Gene Set – TNFSF10

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description tumor necrosis factor (ligand) superfamily, member 10|The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] (NCBI Entrez Gene Database, 8743)
External Link www.broadinstitute.org/gsea/msigdb/cards/GNF2_TNFSF10
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Genes

30 co-expressed genes for TNFSF10 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name

AIF1
allograft inflammatory factor 1

APOBEC3A
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A

ARRB2
arrestin, beta 2

C5AR1
complement component 5a receptor 1

CCR1
chemokine (C-C motif) receptor 1

CLEC7A
C-type lectin domain family 7, member A

CSF3R
colony stimulating factor 3 receptor (granulocyte)

DPEP2
dipeptidase 2

EVI2B
ecotropic viral integration site 2B

FCGR2A
Fc fragment of IgG, low affinity IIa, receptor (CD32)

FPR1
formyl peptide receptor 1

HCK
HCK proto-oncogene, Src family tyrosine kinase

IGSF6
immunoglobulin superfamily, member 6

LILRA2
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2

LST1
leukocyte specific transcript 1

LY96
lymphocyte antigen 96

MNDA
myeloid cell nuclear differentiation antigen

MYO1F
myosin IF

NCF2
neutrophil cytosolic factor 2

P2RY13
purinergic receptor P2Y, G-protein coupled, 13

PILRA
paired immunoglobin-like type 2 receptor alpha

PLXNC1
plexin C1

RGS2
regulator of G-protein signaling 2

S100A4
S100 calcium binding protein A4

SDCBP
syndecan binding protein (syntenin)

SECTM1
secreted and transmembrane 1

SPI1
Spi-1 proto-oncogene

TLR1
toll-like receptor 1

TNFSF10
tumor necrosis factor (ligand) superfamily, member 10

UBE2D1
ubiquitin-conjugating enzyme E2D 1

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