Senior Bioinformatics Scientist (Statistical Geneticist) – Research – Cambridge, UK in San Diego, California

Senior Bioinformatics Scientist – Cambridge, UK

Candidates wishing to work remotely from the Netherlands, France, or Belgium may also be considered.

Overview

Since 2001, the cost of DNA sequencing has dropped more than 100,000-fold, from $100,000,000 USD per human genome to less than $600 USD today. This is resulting in the explosive growth of genomics data, which we are combining with machine learning for data-driven agriculture, cancer treatment, reproductive health, and other life-changing applications.

Illumina is a leading developer, manufacturer, and marketer of life science tools and integrated systems for large-scale analysis of genetic variation and function. Our exceptional AI researchers are unlocking the power of the genome to:

  • Accelerate demand for Illumina sequencing technology
  • Make AI a core part of our company by enabling new business directions and improving processes
  • Enable personalised medicine

As a member of our Genome Interpretation research group, you will be part of an international collaboration between AI researchers and bioinformaticians in the UK, US, and Singapore. Algorithms and models will be published in peer-reviewed journals, as software products, and as patents. This will increase the accuracy, throughput, and reproducibility of genome interpretation, thereby removing barriers to the clinical adoption of whole-genome sequencing. Examples of our work include SpliceAI and PrimateAI, which pioneered the use of deep learning to classify the clinical impact of variations in an individual’s genome.

About You

We are seeking exceptional individuals to work on a number of cutting-edge projects at the interface between bioinformatics and machine learning. 

  • You are likely to have a Ph.D. in a quantitative subject and may also have a subsequent track record of publications in academia, or comparable industry experience.
  • You are experienced in combining bioinformatics tools such as samtools and bcftools into robust and reproducible analysis pipelines.
  • You have demonstrated the ability to write efficient and maintainable code, most likely in Python with exposure to data science libraries such as pandas, NumPy and scikit-learn. Other languages such as R and C++ are also of interest.
  • You are a clear and enthusiastic communicator of your work verbally, in writing, and in presentations.

You combine this with experience of at least one of the following areas:

  • Familiarity with key calculations in statistical genetics such as PCA and GWAS and the ability to apply them in practice. Experience of population-scale datasets such as UK Biobank is a plus.
  • Experience in comparative genomics, perhaps involving datasets such as Zoonomia or Darwin Tree of Life.
  • Computational analysis of common functional genomics assays such as RNA-Seq (especially single-cell), ChIA-PET and Hi-C.
  • Interest in machine learning, as demonstrated by exposure to machine learning frameworks such as PyTorch and TensorFlow.

About Us

The role is based at the Illumina Centre, our purpose-built facility just outside Cambridge UK. Hours are flexible and requests for full or partial remote working will be considered on a case-by-case basis. Candidates wishing to work remotely from the Netherlands, France, or Belgium may also be considered. You will collaborate closely with colleagues in the UK and in the US.

At Illumina, you can expect a highly competitive salary accompanied by a market-leading benefits package. You will be part of the global leader in the DNA sequencing industry, where you will find robust growth opportunities and career development.

Our team members are bright, energetic, and dedicated – they are the driving force behind our innovation and impact. To attract the best and brightest, we offer a competitive employee benefits program. We view it as a smart investment in our people, one that recognizes the tremendous value they bring to our business every day. At Illumina, we push boundaries. We think beyond the conventional. We dream big. With the energy of so many bright and accomplished people, the opportunities are endless.

INDHP

Concerns regarding COVID-19 continue as positive cases are experienced in the communities in which we operate. Please be aware that, as a condition of employment, Illumina may require proof of COVID vaccination in accordance with local statutory requirements (subject to limited exceptions) beginning November 1, 2021.Illumina believes that everyone has the ability to make an impact, and we are proud to be an equal opportunities employer committed to providing employment opportunity regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship status, and genetic information.

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