BioCyc ID: RXN-11174
Enzymes and Genes:
The reaction direction shown is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the
PGDB Concepts Guide for more information.
Mass balance status: Balanced.
shikimate + NADP+ ← 3-dehydroshikimate + NADPH + H+ (22.214.171.124)
Enzyme Commission Primary Name:
quinate/shikimate dehydrogenase [NAD(P)+]
Enzyme Commission Synonyms:
Standard Gibbs Free Energy (ΔrG‘°):
Enzyme Commission Summary:
This is the second shikimate dehydrogenase enzyme found in
Escherichia coli. It can use both
shikimate as substrates and either NAD+ or NADP+ as acceptor. The low catalytic efficiency with both quinate and shikimate suggests that neither may be the physiological substrate. cf
EC 126.96.36.199, quinate/shikimate dehydrogenase (NAD+),
EC 188.8.131.52, quinate/shikimate dehydrogenase (quinone), and
EC 184.108.40.206, shikimate dehydrogenase (NADP+).
Benach03: Benach J, Lee I, Edstrom W, Kuzin AP, Chiang Y, Acton TB, Montelione GT, Hunt JF (2003). “The 2.3-A crystal structure of the shikimate 5-dehydrogenase orthologue YdiB from Escherichia coli suggests a novel catalytic environment for an NAD-dependent dehydrogenase.” J Biol Chem 278(21);19176-82. PMID: 12624088
Michel03: Michel G, Roszak AW, Sauve V, Maclean J, Matte A, Coggins JR, Cygler M, Lapthorn AJ (2003). “Structures of shikimate dehydrogenase AroE and its Paralog YdiB. A common structural framework for different activities.” J Biol Chem 278(21);19463-72. PMID: 12637497
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