Tag: ANGPTL8

Introduction As the prevalence of hyperlipidemia has increased, the assessment of blood lipids is increasingly important.1 At present, fasting lipid indices, including total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) levels are most commonly assessed in clinical practice.2 Among them, the TG level is one of the most…

1Affiliated Hospital of Qinghai University, China The final, formatted version of the article will be published soon. Notify me Receive an email when it is updated You just subscribed to receive the final version of the article Angiopoietin-like protein 8 (ANGPTL8) is a…

ANGPTL8 blockade with a monoclonal antibody promotes triglyceride clearance, energy expenditure, and weight loss in mice – Fingerprint — University of Texas Southwestern Medical Center Sort by Weight Alphabetically Medicine & Life Sciences Energy Metabolism 100% Weight Loss 91% Triglycerides 88% Monoclonal Antibodies 80% Lipoprotein Lipase 66% Body Weight 59%…

(PDF) Angiopoietin-like protein 8 (ANGPTL8)/betatrophin overexpression does not increase beta cell proliferation in mice | Julia Chavez – Academia.edu Academia.edu uses cookies to personalize content, tailor ads and improve the user experience. By using our site, you agree to our collection of information through the use of cookies. To learn…

ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance – Fingerprint — University of Texas Southwestern Medical Center Sort by Weight Alphabetically Chemical Compounds Lipoprotein 91% Clearance 89% Triglyceride 87% Plasma 50% Protein 13% Medicine & Life Sciences Lipoprotein Lipase 100% Triglycerides 66% Angiopoietins 23% Blocking Antibodies 19%…

Int. J. Mol. Sci. 2023, 24(18), 14244; doi.org/10.3390/ijms241814244 (registering DOI) Int. J. Mol. Sci. 2023, 24(18), 14244; doi.org/10.3390/ijms241814244 (registering DOI) Received: 27 July 2023 / Revised: 17 August 2023 / Accepted: 14 September 2023 / Published: 18 September 2023 Round 1 Reviewer 1 Report 1. What was the criteria of DN diagnosis?…

The role of ANGPTL8 in metabolizing lipids and glucose and in metabolic disorders and inflammation is widely recognized [7,8,9,27,44,45,46]. The rs2278426, while a missense (R59W) variant in ANGPTL8, is located in the intron in the DOCK6 gene. The variant downregulates CTC-510F12.4 (a novel transcript) in whole blood, upregulates DOCK6 in…

PRESS RELEASE Published July 10, 2023 “A groundbreaking research paper published in the journal Science Signaling has identified a new hepatokine that promotes triglyceride metabolism” The research was led by Kezhong Zhang, Ph.D., Professor at the Center for Molecular Medicine and Genetics and the Department of Biochemistry, Microbiology, and Immunology…

Fangfang Xu,1,* Lijun Shen,2,* Yongguang Yang,2 Limin Kong,3 Wufan Zu,4 Dandan Tian,5 Xuanchao Cao,1 Gairong Huang1 1Key Laboratory of Geriatrics, Institute of Geriatrics, Department of Geriatric Medicine, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China; 2Department of Clinical Medical Research Center, Henan Provincial People’s…

Background: The ability to predict secondary cardiovascular events could improve health of patients undergoing statin treatment. Circulating ANGPTL8 (angiopoietin-like protein 8) levels, which positively correlate with proatherosclerotic lipid profiles, activate the pivotal proatherosclerotic factor ANGPTL3. Here, we assessed potential association between circulating ANGPTL8 levels and risk of secondary cardiovascular events…

The interplay between hepatocellular carcinoma (HCC) cells and the tumor microenvironment is essential for hepatocarcinogenesis, but their contributions to HCC development are incompletely understood. We assessed the role of ANGPTL8, a protein secreted by HCC cells, in hepatocarcinogenesis and the mechanisms through which ANGPTL8 mediates crosstalk between HCC cells and…

Background: T-cell death-associated gene 51 (TDAG51) belongs to the transcription factor family and is involved in the energy homeostasis of the liver through the regulation of lipogenesis. Aims: To evaluate the role of T-cell death-associated gene 51 in gestational diabetes mellitus. Study design: Experimental study. Methods: A total of 30…

1. Introduction Psoriasis is a common, chronic, stigmatizing and still incurable skin disease, affecting 2% to 4% of the world’s population [1,2]. In the past, it was considered an exclusively dermatological and rheumatic disease, affecting the skin, nails and joints. Since 2000, research into the still-unknown pathogenesis of psoriasis has…

Sci-Hub | ANGPTL8/Betatrophin R59W variant is associated with higher glucose level in non-diabetic Arabs living in Kuwaits. Lipids in Health and Disease, 15(1) | 10.1186/s12944-016-0195-6 ◂ ↓ save Abu-Farha, M., Melhem, M., Abubaker, J., Behbehani, K., Alsmadi, O., & Elkum, N. (2016). ANGPTL8/Betatrophin R59W variant is associated with higher glucose…

ANGPTL8 Recombinant Protein (Mouse) (OPCA03054) | Aviva Systems Biology | Aviva Systems Biology The store will not work correctly in the case when cookies are disabled. JavaScript…

Effect of physical activity in a weight loss program on circulating total ANGPTL8 concentrations in northern Americans with obesity: a prospective randomized controlled trial Abstract Background and Aims The primary goals of this study were to clarify 1) the effect of weight loss by lifestyle intervention on circulating total angiopoietin-like…

Sampson, J. N. et al. Analysis of heritability and shared heritability based on genome-wide association studies for thirteen cancer types. J. Natl Cancer Inst. 107, djv279 (2015). PubMed  PubMed Central  Article  CAS  Google Scholar  Bosse, Y. & Amos, C. I. A decade of GWAS results in lung cancer. Cancer Epidemiol….

Low magnification micrograph of the distal right coronary artery with complex atherosclerosis and luminal narrowing. Credit: Nephron / commons.wikipedia.org. Kyttaro has signed an agreement to obtain an exclusive global licence for Eli Lilly and Company’s anti-angiopoietin-like (ANGPTL) 3/8 monoclonal antibody programme to treat atherosclerotic cardiovascular disease (ASCVD). The antibody will…

Bacterial taxonomic profiling of the gut microbiota from between controls and sh-ANGPTL8. a Relative abundance of the top 10 abundant bacterial phyla in indicated individuals. b, c Heat map of the top 10 abundant bacterial phyla in indicated individuals (b) and T test results (c). d Relative abundance of Bacteroidetes….

Elevated triglyceride (TG) and reduced high-density lipoprotein-cholesterol (HDL-C) plasma levels are risk factors for atherosclerosis and cardiovascular disease. Therefore, a drug that simultaneously reduces TG and increases HDL-C plasma levels has the potential to prevent and treat these diseases. Angiopoietin-like 3 (ANGPTL3) regulates plasma TG and HDL-C levels by inhibiting…