hiPSC-based models to decipher the contribution of human astrocytes to Alzheimer’s disease and potential therapeutics | Molecular Neurodegeneration

  • Arranz AM, De Strooper B. The role of astroglia in Alzheimer’s disease: pathophysiology and clinical implications. Lancet Neurol. 2019;18(4):406–14.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Liao MC, Muratore CR, Gierahn TM, Sullivan SE, Srikanth P, De Jager PL, et al. Single-cell detection of secreted Aβ and sAPPα from human IPSC-derived neurons and astrocytes. J Neurosci. 2016;36(5):1730–46.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Oksanen M, Petersen AJ, Naumenko N, Puttonen K, Lehtonen Š, GubertOlivé M, et al. PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer’s Disease. Stem Cell Reports. 2017;9(6):1885–97.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Oksanen M, Hyötyläinen I, Trontti K, Rolova T, Wojciechowski S, Koskuvi M, et al. NF-E2-related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimer’s disease astrocytes. Glia. 2020;68(3):589–99.

    Article 
    PubMed 

    Google Scholar
     

  • Lin YT, Seo J, Gao F, Feldman HM, Wen HL, Penney J, et al. APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types. Neuron. 2018;98:1–14.

    Article 

    Google Scholar
     

  • TCW J, Qian L, Pipalia NH, Chao MJ, Liang SA, Shi Y, et al. Cholesterol and matrisome pathways dysregulated in astrocytes and microglia. Cell. 2022;185(13):2213–33.e25.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Glasauer SMK, Goderie SK, Rauch JN, Guzman E, Audouard M, Bertucci T, et al. Human tau mutations in cerebral organoids induce a progressive dyshomeostasis of cholesterol. Stem Cell Reports. 2022;17(9):2127–40.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Arnaud L, Benech P, Greetham L, Stephan D, Jimenez A, Jullien N, et al. APOE4 drives inflammation in human astrocytes via TAGLN3 repression and NF-κB activation. Cell Rep. 2022;40(7):111200.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhao J, Davis MD, Martens YA, Shinohara M, Graff-radford NR, Younkin SG, et al. APOE e 4 / e 4 diminishes neurotrophic function of human iPSC-derived astrocytes. Hum Mol Genetics. 2017;26(14):2690–700.

    Article 
    CAS 

    Google Scholar
     

  • Zhao J, Fu Y, Yamazaki Y, Ren Y, Davis MD, Liu CC, et al. APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids. Nat Commun. 2020;11(1):5540.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Guttikonda SR, Sikkema L, Tchieu J, Saurat N, Walsh RM, Harschnitz O, et al. Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer’s disease. Nat Neurosci. 2021;24(3):343–54.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • McAlpine CS, Park J, Griciuc A, Kim E, Choi SH, Iwamoto Y, et al. Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease. Nature. 2021;595(7869):701–6.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Preman P, Tcw J, Calafate S, Snellinx A, Alfonso-Triguero M, Corthout N, et al. Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques. Mol Neurodegener. 2021;16(1):1–18.

    Article 

    Google Scholar
     

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