CO2 [RN:R02055]
Reaction(KEGG) Substrate
phosphatidyl-L-serine [CPD:C02737]
Product Comment

A pyridoxal-phosphate protein. In Escherichia coli, the prosthetic group is a pyruvoyl group.

History

EC 4.1.1.65 created 1976

Pathway
ec00564   Glycerophospholipid metabolism
ec01110   Biosynthesis of secondary metabolites
Orthology
K01613   phosphatidylserine decarboxylase
Genes

 » show all
Reference   Authors

KANFER J, KENNEDY EP.

  Title

METABOLISM AND FUNCTION OF BACTERIAL LIPIDS. II. BIOSYNTHESIS OF PHOSPHOLIPIDS IN ESCHERICHIA COLI.

  Journal

J Biol Chem 239:1720-6 (1964)

Reference   Authors

Satre M, Kennedy EP

  Title

Identification of bound pyruvate essential for the activity of phosphatidylserine decarboxylase of Escherichia coli.

  Journal

J Biol Chem 253:479-83 (1978)

Other DBs
ExplorEnz – The Enzyme Database:  4.1.1.65
ExPASy – ENZYME nomenclature database:  4.1.1.65

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