Anti dsDNA test is a diagnostic blood test that measures the level of antibodies in the blood that are directed against the DNA molecule in its double-stranded form. The test is primarily used to aid in the diagnosis of systemic lupus erythematosus (SLE), a chronic autoimmune disease that can affect various organs in the body, including the skin, joints, kidneys, and brain.
In SLE, the immune system attacks the body’s own cells and tissues, causing inflammation and tissue damage. Elevated levels of anti-dsDNA antibodies are a characteristic feature of SLE and can help confirm the diagnosis of the disease. The price range of the Anti-dsDNA blood test is between Rs 500 and Rs 1800 on average.
Your doctor may recommend an Anti-dsDNA test if you have the following signs and symptoms-
- Joint pain and swelling
- Unexplained fatigue, weakness, and exhaustion
- Skin rashes on the face, scalp, and neck
- A persistent fever
- Kidney problems like proteinuria, hematuria, and impaired kidney function.
- Neurological symptoms such as headaches, seizures, and cognitive dysfunction.
- Photosensitivity (to sunlight and other sources of ultraviolet radiation).
Anti-dsDNA Test Details in Brief
|Also Known As
|dsDNA antibody test, Anti-DNA (native) antibody test, Double-stranded DNA antibody test, Anti-dsDNA Ab test
|To aid in the diagnosis and management of systemic lupus erythematosus (SLE) and other autoimmune disorders.
|Overnight fasting is preferred.
|8 to 24 Hrs.
|Rs 500 to Rs 1800
Anti dsDNA Test Price
Anti-dsDNA Test Price usually ranges on an average from Rs 500 to Rs 1800. The actual price depends on the diagnostic centre and the city. Bookmerilab partners with more than 506 diagnostic centres across India. We provide a 10-50% discount on medical diagnostic tests.
Prices at Popular diagnostic centres
The table below lists the prices at some of the popular diagnostic centres.
|Name of Lab
|Dr Lal path labs
Cost in different cities
Test prices can vary from one city to another. The table below list the prices in major cities of India. You can click on city name to get list of diagnostic centres with their price and discount.
Anti Ds DNA Test Purpose
This test is ordered to help diagnose lupus, especially if there is a positive result with ANA test. The main purposes are mentioned below-
- Aid in the diagnosis of systemic lupus erythematosus (SLE) and other autoimmune disorders.
- Monitor disease activity and response to treatment in individuals with SLE.
- Predict the risk of lupus nephritis, a serious complication of SLE that affects the kidneys.
- Rule out other conditions that can cause similar symptoms, such as viral infections and other autoimmune disorders.
- Help healthcare providers make informed treatment decisions for individuals with SLE based on their disease activity and risk of complications.
- Overnight fasting is preferred.
- Inform your healthcare provider about any medications you are taking, including prescription drugs, over-the-counter medications, and dietary supplements, as they can affect the test results.
- Dress in comfortable, loose-fitting clothing that allows easy access to your arm.
- Several laboratories advise stopping taking Biotin (also known as vitamin B7, B8, H, or coenzyme R) at least 72 hours prior to providing your sample if you are taking it.
It is a fairly simple diagnostic blood test. Below are the steps to draw a blood sample from the vein in your arm or hand-
- A technician (phlebotomist) may tie a tourniquet (elastic band) to your arm.
- The phlebotomist will locate your blood vessel.
- Then the site is cleaned with spirit.
- A Needle is inserted into your vein to draw the blood.
- The blood sample is then withdrawn into a syringe or a vial.
- Cotton is placed on the puncture site with mild pressure till the bleeding stops.
- A small band-aid is then placed, which may be removed after an hour.
The entire procedure takes only a few minutes.
It is a very simple and safe test. The risks involved are the same as that of any other blood test. These include-
- Infection at the puncture site if proper sterilization protocol is not followed and the needle is contaminated. This is, however, very rare. You may ensure that your phlebotomist takes out the needle in front of you from a sterile pack.
- Multiple pricks if the blood vessel is not easily found
- Excessive bleeding at the puncture site- Please inform your healthcare provider if you are taking any blood thinners or have any bleeding disorders.
- Light-headedness due to stress or heavy bleeding.
Minor pain and bruising that might occur will resolve on their own in a very short time.
Anti dsDNA Test Result
Anti-ds DNA Antibodies are measured in the blood sample and if a considerable amount of antibody is detected the test is reported as positive, else negative.
The normal range for anti-ds DNA antibodies in the blood is considered to be less than 200 IU/mL.
- A negative result typically indicates the absence of these antibodies in the blood. However, it’s important to note that a negative result does not necessarily rule out the possibility of an autoimmune disorder, as some individuals with SLE or other autoimmune disorders may have low levels of anti-dsDNA antibodies or may not produce these antibodies at all. Autoimmune diseases such as Sjögren syndrome and mixed connective tissue disease may have low to moderate amounts of autoantibody.
- A positive result indicates that the patient has high levels of anti-dsDNA antibodies in their blood, which is a hallmark of SLE. However, a positive result alone is not sufficient to diagnose SLE, as other conditions can also cause elevated levels of anti-dsDNA antibodies.
- Limited specificity: The test may not be specific to SLE, as elevated levels of anti-dsDNA antibodies can also occur in other autoimmune and infectious diseases.
- False positives: The test may produce false-positive results in individuals without SLE, leading to unnecessary diagnostic tests and treatment.
- False negatives: The test may produce false-negative results in individuals with SLE, particularly in those with low disease activity or who are on immunosuppressive therapy.
- Variability in results: The test results can vary over time, and different laboratories may use different methods and cutoff values, making it challenging to compare results between different testing facilities.
- Inability to predict disease activity: Although the test can indicate the presence of anti-dsDNA antibodies, it cannot predict the severity or course of the disease in an individual with SLE.
In conclusion, the Anti-dsDNA blood test is a useful diagnostic tool in the evaluation of systemic lupus erythematosus and other autoimmune disorders. It can aid in the diagnosis of SLE, monitor disease activity and response to treatment, and predict the risk of lupus nephritis. However, the test has limitations, including its limited specificity and variability in results. Interpretation of the test results should be done in the context of the patient’s clinical presentation, other laboratory tests, and medical history. Overall, the Anti-dsDNA blood test is a valuable tool for healthcare providers in the management of individuals with SLE and other autoimmune disorders.
It is a blood test that measures the levels of antibodies against double-stranded DNA (dsDNA) in the blood.
It is done to help diagnose and monitor autoimmune disorders like systemic lupus erythematosus (SLE).
A healthcare provider will draw blood from a vein in the arm and send it to a laboratory for testing.
No special preparation is needed before the test. However, overnight fasting is preferred.
Elevated levels of anti-dsDNA antibodies can indicate autoimmune disorders like SLE, while normal levels are typically seen in healthy individuals.
The risks are minimal and may include bleeding, infection, or fainting at the site where the blood was drawn.
Yes, certain medications and medical conditions can affect the test results, and it is important to inform the healthcare provider of any medications or medical conditions prior to the test.
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