Diff Bind Questions

Diff Bind Questions

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Hello,

Sorry if these questions may seem a bit dumb, I am very new to CHiP-seq and bioinformatics in general. I am trying to use DiffBind to find differential binding between groups.

What if a peak is present for a gene in one group but not the other? How would the program take that into account for calculating differential binding?

I am also very confused regarding occupancy analysis and differential binding analysis. What exactly differentiates the two in a biological context?

Thanks.


DiffBind


CHiP-Seq

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