A cross-sectional healthy-control study of serum inflammatory biomarkers interleukin (IL)-1B and IL-2R in panic disorder patients and their offspring

Elsevier

Available online 11 March 2022

Journal of Psychiatric Research
doi.org/10.1016/j.jpsychires.2022.03.004Get rights and content

Highlights

Alterations in the immune system have been associated with a variety of mental illnesses.

An increase in circulating inflammatory cytokines is observed not only in people with mental disorders but also in their first-degree relatives.

Panic disorder is associated with increase cytokines levels.

To better understand the role of cytokines in PD pathophysiology, we compared the levels of serum inflammatory biomarkers interleukin (IL)-1B and IL-2R among PD patients, offspring of PD patients and healthy controls.

The levels of proinflammatory markers IL-1B and IL-2R were increased in PD patients compared to those of controls, but offspring of PD patients and healthy controls demonstrated no differences regarding peripheral interleukin levels.

Our findings suggest that interleukins might represent a disease-dependent marker in PD.

Abstract

Alterations in the immune system have been associated with a variety of mental illnesses. An increase in circulating inflammatory cytokines is observed not only in people with mental disorders but also in their first-degree relatives. A considerable amount of data support the link between immune system activation and panic disorder (PD) pathogenesis, while it is still unclear whether differential immunological reactivity represents a propensity, a measure of disease activity, or both. To better understand the role of cytokines in PD pathophysiology, we compared the levels of serum inflammatory biomarkers interleukin (IL)-1B and IL-2R among PD patients, offspring of PD patients and healthy controls. The offspring of PD patients were evaluated by a psychiatrist and were considered unaffected by any mental disorder at the time of the evaluation. Concentrations of the cytokines IL-1B and IL-2R were assessed using the Immulite System (Diagnostic Products Corporation). The levels of proinflammatory markers IL-1B and IL-2R were increased in PD patients compared to those of controls, but offspring of PD patients and healthy controls demonstrated no differences regarding peripheral interleukin levels. Our findings suggest that interleukins might represent a disease-dependent marker in PD.

Keywords

Immune system

Inflammation

Anxiety

Offspring

View full text

© 2022 Published by Elsevier Ltd.

Read more here: Source link

Join us at CRISPR workshops in Koper, Slovenia in 2024. Erasmus+ funds available!
This is default text for notification bar