Escherichia coli K-12 substr. MG1655 EC

BioCyc ID: RXN-11174

EC Number:

Enzymes and Genes:

shikimate dehydrogenaseInferred from experiment:

The reaction direction shown is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the
PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Instance reaction:

shikimate + NADP+ ← 3-dehydroshikimate + NADPH + H+ (

Enzyme Commission Primary Name:
quinate/shikimate dehydrogenase [NAD(P)+]

Enzyme Commission Synonyms:

Standard Gibbs Free Energy (ΔrG‘°):
-1.9282227 kcal/mol

Enzyme Commission Summary:

This is the second shikimate dehydrogenase enzyme found in
Escherichia coli. It can use both
L-quinate and
shikimate as substrates and either NAD+ or NADP+ as acceptor. The low catalytic efficiency with both quinate and shikimate suggests that neither may be the physiological substrate. cf
EC, quinate/shikimate dehydrogenase (NAD+),
EC, quinate/shikimate dehydrogenase (quinone), and
EC, shikimate dehydrogenase (NADP+).


Gene-Reaction Schematic

Relationship Links:


Created in MetaCyc 15-Jan-2010 by
Caspi R,
SRI International

from MetaCyc [See Credit History in MetaCyc] 06-Dec-2018 by
Caspi R,
SRI International


Benach03: Benach J, Lee I, Edstrom W, Kuzin AP, Chiang Y, Acton TB, Montelione GT, Hunt JF (2003). “The 2.3-A crystal structure of the shikimate 5-dehydrogenase orthologue YdiB from Escherichia coli suggests a novel catalytic environment for an NAD-dependent dehydrogenase.” J Biol Chem 278(21);19176-82. PMID: 12624088

Michel03: Michel G, Roszak AW, Sauve V, Maclean J, Matte A, Coggins JR, Cygler M, Lapthorn AJ (2003). “Structures of shikimate dehydrogenase AroE and its Paralog YdiB. A common structural framework for different activities.” J Biol Chem 278(21);19463-72. PMID: 12637497

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Please cite the following article in publications resulting from the use of EcoCyc: Frontiers in Microbiology 2021

Page generated by Pathway Tools version 25.5 (software by SRI International) on Sat Dec 25, 2021, BIOCYC14.

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