Category: mtDNA

Mitochondrial DNA Mutagenesis: Feature of and Biomarker for Environmental Exposures and Aging

Purpose of review: Mitochondrial dysfunction is a hallmark of aging. Mitochondrial genome (mtDNA) instability contributes to mitochondrial dysfunction, and mtDNA mutagenesis may contribute to aging. However, the origin of mtDNA mutations remains somewhat controversial. The goals of this review are to introduce and review recent literature on mtDNA mutagenesis and…

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Extensive analysis of mitochondrial DNA quantity and sequence variation in human cumulus cells and assisted reproduction outcomes

Study question: Are relative mitochondrial DNA (mtDNA) content and mitochondrial genome (mtGenome) variants in human cumulus cells (CCs) associated with oocyte reproductive potential and assisted reproductive technology (ART) outcomes? Summary answer: Neither the CC mtDNA quantity nor the presence of specific mtDNA genetic variants was associated with ART outcomes, although…

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Is my GEDmatch of any use to the Project???

Hello Lawrence, These videos show some of the benefits of having your GEDmatch ID in WikiTree: www.wikitree.com/g2g/1054650/how-does-help-you-register-gedmatch-your-gedmatch-wikitree The following will automatically associate your Y-DNA haplogroup with your direct paternal line. Login to WikiTree and go to your DNA Tests page at  www.wikitree.com/wiki/Special:DNATests and select that you have taken an “Other…

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Santa Fe Soldier Accounted For From World War II

Army Pfc. Juan F. Gutierrez DPAA News: WASHINGTON, D.C. —The Defense POW/MIA Accounting Agency (DPAA) announced Tuesday that Army Pfc. Juan F. Gutierrez, 26, of Santa Fe, who was captured and died as a prisoner of war during World War II, was accounted for Feb. 24, 2021. In late 1941,…

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Single-molecule mitochondrial DNA sequencing shows no evidence of CpG methylation in human cells and tissues

Citation Chinnery, P. Single-molecule mitochondrial DNA sequencing shows no evidence of CpG methylation in human cells and tissues. Nucleic Acids Research www.repository.cam.ac.uk/handle/1810/330529 Abstract Methylation on CpG residues is one of the most important epigenetic modifications of nuclear DNA, regulating gene expression. Methylation of mitochondrial DNA (mtDNA) has been studied using…

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mtDNA in the Pathogenesis of Cardiovascular Diseases

The incidence rate of cardiovascular disease (CVD) has been increasing year by year and has become the main cause for the increase of mortality. Mitochondrial DNA (mtDNA) plays a crucial role in the pathogenesis of CVD, especially in heart failure and ischemic heart diseases. With the deepening of research, more…

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An empirical analysis of mtSSRs: could microsatellite distribution patterns explain the evolution of mitogenomes in plants?

Levinson G, Gutman GA (1987) Slipped-strand mispairing: a major mechanism for DNA sequence evolution. Mol Biol Evol 4:203–221 CAS  PubMed  Google Scholar  Schlotterer C, Tautz D (1992) Slippage synthesis of simple sequence DNA. Nucleic Acids Res 20:211–215 CAS  PubMed  PubMed Central  Google Scholar  Tautz D, Schlotterer C (1994) Simple sequences….

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MtDNA species-level phylogeny and delimitation support significantly underestimated diversity and endemism in the largest Neotropical cichlid genus (Cichlidae: Crenicichla) [PeerJ]

Introduction The cichlid family (Cichlidae) is an important family of Neotropical fishes that is the dominant group of larger sized fishes in Middle America (Myers, 1966; Bussing, 1976, 1985; Říčan et al., 2013, 2016) and the third richest family of fishes in South America (Van der Sleen & Albert, 2018)….

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Different gene rearrangements of the genus Dardanus (Anomura: Diogenidae) and insights into the phylogeny of Paguroidea

1. Boore, J. L. Animal mitochondrial genomes. Nucl. Acids Res. 27, 1767–1780 (1999). CAS  PubMed  PubMed Central  Article  Google Scholar  2. Gyllensten, U., Wharton, D., Josefsson, A. & Wilson, A. C. Paternal inheritance of mitochondrial DNA in mice. Nature 352, 255–257 (1991). ADS  CAS  PubMed  Article  PubMed Central  Google Scholar …

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1. Introduction

CRIGCase Reports in Genetics2090-65522090-6544Hindawi10.1155/2021/99690719969071Case ReportWhole-Exome Sequencing Identifies a Novel POLG Frameshift Variant in an Adult Patient Presenting with Progressive External Ophthalmoplegia and Mitochondrial DNA Depletionorcid.org/0000-0002-1969-8635KurtzJustin1FernandesJoseph AmericoJr2MansukhaniMahesh1CopelandWilliam C.3orcid.org/0000-0002-8030-1115NainiAli B.14SuriMohnish1Division of Personalized Genomic MedicineDepartment of Pathology and Cell BiologyColumbia University630 W. 168th StreetNew YorkNY 10032USAcolumbia.edu2Department of Neurological SciencesUniversity of Nebraska Medical CenterOmahaNEUSAunmc.edu3Mitochondrial…

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Haplogroup L2 (mtDNA)

Haplogroup U (mtDNA) — Haplogroup U Possible time of origin 55,000 BP Possible place of origin Western Asia Ancestor R Descendants U1, U5, U6, U2 3 4 7 8 9 Defining mutations 11467, 12308, 12372 …   Wikipedia Haplogroup H (mtDNA) — Haplogroup H Possible time of origin 25,000 30,000…

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Rett Syndrome Patients Have Higher Copy Number of Mitochondrial DNA

The copy number of mitochondrial DNA (mtDNA) is increased significantly in patients with Rett syndrome, possibly indicating mitochondrial dysfunction, a study reported. Researchers suggest that this increase in the copy number of mtDNA is an attempt to compensate for decreased energy availability. Mitochondria are the producers of energy within a…

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Plasma circulating cell-free mitochondrial DNA in depressive disorders

Background: Plasma circulating cell-free mitochondrial DNA (ccf-mtDNA) is an immunogenic molecule and a novel biomarker of psychiatric disorders. Some previous studies reported increased levels of ccf-mtDNA in unmedicated depression and recent suicide attempters, while other studies found unchanged or decreased ccf-mtDNA levels in depression. Inconsistent findings across studies may be…

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Detection of heteroplasmy and nuclear mitochondrial pseudogenes in the Japanese spiny lobster Panulirus japonicus

Direct nucleotide sequencing Readable electropherograms were obtained from both direction in COI fragments of all three individuals of the Japanese spiny lobster. COI sequences determined by direct nucleotide sequencing ranged from 807 to 864 bp and have been deposited in International Nucleotide Sequence Database Collection (INSDC) under accession numbers of LC571524‒LC571526….

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MyHeritage is a world-renowned genealogy site and it is among the best sites available for genealogical studies.

MyHeritage is a world-renowned genealogy site and it is among the best sites available for genealogical studies. Nowadays, MyHeritage has begun available DNA assessment to compliment her more investigation services. Through getting DNA evaluation finished through MyHeritage DNA, you’ve got the opportunity to relate genuinely to family relations there is…

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Use of whole genome sequencing to determine genetic basis of suspected mitochondrial disorders: cohort study

Katherine R Schon, clinical research fellow1 2 3, Rita Horvath, clinical director of research1, Wei Wei, senior bioinformatician1 2, Claudia Calabrese, research associate1 2, Arianna Tucci, clinical research fellow4, Kristina Ibañez, senior research associate4, Thiloka Ratnaike, clinical research fellow1 2 5, Robert D S Pitceathly, consultant neurologist6, Enrico Bugiardini, clinical…

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Frequent paternal mitochondrial inheritance and rapid haplotype frequency shifts in copepod hybrids

doi: 10.1093/jhered/esab068. Online ahead of print. Affiliations Expand Affiliation 1 University of North Carolina at Chapel Hill, Chapel Hill, NC. Item in Clipboard Jeeyun Lee et al. J Hered. 2021. Show details Display options Display options Format AbstractPubMedPMID doi: 10.1093/jhered/esab068. Online ahead of print. Affiliation 1 University of North Carolina at…

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Cataract Surgery Safe For AMD Patients

Cadaver study finds no evidence of accelerated AMD following cataract surgery. Photo: Jay M. Haynie, OD. Click image to enlarge. Sunlight exposure and inflammation are both considered risk factors for age-related macular degeneration (AMD) pathogenesis, and researchers have considered whether cataract surgery—with surgically-induced inflammation and increased light exposure due to lens…

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Mitochondrial DNA methylation drift and postoperative delirium in mice

Background: Mitochondrial dysfunction is linked to the etiopathogenesis of postoperative delirium (POD), which severely affects the prognosis of elderly patients undergoing surgery. The methylation of mitochondrial DNA (mtDNA), a new and incompletely described phenomenon that regulates the structure and function of mitochondria, is associated with ageing. However, the relationship between…

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Ricinoididae) from El Triunfo Biosphere Reserve, Chiapas, Mexico

COI mtDNA barcoding and morphology for the description of a new species of ricinuleid of the genus Pseudocellus (Arachnida: Ricinulei: Ricinoididae) from El Triunfo Biosphere Reserve, Chiapas, Mexico We’re sorry, but GBIF doesn’t work properly without JavaScript enabled. Our website has detected that you are using an outdated insecure browser…

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A complete sequence of mitochondrial genome of Neolamarckia cadamba and its use for systematic analysis

Assembly of mitochondrial genome MtDNA sequence of N. cadamba was determined using PacBio sequencing technique and was successfully assembled in two genome circles. This probably reflects the feature of rapid evolution of structure of plant mitochondrial genomes38,39,40. Figure 1 shows two parts of circular structure of the mitochondrial genome, designated as…

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“Genetic Goldmine” Uncovered for Plant Survival in One of the Harshest Environments on Earth

Evolutionary genomics approach identifies genes that enable plants to live in the Atacama Desert, offering clues for engineering more resilient crops to face climate change. An international team of researchers has identified genes associated with plant survival in one of the harshest environments on Earth: the Atacama Desert in Chile….

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Intra-individual state-dependent comparison of plasma mitochondrial DNA copy number and IL-6 levels in patients with bipolar disorder

Background: Patients with bipolar disorder (BD) have increased plasma IL-6 levels, which are higher in depressed BD (dBD) than remitted BD (rBD). However, the mechanism that differentiates the cytokine levels between dBD and rBD is not understood. First, we determined whether brain-derived mtDNA can be detected in plasma using neuron-specific…

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The integrity and assay performance of tissue mitochondrial DNA is considerably affected by choice of isolation method

Available online 30 October 2021 doi.org/10.1016/j.mito.2021.10.005Get rights and content Highlights • The procedure chosen for isolation of mtDNA from solid tissues has a considerable effect on the integrity of the product, as routine isolation methods yield mtDNA with numerous single-stranded nicks per mtDNA strand. • Modifications that benefit mtDNA integrity…

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The MOTS-c K14Q polymorphism in the mtDNA is associated with muscle fiber composition and muscular performance

Available online 30 October 2021, 130048 doi.org/10.1016/j.bbagen.2021.130048Get rights and content Highlights • There is an East Asian-specific m.1382A>C polymorphism in the mtDNA that changes the 14th amino acid of MOTS-c (i.e., K14Q). • The C allele carriers of the MOTS-c m.1382A>C polymorphism exhibited a higher percentage of myosin heavy chain-IIx…

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Cell identity and nucleo-mitochondrial genetic context modulate OXPHOS performance and determine somatic heteroplasmy dynamics

Sammendrag Heteroplasmy, multiple variants of mitochondrial DNA (mtDNA) in the same cytoplasm, may be naturally generated by mutations but is counteracted by a genetic mtDNA bottleneck during oocyte development. Engineered heteroplasmic mice with nonpathological mtDNA variants reveal a nonrandom tissue-specific mtDNA segregation pattern, with few tissues that do not show…

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Response to Comment on “Late Pleistocene human skeleton and mtDNA link Paleoamericans and modern Native Americans”

Using an analysis of nucleotide damage patterns and fragment sizes in Illumina sequences from the Hoyo Negro remains, Prüfer and Meyer (1) suggest that the mitochondrial haplogroup D1 sequences we obtained were not endogenous to the sample. Although they raise important concerns, we note that (i) the assignment of this…

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Exploring ExtensionsRemains of a soldier shot down over Vi…

Exploring Extensions Remains of a soldier shot down over Vietnam in 1972 and buried in the Tomb of the Unknown in 1984 were identified in 1998 by the Armed Forces DNA Identification Laboratory (see Section 12.9). The confirmatory tests were based on matching mitochondrial DNA (mtDNA) from the soldier’s bones…

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How is mitochondrial dna (mtdna) typing used in forensic science?

Answers Mitochondrial DNA (mtDNA) typing is used in forensic science for it serves as an important tool in determining the recovered damaged, degraded or small sample source of the DNA. Mitochondrial DNA is a small genome that is found in the mitochondria, just outside of the nucleus of the cell….

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Intergenerational Effects of Maternal Obesity on Offspring Mitochondrial Reactive Oxygen Species Production and DNA Damage

Abstract: Epidemiological studies have shown that offspring from pregnancies complicated by maternal obesity have a 4-fold greater risk for developing childhood obesity and symptoms of metabolic syndrome. The developmental origins of health and disease (DOHaD) hypothesis states that certain environmental exposures during critical windows of development may have consequences for…

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mtDNA-seq by Capture-based hybirdization library method

mtDNA-seq by Capture-based hybirdization library method 0 Hi all, I would like to ask a question. Recently, we used KAPA hyperprep + hyperChoice (mtDNA probe) to do the mtDNA-seq, but we are facing an issue. The heteroplasmy level is different with Sanger Sequencing result by a lot. Could anyone share…

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Cellular response to mitochondrial dysfunction and pathogenic mtDNA mutations

Special Issue Cellular response to mitochondrial dysfunction and pathogenic mtDNA mutations Submission Deadline: 31 December 2017 Articles: 1 Special Issue Editor Guest Editor Ph.D., Center for Mitochondrial Medicine and Free Radical Research Changhua Christian Hospital Changhua City, Taiwan 50046 Expertise: 375 publications, 3 grants, Editor of Frontiers in Bioscience Severance…

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Greece’s Minoans Were Indigenous Europeans, DNA Finds

DNA reveals the origin of Greece’s ancient Minoan culture. Europe’s first advanced civilization was local in origin and not imported from elsewhere, the study in 2013 said. Analysis of DNA from ancient remains on the Greek island of Crete suggests the Minoans were indigenous Europeans, shedding new light on a…

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Diagnostics | Free Full-Text | Mutational Analysis and mtDNA Haplogroup Characterization in Three Serbian Cases of Mitochondrial Encephalomyopathies and Literature Review

Mitochondrial encephalomyopathies (MEMP) are heterogeneous multisystem disorders frequently associated with mitochondrial DNA (mtDNA) mutations. Clinical presentation varies considerably in age of onset, course, and severity up to death in early childhood. In this study, we performed molecular genetic analysis for mtDNA pathogenic mutation detection in Serbian children, preliminary diagnosed clinically,…

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which best describes mitochondrial dna (mtdna)? Archives

which best describes mitochondrial dna (mtdna)? Archives – Naija Edu Info Mastodon Home Tags Which best describes mitochondrial dna (mtdna)? …

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Role of Genetics, Epigenetics, and Environmental Factors in Human Complex Diseases from the Mitochondrial Point of View

Mitochondrial dysfunction due to alterations in mitochondrial DNA (mtDNA) gene expression and replication underlie several human pathologies. However, the exact mechanisms through which these alterations arise are still poorly understood. In recent years, a growing number of studies identified epigenetic mechanisms that act inside mitochondria, thus opening a new…

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Research Breakthrough Could Mean Better Treatment for Most Deadly Form of Brain Cancer

Scientists studying the most common and aggressive type of brain tumor in adults have discovered a new way of analyzing diseased and healthy cells from the same patient. Crucially, the work which has been funded by the charity Brain Tumour Research could pave the way for truly personalized treatment for patients…

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Mitochondrial DNA sequence variation and risk of meningioma

This article was originally published here J Neurooncol. 2021 Oct 20. doi: 10.1007/s11060-021-03878-5. Online ahead of print. ABSTRACT BACKGROUND: Risk factors for meningioma include female gender, African American race, high body mass index (BMI), and exposure to ionizing radiation. Although genome-wide association studies (GWAS) have identified two nuclear genome risk…

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USS Oklahoma sailor from Levelland accounted for from World War II

LEVELLAND, Texas (NEWS RELEASE) – The Defense POW/MIA Accounting Agency (DPAA) announced today that Navy Fireman 1st Class James O. McDonald, 25, of Levelland, Texas, killed during World War II, was accounted for on Dec. 22, 2020. On Dec. 7, 1941, McDonald was assigned to the battleship USS Oklahoma, which…

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Decreasing mitochondrial RNA polymerase activity reverses biased inheritance of hypersuppressive mtDNA

Faithful inheritance of mitochondrial DNA (mtDNA) is crucial for cellular respiration/oxidative phosphorylation and mitochondrial membrane potential. However, how mtDNA is transmitted to progeny is not fully understood. We utilized hypersuppressive mtDNA, a class of respiratory deficient Saccharomyces cerevisiae mtDNA that is preferentially inherited over wild-type mtDNA (rho+), to uncover the…

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Nuclear DNA-encoded fragments of mitochondrial DNA (mtDNA) confound analysis of selection of mtDNA mutations in human primordial germ cells.

Abstract The resilience of the mitochondrial genome to a high mutational pressure depends, in part, on purifying selection against detrimental mutations in the germline. It is crucial to understand the mechanisms of this process. Recently, Floros et al. concluded that much of the purifying selection takes place during the proliferation…

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Mitochondrial genome and its regulator TFAM modulates head and neck tumourigenesis through intracellular metabolic reprogramming and activation of oncogenic effectors

Mitochondrial transcriptional factor A (TFAM) acts as a key regulatory to control mitochondrial DNA (mtDNA); the impact of TFAM and mtDNA in modulating carcinogenesis is controversial. Current study aims to define TFAM mediated regulations in head and neck cancer (HNC). Multifaceted analyses in HNC cells genetically manipulated for TFAM were…

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South Carolina soldier killed in World War II accounted for after 75 years, officials say

WASHINGTON (WYFF) – A South Carolina man who was killed during World War II has finally been accounted for and will receive a proper soldier’s burial in his Anderson County hometown, military officials said Monday. The Defense POW/MIA Accounting Agency, or DPAA, said in a release that Army Staff Sgt. William…

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Research progress on the physiological function of mtDNA and its specific detection and therapy

doi: 10.1002/cbic.202100474. Online ahead of print. Affiliations Expand Affiliations 1 Nanjing Tech University, Institute of Advanced Materials, CHINA. 2 Northwestern Polytechnical University, Institute of Flexible Electronics, CHINA. 3 Nanjing Tech University, Institute of Advanced Materials, 30 South Puzhu Road, 210008, Nanjing, CHINA. Item in Clipboard Congcong Zhang et al. Chembiochem. 2021….

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Following the Trace of HVS II Mitochondrial Region Within the Nine Iranian Ethnic Groups Based on Genetic Population Analysis

Akbari MT, Izadi P, Izadyar M, Kyriacou K, Kleanthous M (2008) Molecular basis of thalassemia intermedia in Iran. Hemoglobin 32:462–470 CAS  Article  Google Scholar  Al-Allawi NA, Jubrael JM, Hughson M (2006) Molecular characterization of β-thalassemia in the Dohuk region of Iraq. Hemoglobin 30:479–486 CAS  Article  Google Scholar  Alibakhshi R, Kianishirazi…

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Precision modeling of mitochondrial disease in rats via DdCBE-mediated mtDNA editing

Author Correction: Generation of somatic mitochondrial DNA-replaced cells for mitochondrial dysfunction treatment “ρ(-)”. Consequently, Figure 2(g) legend has been modified accordingly,. “MirCs were generated from mitochondrial disease patient-derived (7S) fibroblasts. (a) mtDNA CN during the procedure of MirC generation. Fibroblasts that received gene transfer, designated as 7S_ρ(-) were cultivated with…

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Haplotype and phylogenetic analyses suggest that one European-specific mtDNA background plays a role in the expression of Leber hereditary optic neuropathy by increasing the penetrance of the primary mutations 11778 and 14484.

Authors Torroni, A, Petrozzi, M, D’Urbano, L, Sellitto, D, Zeviani, M, Carrara, F, Carducci, C, Leuzzi, V, Carelli, V, Barboni, P, De Negri, A, Scozzari, R Abstract mtDNAs from 37 Italian subjects affected by Leber hereditary optic neuropathy (LHON) (28 were 11778 positive, 7 were 3460 positive, and 2 were…

Continue Reading Haplotype and phylogenetic analyses suggest that one European-specific mtDNA background plays a role in the expression of Leber hereditary optic neuropathy by increasing the penetrance of the primary mutations 11778 and 14484.

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Sex-Specific Migration Patterns in Central Asian Populations, Revealed by Analysis of Y-Chromosome Short Tandem Repeats and mtDNA

Abstract SummaryEight Y-linked short-tandem-repeat polymorphisms (DYS19, DYS388, DYS389I, DYS389II, DYS390, DYS391, DYS392, and DYS393) were analyzed in four populations of Central Asia, comprising two lowland samples—Uighurs and lowland Kirghiz—and two highland samples—namely, the Kazakhs (altitude 2,500 m above sea level) and highland Kirghiz (altitude 3,200 m above sea level). The…

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Risk of developing a mitochondrial DNA deletion disorder.

Authors Chinnery, PF, DiMauro, S, Shanske, S, Schon, EA, Zeviani, M, Mariotti, C, Carrara, F, Lombes, A, Laforet, P, Ogier, H, Jaksch, M, Lochmüller, H, Horvath, R, Deschauer, M, Thorburn, DR, Bindoff, LA, Poulton, J, Taylor, RW, Matthews, JNS, Turnbull, DM Abstract BACKGROUND: Pathogenic mitochondrial DNA (mtDNA) mutations are found…

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Nanopore Single-Molecule Sequencing for Mitochondrial DNA Methylation Analysis: Investigating Parkin-Associated Parkinsonism as a Proof of Concept

doi: 10.3389/fnagi.2021.713084. eCollection 2021. Affiliations Expand Affiliations 1 Institute of Neurogenetics BMF, University of Lübeck and University Hospital Schleswig-Holstein Campus Lübeck, Lübeck, Germany. 2 Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg. 3 Department of Life Sciences and Medicine, University of Luxembourg, Belvaux, Luxembourg. Item in Clipboard Theresa…

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The level of free-circulating mtDNA in patients with radon-induced lung cancer

Available online 14 October 2021, 112215 doi.org/10.1016/j.envres.2021.112215Get rights and content Highlights • Lung cancer patients had significantly higher cf mtDNA copy numbers compared to the control group. • In healthy volunteers living in areas with high radon levels (radon), the mtDNA copy numbers was higher than that in the control…

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Full Sequence MTDNA Haplotype -Subgroup : Genealogy

Hi All… Beginner and learning about this. Have been doing some research on the mtdna full sequence, what the numbers means, etc. Been fun learning. My question is however, I just got the results from the mtdna full sequence and it of course told me my Haplotype, which is H3….

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Mitochondrial DNA leakage induces odontoblast inflammation via the cGAS-STING pathway

Dental caries are the most common health condition worldwide and can progress to pulpitis, a painful dental pulp infection. Odontoblasts at the pulp-dentin interface fight against these conditions by preventing bacterial invasion. In other pathological conditions, mitochondrial DNA (mtDNA)-related cell stress activates the cGAS-STING pathway, which contributes to inflammation, but…

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Collated mutations in mitochondrial DNA (mtDNA) depletion syndrome (excluding the mitochondrial gamma polymerase, POLG1).

Authors Poulton, J, Hirano, M, Spinazzola, A, M Hernandez, A, Jardel, C, Lombès, A, Czermin, B, Horvath, R, Taanman, JW, Rotig, A, Zeviani, M, Fratter, C Abstract These tables list both published and a number of unpublished mutations in genes associated with early onset defects in mitochondrial DNA (mtDNA) maintenance…

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Inflammation mtdna transcription replication mitochondrial biogenesis shirt

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Haplotype Diversity of Mongolian and Tuvan Goat Breeds (Capra hircus) Based on mtDNA and Y-Chromosome Polymorphism

1 Zonaed Siddiki, A., Miah, G., Islam, M.S., et al., Goat genomic resources: the search for genes associated with its economic traits, Int. J. Genomics, 2020, 5940205. doi.org/10.1155/2020/5940205 2 Amills, M., Capote, J., and Tosser-Klopp, G., Goat domestication and breeding: a jigsaw of historical, biological and molecular data with missing…

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Manipulation of mitochondrial genes and mtDNA heteroplasmy.

Authors Bacman, SR, Gammage, PA, Minczuk, M, Moraes, CT Abstract Most patients with mitochondrial DNA (mtDNA) mutations have a mixture of mutant and wild-type mtDNA in their cells. This phenomenon, known as mtDNA heteroplasmy, provides an opportunity to develop therapies by selectively eliminating the mutant fraction. In the last decade,…

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dna seq analysis – Banya

Dna Sequencing Data Analysis Simple Software Tools . Omicscript Pipeline For Dna Seq Data Analysis Array Suite Wiki . Dna Sequencing Data Analysis Simple Software Tools . Omicscript Pipeline For Dna Seq Data Analysis Array Suite Wiki . Dna Sequence Alignment Dna Contig Assembly Software Sequence . Dna Sequence Alignment…

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Delaware Patent of the Month – October 2021

Mitochondrial DNA (mtDNA) is a fantastic diagnostic tool. By sequencing the mtDNA, you can detect mutations which are often preliminary indicators of developing diseases. Certain mutations at certain sites can indicate certain diseases, giving some of the most accurate diagnostics possible. MDNA Life Sciences, Inc. focuses on further developing the…

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Mitochondrial DNA and human evolution

Brigitte Pakendorf , Mark Stoneking Several unique properties of human mitochondrial DNA (mtDNA), including its high copy number, maternal inheritance, lack of recombination, and high mutation rate, have made it the molecule of choice for studies of human population history and evolution. Here we review the current state of knowledge concerning these…

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VIEWCONTENT PHP%3FARTICLE%3DHUNT FOR MTDNA ANSWERS%26CONTEXT%3DPDF

File Name: viewcontent php%3Farticle%3Dhunt for mtdna answers%26context%3Dpdf.pdfSize: 1505 KBType: PDF, ePub, eBook Category: BookUploaded: 10 May 2019, 23:18 PMRating: 4.6/5 from 753 votes. Status: AVAILABLE Last checked: 4 Minutes ago! In order to read or download viewcontent php%3Farticle%3Dhunt for mtdna answers%26context%3Dpdf ebook, you need to create a FREE account. eBook…

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mtDNA microevolution in Southern Chile’s archipelagos

Abstract/Review The genetic variability of four predominantly Indian populations of southern Chile’s archipelagos was examined by determining the frequencies of four mitochondrial DNA haplogroups that characterize the American Indian populations. Over 90% of the individuals analyzed presented Native American mtDNA haplogroups. By means of an unweighted group pair method with…

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Creation of cybrid culture with mtDNA mutation M.14846G>A

ADVERTISEMENT SCROLL TO CONTINUE WITH CONTENT All ContentArticle TitleAuthorsKeywordsAbstractArticle Title, Abstract, Keywords Please enter a term before submitting your search. Ok If you don’t remember your password, you can reset it by entering your email address and clicking the Reset Password button. You will then receive an email that contains…

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Antigen receptor stimulation drives selection against pathogenic mtDNA variants that dysregulate lymphocyte responses

Abstract Pathogenic mitochondrial (mt)DNA molecules can exhibit heteroplasmy in single cells and tissues and cause a range of clinical phenotypes, although their contribution to immunity is poorly understood. Here, in mice carrying heteroplasmic C5024T in mt-tRNA Ala – that impairs oxidative phosphorylation – we found a reduced mutation burden in…

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Mitochondrial DNA is released by cigarette smoke

In a recent study, researchers have discovered that mitochondrial DNA is released extracellularly upon exposure to cigarette smoke and in COPD patients. COPD and its risk factors Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that cause difficulties in breathing. It results in remodelling of airway wall…

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Melatonin ameliorates cognitive deficits through improving mitophagy in a mouse model of Alzheimer’s disease

This article was originally published here J Pineal Res. 2021 Oct 7:e12774. doi: 10.1111/jpi.12774. Online ahead of print. ABSTRACT While melatonin is known to have protective effects in mitochondria-related diseases, aging and neurodegenerative disorders, there is poor understanding of the effects of melatonin treatment on mitophagy in Alzheimer’s disease (AD)….

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Haplogroup I (mtDNA)

Haplogroup U (mtDNA) — Haplogroup U Possible time of origin 55,000 BP Possible place of origin Western Asia Ancestor R Descendants U1, U5, U6, U2 3 4 7 8 9 Defining mutations 11467, 12308, 12372 …   Wikipedia Haplogroup H (mtDNA) — Haplogroup H Possible time of origin 25,000 30,000…

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Hunt For Mtdna Answers

Hunt For Mtdna Answers New Amelia Earhart Hunt Planned After Discovery of Skull |Your mtDNA Full Sequence Results| Yet these blameless persons are treated as accurst and hated like mortal sin. The car screeched down the steep drive, his eyes unblinking,…

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Mitochondrial DNA copy number and heteroplasmy load correlate with skeletal muscle oxidative capacity by P31 MR spectroscopy

The association between blood-based estimates of mitochondrial DNA parameters, mitochondrial DNA copy number (mtDNA-CN) and heteroplasmy load, with skeletal muscle bioenergetic capacity was evaluated in 230 participants of the Baltimore Longitudinal Study of Aging (mean age:74.7 years, 53% women). Participants in the study sample had concurrent data on muscle oxidative…

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Luciole Pharmaceuticals And Cyclica Announce Research Collaboration To Accelerate Discovery Of Novel Medicines

Natick, MA and Toronto, ON /PRNewswire/ – Luciole Pharmaceuticals, a startup company focused on the discovery and development of small molecules that enhance the repair of oxidative damage to mitochondrial DNA (mtDNA), and Cyclica, the partner of choice for data-driven drug discovery, today announced a research collaboration aimed at accelerating…

Continue Reading Luciole Pharmaceuticals And Cyclica Announce Research Collaboration To Accelerate Discovery Of Novel Medicines

IDENTIFYING CIRCULATING MEDIATORS OF CEREBROVASCULAR DISEASE

Abstract:  Many current drugs for stroke act by targeting circulating molecules, yet these have not been exhaustively evaluated for therapeutic potential. A central challenge is that while many molecules correlate with stroke risk, only a subset cause stroke. To disentangle causality from association, a statistical genetics framework called “Mendelian Randomization”…

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Genetic proof for domestication of sheep in Indian subcontinent

The practice was more prevalent in Indus Valley regions in the 6th or 7th millennium BC, says study by CUK researchers Researchers at the Central University of Kerala (CUK) have found that domestication of sheep had taken place in the Indian subcontinent, especially in the Indus Valley civilisation regions in…

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Remains of Ellsworth County sailor killed at Pearl Harbor return home

WICHITA, Kan. (KWCH) – Nearly 80 years after his death, an Ellsworth County native who served his country returns home. Fireman First Class Walter Belt Jr. served in the U.S. Navy. He died at the age of 25 aboard the USS Oklahoma during the attack on Pearl Harbor. In an…

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Luciole Pharmaceuticals and Cyclica Announce Research Collaboration to Accelerate Discovery of Novel Medicines | News

NATICK, Mass. and TORONTO, Oct. 6, 2021 /PRNewswire/ — Luciole Pharmaceuticals, a startup company focused on the discovery and development of small molecules that enhance the repair of oxidative damage to mitochondrial DNA (mtDNA), and Cyclica, the partner of choice for data-driven drug discovery, today announced a research collaboration aimed at accelerating the…

Continue Reading Luciole Pharmaceuticals and Cyclica Announce Research Collaboration to Accelerate Discovery of Novel Medicines | News

Intercellular transfer of mitochondrial DNA carrying metastasis-enhancing pathogenic mutations from high- to low-metastatic tumor cells and stromal cells via extracellular vesicles | BMC Molecular and Cell Biology

Reagents GW4869, a neutral sphingomyelinase inhibitor, and tipifarnib, a farnesyl transferase inhibitor, were obtained from Cayman Chemical (Ann Arbor, MI, USA) and ChemScene LLC (Monmouth, NJ, USA), respectively. MitoTracker Red CMXRos, MitoTracker Deep Red FM (MTDR) and CellLight mitochondria-GFP (mtGFP) were supplied by Thermo Fisher Scientific (Waltham, MA, USA). MitoBright…

Continue Reading Intercellular transfer of mitochondrial DNA carrying metastasis-enhancing pathogenic mutations from high- to low-metastatic tumor cells and stromal cells via extracellular vesicles | BMC Molecular and Cell Biology

Beyond Base Excision Repair: An evolving picture of mitochondrial DNA repair

. 2021 Oct 5;BSR20211320. doi: 10.1042/BSR20211320. Online ahead of print. Affiliations Expand Affiliations 1 Solent University Southampton, Southampton, United Kingdom. 2 University of Gloucestershire – Francis Close Hall Campus, Cheltenham, United Kingdom. Free article Item in Clipboard Kathrin Allkanjari et al. Biosci Rep. 2021. Free article Show details Display options Display…

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Quantitative and qualitative mtDNA-lesions with mitochondrial dysfunction in multiple organs after HAART-associated fatal lactacidosis

@article{Thoden2008QuantitativeAQ, title={Quantitative and qualitative mtDNA-lesions with mitochondrial dysfunction in multiple organs after HAART-associated fatal lactacidosis}, author={Jan Thoden and Dirk Lebrecht and Nils Venhoff and J. Neumann and Klaus M{“u}ller and UA Walker}, journal={Journal of the International AIDS Society}, year={2008}, volume={11}, pages={1-2} } Background We describe a 62 year-old HIV-infected male,…

Continue Reading Quantitative and qualitative mtDNA-lesions with mitochondrial dysfunction in multiple organs after HAART-associated fatal lactacidosis

New evidence for panselective evolution

Abstract/Review Analysis for the homogeneity of the distribution of the second base of dinucleotides in relation to the first, whose bases are separated by 0, 1, 2, 21 nucleotide sites, was performed with the VIH-1 genome (cDNA), the Drosophila mtDNA, the Drosophila Torso gene and the human β-globin gene. These…

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Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease

dc.contributor.author Dölle, Christian dc.contributor.author Flønes, Irene Hana dc.contributor.author Sanchez Nido, Gonzalo dc.contributor.author Miletic, Hrvoje dc.contributor.author Osuagwu, Nelson dc.contributor.author Kristoffersen, Stine dc.contributor.author Lilleng, Peer Kåre dc.contributor.author Larsen, Jan Petter dc.contributor.author Tysnes, Ole-Bjørn dc.contributor.author Haugarvoll, Kristoffer dc.contributor.author Bindoff, Laurence dc.contributor.author Tzoulis, Charalampos dc.date.accessioned 2017-05-18T07:49:32Z dc.date.available 2017-05-18T07:49:32Z dc.date.created 2016-12-18T15:13:21Z dc.date.issued 2016-11 dc.identifier.citation Dölle,…

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No evidence for ‘skewed’ inactivation of the X-chromosome as cause of Leber’s hereditary optic neuropathy in female carriers

@article{6dd0b2f774db4eb6acf1d75e92758f2e, title = “No evidence for ‘skewed’ inactivation of the X-chromosome as cause of Leber’s hereditary optic neuropathy in female carriers”, abstract = “Leber’s hereditary optic neuropathy (LHON) is a maternally inherited disorder of the optic nerves. It has been proposed that the specific mutations in the mitochondrial DNA (mtDNA)…

Continue Reading No evidence for ‘skewed’ inactivation of the X-chromosome as cause of Leber’s hereditary optic neuropathy in female carriers

Cell reprogramming shapes the mitochondrial DNA landscape.

dc.contributor.author Wei, Wei dc.contributor.author Gaffney, Daniel J dc.contributor.author Chinnery, Patrick F dc.date.accessioned 2021-10-05T00:26:36Z dc.date.available 2021-10-05T00:26:36Z dc.date.issued 2021-09-02 dc.identifier.issn 2041-1723 dc.identifier.other 34475388 dc.identifier.other PMC8413449 dc.identifier.uri www.repository.cam.ac.uk/handle/1810/328995 dc.description.abstract Individual induced pluripotent stem cells (iPSCs) show considerable phenotypic heterogeneity, but the reasons for this are not fully understood. Comprehensively analysing the mitochondrial genome…

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Gitelman-Like Syndrome Caused by Pathogenic Variants in mtDNA

This article was originally published here J Am Soc Nephrol. 2021 Oct 4:ASN.2021050596. doi: 10.1681/ASN.2021050596. Online ahead of print. ABSTRACT Background: Gitelman syndrome (GS) is the most frequent hereditary salt-losing tubulopathy characterized by hypokalemic alkalosis and hypomagnesemia. GS is caused by biallelic pathogenic variants in SLC12A3, encoding the Na+-Cl– cotransporter…

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mtDNA, 45-1 Ramsey Road, Shirley, NY 11967, USA, 45-1 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY, 11967

mtDNA Category: Science Centres Address: 45-1 Ramsey Road, Shirley, NY 11967, USA, 45-1 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY, 11967 Landline: 020 721… Landline: 020 721…  Website: www.cd-genomics.com/Mitochondrial-DNA-mtDNA-sequencing.html  Website: Visit Website  Message now Report a problem with this listing Reviews Leave a review Read more here: Source link

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Evidence for independent domestication of sheep mtDNA lineage A in India and introduction of lineage B through Arabian sea route

1. Sharma, R. et al. Microsatellite and mitochondrial DNA analyses unveil the genetic structure of native sheep breeds from three major agro-ecological regions of India. Sci. Rep. 10, 20422. doi.org/10.1038/s41598-020-77480-6 (2020). CAS  Article  PubMed  PubMed Central  Google Scholar  2. Wood, N. J. & Phua, S. H. Variation in the control…

Continue Reading Evidence for independent domestication of sheep mtDNA lineage A in India and introduction of lineage B through Arabian sea route

Mitochondrial DNA Copy Number in Rett Syndrome Caused by MECP2 Variants

Available online 4 October 2021 doi.org/10.1016/j.jpeds.2021.09.052Get rights and content Abstract Objective To determine changes of mitochondrial DNA (mtDNA) copy number in peripheral blood in Rett syndrome caused by methyl-CpG-binding protein-2 (MECP2) variants and explore the mechanism of mitochondrial dysfunction in RTT. Study design Female patients who were diagnosed as RTT…

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Mitochondrial deoxyribonucleic acid deletions in oocytes and reproductive aging in women

doi.org/10.1016/S0015-0282(16)57796-6Get rights and content Objective To determine whether oocytes from women harbor deletions in mitochondrial DNA (mtDNA) and whether deleted mtDNA is more common in oocytes from older women than oocytes from younger women. Design A polymerase chain reaction (PCR)-based strategy, which depends on deletions approximating otherwise widely separated primers…

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Is the Dinoflagellate Amoebophrya… preview & related info

Abstract Mitochondrial DNA (mtDNA) is a universal hallmark of aerobic eukaryotes. That is why the recent suggestion by John et al. (2019. An aerobic eukaryotic parasite with functional mitochondria that likely lacks a mitochondrial genome. Sci Adv. 5(4):eaav1110.) that the aerobic dinoflagellate Amoebophrya sp. strain AT5 (Syndiniales) lacks mtDNA was so…

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Using Synthetic Biology To Shed Light on “Biological Dark Matter”

A new body of research, published in Nature Communications, suggests synthetic biology could help to better characterize complex microbial communities, unlocking their potential for industrial and medical biotechnology. Communities of microorganisms control many of Earth’s most important environmental processes. For example, photosynthetic ocean microbes produce at least 50 percent of…

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Encounter networks from collective mitochondrial dynamics support the emergence of effective mtDNA genomes in plant cells

Abstract Mitochondria in plant cells form strikingly dynamic populations of largely individual organelles. Each mitochondrion contains on average less than a full copy of the mitochondrial DNA (mtDNA) genome. Here, we asked whether mitochondrial dynamics may allow individual mitochondria to ‘collect’ a full copy of the mtDNA genome over time,…

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Mitofusin 2: the missing link between mtDNA maintenance defects and neurotransmitter disorders

Available online 30 September 2021 doi.org/10.1016/j.mito.2021.09.011Get rights and content Highlights • MFN2 pathogenic variants classically cause Charcot-Marie-Tooth disease type 2A, but patients with complex and unusual phenotypes have been described. • MFN2 is actually recognized as a novel gene associated with “mtDNA-maintenance defects”, due to its essential role in mitochondrial…

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A broad comparative genomics approach to understanding the pathogenicity of Complex I mutations

Variants classed as definitely pathogenic in humans Among the 18 mutations of Complex 1 that are definitely pathogenic after application of the modified scoring system, 11 were found in at least one species from our dataset, and four of them occurred on the phylogenetic tree more than once (Table 1,…

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17. Estimating Haplogroup Affiliation through Ancient mtDNA Analysis from the Huaca Prieta Burials

Tung, Tiffiny A., Blair, Jessica, Summar, Marshal, Tito, Raúl and Lewis, Cecil. “17. Estimating Haplogroup Affiliation through Ancient mtDNA Analysis from the Huaca Prieta Burials”. Where the Land Meets the Sea: Fourteen Millennia of Human History at Huaca Prieta, Peru, edited by Tom D. Dillehay, New York, USA: University of…

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Decreased mitochondrial DNA copy number in nerve cells and the hippocampus during nicotine exposure is mediated by autophagy

doi.org/10.1016/j.ecoenv.2021.112831Get rights and content Highlights • Long-term nicotine exposure induces detrimental effects on mitochondria. • Markedly lower mtDNA copy number is a potential biomarker of nicotine addiction. • Decreased mtDNA copy number induced by nicotine is mediated by autophagy. Abstract Cigarette smoke is a harmful air pollutant and nicotine dependence…

Continue Reading Decreased mitochondrial DNA copy number in nerve cells and the hippocampus during nicotine exposure is mediated by autophagy

Analysis of cf-mtDNA and cf-nDNA fragment size distribution using different isolation methods in BV-2 cell supernatant of starvation-induced autophagy

Available online 30 September 2021, 119147 doi.org/10.1016/j.bbamcr.2021.119147Get rights and content Highlights • Autophagy-associated cfDNA could be visualized as an oligonucleosomal DNA ladder pattern • Autophagy-associated cf-mtDNA and cf-nDNA were both highly enriched in <mono-nucleosomes fragments • Autophagy-associated cf-mtDNA and cf-nDNA showed no significant differences in the relative percentages for <mono,…

Continue Reading Analysis of cf-mtDNA and cf-nDNA fragment size distribution using different isolation methods in BV-2 cell supernatant of starvation-induced autophagy

Mitochondrial DNA heteroplasmy is modulated during oocyte development propagating mutation transmission

Citation Chinnery, P. Mitochondrial DNA heteroplasmy is modulated during oocyte development propagating mutation transmission. Science Advances doi.org/10.17863/CAM.76113 Abstract Heteroplasmic mitochondrial DNA (mtDNA) mutations are a common cause of inherited disease, but a few recurrent mutations account for the vast majority of new families. The reasons for this are not known….

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Preprint Highlight: ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA- dependent STING signaling

Loss-of-function mutations in VPS13C cause familial Parkinson’s disease (PD) and increase the risk to develop the sporadic form of the disease. However, the underlying disease mechanisms remain unclear. It has been previously established that VPS13C tethers lysosomes with the endoplasmic reticulum (ER) and promotes lipid interchange between both organelles. This…

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genbank submission tutorial

These are just a few of the questions answered in this comprehensive overview of Bayesian approaches to phylogenetics. Finally, make sure the Include Primers box is unchecked, as we are not submitting primers with this sequence. Influenza virus sequences. September, 2008. Please download the current version. Some mitochondrial genomes contain CDS’s that…

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Genome-wide autosomal, mtDNA, and Y chromosome analysis of King Bela III of the Hungarian Arpad dynasty

The ancient Hungarians, “Madzsars”, established their control of the Carpathian Basin in the late ninth century and founded the Hungarian Kingdom around 1000AD. The origin of the Magyars as a tribal federation has been much debated in the past. From the time of the conquest to the early fourteenth century…

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MtDNA Analysis Indicates Human-Induced Temporal Changes of Serbian Honey Bees Diversity

Local populations of Apis mellifera are rapidly changing by modern beekeeping through the introduction of nonnative queens, selection and migratory beekeeping. To assess the genetic diversity of contemporary managed honey bees in Serbia, we sequenced mitochondrial tRNAleu-cox2 intergenic region of 241 worker bees from 46 apiaries at eight localities. Nine…

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