. 2021 Dec 31;33(6):708-718.
doi: 10.21147/j.issn.1000-9604.2021.06.07.
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Chin J Cancer Res.
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Abstract
The profiling of plasma cell-free DNA (cfDNA) is becoming a valuable tool rapidly for tumor diagnosis, monitoring and prognosis. Diverse plasma cfDNA technologies have been in routine or emerging use, including analyses of mutations, copy number alterations, gene fusions and DNA methylation. Recently, new technologies in cfDNA analysis have been developed in laboratories, and potentially reflect the status of epigenetic modification, the immune microenvironment and the microbiome in tumor tissues. In this review, the authors discuss the principles, methods and effects of the current cfDNA assays and provide an overview of studies that may inform clinical applications in the near future.
Keywords:
cancer diagnosis; cfDNA; liquid biopsy; recurrence monitoring; therapy response.
Copyright ©2021Chinese Journal of Cancer Research. All rights reserved.
Conflict of interest statement
Conflicts of Interest: The authors have no conflicts of interest to declare.
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