Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals

  • U.A.T., D.H.K., J.A.-P., A.G.B., T.J.W., J.G.W., C.B.P., P.N., and R.E.G contributed to the original concept of the project, planned these analyses, and formulated the methods. D.H.K., U.A.T., D.N., M.D.B., Z-Z.C., J.M.R., D.E.C., SD, L.F., S.S.R., M.E.H., A.C., J.G.W., and R.E.G., collected, organized, and contributed to the quality control and management of JHS metabolomics data. D.H.K., U.A.T., X.S., S.Z., D.N., M.D.B., J.M.R., D.E.C., S.D., L.F., S.S.R., D.S, R.P.T., P.D., K.D.T., Y.L., W.C.J., X.G., J.Y., Y.-D.I.C, A.W.M., S.S.R., J.I.R., and R.E.G., collected, generated, organized, and contributed to the quality control and management of MESA metabolomics data. D.H.K., U.A.T., D.N., M.D.B., J.M.R., D.E.C., S.D., L.F., S.S., D.S, C.B., M.A.S., and R.E.G. collected, generated, organized, and contributed to the quality control and management of HERITAGE Family Study metabolomics and genomic data. F.L.R and W.S.B contributed to the validation of unknown metabolite identities. D.J. and TOPMed performed W.G.S. from JHS and MESA. D.H.K., U.A.T, A.G.B, A.P., Z.Y., A.E., S.D., P.N., and R.E.G. developed the WGS analysis pipeline and statistical methods across all metabolomics data. D.H.K., U.A.T., J.A.-P., C.B.C., P.N., and R.E.G. analyzed the data and wrote/revised the article.

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