Sr. Scientist, Heme BioInformatics, Translational Medicine Onc R&D – AstraZeneca

AstraZeneca is a global, science-driven biopharmaceutical company. We are dedicated to discovering, developing, and delivering innovative, meaningful medicines and healthcare solutions that enrich the lives of patients. The vision of AstraZeneca Oncology is to redefine cancer, redefine our solutions to cancer, and restore patients’ lives.

Within Hematology R&D, we are committed to advancing the science to deliver life-changing medicines to patients most in need. With a combination-focused pipeline that exploits the power of six scientific platforms (Immuno-Oncology, Tumor Drivers and Resistance, DNA Damage Response, Antibody-drug Conjugates, Cell Therapy, and Epigenetics) to help address unmet clinical needs in a host of hematological cancers, we are motivated by a dedication to the scientific discovery and collaboration that will one day help eliminate cancer as a cause of death. This unit has responsibility for the value chain from discovery through to late-stage development, enabling rapid acceleration of promising early-stage assets and life-cycle management programs.

The Translational Medicine function exists within Hematology R&D to ensure effective and strategic biomarker studies for Hematology & Oncology project teams. Closely interacting with the pre-clinical Discovery, Early Clinical Development, and Precision Medicine & Biosamples diagnostics functions, the Hematology Translational Medicine team is the single point of accountability for delivery of robust, scientifically-driven biomarkers to all Hematology project teams, providing feasibility assessments, technical validation, centralized biomarker analysis capability for clinical samples, delivery of translational science research and early clinical phase engagement.

Main Duties and Responsibilities:
Develop and perform innovative computational analyses of multi-modal data from clinical trial samples in AZ’s key targeted assets.

Be an integral part of drug project and clinical teams to understand their scientific and technical challenges and proactively impact these using bioinformatics.

Apply data and knowledge analytics to deliver actionable insights driving discovery and development of the next generation of cancer medicines.

Discover new insights from complex biological data via innovative analysis or visualization.

Work with internal groups, collaborators, and external companies to influence generation of data assets and analytical methods.

Build internal analytical capabilities to enable peers and bench scientists to explore and understand complex data.

Positively contribute to the field of oncology via presentations at conferences and publications in high impact journals.

Minimum Requirements:
Relevant Ph.D (or equivalent graduate degree plus proven applied experience), combining:

technical expertise in either bioinformatics, computational biology, or biostatistics.

a deep understanding of the molecular mechanisms driving cancer and/or ctDNA biology.

R and/or Python programming and visualization expertise, experience with Unix environment and high-performance computing environments and/or cloud computing environments (AWS, etc.).

Skilled in effective communication of complex data to non-experts.

Enthusiasm and persistence in the application of analytical methods to complex biological problems.

Capability of successfully managing multiple simultaneous projects.

Working effectively within cross-disciplinary science teams.

Experience contributing to the research community through publication, conferences, and code sharing.

Desirable Requirements:
Working experience with machine learning, artificial-intelligence, Bayesian analytics or other non-traditional approaches to model biological data

Strong publication record.

Strong established network within external bioinformatics and oncology communities.

Working at AstraZeneca

Here you’ll have the chance to create a substantial difference to patients’ lives! With science at its heart, this is the place where breakthroughs born in the lab become transformative medicines – for the world’s most complex diseases. Answer unmet medical needs by pioneering the next wave of science, focusing on outcomes and crafting the patient ecosystem.

Next Steps? Apply now!

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

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