Bioinformatics Scientist I/II – Codexis


Are you ready to join our mission to improve the health of people and the planet?  Do you have a passion for science and the transformational role that enzymes are playing?   Come be part of our team at Codexis, Inc. We are a leading enzyme engineering company leveraging our proprietary CodeEvolver® technology platform to discover and develop novel, high performance enzymes and novel biotherapeutics.  

Codexis combines bioinformatics with directed evolution to uniquely engineer enzymes  with applications in sustainable manufacturing of pharmaceuticals, food and industrial productsand  along with next generation biotherapeutics with transformative properties. We engineer proteins with high efficacy and safety with the goal of delivering the therapeutic to patients as an oral biologic, or gene therapy.

We are hiring a Bioinformatics Scientist I/II to join our Computational Biology Team

If any of the below describes you, we would love to meet you! 

  • Do you have a solid foundation in structural biology?
  • Do you find it exciting to utilize novel technologies for protein engineering and directed evolution?
  • Can you see yourself working in a collaborative team environment where you get play a role in the success of cross functional projects?

In this role you will be responsible for:

  • Providing project support to laboratory scientists for the engineering of novely developed enzymes for our performance enzymes business unit.
  • Generating reliable structural models of enzymes using software such as MOE, Discovery Studio, Rosetta and AlphaFold.
  • in-silico docking of substrates/products/transition states into the active site of an enzyme. 
  • Structural modeling, docking, analysis and visualization of proteins via HTS.
  • Working with next-generation sequencing data to help indentify/model more robust variants for development.
  • Utilizing machine learning techniques as it applies to structural biology 

To be successful in this role, your background and experience should include:

  • A PhD is required plus Postdoctoral work with emphasis in computational or structural biology with proteins, preferably enzymes.
  • A solid understanding of enzyme mechanisms reflected in publication record and/or resume.
  • Two years of experience in a biotechnology working environment is preferred
  • A good understanding of molecular biology and biochemistry.
  • Some hands on wet-lab experience or extensive experience working directly with wet-lab scientists
  • Some experience with Python, Java, or another programming language.
  • Experience or background with wet lab techniques.
  • Strong multitasking and organizational skills
  • A team player who is comfortable collaborating with experimentalists.
  • Self-motivated with a history of identifying solutions to complex problem
  • Level of role is determined by level of experience

What can Codexis offer you? (besides an amazing and collaborative culture?)

  • Full benefits your first day
  • 100% match on 401k (up to 4%)
  • Generous flex time off
  • Fitness reimbursement
  • Free fitness classes
  • Back up child/dependent care
  • Student loan assistance
  • Commuter vouchers


Codexis is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status.


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