Time change in expression vs time change in phenotype

Time change in expression vs time change in phenotype

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Hello everyone;

We have a prospective study for which at two time points (t1,t2) we collected blood samples and some quantitative traits Q. Using DESeq2, we can ask if the blood gene expression E at t1 or t2 is associated with these traits. In other words, we can test E_t1 ~ Q_t1, then E_t2 ~ Q_t2.

Question: is there a way to test: (E_t2 – E_t1) ~ (Q_t2 – Q_t1) ??? We would like to know if the change in Q is associated with the change in E. What would be the design equation in DESeq2 for that?

Thank you very much!


RNA-Seq


DGE


DESeq2

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