Category: crispr

New study offers genetic insight into why we look the way we do

Which genes control the defining features that make us look as we do? And how do they make it happen? In 1990, University of California San Diego biologist William McGinnis conducted a seminal experiment that helped scientists unravel how high-level control genes called Hox genes shape our appearance features. The…

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Study encourages cautious approach to CRISPR

LA JOLLA, CALIF. – Nov 11, 2021 – A comprehensive study—conducted by researchers at Sanford Burnham Prebys, the National Cancer Institute (NCI) and other groups—has shown that gene editing, specifically gene knockout (KO), with CRISPR -Cas9 can favor cells with mutated forms of genes linked to cancer. The findings highlight…

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Study encourages cautious approach to CRISPR

LA JOLLA, CALIF. – Nov 11, 2021 – A comprehensive study—conducted by researchers at Sanford Burnham Prebys, the National Cancer Institute (NCI) and other groups—has shown that gene editing, specifically gene knockout (KO), with CRISPR -Cas9 can favor cells with mutated forms of genes linked to cancer. The findings highlight…

Continue Reading Study encourages cautious approach to CRISPR

Over a third of strawberries harvested are discarded due to their short shelf life. Here’s how CRISPR could help them last longer

The GLP Needs Your Help It is easier than ever for advocacy groups to spread disinformation on pressing science issues, such as the ongoing coronavirus pandemic. No, vaccines are not harmful. Yes, the use of biotechnology, GMOs or gene editing to develop antigens for treatments including vaccines are part of…

Continue Reading Over a third of strawberries harvested are discarded due to their short shelf life. Here’s how CRISPR could help them last longer

RUBY Trial of SCD Gene Editing Cell Therapy EDIT-301 Now Enrolling

Enrollment is underway for a Phase 1/2 trial evaluating the safety and efficacy of EDIT-301, an experimental gene editing cell therapy for people with sickle cell disease (SCD). The trial, called RUBY (NCT04853576), had been cleared for launch by the U.S. Food and Drug Administration earlier this year, and will…

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Approach improves avoidance of ‘bystander’ edits in CRISPR-base editor treatments — ScienceDaily

Want to keep the riffraff out of the gene pool party? Sneak in and slam the gate before they arrive. That’s the central idea of a new strategy by Rice University scientists who seek to avoid gene-editing errors by fine-tuning specific CRISPR-base editing strategies in advance. Rice chemical and biomolecular…

Continue Reading Approach improves avoidance of ‘bystander’ edits in CRISPR-base editor treatments — ScienceDaily

Exavir Aims CRISPR Program at HIV, Sees Powerful Preclinical Results

Since HIV first reared its deadly head 40 years ago, multiple medications have been developed, and drug makers continue to search for the Holy Grail in HIV treatment and create a potential cure for the disease. Exavir Therapeutics believes it has a chance to hit that mark with its gene editing…

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Ark Invest’s genomic revolution analyst Ali Urman on DNA sequencing

Ali Urman has been fascinated by medicine since an early age. She focused on epidemiology and biostatistics at university before taking up research positions at the Memorial Sloan Kettering Cancer Centre and Montefiore Health System. Driven to explore the intersection between medicine and technology, Urman worked at IBM’s artificial intelligence…

Continue Reading Ark Invest’s genomic revolution analyst Ali Urman on DNA sequencing

Ark Invest’s genomic revolution analyst Ali Urman on DNA sequencing

Ali Urman has been fascinated by medicine since an early age. She focused on epidemiology and biostatistics at university before taking up research positions at the Memorial Sloan Kettering Cancer Centre and Montefiore Health System. Driven to explore the intersection between medicine and technology, Urman worked at IBM’s artificial intelligence…

Continue Reading Ark Invest’s genomic revolution analyst Ali Urman on DNA sequencing

Studies encourage a cautious approach to CRISPR treatment

Credit: CC0 public domain In a comprehensive study conducted by Sanford Burnham Prebys, the National Cancer Institute (NCI), and other groups of researchers, gene editing using CRISPR-Cas9, especially gene knockout (KO), is cancerous. The findings highlight the need to monitor cancer-related mutations in patients receiving CRISPR-Cas9-based gene therapy.The study was…

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A strategy to refine genetic base editors

A new strategy by Rice University scientists seeks to avoid gene-editing errors by fine-tuning specific CRISPR-base editing strategies in advance. Their theoretical framework is intended to eliminate trial and error in the design of a library of editors. Credit: Qian Wang/Rice University Want to keep the riffraff out of the…

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Senior Scientist Bioinformatics at Parexel

The Senior Scientist operationally delivers client projects for Biomarker and Genomic Medicine (BGM) services. S/he demonstrates deep knowledge of scientific principles and concepts related to one or more capabilities and is experienced in industry standards. S/he will provide support for the BGM strategy and interpretation to other SBUs and clients….

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Annotation tools (prokaryotes): prokka vs eggnog

Annotation tools (prokaryotes): prokka vs eggnog 1 Are there any obvious advantages/disadvantages to using one over the other? Both use HMM (I think), both are hierarchical (starting with EggNOG 4.5). Are they simply competitors? Perhaps there is a trade-off between database size (Prokka is smaller) and the quality of curation?…

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Turning Genes “On” and “Off” With New Epigenetic Editing Technique

All the cells in an individual’s body bear the same genetic code. It is the reading and writing of this code – the “turning on” and “turning off” of specific genes in specific cells – that gives the cells their identities. Imagine, for example, the disastrous situation wherein the genes…

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Editas Medicine (EDIT) falls 0.03% to Close at $40.56 on November 9

Last Price $ Last Trade Change $ Change Percent % Open $ Prev Close $ High $ low $ 52 Week High $ 52 Week Low $ Market Cap PE Ratio Volume Exchange EDIT – Market Data & News Trade Editas Medicine Inc (NASDAQ: EDIT) shares fell 0.03%, or…

Continue Reading Editas Medicine (EDIT) falls 0.03% to Close at $40.56 on November 9

CRISPR-Cas9 Mediated Exonic Disruption for HIV-1 Elimination

Abstract Background A barrier to HIV-1 cure rests in the persistence of proviral DNA in infected CD4+ leukocytes. The high HIV-1 mutation rate leads to viral diversity, immune evasion, and consequent antiretroviral drug resistance. While CRISPR-spCas9 can eliminate latent proviral DNA, its efficacy is limited by HIV strain diversity and…

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CRISPR-Cas9: A weapon against antibiotic-resistant superbugs? | Science | In-depth reporting on science and technology | DW

Before the discovery of penicillin in 1928, even such common infections as strep throat could be terminal diagnoses. Antibiotics gave us a great advantage in the battle against harmful bacteria. Since then, antibiotic medicine has improved a lot. But so have bacteria. The fast rise in antibiotic resistance is one…

Continue Reading CRISPR-Cas9: A weapon against antibiotic-resistant superbugs? | Science | In-depth reporting on science and technology | DW

Exavir Therapeutics announces preclinical data demonstrating complete elimination of HIV from human cells with LNP-delivered Tat-targeted CRISPR-Cas9

Early candidate from XVIR-TAT series demonstrated genetic elimination of HIV and robust anti-retroviral activity with CRISPR-Cas9 based excision Exavir lipid nanoparticles (LNPs) with mRNA encoding Cas9 nuclease and proprietary Tat-targeted gRNAs demonstrated up to 100% HIV suppression in infected human cells Exavir is optimizing LNP formulations for tissue tropism, and…

Continue Reading Exavir Therapeutics announces preclinical data demonstrating complete elimination of HIV from human cells with LNP-delivered Tat-targeted CRISPR-Cas9

RISPR-Cas9: A weapon against antibiotic-resistant superbugs? | Health

Before the discovery of Penicillin in 1928, even common infections like strep throat could be a terminal diagnosis. Antibiotics gave us a great advantage in the battle against harmful bacteria. Since then, antibiotic medicine has improved a lot. But so have bacteria. The fast rise in antibiotic resistance is one…

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ASM222144v1 – Genome – Assembly

##Genome-Annotation-Data-START## Annotation Provider::NCBI Annotation Date::07/14/2017 16:46:34 Annotation Pipeline::NCBI Prokaryotic Genome Annotation Pipeline Annotation Method::Best-placed reference protein set; GeneMarkS+ Annotation Software revision::4.2 Features Annotated::Gene; CDS; rRNA; tRNA; ncRNA; repeat_region Genes (total)::3,436 CDS (total)::3,380 Genes (coding)::2,817 CDS (coding)::2,817 Genes (RNA)::56 rRNAs::1, 1, 2 (5S, 16S, 23S) complete rRNAs::1 (5S) partial rRNAs::1, 2…

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Promising future in preventing kidney stones

Although they are very different, both processes are aimed at providing alternatives to patients. Kidney stones can affect any part of the urinary tract, from the kidneys to the bladder. Gene therapy, new therapies currently in clinical trials, and a promising dietary supplement fuel the kidney stone expert’s optimism, according…

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CRISPR-editing biotech Arbor Bio adds $215M for liver, CNS disease therapies

  Arbor Biotechnologies, a genetic medicines company that claims to have the most extensive gene-editing toolbox in the industry, is also building a substantial war chest. The company has raised $215 million in financing as it works to advance its lead programs toward clinical testing. The Series B financing announced…

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How to turn specific genes on and off

Type 1 diabetes, rheumatoid arthritis, and cancer are just some of the disorders associated with specific genes not “turning on” and “turning off” as they should. By using new CRISPR/Cas9 genome editing technology, in a recent paper in Nature Communications, McGill University researchers have described a new technique that scientists…

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Ugandan students push biotechnology outreach and biosafety law

After growing frustrated with legislative inaction, biotechnology students in Uganda have started an initiative to advocate for biotechnology, gene editing and the passage of a biosafety law. The Biotechnology Online Series features students and researchers using Zoom and other social media channels to discuss how biotechnology and newer tools such…

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Will NFTs Revolutionize Patent Law?

NFTs continue to make waves, even as there is much speculation about their long-term future. As we have previously written, non-fungible tokens, or NFTs, present novel challenges and opportunities for intellectual property holders. This article explains how NFTs have been creating new challenges and opportunities specifically in the patent space. NFTs as…

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Arbor’s autumn: A $1.2B Vertex pact, now a $215M series B for liver, CNS diseases

It appears a $1.2 billion biobucks pact with Vertex wasn’t enough for Arbor Biotechnologies. The biotech added to its treasure chest with $215 million in series B funds to bankroll work in liver and central nervous system diseases.  The financing will help the Cambridge, Massachusetts, biotech get closer to the…

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Treatment of a wide range of diseases may advance thanks to new epigenetic editing technique — ScienceDaily

Type 1 diabetes, rheumatoid arthritis, and cancer are just some of the disorders associated with specific genes not “turning on” and “turning off” as they should. By using new CRISPR/Cas9 genome editing technology, in a recent paper in Nature Communications, McGill University researchers have described a new technique that scientists…

Continue Reading Treatment of a wide range of diseases may advance thanks to new epigenetic editing technique — ScienceDaily

Genome Engineering Research Scientist

Genome Engineering Research Scientist – 94152 Organization: JG-Joint Genome Institute Lawrence Berkeley National Lab’s (LBNL, www.lbl.gov/) Environmental Genomics and Systems Biology Division (biosciences.lbl.gov/divisions/egsb/) has an opening for a Genome Engineering Research Scientist to join the team. In this exciting role, you will work as part of the Center for Advanced…

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Research Associate at Imperial College London

Location: South Kensington Campus Job Summary  A bioinformatics research associate post with an emphasis on insect genomics is available in the research group of Dr. Nikolai Windbichler ((www.windbichlerlab.org/) working in collaboration with Dr. Angela Meccariello and Prof. George Christophides ((www.vigilab.org/) at Imperial College. Our joint research aims to build and…

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DNA Script on Track for Release of Enzymatic DNA Synthesis Platform in 2022

NEW YORK – DNA Script is expanding its operations and is on track to commercially launch its Syntax enzymatic DNA synthesis platform early next year after gathering feedback from early-access users at the Broad Institute and elsewhere. Last month, the French company, which has locations in Paris and South San…

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China’s gene-editing landscape advances as CVC’s second CRISPR/Cas9 patent granted | News

DUBLIN, Nov. 9, 2021 /PRNewswire/ — ERS Genomics Limited (‘ERS’) is pleased to report that China Patent No. 2017105856905 has been granted. This new patent covers methods and compositions for use of CRISPR/Cas9 in eukaryotes. ERS, co-founded by Dr. Emmanuelle Charpentier, 2020 Nobel Prize winner for gene-editing, provides access to the…

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The Shh/Gli3 gene regulatory network precedes the origin of paired fins and reveals the deep homology between distal fins and digits

Significance In this study, we show that the inactivation of the gli3 gene in medaka fish results in the formation of larger dorsal and paired fins. These mutant fins display multiple radial bones and fin rays which resemble polydactyly in Gli3-deficient mice. Our molecular and genetic analyses indicate that the…

Continue Reading The Shh/Gli3 gene regulatory network precedes the origin of paired fins and reveals the deep homology between distal fins and digits

Cambridge gene-editing startup Arbor Biotechnologies raises $215 million

With the oversubscribed second financing round, Arbor Biotechnologies has now raised more than $300 million to discover and develop a new generation of CRISPR editing tools. Over the past decade, CRISPR has emerged as one of the most promising approaches to treating deadly genetic diseases, with scientists discovering enzymes that…

Continue Reading Cambridge gene-editing startup Arbor Biotechnologies raises $215 million

China’s gene-editing landscape advances as CVC’s second CRISPR/Cas9 patent granted

ERS, co-founded by Dr. Emmanuelle Charpentier, 2020 Nobel Prize winner for gene-editing, provides access to the foundational CRISPR/Cas9 intellectual property. With this patent in China, the fundamental value of gene-editing technology is officially validated within the scientific community. The patent covers methods and compositions for RNA-Directed target DNA modification and…

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Beam Gets FDA Nod for First Gene-Editing Trial

Text size The Beam technology nicks one of DNA’s two twisted strands and then changes a single genetic-code letter in a way that’s less disruptive of the cell. Dreamstime Beam Therapeutics will begin the first clinical trial of its gene-editing technology after getting the go-ahead from U.S. regulators, the biotech…

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Genetically Steady and Cost-Effective Gene Knockout Stable Cell Lines Products at Creative Biogene

New York, NY, November 06, 2021 –(PR.com)– Creative Biogene creatively develops a series of genetically steady and cost-effective gene knockout stable cell lines products for domestic and overseas clients. With years of experience in the gene-engineering field, Creative Biogene has built a team of experts to perform genome editing with CRISPR/Cas9…

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Lizards Regenerate Perfect New Tails With Bone and Nerves After Being Injected With Gene-Edited Stem Cells

Lizards are known for their ability of tail autotomy wherein they drop their tails to distract a predator as they scurry away. Then they regrow it, but this time it is only a cartilage tube that lacks all the skeletal and neural structures of their original tail. But a new study showed…

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Science Papers Explore Nanopore Approach to Read Proteins, Role of Noncoding DNA in Forming 3D Structure

A nanopore-based system for reading individual proteins at single-amino acid resolution is described in this week’s Science. The approach, developed by a team led by Delft University of Technology scientists in the Netherlands, involves pulling a DNA-peptide conjugate through a biological nanopore by a helicase walking on the DNA section….

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Researchers Develop CRISPR-based Rapid Diagnostic Tool for SARS-CoV-2

Study lead author Dan Brogan (left) and coauthor Calvin Lin review results from a SENSR reaction using a light cycler qPCR machine. Photo by Michelle Fredricks, UC San Diego Physical Sciences Blending experts from molecular genetics, chemistry and health sciences, researchers at the University of California San Diego have created a…

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New insights into kidney disease with tropical frog models — ScienceDaily

Using cutting-edge genetic engineering, researchers have developed a model to study hereditary kidney disease with the help of tropical frogs. The method allows them to collect large amounts of data on anomalies, which can then be analyzed using artificial intelligence. The research opens up new opportunities in the search for…

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Weekend Crossword: 3 incredible scientific breakthroughs from the past decade

More than 3,000 ancient genomes have been sequenced since 2010, thanks to rapid advancements in DNA sequencing technology. Image Credit: Stock photo/Pixabay What do you think of, when you hear the words scientific discovery? Perhaps the discovery of the first antibiotic, penicillin, or the unearthing of the double-helix structure of…

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Surrogate Reproduction Achieved between Fish Species of Different Subfamilies

The inter-specific spermatogonial stem cells (SSCs) transplantation (SSCT) is a surrogate reproduction technique. It can produce the functional gametes of species B with the gonads of species A, thus providing a powerful tool for production of gametes derived from endangered species or those with desirable traits. However, generation of genome-edited…

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How Big Data is Influencing Genetic Research?

by Madhurjya Chowdhury November 3, 2021 From start-ups to Fortune 500 companies, big data and its applications are changing the way we do business throughout the world. Data collecting, data analytics, and the comprehension of that data have grown more accessible, with far-reaching implications, regardless of what area you work…

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Simplot, PSI announce plan for first commercially gene edited strawberry | 2021-10-29

The J.R. Simplot Company and Plant Sciences Inc., have announced a strategic partnership to bring the first commercially gene-edited strawberry to supermarkets.  The alliance plans to leverage the gene editing techniques from Simplot and proprietary strawberry germplasm and growth expertise of PSI.  Approximately 35% of fresh strawberries are discarded by…

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Creative Biogene Offers One-Stop Customized CRISPR-Based Microbe Genome Editing Service

New York, NY, November 03, 2021 –(PR.com)– Creative Biogene has been dedicating itself to undertaking the cause of bioscience for decades and enjoys rich experiences and expertise in CRISPR gene-editing areas. Through years of efforts and competitive advantages, its CRISPR-based microbe genome editing service is rather renowned at home and abroad….

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Top Biotech Opportunities for the End-of-Year Run (CRSP, ATRX, PTPI, ALNA, MRNA, VRTX, IBB)

The Biotech space made a big move on Wednesday, sparking a rebirth in excitement about the space following the Federal Reserve’s move to start tapering its bond purchases. The move was expected to be a big hurdle for tech stocks, including biotechs. Instead, we got a melt-up, which included a…

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Vor to Present New Platform and Preclinical Data at ASH

Knock out of CD123 or CLL-1 by CRISPR-Cas9 from Human Hematopoietic Stem Cells Maintains Hematopoietic Function and is Resistant to Targeted Therapies Multiplex Engineering of Human CD34+ HSPCs Enables Dual Gene Knock-out with High Engraftment Potential Dual-Mobilized Donor Derived CD33 CAR T-Cells as Potent and Effective AML Therapy in Preclinical…

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Great for medicine but ethical issues arise

Genome editing allows scientists to alter the DNA in an organism, whether through adding, subtracting, or changing the genetic code at a specific location. There are many methods for editing DNA, but the most commonly mentioned are CRISPR-Cas9 and TALENs. CRISPRs are repeated sequences of DNA interspersed with unique sequences of…

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Global Roundup: Singapore Researchers Create Atlas of Gastric Cancer

Researchers in Singapore have developed the world’s largest and highest-resolution atlas of gastric cancer. It is believed that this world’s largest analysis of gastric tumor cells will provide a launchpad for scientists to plan more effective therapies for this type of cancer. Findings from the study have shown new insights…

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Broad Files Reply to ToolGen Opposition to Broad Preliminary Motion No. 1 | McDonnell Boehnen Hulbert & Berghoff LLP

On May 28th, Junior Party the Broad Institute, Harvard University, and MIT (collectively, “Broad”) filed its Substantive Preliminary Motion No. 1 in CRISPR Interference No. 106,126, where ToolGen is the Senior Party.  On August 6th, ToolGen filed its Opposition and on September 24th Broad filed its Reply. Broad’s Motion sought to…

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Investing in high-purity guide RNA-Sumitomo Chemical Europe

The world urgently needs new manufacturing capabilities to realise the huge potential of genome editing therapy. Equipped with CRISPR-Cas9 technology, researchers have revealed opportunities to address major unmet medical needs through genome editing and to transform the lives of millions of patients. Yet, that promise will remain unfulfilled unless large…

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Trace the cellular origin of neuroblastoma relapse

Category Research / Academic Location Amsterdam A postdoc position is available at the department of Oncogenomics, Amsterdam UMC, to study mechanisms of therapy resistance and development of relapse in the pediatric tumor neuroblastoma. About your role We have established that neuroblastoma is composed of two phenotypically divergent types of tumor cells (van…

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Using CRISPR Technology, Scientists Plan to Grow a More Durable Strawberry | Smart News

Using CRISPR technology, scientists plan to modify the strawberries’ genes to improve their shelf life, extend the growing season and reduce food waste. kahvikisu via Flickr under CC BY 2.0 More than a third of all fresh strawberries that consumers buy end up getting tossed out because they’re bruised, moldy…

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Moderna finally cracks into gene editing with Metagenomi pact thanks to ‘irresistible’ data

We finally know who Moderna has been courting behind the scenes to make the big jump into gene editing. The famed biotech has signed a research partnership with CRISPR gene editing company Metagenomi. Both parties are keeping mum on a lot of the details. We don’t know what indications they’ll…

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How Gene Editing Can Support Sustainable Agriculture

By Ingrid Fung When the CRISPR-Cas9 system was discovered in 2012, its precision and relative simplicity of use captured the imaginations of popular media, investors, and scientists alike. It was expected that CRISPR-Cas9 would make genome editing economically viable for a vast array of commercial applications. Suddenly, gene editing was…

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CRISPR-Cas Can Help Reduce Climate Change

By Monika Paulė, PhD Monika Paulė, PhDCo-Founder and CEO, CasZyme Many industries and fields of science are investigating innovative technologies to mitigate the effects of climate change—effects that are already evident as an alarming collection of environmental, social, and economic problems. CRISPR-Cas gene editing has been successfully applied in human…

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Microbialtec Provides One-stop Bacillus Genome Editing Services to Support Researches in the Field of Microbial Genome Editing

Microbialtec announced the release of one-stop bacillus genome editing service to process professional studies in the field of microbial genome editing. New York, USA – November 1, 2021 – Microbialtec, the division of Creative Biogene, is a high-tech service provider specialized in the microbiological field, focusing on developing cutting-edge technologies…

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New method refines CRISPR base editing

1 November 2021 Splitting and reconstituting the enzyme used in the base editing method of genome editing may make more controlled changes possible.  Base editing differs from the CRISPR/Cas9 method because instead of cutting and replacing a section of DNA, an enzyme called DNA deaminase chemically changes a target base. However, unregulated DNA…

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Bioconductor – sparrow

DOI: 10.18129/B9.bioc.sparrow     Take command of set enrichment analyses through a unified interface Bioconductor version: Release (3.14) Provides a unified interface to a variety of GSEA techniques from different bioconductor packages. Results are harmonized into a single object and can be interrogated uniformly for quick exploration and interpretation of…

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Mammoth Biosciences hiring Scientist, Bioinformatics in Brisbane, CA, US

About Mammoth Biosciences The CRISPR-based platform for disease detection. Mammoth’s vision is to provide a CRISPR-based platform on which an infinite number of tests can be built by both ourselves and our partners – democratizing access to an endless variety of tests for bio sensing in healthcare, as well as…

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DCAF1-targeting microRNA-3175 activates Nrf2 signaling and inhibits dexamethasone-induced oxidative injury in human osteoblasts

This article was originally published here Cell Death Dis. 2021 Oct 29;12(11):1024. doi: 10.1038/s41419-021-04300-8. ABSTRACT Activation of nuclear-factor-E2-related factor 2 (Nrf2) signaling can protect human osteoblasts from dexamethasone-induced oxidative injury. DDB1 and CUL4 associated factor 1 (DCAF1) is a novel ubiquitin E3 ligase for Nrf2 protein degradation. We identified a…

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Identify and annotate mutations from genome editing assays

Here we propose our CRISPR-detector to facilitate the CRISPR-edited amplicon and whole genome sequencing data analysis, with functions that existing tools are not able to provide. CRISPR-detector brings the following four key innovations : optimized processing time allowing for hundreds of amplicons or whole genome sequencing data; integrated structural variation…

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DNA Script tallies up $165M to help launch its desktop DNA printer

Following the launch of its benchtop DNA printer earlier this year, DNA Script has secured a hefty $165 million to take its platform to the masses. The nine-digit proceeds represent a big leap in DNA Script’s funding, bringing the startup’s lifetime venture capital total up to $280 million since it…

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New Products Posted to GenomeWeb: Roche, Jumpcode Genetics, Mikrogen, More

Roche Avenio Tumor Tissue Comprehensive Genomic Profiling Kit Roche has launched its Avenio Tumor Tissue Comprehensive Genomic Profiling (CGP) Kit for research use. The jointly developed project from Roche and Foundation Medicine delivers information about complex genomic signatures, including tumor mutational burden, microsatellite instability, and loss of heterozygosity, in addition…

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Study uncovered complex dance of developmental genes

The world of genetics is staggeringly complex. Proteins, the product of genes, interact with genes, influencing and regulating the rhythm of their expression. But how do these genes activate, what to make, and when to stop? How do they work as part of intricate molecular machinery without being confused with…

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US companies announce plans for gene-edited strawberries News

BOISE – An Idaho company has reached an agreement to help a California-based plant breeding firm grow strawberries. They claim that the plants will keep fresher for longer periods of time and last longer. Plant Sciences Inc. and J.R. Simplot Company, both privately held companies, stated that they plan to…

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Vertex and Mammoth Biosciences Ink $700M Deal for Ultra-Small CRISPR Systems | Rothwell, Figg, Ernst & Manbeck, P.C.

Vertex Pharmaceuticals and Mammoth Biosciences, a Brisbane, California-based genetic research company, announced a new collaboration for the development of in vivo gene therapies for rare diseases using Mammoth’s ultra-small CRISPR systems. Over the past couple of years, Mammoth Biosciences, the brainchild of CRISPR pioneer and 2020 Nobel Prize Laureate Jennifer…

Continue Reading Vertex and Mammoth Biosciences Ink $700M Deal for Ultra-Small CRISPR Systems | Rothwell, Figg, Ernst & Manbeck, P.C.

CRISPR AG (CRSP) gains 1.32% for October 28

Last Price $ Last Trade Change $ Change Percent % Open $ Prev Close $ High $ low $ 52 Week High $ 52 Week Low $ Market Cap PE Ratio Volume Exchange CRSP – Market Data & News Trade CRISPR Therapeutics AG (NASDAQ: CRSP), a Zug, Zug, company,…

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The role of CRISPR in viral diagnostics

A comprehensive new review paper, published in the journal Virsues, explains in depth how CRISPR can be utilized as a reliable tool to investigate the viral life cycles – and especially how many new CRISPR systems can be repurposed for diagnostics. Study: CRISPR Tackles Emerging Viral Pathogens. Image Credit: Nathan…

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US companies announce plans for gene-edited strawberries

BOISE, Idaho — An Idaho company that successfully brought genetically modified potatoes to the market announced an agreement Thursday to help a California-based plant breeding company grow strawberries they say will stay fresh longer and have a longer growing season. J.R. Simplot Company and Plant Sciences Inc., both privately-held companies,…

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FDA, NIH, and 15 Partners Advance Gene Therapy Development in Rare Diseases

A gene therapy development initiative from the FDA, National Institute of Health and 15 other organizations may move CRISPR closer to use in patients with rare cancers. The FDA, the National Institutes of Health (NIH), and 15 other organizations have joined forces to accelerate the development of gene therapies to…

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AKIRIN2 controls the nuclear import of proteasomes in vertebrates

1. Johnston, L. A., Prober, D. A., Edgar, B. A., Eisenman, R. N. & Gallant, P. Drosophila myc regulates cellular growth during development. Cell 98, 779–790 (1999). CAS  PubMed  Article  Google Scholar  2. Sabo, A. et al. Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis. Nature 511,…

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US companies unveil gene-edited strawberries, improving freshness and reducing waste | News

Two companies jointly announced Thursday that they had plans to start producing genetically edited strawberries in order to improve freshness and reduce waste. The J.R. Simplot Company, a family-owned agriculture company, and Plant Services, a California-based plant reproduction company, issued a statement announcing the agricultural collaboration. By producing genetically edited…

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Regeneron’s Yancopoulos on CRISPR, Gene-Editing Challenges

Gene-editing biotechs overvalue CRISPR technology, Regeneron’s top scientist George Yancopoulos said. “It’s not just about the simple, initial CRISPR technology and IP,” Yancopoulos told Insider. The future of gene editing depends on solving delivery challenges for these treatments, he said. Gene editing is one of the hottest spaces in biotech,…

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Genome Spotlight: Mandarinfish (Synchiropus splendidus)

If any fish deserves the name spendidus, it is the mandarinfish. Its magnificent colors have made this fish popular in the aquarium industry despite the fact that it’s covered in poison, has notoriously picky eating habits, and smells terrible. The secrets of how it produces its vibrant hues and foul…

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Bioconductor – Bioconductor 3.14 Released

Home Bioconductor 3.14 Released October 27, 2021 Bioconductors: We are pleased to announce Bioconductor 3.14, consisting of 2083 software packages, 408 experiment data packages, 904 annotation packages, 29 workflows and 8 books. There are 89 new software packages, 13 new data experiment packages, 10 new annotation packages, 1 new workflow,…

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New mouse model shows that it is never too late to treat Hutchinson-Gilford Progeria Syndrome

Scientists at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) and the Spanish Cardiovascular Research Network (CIBERCV), led by Dr Vicente Andrés, have generated the HGPSrev experimental mouse model. This is the first animal model to develop Hutchinson-Gilford Progeria Syndrome (HGPS) and also allow its suppression through the controlled…

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Exploring the dual function of the CTCF protein

A mouse embryo. Credit: Denis Duboule (EPFL/UniGe) The rapid scientific advancements that followed the mapping of the human genome have revealed just how staggeringly complex the world of genetics is. We now know that proteins are not just the products of genes, but that they also interact with genes, influencing…

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Is there a public database where I could download mRNA seq (transcriptome) data of 293T cells

Is there a public database where I could download mRNA seq (transcriptome) data of 293T cells 0 Dear Biostars forum members, Are there any public mRNA seq databases where I could download mRNA seq (transcriptome) data of 293T cells (prefer plain 293T cells without any siRNA or CRISPR treatment)? I…

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Why ‘junk DNA’ is critical for our survival

Nearly half of our DNA has been written off as junk, the discards of evolution: sidelined or broken genes, viruses that got stuck in our genome and were dismembered or silenced, none of it relevant to the human organism or human evolution. But research over the last decade has shown…

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Surrogate production of genome edited sperm f

image: The technical route of this study and SSCs isolation and transplantation. view more  Credit: ©Science China Press Spermatogonial stem cells (SSCs) are the only type of stem cells in the adult testis that maintain the activity of self-renewal and has the potential for differentiation. By utilizing the technique of SSCs…

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Acta Pharmaceutica Sinica B Volume 11, Issue 10 publishes

In 2021 Acta Pharmaceutica Sinica B (APSB) is celebrating its 10th anniversary. The journal was founded with the goal of creating a global high-level forum centred around drug discovery and pharmaceutical research/application. APSB was included by Chemical Abstracts in 2011, accepted by PubMed Central in 2015, indexed by Science Citation…

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Vertex goes small with Mammoth deal

Vertex Pharmaceuticals was already an enthusiastic backer of very early gene editing projects, with deals in place with the likes of Crispr Therapeutics and Arbor Biotechnologies. The group spread its bets even further today, signing up another Crispr player, Mammoth Biosciences, for $41m up front. The agreement involves in vivo…

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CRISPR interference | Lab Equipment

CRISPR interference (CRISPRi) is a novel method for specific gene knockdown. It’s CRISPR, without the cut. The Horizon CRISPRi system uses a deactivated Cas9 nuclease (dCas9) fused to our proprietary SALL1-SDS3 repressor construct to block transcription of target genes, without cutting the DNA.The Horizon CRISPRi system requires two components: a…

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Help determine the future of soft fruit pre-breeding research

The views of the UK soft fruit industry, from growers to retailers, could be critical in determining its future, urges NIAB and the James Hutton Institute. The two research organizations are developing a business case for the establishment of a Soft Fruit Genetic Improvement Network, following in the footsteps of…

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Vertex signs another Mammoth-sized CRISPR deal with $650M in biobucks on the line

Autumn is in full swing for those in leafy locales and it turns out that Vertex is enjoying the crispy, crunchy season, too: the pharma has signed another CRISPR gene editing pact, this time for $650 million in biobucks with Mammoth Biosciences. Vertex will dole out $41 million upfront and up to $650 million in biobucks…

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Decreasing the reproductive fitness of mosquitos

Nouzova and Noriega. Credit: Florida International University The secret of the world’s deadliest animal’s reproductive success could lead to fewer baby mosquitoes. That could mean improved pest control. FIU Biomolecular Sciences Institute researchers collaborated with an international team to study juvenile hormone, a molecule that regulates development, reproduction and behavior…

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Therapeutic Exon Skipping via a CRISPR-guided Cytidine Deaminase Rescues Dystrophic Cardiomyopathy In Vivo

This article was originally published here Circulation. 2021 Oct 26. doi: 10.1161/CIRCULATIONAHA.121.054628. Online ahead of print. ABSTRACT Background: Loss of dystrophin protein causes Duchenne muscular dystrophy (DMD), characterized by progressive degeneration of cardiac and skeletal muscles, and mortality in adolescence or young adult. Although cardiac failure has risen as the…

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Vertex, Mammoth Launch Up-to-$695M CRISPR Gene-Editing Collaboration

Vertex Pharmaceuticals will develop in vivo gene-editing therapies for two genetic diseases using Mammoth Biosciences’ CRISPR systems through a collaboration that could generate more than $695 million for Mammoth, the companies said today. The companies is not disclosing which diseases they will target. “We are focused on developing in vivo…

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FAP Gene-editing Therapy NTLA-2001 Given Orphan Drug Status by FDA

The U.S. Food and Drug Administration (FDA) has given an orphan drug designation to NTLA-2001, an investigational gene-editing therapy for familial amyloid polyneuropathy (FAP) and other forms of transthyretin (ATTR) amyloidosis. This designation is given to experimental medicines that have the potential to improve care for people with rare diseases…

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CRISPR Revolution: Do We Need Tighter Gene-Editing Regulations? No

Life goes on as gene-edited foods begin to hit the market. Japanese consumers have recently started buying tomatoes that fight high blood pressure, and Americans have been consuming soy engineered to produce high amounts of heart-healthy oils for a little over two years. Few people noticed these developments because, as scientists…

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Understanding DNA repair mechanisms allows for crisper CRISPR genome editing | 2021-10-25

Gene editing technologies, such as CRISPR, can cause unintended alterations in the genome which may be potentially dangerous. A multidisciplinary team of scientists led by Britt Adamson at Princeton University along with collaborators from the Massachusetts Institute of Technology, the genome editing company Editas Medicine, and University of California, San…

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Early Successes Make CRISPR-Based Medicine a Possibility

Preliminary results from an ongoing trial by Intellia Therapeutics show that a CRISPR-Cas9-based drug can be delivered into the body to target the liver and reduce expression of the gene that causes transthyretin amyloidosis (ATTR).1 This is the first clinical trial demonstrating successful in vivo gene editing; the results suggest…

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Mosquitoes are good at sucking blood and having babies | FIU News

The secret of the world’s deadliest animal’s reproductive success could lead to fewer baby mosquitoes. That could mean improved pest control. FIU Biomolecular Sciences Institute researchers collaborated with an international team to study juvenile hormone, a molecule that regulates development, reproduction and behavior in insects. They produced genetically modified Aedes…

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New method giving insight into DNA repair pathways could improve genome editing

25 October 2021 In-depth mapping of DNA repair mechanisms of the double-stranded and single-stranded breaks required for genome editing, could enhance the efficacy of these approaches, new research has revealed. Scientists at Princeton University, New Jersey, and Massachusetts Institute of Technology (MIT) have published research untangling the complex mechanisms controlling…

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Broad Files Reply to ToolGen’s Opposition to Broad’s Preliminary Motion No. 3 | McDonnell Boehnen Hulbert & Berghoff LLP

On May 28th, Junior Party the Broad Institute, Harvard University, and MIT (collectively, “Broad”) filed its Substantive Preliminary Motion No. 3 in CRISPR Interference No. 106,126 (where ToolGen is the Senior Party).  This motion, pursuant to 37 C.F.R. §§ 41.121(a)(1)(iii) and 41.208(a)(1) requested that the Board de-designate Broad claims in these…

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How do we use CRISPR gene editing to study diseases? | Facts

CRISPR-Cas9 is a genome editing tool used to alter specific sequences of DNA in a cell. It has many uses both in research and in helping us understand disease. Many fantasies of gene editing have been made reality with the development of the gene editing tool known as CRISPR-Cas9. Whilst…

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Soft Fruit Genetic Improvement Network: have your say

GINs are Genetic Improvement Networks that provide a key link between industry and academia to ensure that genetic research addresses the needs of the industry, and tackles some of the longer-term issues through breeding efforts. A recent article in the ‘Crop Production Magazine’ (Oct 2021) suggested, “while the problems facing…

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Brazil may have pig-to-human kidney test in 2 years

REUTERS/Michaela Rehle. Photo: Reuters In the United States, for the first time, a human being received a pig kidney without an immediate rejection being triggered in his immune system. The feat encourages research associated with the University of São Paulo (USP), with similar line and commanded by Silvano Ray, pioneer…

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New technology allows molecules to enter cells safely

Graphical abstract. Credit: DOI: 10.1038/s41565-021-00976-3 Professor Kevin Braeckmans from Ghent University focused the last 10 years on a method for safe engineering of therapeutic cells with photothermal nanofibers. Today, Nature Nanotechnology gives insight in how these biocompatible photothermal nanofibers were developed, and how, upon laser irradiation, cells that come in…

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