Tag: A375

Received: 10 October 2023 / Revised: 2 November 2023 / Accepted: 10 November 2023 / Published: 15 November 2023 Round 1 Reviewer 1 Report Comments and Suggestions for Authors The manuscript by Dutriaux et al. is of moderate to high significance to ncRNA readership. The model and techniques used are…

Introduction Tumors are the second leading cause of death worldwide, with approximately 1670 deaths per day in the United States and 7700 deaths per day in China.1,2 The fundamental reason why cancers are still considered “frightening” is the difficulty of early tumor detection and the variety of issues present in…

Introduction Cutaneous melanoma is a kind of highly aggressive and metastatic cancer.1 It only occurs in 5% of all skin cancers but causes more than 75% of deaths.2,3 Melanoma can be cured by surgical removal at an early stage.4 However, when the disease progresses to an advanced stage (stage IV),…

Cell lines Human melanoma cell lines (A375 and A875) were kindly donated by the Department of Dermatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology. Cells were cultured in Dulbecco’s modified Eagle’s medium (DMEM) supplemented with 10% FBS, 100 μg/ml penicillin and 100 μg/ml streptomycin at 37 °C in a…

Abstract Lung cancer is the leading cause of cancer-related death worldwide, with the lung cancer incidence rate expected to rise further. Despite recently developed novel therapy options, 5-year survival rates for lung cancer patients remains below 20% generally and below 5% for late-stage diagnosis, thus additional therapy options are still…

Antisense vector design to accommodate independent promoters Here we sought to optimize lentivirus vector-mediated independent co-expression of two genes in transduced human T cells, with one gene under a constitutive promoter and the other under an inducible promoter, to improve adoptive T-cell transfer (ACT) of cancer. We began by building…

Overview Product name Description Rabbit monoclonal [EPR4389(2)] to XRCC1 Host species Rabbit Tested applications Suitable for: WB, IHC-P, ICC/IFmore detailsUnsuitable for: Flow Cyt or IP Species reactivity Reacts with: …

Introduction Melanoma is the deadliest type of skin cancer, with a rising yearly incidence.1,2 Despite the rapid development of checkpoint immunotherapy and targeted therapies, the main melanoma treatment methods include surgical resection and chemotherapy.3,4 Recent immunosuppressive agents increase the one-year survival rate of melanoma patients to more than 50%. However,…

No products found because this supplier’s products are not listed. Arpita Sarkar, Sophie Lanciano, Gael Cristofari, bioRxiv – Genomics 2022 Quote: EnGen sgRNA synthesis kit (NEB) No products found because this supplier’s products are not listed. Jitendra S. Kanshana, et al., bioRxiv – Genetics 2021 Quote: … A PCR-generated sgRNA…

Background: Thymidine kinase 1 (TK1) is a cell cycle-dependent kinase that catalyzes the addition of a gamma-phosphate group to thymidine. The protumorigenic role of TK1 has been reported in various malignancies. However, the role of TK1 in skin cutaneous melanoma (SKCM) remains unclear. This study aimed to explore the molecular…