Principal BioInformatics Software Engineer at Roche in Pleasanton, CA 202303-107415

The Position

Impact Healthcare
Roche Sequencing is not only changing science, but we are changing lives! Our team is pushing the boundary of technology with next-generation genomic sequencing. You will develop products that scientists and others in the life sciences will use to diagnose, find treatments, and eventually beat diseases like cancer.

Make a Big Difference
Do you want a career that enables you to make a huge difference? If so, we want you on our team! We are seeking a Principal Software Engineer to partner with bioinformatics scientists and software developers in support of building the underlying bioinformatics analysis algorithms and workflows to support Next-Generation Targeted Sequencing solutions. Own the efforts to productionize and optimize bioinformatics software working with collaborative and multi-disciplinary teams.


  • Develop efficient, maintainable, and documented production software from scientific prototype code or specifications using software development best practices.

  • Define requirements for sophisticated bioinformatics software applications to develop solutions to complex algorithmic and machine learning problems; such as in the area of secondary analysis (read processing, variant calling) for next generation sequencing.

  • Conduct system-level analysis of software to include requirements, design, testing, modifications, planning, and performance.

  • Review software / algorithm specifications and code to provide feedback on potential areas of improvement. Ex. efficiently leveraging accelerated/parallel computing.

  • Continuously improve software development processes by implementing innovative methodologies and standards used by the Bioinformatics department for software development and testing.

  • Document work and provide updates at team and project meetings.

  • Mentor, train, and guide other developers in software standard methodologies including other bioinformaticians in the department.

  • Represent the project and team at various stakeholder meetings.

  • Conduct risk analysis and assessment of integrated software projects.


  • Master’s degree in Computer Science, Computational Biology or equivalent technical field; or equivalent combination of education and experience to perform at this level.

  • 8+ years of experience developing software for enterprise-level customer-facing applications, including 3+ years of experience working as a BioInformatics engineer or computational biologist contributing to Next Generation Sequencing.

  • Expertise in programming languages such as Python and Java development.

  • Proficient in microservices architecture and distributed computing in a Linux environment.

  • Experience with various software development and support related tools such as PyTest, jUnit, Cucumber, Behave, and Command Line Tools (Linux Shell), Maven, Github.

  • A demonstrated skill set for developing and tuning algorithms is preferred.

  • Experience with workflow management tools such as Nextflow or Snakemake is preferred.

  • Experience with Machine learning / Deep learning (used in NGS context) is a plus.

  • Experience with C/C++ is a plus.

  • Experience developing for cloud platforms such as AWS or Google Cloud is a plus.

  • Experience with GPU acceleration architecture and development is a plus.

  • Experience developing software for diagnostics or medical devices is a plus.

  • Experience with Behavioral and Test Driven Development (BDD) principles is a plus.

Relocation assistance is not available for this role.
The expected salary range for this position based on the primary location of Pleasanton CA is $111,000-$206,100. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Unless entitled to a reasonable accommodation under applicable law, employees are required to be fully vaccinated against COVID-19 in accordance with customer requirements, the company’s health and safety obligations and/or applicable law or guidelines.

Roche is an equal opportunity employer and strictly prohibits unlawful discrimination based upon an individual’s race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law.

If you have a disability and need an accommodation in connection with the on-line application process, please email us at [email protected] .

Read more here: Source link