KEGG ENZYME: 5.5.1.31


KEGG ENZYME: 5.5.1.31


KEGG     ENZYME: 5.5.1.31
Entry
EC 5.5.1.31                 Enzyme                                 
Name

hapalindole H synthase;
famC2 (gene name);
famC3 (gene name)

Class

Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)

Sysname

3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole cyclase (hapalindole H-forming)

Reaction(IUBMB)
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = hapalindole H [RN:R12004]
Reaction(KEGG)
Substrate
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole [CPD:C21837]
Product
Comment

The enzyme, characterized from the cyanobacterium Fischerella ambigua UTEX 1903, forms the core structure of the hapalindole family of alkaloids. The enzyme is a heterodimeric complex.

History

EC 5.5.1.31 created 2018

Orthology
K22971   hapalindole H/12-epi-hapalindole U/12-epi-fischerindole U synthase
Reference
  Authors

Li S, Lowell AN, Newmister SA, Yu F, Williams RM, Sherman DH

  Title

Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids.

  Journal
  Sequence
Other DBs
ExplorEnz – The Enzyme Database:  5.5.1.31
ExPASy – ENZYME nomenclature database:  5.5.1.31

DBGET integrated database retrieval system

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