Category: UGENE

Haplotype Diversity of Mongolian and Tuvan Goat Breeds (Capra hircus) Based on mtDNA and Y-Chromosome Polymorphism

1 Zonaed Siddiki, A., Miah, G., Islam, M.S., et al., Goat genomic resources: the search for genes associated with its economic traits, Int. J. Genomics, 2020, 5940205. doi.org/10.1155/2020/5940205 2 Amills, M., Capote, J., and Tosser-Klopp, G., Goat domestication and breeding: a jigsaw of historical, biological and molecular data with missing…

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RNA-Guided Systems May Be Present in Eukaryotes, Hold Promise as Biotech Tools

NEW YORK – A recent study on a new class of transposon-encoded RNA-guided nucleases suggests not only that they could be used as biotechnology tools, but also that such mechanisms could permeate all domains of life. The paper published earlier this month in Science by the Broad Institute’s Feng Zhang, the…

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RNA targeting enzyme extends CRISPR toolkit

McGavan Fellow Jonathan Gutenberg (left) and Omar Abdaier are in the lab. Credit: Caitlin Cunningham Researchers at MIT’s McGovern Institute for Brain Research have extended scientists’ CRISPR toolkits to easily cleave and edit RNA with precision that was previously only available for DNA editing. I found. This enzyme, called Cas7-11,…

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RNA-targeting enzyme expands the CRISPR toolkit

McGovern Fellows Jonathan Gootenberg (left) and Omar Abudayyeh in their lab. Credit: Caitlin Cunningham Researchers at MIT’s McGovern Institute for Brain Research have discovered a bacterial enzyme that they say could expand scientists’ CRISPR toolkit, making it easy to cut and edit RNA with the kind of precision that, until…

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The Current Molecular Treatment Landscape of Advanced Colorectal Cancer and Need for the COLOMATE Platform

Next-Generation Sequencing Utilizing Tumor Tissue and/or Blood The identification of actionable genomic alterations in tumors such as mCRC was once performed by Sanger DNA sequencing of tumor DNA that was extracted from fixed paraffin-embedded tumor tissue, but this has now been replaced by next-generation sequencing (NGS), which allows for larger-scale…

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CRISPR Convenience: Cas7-11 Redefines RNA Editing

Scientists, typically, are on their own after their post-doc ends. Sometimes, albeit rarely, they team up, blending their ideas, money, and people. Connie Cepko, PhD, and Cliff Tabin, PhD, pioneered the idea of a lab partnership, spending the last few decades working together in their shared lab at Harvard Medical…

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Analysing Microarray Data In Bioconductor

I was thinking about creating a tutorial on how to do a simple microarray analysis in Bioconductor. But, I realized this has already been done quite nicely at the Bioinformatics Knowledgeblog. Their first tutorial on the subject covers installation of necessary packages, downloading of cel files, describing the experiment, loading…

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Scientists Harness Human Protein To Deliver RNA Molecular Medicines to Cells

A fully assembled SEND package is released from the cells and collected for gene therapy. Credit: McGovern Institute Programmable systems, made up of components found in the human body, are a step towards safer targeting and delivery of genetic editing and other targeted therapies. Researchers from MIT, MIT’s McGovern Institute…

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A Biopython-based method for comprehensively searching for eponyms in Pubmed

doi: 10.1016/j.mex.2021.101264. eCollection 2021. Affiliations Expand Affiliations 1 Department of Pathology, University of Colorado School of Medicine, Aurora, CO, USA. 2 Department of Pathology & Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. 3 Department of Pathology and the Eugene McDermott Center for Human…

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[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version], hugene10sttranscriptcluster.db, AnnotationDbi

[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version], hugene10sttranscriptcluster.db, AnnotationDbi 1 Hello, I have microarray data from the chip [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version], and I am trying to annotate the probe IDs in R using the hugene10sttranscriptcluster.db package and the following function:…

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