NIH-SOAR-NCI-Bioinformatics Scientist in Rockville, MD

Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations around the globe. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH). Axle is seeking a highly ambitious, adaptable, structured, and detail-oriented Bioinformatics Scientist to join our vibrant team at the National Institutes of Health (NIH), the National Cancer Institute (NCI) located in Bethesda, MD.Overall Position Summary and Objectives:Independently provide support services to satisfy the overall operational objectives of the National Cancer Institute, Center for Cancer Research, Genetics Branch, OMICS Facility. The primary objective is to provide services and deliverables through performance of support services.Deliverables:+ Work products and documents related to designing and implementing state-of-the-art computational methods; use existing algorithms to answer key cancer genomics questions; improve and develop pipelines for the analysis, interpretation and visualization of next-generation sequencing data. – Ad-Hoc+ Work products and documents related to incorporating gene expression and omics data sets in large scale database to support data mining; integrate data with Drug Information for Personalized Therapy project; utilize genomic data for target discovery, drug mechanism and patient stratification efforts. – Ad-Hoc+ Document work products related to pipelines developed, scripts and tools made in house for the statistical analysis of the above both locally at deposit into GitHub. – Ad-Hoc+ Work products and documents related to incorporating RNAseq data into RNASeq Database; incorporate somatic mutations, translocations, amplifications, deletions and other druggable genomic alterations into the existing platform. – Ad-Hoc+ Work products and documents related to making improvements to the current platform; prepare summaries and reports; attend meetings; present results and findings to staff. – Ad-Hoc+ Work products and documents related to incorporating Omics data into databases; incorporate somatic mutations, translocations, amplifications, deletions and other druggable genomic alterations into the existing platform. – Ad-Hoc+ Work products and documents related to making improvements to the current platform; prepare summaries and reports; attend meetings; present results and findings to staff – Ad-Hoc+ Writing manuscripts as co-authors. – Ad-Hoc+ Document and update meeting discussions and tasks in Jira and Confluence weekly online. – Ad-Hoc+ Presentations of research and manuscripts. – Ad-HocStatement of Work:Provides programming and troubleshooting support to the Federal Government in the dissemination of research data. + Ensuring that Github is maintained for all codes developed by incumbent Performs computations on research data analysis. + Design and implement state-of-the-art computational methods; use existing open-source algorithms and develop custom algorithms to answer key cancer genomics questions using data from short Illumina and long-read multiple technologies whole genomics sequencing, short-read Illumina and long-read PACBio whole transcriptome sequencing, single cell RNAseq, single cell ATACseq, ChipSeq, HiC, HiChiP, spatial transcriptomics, mass spec proteomics, immunopeptidomics, and spatial proteomics including CyTOF Imaging Mass Spectrometry and microarray data sets – 2+ Participate in the optimization of the data life cycle for each project including the use of local and central archival storage, and the submission of mature datasets to the appropriate public databases+ Updating codes to current versions on a 6 monthly basis and making and documenting improvements to the current codes+ Integrating somatic mutations, translocations, amplifications, deletions, proteomics and epigenetics data into databases for visualization+ Incorporate newly generated omics data sets in large-scale databases to support data-mining including integration with publicly available omics databases + Develop and implement machine learning including artificial- and convolutional neural networks and other sophisticated algorithmsWorks with staff on scientific programming and experimental design. + Work with GB collaborators+ Work with staff on scientific programming and experimental design Prepare summaries and reports; attend meetings; present results and findings to staffRecords observations and report results at weekly laboratory meetings. + Reading and presentation of current literature relevant to current ongoing effortsProvides statistical support / analysis on research data. + Develop and implement codes to analyze histological images, spatial transcriptomic or proteomic and other digital imaging data – 3Evaluates new types of experimental approaches to protocols based on knowledge of scientific literature, available facilities and research needs. + Create generalizable code bases to improve and support development of pipelines for the analysis, interpretation and visualization of next-generation sequencing data Develop interactive shareable code solution using technologies like Jupyter KnitR for collabora-tors and actively maintain them in a centralized version controlled repository in Github+ Collaborate with Genetics Branch PIs, biologists, clinicians, PI team based computational staff, and OMICS facility staff to understand their experimental and technical goals and suggest statistical and bioinformatics solutions for biological and translational questions such as mechanisms of oncogenesis, drug target discovery, drug mechanism elucidation and patient stratification efforts – 1Initiates interdisciplinary collaborations with other research centers. Deliver at least one presentation per year to audiences outside the Government. + Manuscript writing, presentation of scientific projects at lab, local, and national scientific meetings1, 2, 3, 4, 5 represents priority rankings, where 1 is highest priority and 5 is lowest priority of those rankedMinimum Education+ + + Master’sCertifications & Licenses+ Ph.D in Biology, Life Sciences or a related discipline. + Three (3) years of specialized experience plus a Master s degree is equivalent to a Ph.D. + Five (5) years of specialized experience plus a Bachelor s degree is equivalent to a Ph.D.+ Minimum of four (4) years of experience in a laboratory environment.Skills (Ranked By Priority)+ Knowledge of laboratory safety procedures.+ Research experience in T cell culture, and T cell phenotype and function assays including multiparametric flow cytometry and ELISA.+ Research experience in molecular biology including DNA cloning and the construction and use of viral vectors.+ Research experience using murine models and animal-handling skills. + Research experience with T cell receptor (TCR) or chimeric antigen receptor (CAR) gene therapy is preferred but not required.+ Strong communications skills, both oral and written.+ Excellent analytical, organizational and time management skills.1, 2, 3, 4, 5 represents priority rankings, where 1 is highest priority and 5 is lowest priority of those rankedSoftware+ Expertise in Microsoft Office Suite (MS Word, PowerPoint, Excel, Outlook).Field of Study+ BiologyBenefits:+ 100% Medical, Dental & Vision premium coverage for Employees+ Paid Time Off (Including Holidays)+ Employee Referral Bonus+ 401K Match+ Tuition reimbursement and professional development opportunities+ Flexible Spending Accounts:+ Healthcare (FSA)+ Parking Reimbursement Account (PRK)+ Dependent Care Assistant Program (DCAP)+ Transportation Reimbursement Account (TRN)The diversity of Axle s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment-based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.Accessibility: If you need an accommodation as part of the employment process, please contact …@axleinfo.com.Disclaimer: The above is meant to illustrate the general nature of work and level of effort being performed by individual s assigned to this position or job. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job or responsibilities as needed.ID: 2021-2421 External Company URL: www.axleinfo.com Street: 6116 Executive Blvd

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