Phenotypes for Epcam MGI:5476929 MGI Mouse


Phenotypes Associated with This Genotype

Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:

EpcamGt(RST412)Byg mutation

(0 available);
any

Epcam mutation

(26 available)



Tufting enteropathy in EpcamGt(RST412)Byg/EpcamGt(RST412)Byg mice

mortality/aging

digestive/alimentary system


• smaller at 3 days of age



• epithelial tufts increase over time in the small intestine and colon



• surface enterocyte disorganization and crowding is focally distributed along the small intestine

• necrosis is seen



• progressive villous atrophy starting at birth and resulting in essential loss of normal mucosal architecture by P4



• colon crypts show aberrant pseudo-cyst aspects and highly proliferative enterocytes



• crypts show aberrant pseudo-cyst aspects and highly proliferative enterocytes



• hemorrhagic enteritis is evident from P0


growth/size/body


• smaller than littermates by P2



• unable to gain weight


cardiovascular system


• hemorrhagic enteritis is evident from P0


endocrine/exocrine glands


• colon crypts show aberrant pseudo-cyst aspects and highly proliferative enterocytes




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