SR. SCIENTIST, HUMAN GENETICS BIOINFORMATICS in San Francisco, CA for Genentech

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People come to Genentech from across disciplines and across the world to solve our most challenging medical conditions. You’ll find inspiration in our passion for biotechnology, our purpose to positively impact the lives of millions of patients and our dedication to our people. Joining Genentech means being part of a tradition of inquiry that will change the world. It means embracing our failures as much as our successes. It requires a willingness to look beyond the edge of what’s possible. And a focus on doing the day-to-day work that makes great science happen.

The following opportunity exists in South San Francisco, CA: 

SR. SCIENTIST, HUMAN GENETICS BIOINFORMATICS

The Department of Human Genetics is seeking a Computational Biologist with a record of high impact research for a Senior Scientist position. Genentech has access to vast, and growing, repositories of genetic, genomic and clinical data, from internal studies (including our clinical trials and high throughput screens), collaborations with academic and industry partners,  and public external data sets. The new hire will lead development of analytical approaches to integrate and interpret these data, delivering insights into disease biology to propel our translational goals, most obviously through the identification of novel therapeutic targets and biomarkers for disease onset and/or progression, and treatment response.

• We are particularly interested in candidates with skill sets that position them to tackle challenges in multimodal data integration as it relates to human biology. What are the effective strategies for insightful integration of multimodal data at scale to deliver causal inference regarding disease pathogenesis? How do we connect association signals from GWAS to the effector genes and identify the cell-types, pathways, and processes through which they exert their effects? How do we integrate a diversity of data types, relevant to efficacy, safety, and druggability, to prioritize the most promising targets for a given disease? Thus to be successful, the candidate will need to have a broad range of skills in areas that include: association analysis in array- and sequence-based genotype data, analysis of sequence-based molecular assay data (eg RNA-Seq), integration of genetic and molecular data, AI/ML approaches, and a profound understanding of causal inference. Proficiency in the use of high performance computing is a must.

As well as developing and implementing a transformational research program in these areas, working closely with colleagues and mentors in Human Genetics, the appointee will be responsible for:

• Extensive collaboration with colleagues across “Translational Genomics” who are responsible for the generation and analysis of data arising from our capabilities in molecular profiling, spatial analysis and perturbation assays

• Extensive collaboration with colleagues in Neuroscience (and other Therapeutic Areas) who will take the biological insights generated and turn them into actionable hypotheses and lead molecules

• Design and execution of targeted analyses to uncover novel therapeutic targets and biomarkers of disease heterogeneity, progression, and treatment response

  • Maintaining an excellent publication record

  • Presentation and communication of findings in cross-functional teams

  • Initiation of and participation in strategic external collaborations in pursuit of these goals.

Genentech is committed to the development and delivery of precision medicines, which take individual variation as well as diagnosis into account in the delivery of health care. Because genetic makeup is a major component of individual variation, the work of the Human Genetics Department is a central pillar for achieving our vision of modern medicine, and the scientists in the Department are key contributors to making this happen. Major disease areas of interest to Genentech include a range of chronic inflammatory and neuro-degenerative conditions, as well as diverse cancers, and a number of ophthalmic and metabolic diseases. Though the principal focus of this position will be in Neuroscience, we expect the research findings to have broad relevance across all disease areas.

Genentech provides an exceptional research environment composed of internationally recognized scientific leaders, as well as state of the art core facilities with cutting edge technologies and computational resources to support your research activities. We provide a highly collaborative community, and as such, you will interact closely with clinical development teams and other scientists in the areas of biomarkers, bioinformatics, and research discovery departments including Immunology, Neuroscience, Infectious Diseases, Cancer Immunotherapy, and Molecular Oncology.

Qualified candidates will typically have the following attributes:

• PhD training with a strong focus on human genetics, Computational Biology or a related field

• Substantial (typically at least 3-5y) experience in academia or industry (as a postdoc or equivalent role) engaged in computational biology research or a related field

• A thorough understanding of biostatistics & statistical genetic methods

• Extremely strong computational skills, with demonstrable competence in the management and analysis of large scale data, proficiency in high-level programming languages and statistical computing

• An excellent record of scientific publications in top tier journals

• Strong communication and interpersonal skills with the ability to present and explain findings to a diverse audience

• Motivation and ability to succeed in a fast-paced, highly collaborative environment

• A keen interest in applying computation to solve biological problems and achieve translational goals

• A scientific background in neuroscience would be a plus, but is not essential

• Experience in the application of AI/ML methods would be a major plus

Relocation benefits are available for this position.

Who We Are

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work. Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page

Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.

Genentech requires all new hires to be fully vaccinated against COVID-19 as of their start date. This requirement is a condition of employment at Genentech, and it applies regardless of whether the position is located at a Genentech campus or is fully remote.  If you are unable to receive the vaccine due to a disability or serious medical condition, or because it is prohibited as a result of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.