Publication A specific nuclear DNA background is required for high frequency lymphoma development in transmitochondrial mice with G13997A mtDNA.

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First Author 

Hashizume O Year 

2015
Journal 

PLoS One Volume 

10
Issue 

3 Pages 

e0118561
PubMed ID 

25738506 Mgi Jnum 

J:233444
Mgi Id 



MGI:5784636

Doi 

10.1371/journal.pone.0118561
Citation 

Hashizume O, et al. (2015) A specific nuclear DNA background is required for high frequency lymphoma development in transmitochondrial mice with G13997A mtDNA. PLoS One 10(3):e0118561
abstractText 

We previously found that mouse mitochondrial DNA (mtDNA) with a G13997A mutation (G13997A mtDNA) controls not only the transformation of cultured lung carcinoma cells from poorly metastatic into highly metastatic cells, but also the transformation of lymphocytes into lymphomas in living C57BL/6 (B6) mice. Because the nuclear genetic background of the B6 strain makes the strain prone to develop lymphomas, here we examined whether G13997A mtDNA independently induces lymphoma development even in mice with the nuclear genetic background of the A/J strain, which is not prone to develop lymphomas. Our results showed that the B6 nuclear genetic background is required for frequent lymphoma development in mice with G13997A mtDNA. Moreover, G13997A mtDNA in mice did not enhance the malignant transformation of lung adenomas into adenocarcinomas or that of hepatocellular carcinomas from poorly metastatic into highly metastatic carcinomas. Therefore, G13997A mtDNA enhances the frequency of lymphoma development under the abnormalities in the B6 nuclear genome, and does not independently control tumor development and tumor progression.

 

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