EC                Enzyme                                 

hydroxyphenylpyruvate reductase;


Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor


(R)-3-(4-hydroxyphenyl)lactate:NAD(P)+ oxidoreductase

(1) (R)-3-(4-hydroxyphenyl)lactate + NAD(P)+ = 3-(4-hydroxyphenyl)pyruvate + NAD(P)H + H+ [RN:R03337 R03339];
(2) (R)-3-(3,4-dihydroxyphenyl)lactate + NAD(P)+ = 3-(3,4-dihydroxyphenyl)pyruvate + NAD(P)H + H+ [RN:R03373 R12252]
Reaction(KEGG) Substrate
(R)-3-(4-hydroxyphenyl)lactate [CPD:C03964];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
(R)-3-(3,4-dihydroxyphenyl)lactate [CPD:C22038]
Product Comment

The enzyme participates in the biosynthesis of rosmarinic acid. It belongs to the family of D-isomer-specific 2-hydroxyacid dehydrogenases, and prefers NADPH to NADH.


EC created 1992, modified 2018

ec00130   Ubiquinone and other terpenoid-quinone biosynthesis
ec00360   Phenylalanine metabolism
ec00960   Tropane, piperidine and pyridine alkaloid biosynthesis
ec01110   Biosynthesis of secondary metabolites
K13574   hydroxycarboxylate dehydrogenase B
K18606   hydroxyphenylpyruvate reductase
NTA 107815351 107815507
OEU 111367158 111370835
SSPL 121768515 121771586 121795126 121795127 121795132 121795133 121797828
ECAD 122588587 122595340 122596024
LSV 111910276 111910278
CSIN 114279513 114323921
MING 122066597 122066860 122082675 122082676
TSS 122653576 122666837 122667233
PSOM 113348278 113349087
ZOF 122010230 122016476
ECOK ECMDS42_0651(ybiC)
ECOO ECRM13514_0878(ybiC)
ECOH ECRM13516_0833(ybiC)
EDJ ECDH1ME8569_0754(ybiC)
ECOI ECOPMV1_00803(ybiC)
KOX KOX_18735 KOX_22540
KOE A225_2618 A225_3382
KOY J415_15110 J415_18885
KOM HR38_17100 HR38_20840
KOK KONIH1_12525 KONIH1_16575
RTG NCTC13098_02582(ybiC_1) NCTC13098_03134(ybiC_2)
REE electrica_01980(ybiC_1) electrica_02154(ybiC_2)
METY MRY16398_29140(ybiC) MRY16398_42030
AHN NCTC12129_02563(ybiC)
KIN AB182_12390 AB182_18530
PDZ HHA33_15075 HHA33_21005
EBC C2U52_23280 C2U52_29745
SMW SMWW4_v1c20410(ybiC)
SFJ SAMEA4384070_2085(ybiC_2)
SOF NCTC11214_04882(ybiC)
GQU AWC35_00900 AWC35_03550
PWA Pecwa_1798 Pecwa_2132
PPAR A8F97_08210 A8F97_09785
PWS A7983_18130 A7983_22515
PPOA BJK05_02250 BJK05_04260
PARI I2D83_10070 I2D83_14995
PVZ OA04_24140 OA04_28810
PPOO LW347_07580 LW347_09670
DDD Dda3937_02253 Dda3937_02692
DSO A4U42_00945 A4U42_16640
CED LH89_04530 LH89_21165
DFN CVE23_08230 CVE23_13820
DIC Dpoa569_001506 Dpoa569_002383
DDA Dd703_1300 Dd703_1601
BGJ AWC36_08580 AWC36_10535
BNG EH206_12170 EH206_14470
GAI IMCC3135_12715(ybiC)
REH H16_B0942(h16_B0942)
BCON NL30_01730 NL30_16180
BUO BRPE64_BCDS06860(ybiC)
PVAC HC248_02881(hcxB_2)
LIM L103DPR2_00626(ybiC)
LIH L63ED372_02625(ybiC)
BJU BJ6T_67890 BJ6T_68480
BJP RN69_32930 RN69_33220
BRC BCCGELA001_13060 BCCGELA001_13315
BRAD BF49_1720 BF49_1774
BSYM CIT39_08165 CIT39_08460
BVZ BRAD3257_5784(ybiC)
BDG LPJ38_17615 LPJ38_17875
BBAN J4G43_016705 J4G43_016990
BCAN BcanWSM471_13885 BcanWSM471_14145
VGO GJW-30_1_02181(ybiC)
RBM TEF_07945 TEF_09375
SRF LHU95_03030 LHU95_11910
RAP RHOA_0566(hcxB) RHOA_1359(hcxB)
SHUM STHU_18420 STHU_40300 STHU_51190
SVC STVA_34900 STVA_51100
STEL STAQ_17320 STAQ_46330
AZL AZL_a00760 AZL_a06180
AZM DM194_19645 DM194_22170
ELIO KO353_01085 KO353_03675 KO353_05605
NACI NUH88_01885 NUH88_11400

 » show all



Petersen, M. and Alfermann, A.W.


Two new enzymes of rosmarinic acid biosynthesis from cell cultures of Coleus blumei: hydroxyphenylpyruvate reductase and rosmarinic acid synthase.


Z Naturforsch C: Biosci 43:501-504 (1988)

Reference   Authors

Kim KH, Janiak V, Petersen M


Purification, cloning and functional expression of hydroxyphenylpyruvate reductase involved in rosmarinic acid biosynthesis in cell cultures of Coleus blumei.

  Journal   Sequence Reference   Authors

Kim YB, Uddina MR, Kim Y, Park CG, Park SU


Molecular cloning and characterization of tyrosine aminotransferase and hydroxyphenylpyruvate reductase, and rosmarinic acid accumulation in Scutellaria  baicalensis.


Nat Prod Commun 9:1311-4 (2014)

Reference   Authors

Wang GQ, Chen JF, Yi B, Tan HX, Zhang L, Chen WS


HPPR encodes the hydroxyphenylpyruvate reductase required for the biosynthesis of hydrophilic phenolic acids in Salvia miltiorrhiza.

  Journal   Sequence Other DBs
ExPASy – ENZYME nomenclature database:

Read more here: Source link