Sr. Research Associate, Bioinformatics job with F. Hoffmann-La Roche AG

The Bioinformatics Senior Research Associate is responsible for designing and troubleshooting PCR-based assays for use with the GenMark Dx ePlex platform. The ideal candidate must be able to work in a collaborative research and IVD product development environment and demonstrate ability to analyze sequence data to drive assay development.

The ideal candidate will have a strong background in molecular diagnostics and assay development and possess the ability to solve problems efficiently and creatively. This person will have the ability to balance dynamic priorities, adapt positively to new challenges, and work well with team members from varying internal organizations including scientists, engineers, clinical specialists, and the commercial organization.

Your key responsibilities

  • Design primers and probes for PCR-based assays for use on the GenMark Dx ePlex platform.

  • Perform bioinformatics analysis of sequence data to increase specificity and sensitivity in the context of multiplexed PCR and detection reactions.

  • Assist in maintaining and optimizing scripted tools as a part of the assay design pipeline.

  • Provide presentations, feedback, and suggestions to lab scientists based on data analysis.

  • Provide bioinformatics support for commercially available molecular diagnostics tests (3rd tier customer support).

Who you are

  • B.S., M.S., or Ph.D. in Bioinformatics, Genomics, Genetics, or related field

  • Must be consistent with college level education. Knowledge of basic statistics relevant to interpretation and analysis of scientific data, including characterization of assay performance is required.

  • Proficient in one or more languages: R, Python, Perl, and/or Excel VBA.

  • Comprehensive understanding of the multiple public data repositories and how to obtain data from them.

  • Hands-on experience analyzing biological sequence data, both from public databases and raw chromatograms.

  • Experience with standard assay design software such as Geneious.

  • Proficient using MS Office software.

  • Commitment to adhere to internal processes and maintain accurate and complete documentation of design work.

Who we are

A member of the Roche Group, GenMarks ePlex true sample-to-answer system symbolizes the evolution of eSensor technology combined with digital microfluidics. ePlex offers unique solutions to address the most significant challenges facing clinical laboratories, while supporting hospital systems to deliver patient-centered, value-based care. ePlex streamlines the diagnostic workflow from physician order entry to the final test report and is the only true sample-to-answer solution designed to improve patient care, reduce costs, and increase lab efficiency. GenMark is headquartered in Carlsbad, California.

GenMark is an equal opportunity employer and strictly prohibits unlawful discrimination based upon an individuals race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law.

Job Level:

Individual contributor

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