Dissertations.se: MITOCHONDRIAL DNA REPLICATION

Author : Josefin M. E. Forslund; Sjoerd Wanrooij; Nasim Sabouri; Erik Johansson; Claes Gustafsson; Umeå universitet; []
Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mitochondria; mitochondrial DNA; DNA replication; DNA lesions; DNA polymerase γ; ribonucleotide incorporation; medicinsk biokemi; Medical Biochemistry;

Abstract :
Eukaryotic cells have their own energy-producing organelles called mitochondria. The energy is stored in the adenosine triphosphate (ATP) molecule and is produced via the oxidative phosphorylation process inside the mitochondria. Thirteen of the essential proteins required for this process are encoded on the mitochondrial DNA (mtDNA). READ MORE

Author : Ali Al-Behadili; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mitochondria; Mitochondrial DNA replication; DNA replication; Primer removal; RNase H1; Primer formation; Replication initiation; mitochondrial diseases;

Abstract :
Mitochondria are vital for cell survival, and the primary producers of ATP, the energy currency used for various metabolic processes. Mitochondria are unique from other cellular compartments because they have their own genomes of circular small double-stranded DNA (mtDNA) of approximately 16. READ MORE

Author : Elisabeth Jemt; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
Keywords : NATURVETENSKAP; NATURAL SCIENCES; mitochondria; mtDNA; DNA replication;

Abstract :
Mitochondria produce most of the adenosine triphosphate required in a eukaryotic cell and they contain their own genome. The mitochondrial DNA (mtDNA) is a double stranded circular molecule that codes for proteins required for cellular respiration and RNA molecules involved in translation of these proteins. READ MORE

Author : Katrin Kreisel; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ribonucleotides; DNA instability; DNA polymerase eta; nuclear DNA; mitochondrial DNA;

Abstract :
The genetic code in the eukaryotic cell is stored in the form of DNA, which is more resistant to hydrolysis than RNA. Replication fidelity and DNA repair mechanisms are in place to ensure genomic integrity to preserve the information encoded. READ MORE

Author : Majda Mehmedovic; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mitochondria; mtDNA; replication; transcription; TFAM;

Abstract :
Mitochondria are organelles in eukaryotic cells, which through oxidative phosphorylation (OXPHOS) produce most of the ATP used to drive cellular processes. The organelle contains its own genetic material, mitochondrial DNA (mtDNA), which encodes 13 key components of the OXPHOS machinery. READ MORE