Merck’s Keytruda Combo Therapy Less Effective Than Chemo In Lung Cancer Patients, Data Shows

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  • Merck & Co Inc’s (NYSE: MRK) MK-7684A failed the open-label portion of a Phase 2 study KeyVibe-002 trial.

  • MK-7684A, a combination of Keytruda (pembrolizumab) and in-house anti-TIGIT compound vibostolimab, did not improve patients’ progression-free survival compared to chemotherapy in patients with metastatic non-small cell lung cancer (NSCLC) with progressive disease after treatment with immunotherapy and platinum-doublet chemotherapy.

  • Also Read: Merck’s Keytuda+Chemo Combo Improves Overall Survival In Patients With Advanced Mesothelioma.

  • Results also showed that the coformulation was numerically less effective than docetaxel (chemo).

  • Merck is notifying study investigators that patients in this arm of the study should be switched to a standard of care unless their physician considers the patient is benefitting from MK-7684A alone.

  • The blinded arms of the study will continue to evaluate MK-7684A with docetaxel versus docetaxel alone further.

  • Last year, Merck discontinued the Phase 3 KEYNOTE-641 trial evaluating Keytruda (pembrolizumab) combined with enzalutamide and androgen deprivation therapy for metastatic castration-resistant metastatic prostate cancer, and the Phase 3 KEYNOTE-789 trial of Keytruda plus pemetrexed plus platinum-based chemotherapy in metastatic nonsquamous non-small cell lung cancer.

  • Price Action: MRK shares are down 1.15% at $106.11 on the last check Friday.

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This article Merck’s Keytruda Combo Therapy Less Effective Than Chemo In Lung Cancer Patients, Data Shows originally appeared on Benzinga.com

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