Fbxw7 Targeted Allele Detail MGI Mouse (MGI:3038749)

Fbxw7tm1Sje
Targeted Allele Detail


Symbol: Fbxw7tm1Sje
Name: F-box and WD-40 domain protein 7; targeted mutation 1, Stephen Elledge
MGI ID: MGI:3038749
Synonyms: Fbw7
Gene: Fbxw7  Location: Chr3:84722575-84886505 bp, + strand  Genetic Position: Chr3, 37.7 cM, cytoband E3.3
Alliance: Fbxw7tm1Sje page
Germline Transmission:  Earliest citation of germline transmission:

J:88903

Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin: 

129S7/SvEvBrd-Hprtb-m2

Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion

 
Mutation detailsExons 5 and 6, which encode the F-box, were deleted via cre mediated recombination of loxP sites inserted in introns 4 and 6. An frt-flanked neo cassette remained in intron 4 after the excision of the floxed fragment.
(J:88903)

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View phenotypes and curated references for all genotypes (concatenated display).
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available
    
Cell Lines: 0 lines available
Carrying any Fbxw7 Mutation:  64 strains or lines available
Original:  J:88903 Tetzlaff MT, et al., Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3338-45
All:  1 reference(s)

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