Tag: ALS

What Is Stem Cell Research?

There are cells within our bodies that have a spectacular power. Known as stem cells, they build our bodies before we’re born and regenerate our tissues to keep us alive. For example, stem cells in the skin help us heal from cuts and other stem cells deep in the bone…

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Dementia with Lewy bodies post-mortem brains reveal differentially methylated CpG sites with biomarker potential

Weisman, D. & McKeith, I. Dementia with Lewy Bodies. Semin. Neurol. 27, 042–047 (2007). Article  Google Scholar  Foguem, C. & Manckoundia, P. Lewy Body Disease: Clinical and Pathological “Overlap Syndrome” Between Synucleinopathies (Parkinson Disease) and Tauopathies (Alzheimer Disease). Curr. Neurol. Neurosci. Rep. 2018 18:5 18, 1–9 (2018). CAS  Google Scholar …

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RNA vaccines rose to prominence during COVID, but we’ve only scratched the surface of their potential

In high school biology, students are taught the central concept of genetics in a very simple way: DNA makes RNA, RNA makes protein, and protein makes life. In this way, RNA is central to everything in biology — and, you could argue, central to life itself. Biologically, DNA is the…

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Profiling non-coding RNA expression in cerebrospinal fluid of amyotrophic lateral sclerosis patients

Objective biomarkers for the fatal neurodegenerative disease amyotrophic lateral sclerosis or motor neuron disease (ALS/MND) are critical for diagnosis, drug development, clinical trials, and insight into disease pathology. Key candidates for biomarkers present in biofluids include non-coding RNA (ncRNA) transcripts including microRNA, piwi-interacting RNA and transfer RNA. To determine if…

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MatteoFasulo/H-M-Recommendations: H&M Personalized Fashion Recommendations an Implicit ALS Product Recommendations System

GitHub – MatteoFasulo/H-M-Recommendations: H&M Personalized Fashion Recommendations an Implicit ALS Product Recommendations System This commit does not belong to any branch on this repository, and may belong to a fork outside of the repository. You can’t perform that action at this time. You signed in with another tab or window….

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Elektroporationsinstrumente Detaillierter Analysebericht zu Marktnachfrage und Wachstumschancen

Die globale  Elektroporationsinstrumente-Marktstudie  bietet eine umfassende Untersuchung des Marktes in der gesamten Projektionsmenge. Die Studie umfasst eine Erweiterung der Abschnitte ebenso wie eine begleitende Analyse der Ereignisse und Faktoren, die auf lange Sicht wahrscheinlich zeitweise eine ernsthafte Rolle spielen werden. Diese Elemente, die als Marktdynamik bezeichnet werden, umfassen die Treiber,…

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Pasithea Therapeutics to Present Tolerizing Vaccine Program Results at Immunotherapy 2022 International Course and Symposium

Pasithea Pasithea’s Chairman, Prof. Lawrence Steinman, to be Awarded Honorary Doctorate by University of Buenos Aires MIAMI BEACH, Fla., Oct. 17, 2022 (GLOBE NEWSWIRE) — Pasithea Therapeutics Corp. (NASDAQ: KTTA) (“Pasithea” or the “Company”), a biotechnology company focused on the research and discovery of new and effective treatments for psychiatric…

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Population-level variation in enhancer expression identifies disease mechanisms in the human brain

Schizophrenia Working Group of the Psychiatric Genomics Consortium. Biological insights from 108 schizophrenia-associated genetic loci. Nature 511, 421–427 (2014). PubMed Central  Article  CAS  Google Scholar  Visscher, P. M. et al. 10 years of GWAS discovery: biology, function, and translation. Am. J. Hum. Genet. 101, 5–22 (2017). CAS  PubMed  PubMed Central …

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KGDCMI: A New Approach for Predicting circRNA-miRNA Interactions From Multi-Source Information Extraction and Deep Learning

doi: 10.3389/fgene.2022.958096. eCollection 2022. Affiliations Expand Affiliations 1 School of Information Engineering, Xijing University, Xi’an, China. 2 College of Grassland and Environment Sciences, Xinjiang Agricultural University, Urumqi, China. 3 School of Computer Science, Northwestern Polytechnical University, Xi’an, China. Item in Clipboard Xin-Fei Wang et al. Front Genet. 2022. Show details Display…

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Postdoc in Computational method development for precision medicine in

Area of research: Scientific / postdoctoral posts Job description: : Discover personalized medical solutions for environmentally triggered diseases to promote a healthier society in a rapidly changing world. The Institute of Computational Biology (ICB) is globally recognised for its innovations in data analysis and modelling of biological systems and diseases,…

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EMBL Rome’s Gene Editing and Embryology Facility generates transgenic mice to understand human diseases

The facility supports scientists worldwide with scientific expertise and state-of-the-art gene editing technologies. The GEEF facility supports scientists worldwide with scientific expertise and state-of-the-art gene editing technologies.EMBL’s services and facilities provide scientific and technical expertise to EMBL staff, as well as to scientists from EMBL’s member states and around the…

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Researchers Suspect New Variants of Rapidly-Progressing Brain Degenerating Diseases from COVID-19 Vaccines

Things have not been the same since June 2021 for 53-year-old Douglas Howey from Colorado. Around a year after he received the second dose of the Moderna COVID-19 vaccine, the 6 foot 4 and a half inch paraplegic man who once weighed 262 pounds lost over 100 pounds after the…

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Postdoctoral Researcher in Computational Biology at Karolinska Institute, Sweden 2022

Postdoctoral Researcher in Computational Biology is available for doctoral degree candidates in Bioinformatics, Computer science, Mathematics, Biostatistics, Neuroscience, or similar field at the Department of Clinical Neuroscience, Karolinska Institute, Sweden 2022 Qualification Details Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent…

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Mass Vaccination Triggers Spike in Cases, Deaths

Researchers have confirmed that it’s not the SARS-CoV-2 virus itself damaging the body’s cells, it’s the spike protein. And it does this by binding ACE2, which can lead to mitochondrial damage. STORY AT-A-GLANCE Doctors for COVID Ethics have been warning about the potential for gene-based COVID-19 “vaccines” to cause blood…

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Circulating cell-free mtDNA release is associated with the activation of cGAS-STING pathway and inflammation in mitochondrial diseases

Craven L, Alston C, Taylor R, Turnbull D (2017) Recent advances in mitochondrial disease. Annu Rev Genomics Hum Genet 18:257–275. doi.org/10.1146/annurev-genom-091416-035426 CAS  Article  PubMed  Google Scholar  El-Hattab AW, Adesina AM, Jones J, Scaglia F (2015) MELAS syndrome: clinical manifestations, pathogenesis, and treatment options. Mol Genet Metab 116(1–2):4–12. doi.org/10.1016/j.ymgme.2015.06.004 CAS  Article …

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Bernstein wraps postdoc, joins cancer research startup

Tumors are complicated. Scientists can examine individual tumor cells and find varying patterns of gene expression. Sample those same locations again at a later time, and new patterns may emerge. Multiply these experiments by dozens of locations, thousands of genes, and several time points, and now there is a huge…

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Research Roundup: New Insights into Alzheimer’s, ALS and FTD

BSIP/UIG Via Getty Images One particular gene variant, APOE4, is associated with an increased risk of Alzheimer’s disease. But why that is the case, what the mechanism of action is, has eluded researchers. At least one pathway has been determined, and it has possible repercussions in developing therapies against the…

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Dissection and Immunohistochemistry of the Drosophila Adult Leg to Detect Changes at the Neuromuscular Junction for an Identified Motor Neuron

The overall goal of this procedure is to demonstrate dissection methods for the adult leg of Drosophila. This technique removes a portion of the cuticle, exposing the underlying tissue in a way that preserves neuronal and muscle architecture. This procedure allows us to characterize the neuromuscular junction for identified motor…

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Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae

We describe a protocol to induce phase transition of TAR DNA-binding protein 43 (TDP-43) by light in the spinal motor neurons using zebrafish as a model. So this protocol enables us to induce pathological phase transitions of TDP-43 and address their cellular consequence in the spinal motor neurons in vivo,…

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Drosophila carrying epilepsy-associated variants in the vitamin B6 metabolism gene PNPO display allele- and diet-dependent phenotypes

Pyridox(am)ine 5′-phosphate oxidase (PNPO; Enzyme Commission Number 1.4.3.5) is a rate-limiting enzyme in the synthesis of vitamin B6 (VB6) (1). Mutations in PNPO can cause neonatal epileptic encephalopathy, a devastating disease that usually leads to death if untreated (2). Recently, PNPO mutations have also been reported in patients with infantile…

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The Genetic Architecture of Sleep Health Scores in the UK

Introduction Sleep is a complex neurological and physiological state. It is defined as a natural and reversible state of reduced responsiveness to external stimuli and relative inactivity, accompanied by a loss of consciousness.1 Sleep disorders can be classified as seven major categories: insomnia disorders, sleep-related breathing disorders, central disorders of…

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Science snapshots from Berkeley Lab

image: 3D image of melanin in a zebrafish sample captured by micro-computed tomography. view more  Credit: Spencer R. Katz and Daniel J. Vanselow, Penn State College of Medicine) Adapted from a UC Berkeley news release To date, CRISPR enzymes have been used to edit the genomes of one type of cell…

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Rapid generation of ventral spinal cord-like astrocytes from human iPSCs for modeling non-cell autonomous mechanisms of lower motor neuron disease

Abstract Background: Astrocytes play important roles in the function and survival of neuronal cells. Dysfunctions of astrocytes are associated with numerous disorders and diseases of the nervous system, including motor neuron diseases such as amyotrophic lateral sclerosis (ALS). Human induced pluripotent stem cell (iPSC)-based approaches are becoming increasingly important for…

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Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands Wouter van Rheenen, Rick A. A. van der Spek, Mark K. Bakker, Joke J. F. A. van Vugt, Paul J. Hop, Ramona A. J. Zwamborn, Annelot M. Dekker, Klara Gawor, Henk-Jan Westeneng, Gijs H. P. Tazelaar, Kristel R. van Eijk, Maarten Kooyman, Ewout J. N. Groen, Michael…

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Focus on Design Tools, Plasmid and Vector, Cas9 and g-RNA, Delivery System Products

DUBLIN, Sept. 21, 2021 /PRNewswire/ — The “CRISPR Market – Forecasts from 2021 to 2026” report has been added to ResearchAndMarkets.com‘s offering. The global CRISPR market is evaluated at US$0.979 billion for the year 2019 and is estimated to grow at a CAGR of 35.96% to reach a market size…

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SCIRP Open Access

Add your e-mail address to receive free newsletters from SCIRP. Select Journal AA AAD AAR AASoci AAST ABB ABC ABCR ACES ACS ACT AD ADR AE AER AHS AID AiM AIT AJAC AJC AJCC AJCM AJIBM AJMB AJOR AJPS ALAMT ALC ALS AM AMI AMPC ANP APD APE APM ARS ARSci AS ASM BLR CC CE CellBio ChnStd CM CMB CN CRCM CS CSTA CUS CWEEE Detection EMAE ENG EPE ETSN FMAR FNS GEP GIS GM Graphene GSC Health IB ICA IIM IJAA IJAMSC IJCCE IJCM IJCNS IJG IJIDS IJIS IJMNTA IJMPCERO IJNM IJOC IJOHNS InfraMatics JACEN JAMP JASMI JBBS JBCPR JBiSE JBM JBNB JBPC JCC JCDSA JCPT JCT JDAIP JDM JEAS JECTC JEMAA JEP JFCMV JFRM JGIS JHEPGC JHRSS JIBTVA JILSA JIS JMF JMGBND JMMCE JMP JPEE JQIS JSBS JSEA JSEMAT JSIP JSS JSSM JST JTR JTST JTTs JWARP LCE MC ME MI MME MNSMS MPS MR MRC MRI MSA MSCE NJGC NM NR NS OALib OALibJ ODEM OJA OJAB OJAcct OJAnes OJAP OJApo OJAppS OJAPr OJAS OJBD OJBIPHY OJBM OJC OJCB OJCD OJCE OJCM OJD OJDer OJDM OJE OJEE OJEM OJEMD OJEpi OJER OJF OJFD OJG OJGas OJGen OJI OJIC OJIM OJINM OJL OJM OJMC OJMetal OJMH OJMI OJMIP OJML OJMM OJMN OJMP OJMS OJMSi OJN OJNeph OJO OJOG OJOGas OJOp OJOph OJOPM OJOTS OJPathology OJPC OJPChem OJPed OJPM OJPP OJPS OJPsych OJRA OJRad OJRD OJRM OJS OJSS OJSST OJST OJSTA OJTR OJTS OJU OJVM OPJ POS PP PST PSYCH SAR SCD SGRE SM SN SNL Soft SS TEL TI UOAJ VP WET WJA WJCD WJCMP WJCS WJET WJM WJNS WJNSE WJNST WJV WSN YM Read more here: Source link

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