Recommendations needed for a tool for comparative gene set enrichment analyses via a webserver

Recommendations needed for a tool for comparative gene set enrichment analyses via a webserver

1

dear All,

I’d like to compare 6 gene expression datasets (multiple conditions / time-points)
in terms of joint patterns in the enrichments of the differentially expressed genes.
The DEG lists I have prepared (logFC,padj). GO and KEGG enrichments would be nice, the more
options the better. All should be doable via a Webserver. And the enrichment method should
be state-of-the-art, GSEA may be a very good choice. The geneset databases should be up-to-date.

Long ago, I used ToppCluster, which I liked because I could simultanously enter all the
datasets, and it returned similar enrichments in some of the datasets in a nice table.

  • Are there other good options, maybe better ones? Optimally, the tool allows further useful
    analyses and visualizations.
  • For the time-series, considering the temporal aspect explicitly would be nice, but usually
    the first and the last time-point are most informative so that it boils down to two conditions.

kind regards,

georg


set


webserver


enrichment


gene


analyses

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