EC               Enzyme                                 

palmitoyl-CoA 14-(E/Z)-desaturase


Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water


palmitoyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (14,15 cis/trans-dehydrogenating)

(1) palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = (14E)-hexadec-14-enoyl-CoA + 2 ferricytochrome b5 + 2 H2O [RN:R11011];
(2) palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = (14Z)-hexadec-14-enoyl-CoA + 2 ferricytochrome b5 + 2 H2O [RN:R11012]
Reaction(KEGG) Substrate Product
(14E)-hexadec-14-enoyl-CoA [CPD:C20996];
ferricytochrome b5 [CPD:C00996];
H2O [CPD:C00001];
(14Z)-hexadec-14-enoyl-CoA [CPD:C20997]

The enzyme, found in the moth Ostrinia furnacalis (Asian corn borer), produces a mixture of (E)- and (Z)- isomers. The products are subsequently truncated by partial beta-oxidation to a blend of 12(E/Z)-tetradec-12-enoyl-CoA, which are converted to the species-specific sex pheromones (E)- and (Z)-tetradec-12-enoyl acetates.


EC created 2015

Reference   Authors

Roelofs WL, Liu W, Hao G, Jiao H, Rooney AP, Linn CE Jr


Evolution of moth sex pheromones via ancestral genes.

  Journal Reference   Authors

Xue B, Rooney AP, Kajikawa M, Okada N, Roelofs WL


Novel sex pheromone desaturases in the genomes of corn borers generated through gene duplication and retroposon fusion.

  Journal Reference   Authors

Sakai R, Fukuzawa M, Nakano R, Tatsuki S, Ishikawa Y


Alternative suppression of transcription from two desaturase genes is the key for species-specific sex pheromone biosynthesis in two Ostrinia moths.

  Journal Other DBs
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