Dissertations.se: SCHWANNOMA

  • Author : Patrick Buckley; Jan Dumanski; Olivier Delattre; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Genomic microarray; Array-CGH; DNA copy number variation; Neurofibromatosis type-2; Schwannomatosis; Schwannoma; Meningioma; NF2; Chromosome 22; Genetik; Clinical genetics; Klinisk genetik;

    Abstract :
    Neurofibromatosis type-2 (NF2) is an autosomal dominant disorder with the clinical hallmark of bilateral eighth cranial nerve schwannomas. However, the diagnostic criterion is complicated by the presence of a variable phenotype, with the severe form presenting with additional tumors such as peripheral schwannoma, meningioma and ependymoma. READ MORE

  • Author : Henryk Domanski; Tumörmikromiljö; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Patologi allmän ; patologisk anatomi; General pathology; pathological anatomy; spindle cell lipoma; soft tissue; spindle cell tumors; Medicine human and vertebrates ; Medicin människa och djur ; schwannoma; neurilemoma; leiomyosarcoma; immunocytochemistry; FNA; fine needle aspiration; dermatofibrosarcoma protuberans; elastofibroma dorsi; Cytology; electron microscopy;

    Abstract :
    Fine needle aspiration cytology (FNAC) is gaining increased popularity in the diagnosis of soft tissue lesions. FNAC used as a primary examination method to obtain a morphologic diagnosis, has been part of the diagnostic work-up of patients admitted to the Musculoskeletal Tumor Center of the Lund University Hospital since 1972. READ MORE

  • Author : Caisa Marie Hansson; Jan P. Dumanski; Juha Kere; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Neurofibromatosis type 2; schwannoma; schwannomatosis; meningioma; array-CGH; chromosome 22; DNA copy number variation; methylation; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Abstract :
    Neurofibromatosis type 2 (NF2) is an autosomal dominant disorder with the clinical hallmark of bilateral vestibular schwannomas (VS). Patients affected by a severe NF2 phenotype also presents with peripheral schwannomas, meningiomas and ependymomas. The closely related disorder schwannomatosis also displays multiple schwannomas, but never VS. READ MORE

  • Author : Magdalena Benetkiewicz; Jan Dumanski; Niklas Dahl; Frank Speleman; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; DNA copy number changes; chromosome 22; genomic microarray; array-CGH; schwannoma; neurofibromatosis type 2; ovarian carcinoma; breast cancer; Wilms tumor; Genetik; Genetics; Genetik;

    Abstract :
    The array-based form of comparative genomic hybridization (array-CGH) is a new methodology that has shown to be of significant importance. This thesis focuses on the development of array-CGH with the aim to define candidate regions/genes on chromosome 22 in a wide spectrum of cancer-related conditions. READ MORE

  • Author : Abdul Rahman Mohummad Al-Shudifat; Neurokirurgi; []
    Keywords : Skull base tumors; Vestibular schwannoma; Prognostic factors;

    Abstract :
    Skull base tumors comprise different pathological entities, making establishment of management guidelines challenging. All trials to define the ideal outcome measurement which can be reflected on treatment and prognosis improvement, are not conclusive with a lot of methodological criticism. READ MORE

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