DMRs, how common are they and how long?
Hi!
Does anyone know how common differentially methylated regions (DMRs) (or just methylated regions) are? Say, in a 10,000bp region how many DMRs can one expect?
Also, does anyone know about the distribution of the size/length of DMRs, i.e. how many CpGs are usually in a DMR? Or the usual range? E.g. is a region consisting of just 2 CpGs can be considered a methylated region?
Thanks and good day!
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That’s like asking “how many differentially expressed genes do you expect?”
That question cannot be answered without additional context, i.e. if I’m comparing cancer cells vs. normal cells, I expect a lot more differentially expressed genes than when comparing technical replicates of normal cells to each other.
GC content and CpG islands and so on are notoriously species-specific — in mammalian genomes, if you look at random 10KB regions in gene-poor loci, you’re going to find much fewer CpG clusters than when looking in 10KB regions covering multiple gene loci.
What exactly is it you’re after? I.e. why are you asking these questions in the first place?
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