Tag: apex

Integrated taxonomy reveals new threatened freshwater mussels (Bivalvia: Hyriidae: Westralunio) from southwestern Australia

Genetic variation The best fitting substitution models for COI codons 1–3 were identified as TN + F + G4, F81 + F + I, and TN + F, respectively. The maximum likelihood (ML) and Bayesian inference (BI) trees showed similar topologies of the main nodes, although the BI tree displayed greater resolution of the ingroup branches (Fig. 1). Furthermore, the BI…

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Multiplex Chemical Imaging Based on Broadband Stimulated Raman Scattering Microscopy

We present a protocol to acquire chemical images with broadband stimulated Raman scattering (SRS) microscopy. Based on an SRS microscope that operates with differential multichannel-lock-in detection, the protocol describes the sample preparation, adjustment of the SRS apparatus, and chemometrics to disentangle different constituents of chemically heterogeneous samples. Our protocol describes…

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How to Choose the Right Bioinformatics Position in 2022?

When you’re looking to land a good bioinformatics job, whether you’re a fresher, a career changer, or an experienced candidate, there’s usually a lot on your mind. And although the job search phase can look intimidating and exhausting, there has never been a better time to start a career in…

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Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma

Chu, B. B. et al. Cholesterol transport through lysosome-peroxisome membrane contacts. Cell 161, 291–306 (2015). CAS  Article  Google Scholar  Luo, J., Yang, H. & Song, B. L. Mechanisms and regulation of cholesterol homeostasis. Nat. Rev. Mol. Cell Biol. 21, 225–245 (2020). CAS  Article  Google Scholar  Luo, J., Jiang, L., Yang,…

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Live-seq enables temporal transcriptomic recording of single cells

Biological materials RAW264.7, 293T and HeLa cells were obtained from ATCC. RAW264.7 cells with Tnf-mCherry reporter and relA-GFP fusion protein (RAW-G9 clone) were kindly provided by I.D.C. Fraser (National Institutes of Health). The IBA cell line derived from the stromal vascular fraction of interscapular brown adipose tissue of young male…

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Fertility Sparing Procedure using Carbon Dioxide Fiber Laser Vaporization of Ovarian Endometrioma

Summary July 6th, 2022 In this protocol, CO2 fiber laser technique is demonstrated for the surgical treatment of ovarian endometriosis, which represents a viable alternative in terms of fertility preservation with the major advantage of not being dependent on the surgeon’s skills and personal experience. Transcript In light of the…

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Cogent Biosciences Reports Recent Business Highlights and First Quarter 2022 Financial Results

Cogent Biosciences, Inc. Initial bezuclastinib APEX data to be presented at the European Hematology Association (EHA) 2022 Annual Congress Building a portfolio of discovery stage programs, creating potential best-in-class small molecule kinase inhibitors for genetically defined oncology indications and rare diseases Ended 1Q 2022 with $191.0 million in cash, sufficient…

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‘Nobody can be forced to get vaccinated against Covid-19’: Supreme Court to Centre

The number of Covid-19 cases in India is on the rise again and as an effort, the Centre has decided to ramp up the pace of vaccination and reimpose some of the Covid-19 restrictions that were done away with after the third wave of the pandemic subsided. Amid this,…

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AIM brings innovations from labs to hospitals and masses

Human body like the Space is an endless frontier made even more complex by the irreversibility of life by the arrow of time. Similar to the mystery of origin of the Universe some problems in the human body are so complex, for example, the problem of qualia or the Hard…

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Creation of Patient-Specific Silicone Cardiac Models with Applications in Pre-surgical Plans and Hands-on Training

Patient-specific models improve surgeon and fellow confidence when developing or learning surgical plans. Three-dimensional (3D) printers generate adequate detail for surgical preparation, but fail to replicate tissue haptic fidelity. A protocol is presented detailing the creation of patient-specific, silicone cardiac models, combining 3D printing precision with simulated silicone tissue. Complex…

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Spatial components of molecular tissue biology

1. Okabe, Y. & Medzhitov, R. Tissue biology perspective on macrophages. Nat. Immunol. 17, 9–17 (2016). CAS PubMed  Google Scholar  2. Xia, C., Fan, J., Emanuel, G., Hao, J. & Zhuang, X. Spatial transcriptome profiling by MERFISH reveals subcellular RNA compartmentalization and cell cycle-dependent gene expression. Proc. Natl Acad. Sci. USA…

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Intern with UCSB IT | UC Santa Barbara Information Technology

All of our UCSB IT internships are now full. Please check back for future internship opportunities.  UCSB IT offers student interns a paid opportunity to complement their academic training by learning practical skills in a high demand field. UCSB IT values our students’ opinions and believes their ideas drive the successful…

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Best Launch Options For Gmod

The -safe launch option will cause the game to launch with minimal video settings, in windowed mode and with a x resolution. This can be helpful for solving video configuration problems. Jonah’s O5 Application – Whitelist Applications – Werwolf This can be helpful for solving video configuration problems.  I finally…

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S.T.E.M. Students Discuss Their Summer Research and Internship Experiences

Kayla Bertholf Science and Environment Editor   Sobika Thapa ‘23, Computer Science What was your summer experience/internship called? I interned as an user interface design (UI/UX) intern for a software company in Nepal. Give a summary of your experience. During my internship, I participated in user research and interaction studies,…

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Bioinformatics Analyst I

Dr. Fazal is seeking a Bioinformatics Analyst I to develop and apply genomic analysis tools to identify cis- and trans- factors associated with RNA localization. The Fazal lab is a young laboratory focusing on systematically interrogating the subcellular transcriptomes of mammalian cells and characterizing the scope, regulation, and function of…

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Irreversible Electroporation for Patients with Localised Prostate Cancer: Expert Opinion on this Versatile Therapeutic Approach

Interviewees: Olivier Cussenot,1 Phillip Stricker2,3,4 1. Department of Urology, APHP-Sorbonne University, Tenon Hospital, Paris, France2. Department of Urology, St Vincent’s Private Hospital and Clinic, Sydney, Australia3. Garvan Institute of Medical Research, Sydney, Australia4. Australian PC Centre, Sydney, Australia Disclosure: Cussenot is an expert for INCa (French National Cancer Institute) and…

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Sequence (annotation) databases in 2021

Forum:Sequence (annotation) databases in 2021 1 Hi everyone, So I know there are several threads on this topic already (or tangentially related to it). For example: But these threads are really old now. Things have probably changed quite significantly in the mean time. So I would like to start a…

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Kaggle Lyft Motion Prediction for Autonomous Vehicles 4th place solution

Lyft Motion Prediction for Autonomous Vehicles Code for the 4th place solution of Lyft Motion Prediction for Autonomous Vehicles on Kaggle. Directory structure input — Please locate data here src |-ensemble — For 4. Ensemble scripts |-lib — Library codes |-modeling — For 1. training, 2. prediction and 3. evaluation…

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