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Which statement describes the results for the transgenic CRISPRa Sim mice produced by the TARGATT knockin system? neither promoter nor enhancer activation leads to upregulation and reduced weight in transgenic mice only promoter activation leads to Sim 1 upregulation and reduced weight in transgenic mice promoter and enhancer activation lead to upregulation and reduced weight in transgenic mice promoter and enhancer activation lead to downregulation and reduced weight in transgenic mice promoter and enhancer activation lead to Sim1 upregulation and increased weight in transgenic mice
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