Bioinformatics Software Developer in Protein Structure and Genetic Variant Modelling (2 posts) at Imperial College London

Location: South Kensington Campus

Job Summary 

The groups of Mike Sternberg and Alessia David at Imperial College London are looking to recruit up to two experienced Bioinformatics Software Developers to develop two resources: (i) The Missense3D portal that predicts the damaging effect of genetic variants via structure-based analysis. Missense3D had over 8,000 users in 2022. And (ii) The Phyre portal that predicts protein structure from sequence. Work on Phyre will develop complementary resources to the methods such as AlphaFold. Phyre is widely used by the community with over 50,000 unique users in 2022. Each post is for up to three years on a salary range £51,115 to £61,549 per annum.

The project will involve enhancing the underpinning algorithms and the dynamic web interfaces for both resources. The project will be supervised by Professor Michael Sternberg and Dr Alessia David at Imperial in collaboration with Professor Richard Houlston FRS at the Institute of Cancer Research (Sutton, London).

You will be a member of the team working in the Centre for Integrative and System Biology and Bioinformatics. The Centre also run a popular master’s course in Bioinformatics and Theoretical System Biology attended by about 20 students every year. You will have the opportunity to help in supervising master’s and undergraduate projects in bioinformatics related to your research. 

Duties and responsibilities

You will develop and support the protein modelling resources Missense3D and Phyre working on both the algorithmic back end and the dynamic web site front end. In addition, you will help in disseminating and supporting the use of these resources. The major language for software development will be Python.

Essential and desirable requirements

  • You will have an undergraduate degree in a biological, physical, numerical or computational discipline
  • You will have extensive experience of coding to a professional level in a high-level language (including Python)
  • Experience of developing a dynamic web site.
  • You will have experience of coding in the development of a dynamic web site using technologies such as Django, Tomcat, CSS and JavaScript.
  • You will have experience of the Linux operating system.
  • You will also have knowledge of Bioinformatics, including about protein structure, from software development and/or a relevant postgraduate degree.
  • In addition, it is desirable that you have (i) previously developed a bioinformatics resource, (ii) have had experience of working on computational studies on protein 3D structure and (iii) have developed algorithms using machine learning. 

Further Information

The posts are full-time, fixed term for up to 30 months in the first instance with a working week of not normally less than 35 hours per week. You will be based at South Kensington Campus.

Please note this is a re-advertisement; previous applicants need not apply.

The post is on the Professional, Technical and Operational Services Job Family at Level 4. The starting salary will be in the range of £51,115 – £61,549 depending on experience. Appointments will usually be made at the bottom of the scale.  

The appointee will be able to join the USS pension scheme into which Imperial College London will contribute.

For informal enquiries please contact Professor Michael Sternberg via m.sternberg@imperial.ac.uk

Read more here: Source link