Tag: ATM

Exploring the Latest Advances in Transcriptomics

Since the idea of genetic regulation was first postulated back in the 1950s, our scientific understanding of the transcriptome has deepened greatly.1 Looking into the transcriptome of cells and tissues has helped scientists to understand the biological processes that drive both health and disease; however, the complex and occasionally mysterious…

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Expert Guidelines Detail Optimal Sequencing of Emerging Therapies for Metastatic Castration-Resistant Prostate Cancer, Journal Club

Read the Full Video Transcript Rashid Sayyid: Hello everyone and thank you for joining us in this UroToday recording. I’m Rashid Sayyid, the Urologic Oncology Fellow at the University of Toronto, and along with Zach Klaassen, Associate Professor Program Director at Wellstar MCG Health, we’ll be discussing the recently amended…

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Whole-genome sequencing reveals the molecular implications of the stepwise progression of lung adenocarcinoma

Whole-genome sequencing (WGS) analysis of early and advanced adenocarcinomas Whole-genome short read and long read sequencing datasets of 76 lung cancer specimens were analyzed. The datasets included newly generated data for 48 early small-sized lung adenocarcinoma cases (collectively called “Early-Ad” hereafter). These cases included 26 AIS (9 and 17 cases…

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Zanubrutinib Favored Over Bendamustine/Rituximab Combination Across Biomarker Subgroups in CLL/SLL Without del(17p)

Treatment with the BTK inhibitor zanubrutinib (Brukinsa) conferred a progression-free survival (PFS) benefit compared with bendamustine plus rituximab (Rituxan) across most biomarker subgroups of patients with treatment-naive chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) without del(17p), according to findings from the phase 3 SEQUOIA trial (NCT03336333) presented as…

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Formononetin | FGFR2 inhibitor | Axon 4067

All All Products Enzymes Receptors Ion Channels Research Areas Oxidoreductases Transferases Lyases Isomerases Ligases Nuclear Receptors Ligand-gated ATP-Sensitive Angiogenesis Apoptosis Cardiovascular Cell Cycle Regulation Cell Signaling & Oncology CNS Diabetes & Metabolism Epigenetics Immunology Miscellaneous Pain & Inflammation Stem Cell Oxidases MAO Cys-loop, cationic Cis-Trans Isomerase CypA DNA Topoisomerase Synthetases…

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cGAS-STING signalling regulates microglial chemotaxis in genome instability

doi: 10.1093/nar/gkad1184. Online ahead of print. Affiliations Expand Affiliations 1 Department of Biochemistry, University of Cambridge, Cambridge, UK. 2 Neuroscience, R&D BioPharmaceuticals, AstraZeneca, Cambridge, UK. 3 Translational Genomics, Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Mölndal, Gothenburg, Sweden. 4 Department of Data Sciences & Quantitative Biology, AstraZeneca, Cambridge, UK. Item…

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Standalone Building DLF Phase3 Rent – WITHOUT BROKERAGE Fully furnished 1 RK Rental Flat in Standalone Building , DLF Phase3, Gurgaon for Rs. 14,000

Description Livability Score is a measure of proximity of the property to essential facilities and amenities on a scale of 0 to 10 8.5 Transit Score is a measure of how well a property is served by public transit on a scale from 0 to 10 5.5 Powered By: Smart…

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Machine Learning PyTorch Scikit-Learn Reviews

User Ratings 5.0 out of 5 stars ★★★★★ ★★★★ ★★★ ★★ ★ ease 1 of 5 2 of 5 3 of 5 4 of 5 5 of 5 5 / 5 features 1 of 5 2 of 5 3 of 5 4 of 5 5 of 5 5 / 5…

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Data Support Wider Use of Germline Genetic Testing in Lung Cancer

Results of a new study support wider use of germline genetic testing in patients with lung cancer, according to researchers. The study showed that about 1 in 7 lung cancer patients who underwent genetic testing had a pathogenic germline variant. This frequency is higher than previously reported and suggests it…

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Germline PTEN genotype-dependent phenotypic divergence during the early neural developmental process of forebrain organoids

American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Arlington, VA: American Psychiatric Publishing; 2013. Lewis MH, Bodfish JW. Repetitive behavior disorders in autism. Ment Retard Dev D R. 1998;4:80–9. Article  Google Scholar  Bodfish JW, Symons FJ, Parker DE, Lewis MH. Varieties of repetitive behavior in…

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Serial Next Generation Sequencing and the Role of PARP Inhibitor Therapy in 2024

(UroToday.com) The 2023 Society of Urologic Oncology (SUO) annual meeting held in Washington, D.C. between November 28th and December 1st, 2023, was host to a prostate cancer course. Dr. Alan Bryce provided an overview of the use and application of serial next generation sequencing (NGS) in the castrate-resistant prostate cancer disease…

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Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy | Molecular Cancer

Rowe RG, Daley GQ. Induced pluripotent stem cells in disease modelling and drug discovery. Nat Rev Genet. 2019;20:377–88. Article  CAS  PubMed  PubMed Central  Google Scholar  Li L, Papadopoulos V. Advances in stem cell research for the treatment of primary hypogonadism. Nat Rev Urol. 2021;18:487–507. Article  CAS  PubMed  Google Scholar  Lawrence…

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Estimating the proportion of nonsense variants undergoing the newly described phenomenon of manufactured splice rescue

Richards S, Aziz N, Bale S, Bick D, Das S, Gastier-Foster J, et al. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Med. 2015;17:405–24. Article  PubMed  Google Scholar  Abou…

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Decline of DNA damage response along with myogenic differentiation

Introduction Proper functioning of all living organisms depends on the faithful maintenance and transmission of genomic information stored in the molecule of DNA. However, DNA integrity is continuously challenged by a variety of endogenous and exogenous agents causing DNA lesions which have a critical impact on cellular activities and homeostasis….

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Knockdown of GNL3L alleviates the progression of COPD

Introduction Chronic obstructive pulmonary disease (COPD) is a common chronic bronchitis disease characterized by persistent airflow limitation, which can be prevented and treated. COPD is the third leading cause of death in the world reported in 2020.1 With the progression of the disease, COPD will lead to respiratory failure, pulmonary…

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Fonsecaea monophora causing cerebral phaeohyphomycosis

Introduction Phaeohyphomycosis (PHM) is a group of superficial and deep mycoses, including central nervous system (CNS) infections, pulmonary infections, cutaneous and subcutaneous infections, associated with high mortality and caused by dematiaceous fungi that have brown-pigmented cell walls due to the formation of melanin.1,2 Previously, fungal brain infections generally occurred in…

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2023-11-07 | NDAQ:ARVN | Press Release

– Enrollment continues in the 2L Phase 3 VERITAC-2 trial and study lead-in for the VERITAC-3 1L Phase 3 trial with vepdegestrant; Top-line data readout for VERITAC-2 remains on-track for 2H 2024 – – Bavdegalutamide mCRPC data presented at ESMO showed median rPFS of 11.1 months in patients with AR…

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Compugen Reports Third Quarter 2023 Results

Rilvegostomig, AstraZeneca’s (LSE/STO/Nasdaq: AZN) PD-1/TIGIT bi-specific derived from Compugen’s COM902, has progressed into Phase 3 as adjuvant therapy for biliary tract cancer after resection in combination with chemotherapy Clinical data presented at SITC 2023 reinforces COM701 (anti-PVRIG) mediated anti-tumor activity in tumors typically not responding to immunotherapy and initial data suggest…

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Expression profiles of circRNAs and biomarkers for COPD

Introduction Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease featured by airflow obstruction with high prevalence, morbidity, and mortality. It is reported that COPD is the third leading cause of death globally at present, and the incidence of COPD in adults over 40 years is more than…

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Impact of germline DNA repair gene variants on prognosis and treatment of men with advanced prostate cancer

In this study, we demonstrate an independent effect of germline DNA repair gene variants on the outcomes of patients with advanced PC. Despite carrier numbers being limited, we were able to identify germline DRG carrier status as an independent prognostic factor for PFS on first-line ARSI treatment, time to progression…

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COMPASS Pathways Q3 2023 Results: Cash Injection To Sustain Phase 3 Psilocybin Program – Compass Pathways (NASDAQ:CMPS)

COMPASS Pathways plc CMPS, the London-headquartered psychedelics biotech company reported financial results for the third quarter 2023 ended September 30, showing:  Cash and cash equivalents of $248.0 million as of Sept. 30, 67% more than that held on last quarter’s closing (June 30,) and 73% than by Dec. 31,…

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BridgeBio Pharma Reports Third Quarter 2023 Financial Results and Business Update

BridgeBio Pharma, Inc. – Presented detailed positive results from the ATTRibute-CM Phase 3 study of acoramidis at the European Society of Cardiology (ESC) Congress, demonstrating that patients survived more and were hospitalized less than has been seen in other interventional studies of transthyretin amyloid cardiomyopathy (ATTR-CM) to the Company’s knowledge,…

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DNA damage response(DDR): a link between cellular senescence and human cytomegalovirus | Virology Journal

Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res. 1961;25:585–621. Article  CAS  PubMed  Google Scholar  Hayflick L. THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS. Exp Cell Res. 1965;37:614–36. Article  CAS  PubMed  Google Scholar  Schmitt CA, Tchkonia T, Niedernhofer LJ, Robbins PD,…

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What does the future hold?

In this interview, Adanma Ayanambakkam, MD, discusses the current state of treatment of advanced bladder cancer, including the need for predictive and prognostic markers for immune therapy as well as the potential showed by circulating tumor DNA (ctDNA). Ayanambakkam is an assistant professor of medicine in the section of hematology/oncology…

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Mosaic chromosomal alterations in blood across ancestries using whole-genome sequencing

Study population We included 67,390 participants from 19 TOPMed studies: Genetics of Cardiometabolic Health in the Amish (n = 1,109) (ref. 32), Atherosclerosis Risk in Communities Study (n = 3,780) (ref. 33), Barbados Genetics Asthma Study (n = 980), Mount Sinai BioMe Biobank (n = 9,392) (ref. 34), Coronary Artery Risk Development in Young Adults (n = 3,293) (ref. 35),…

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Final Multivariate Analysis from the Phase 3 MAGNITUDE Study Shows Trend Toward Improvement in Overall Survival in Patients with mCRPC with BRCA Alterations Treated with Niraparib and Abiraterone Acetate Plus Prednisone

Niraparib and abiraterone acetate plus prednisone combination therapy also showed clinically relevant improvement versus standard of care in time to symptomatic progression and time to cytotoxic chemotherapy MADRID, Oct. 22, 2023 /PRNewswire/ — The Janssen Pharmaceutical Companies of Johnson & Johnson today announced results from the final analysis (FA) of…

Continue Reading Final Multivariate Analysis from the Phase 3 MAGNITUDE Study Shows Trend Toward Improvement in Overall Survival in Patients with mCRPC with BRCA Alterations Treated with Niraparib and Abiraterone Acetate Plus Prednisone

How chromatin compartmentalization affects DNA damage response

In a recent study published in the journal Nature, researchers identify the mechanisms through which double-stranded break (DSB)-induced compartment formation orchestrates the deoxyribonucleic acid (DNA) damage response (DDR). Study: Chromatin compartmentalization regulates the response to DNA damage. Image Credit: CI Photos / Shutterstock.com Background DNA DSBs are extremely hazardous lesions that could…

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Final Multivariate Analysis from the Phase 3 MAGNITUDE

Niraparib and abiraterone acetate plus prednisone combination therapy also showed clinically relevant improvement versus standard of care in time to symptomatic progression and time to cytotoxic chemotherapy1 BEERSE, BELGIUM, Oct. 22, 2023 (GLOBE NEWSWIRE) — The Janssen Pharmaceutical Companies of Johnson & Johnson today announced results from the final analysis…

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Global Access Considerations in Systemic Treatment of Genitourinary Cancers

(UroToday.com) The 2023 European Society of Medical Oncology (ESMO) Annual Congress held in Madrid, Spain between October 20th and 24th, 2023 was host to a new diagnostic tools abstracts poster session. Dr. Xin Ye presented the results of a study evaluating a novel next generation sequencing (NGS) assay for the…

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Multicentric pilot study to standardize clinical whole exome sequencing (WES) for cancer patients

Paired tumor and normal DNA samples from 30 patients were subjected to WES at four ZPM laboratories with subsequent data analysis performed at five ZPM bioinformatic institutions (Fig. 1). DNA was originally derived from fresh-frozen samples that had been analyzed by WES within the multicenter MASTER (Molecularly Aided Stratification for…

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Chromatin compartmentalization regulates the response to DNA damage

Cell culture and treatments DIvA (AsiSI-ER-U2OS)19, AID-DIvA (AID-AsiSI-ER-U2OS)23 and 53BP1-GFP DIvA20 cells were developed in U2OS (ATCC HTB-96) cells and were previously described. Authentication of the U2OS cell line was performed by the provider ATCC, which uses morphology and short tandem repeat profiling to confirm the identity of human cell…

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Crohn’s Disease treatment after failure of anti-TNF therapy

Introduction Crohn’s Disease (CD) is a typical group of inflammatory bowel disease, a chronic intestinal disease with an unclear cause that fluctuates between clinical remission and relapse. The disease may affect the entirety of the gastrointestinal tract, frequently manifesting as segmental, asymmetric, and transmural lesions. 21–47% of patients present with…

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Jumpstart AI-cessibility with Google Cloud

Problem statement: Organizations want AI and machine learning to understand the context of their business so that it can give answers from the organization’s vast data set. The bigger the corporations are, the more mature they tend to be with automation, analytics, and the more prepared they can be in…

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DICT: Hackers leaked PhilHealth data

Hackers leaked the compromised data from a recent ransomware attack against the Philippine Health Insurance Corporation (PhilHealth), the Department of Information and Communications Technology (DICT) said Thursday. The DICT said the Medusa ransomware group uploaded a copy of over 600 gigabytes of files to a website and a Telegram channel…

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FDA Grants Marketing Authorization to First DNA Test to Assess Genetic Predisposition to Select Cancers

The FDA has granted de novo marketing authorization for the Invitae Common Hereditary Cancers Panel, an in vitro diagnostic test designed to detect genetic variants associated with an elevated risk of developing certain types of cancer.1 Additionally, the panel could also help identify potential cancer-associated variants in patients who have…

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Metagenomics as new tool for diagnosis of scrub typhus

Introduction Scrub typhus, a kind of zoonotic bacterial infection, is becoming a threat to public health,1 which usually occurs to field operators, especially those living in remote and rural areas.2 Scrub typhus is caused by Orientia tsutsugamushi that is a kind of bacteria of gram-negative coccobacillus,3 the latent period is…

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Genes Linked to Aggressive Prostate Cancer

Researchers say they have identified genes that should be considered for gene panel testing in prostate cancer. The researchers found evidence to suggest that variants in BRCA2, ATM, NBN, MSH2, XRCC2, and MRE11A are associated with aggressive prostate cancer. These findings were published in JAMA Oncology. For this study, researchers…

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Targeting MTHFD1 and MTHFD2 as cancer treatment

Abstract: One-carbon (1C) metabolism provides building blocks for nucleotide synthesis and therefore plays a central role in DNA replication and repair. To sustain rapid proliferation, cancer cells often upregulate their 1C metabolism, including the enzymes MTHFD1 and MTHFD2, as a part of their metabolic rewiring. Previously, MTHFD2 in particular has…

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Brain microvascular endothelial cells and blood-brain barrier dysfunction in psychotic disorders

Murray CJL, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380:2197–223. Article  PubMed  Google Scholar  Martin J, Taylor MJ, Lichtenstein P….

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The impact of mutational clonality in predicting the response to immune checkpoint inhibitors in advanced urothelial cancer

Genomic analysis and cohort description We generated whole-exome sequencing (WES) and RNA sequencing (RNA-Seq) data from tumors and blood samples from 27 advanced urothelial cancer patients treated with anti-PD-1/PD-L1 ICIs at Hospital del Mar (Fig. 1a). WES data was obtained from the tumors before treatment as well as from blood samples,…

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Section 2: ggplot2 Functions (2 pts) In this section,

Transcribed image text: Section 2: ggplot2 Functions (2 pts) In this section, you will be asked to explain the purpose of various ggplot2 functions and their syntax. Each question has two parts, A and B. We’re looking to evaluate if you understand the use and syntax of the functions. Please…

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Genome-wide identification of lncRNA & mRNA for T2DM

Department of Biotechnology, College of Science, Taif University, Taif, 21944, Saudi Arabia Correspondence: Sarah Albogami, Department of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia, Email [email protected] Purpose: According to the World Health Organization, Saudi Arabia ranks seventh worldwide in the number of patients with…

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How Israel’s supercomputer revolution could change

Now’s not the best of times for Israeli high-tech, to put it mildly, but even in the dead of summer, a slight breeze can be felt. Israel’s economic engine has been faltering for the past 18 months. It started with a global crash, but in the meantime, the industry around…

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BioVie: Well-Powered Phase 3 Trial In Alzheimer’s Could Greatly Benefit Investors

KanawatTH/iStock via Getty Images Thesis It has been about five months since I last covered BioVie. This should be the last article on the company prior to topline data from its Phase 3 trial in Alzheimer’s disease [AD] in October-November 2023. I believe there are good chances of success for…

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ST11 and ST15 carbapenem-resistant hypervirulent Klebsiella

Introduction Klebsiella pneumoniae is a gram-negative opportunistic pathogen that can cause both community and hospital-acquired pneumonia, urinary tract infections, and bacteremia primarily in immunocompromised patients.1 Most experts agree that carbapenems are an effective treatment for serious infections brought on by Enterobacteriaceae that produce extended-spectrum beta-lactamases (ESBLs).2–4 Because of the wide…

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Role of the cGAS-STING pathway in radiotherapy for non-small cell lung cancer | Radiation Oncology

Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and Mortality Worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49. doi.org/10.3322/caac.21660 Article  PubMed  Google Scholar  Duma N, Santana-Davila R, Molina JR. Non-Small Cell Lung Cancer: Epidemiology, Screening, diagnosis, and treatment….

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The cGAS-STING pathway regulates microglial chemotaxis in genome instability

Abstract Defective DNA damage signalling and repair is a hallmark of age-related and genetic neurodegenerative disease. One mechanism implicated in disease progression is DNA damage-driven neuroinflammation, which is largely mediated by tissue-resident immune cells, microglia. Here, we utilise human microglia-like cell models of persistent DNA damage and ATM kinase deficiency…

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Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk

UKB The UKB is a population-based prospective cohort study of more than 500,000 subjects. More detailed information on the UKB is given elsewhere34,35. The study received ethics approval from the North West Multi-center Research Ethics Committee. All participants signed written informed consent before participating. WES data for 450,000 subjects were…

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Annotating gene function categorisation in r

Annotating gene function categorisation in r 1 Hi A quick quesiton. I have generated a list of filtered gene symbol ids. However I would now like to list the functioinal category of each gene. So my current gene list looks like IDH1 IDH2 AKT1 ATM ATP50 NCOR ABC I would…

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Innovative research on schistosomiasis-associ | EurekAlert!

image: Genomic landscape of schistosomiasis-associated colorectal cancer. (A) Genetic characteristics of the SA-CRC. The number of mutations, the tumor mutation burden, the estimated MSI scores, and the predicted number of neo-epitopes of each sample were present. (B) Mutational landscape of recurrently mutated genes in SA-CRCs. Red arrow corresponds to the known…

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Unique Genetic Insights Revolutionize SA-CRC Treatment

In a study published in the journal Genes & Diseases, researchers from Naval Medical University and Soochow University conducted an in-depth investigation into the genomic landscape of schistosomiasis-associated colorectal cancer (SA-CRC). By utilizing whole exome sequencing on tumor tissues and their non-tumor counterparts obtained from thirty SA-CRC patients diagnosed at…

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2023-08-14 | NDAQ:AVTE | Press Release

WALTHAM, Mass., Aug. 14, 2023 (GLOBE NEWSWIRE) — Aerovate Therapeutics, Inc. (Nasdaq: AVTE), a clinical stage biopharmaceutical company focused on developing drugs that meaningfully improve the lives of patients with rare cardiopulmonary disease, today announced financial results for the quarter ended June 30, 2023, and recent business highlights. Recent Highlights…

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PDS Biotechnology: Interim Data Reinforces Push Towards Phase 3 Study (NASDAQ:PDSB)

gerenme/iStock via Getty Images PDS Biotechnology Corporation (NASDAQ:PDSB) has been able to make great progress with respect to advancing the use of its lead candidate known as PDS0101, which is being developed in combination with Merck’s (MRK) Keytruda to treat certain patients with HPV16-positive head and neck cancer. The last…

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What is the best way to combine machine learning algorithms for feature selection such as Variable importance in Random Forest with differential expression analysis?

NB – this answer has been updated January 28th, 2020 Update: It is important to point out that the assumptions of RandomForest® differ from those of, e.g., a regression model. So, RandomForest® and other classification algorithms certainly must be considered. Just use my general pointers here as just that, i.e.,…

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Akero Therapeutics Reports Second Quarter 2023 Financial Results and Provides Business Update

Positive Results from Phase 2b SYMMETRY Cohort D, an expansion cohort of Type 2 diabetic, pre-cirrhotic NASH patients treated with EFX or placebo in combination with a GLP-1 receptor agonist, reported during the second quarter of 2023 Phase 3 SYNCHRONY studies on track to begin enrolling in the…

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Additional Funding Awarded to Howard University Researcher to Enhance Effectiveness of Immunotherapy in Gastric Cancer

NEW YORK, Aug. 9, 2023 /PRNewswire/ — The DeGregorio Family Foundation with the support of the Price Family Foundation and the Esophageal Cancer Awareness Association has awarded $87,500 to Dawit Kidane-Mulat, PhD, Associate Professor at Howard University College of Medicine to complete his grant. Dr. Kidane-Mulat is working to enhance the effectiveness…

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Identification of immuno-inflammation-related biomarkers | JIR

Introduction Acute myocardial infarction (AMI) is the sudden irreversible necrosis of heart muscle, which commonly results from atherosclerotic plaque disruption and subsequent interruption of blood flow.1 It is one of the heart diseases with the highest prevalence and incidence and brings enormous health and financial burdens.2 Despite the rapid development…

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SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response

SF3B1 MUT cells show selective sensitivity to PARP inhibitors To identify candidate therapeutic targets for cancers with SF3B1 hotspot mutations, we utilized the leukemia K562K700E (SF3B1K700E) and parental (SF3B1WT) isogenic cells1, to model one of the most prevalent SF3B1 hotspot mutations seen in patients8,19,20 (Fig. 1a,b and Supplementary Fig. 1a)….

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Moringa oleifera leaves extract ameliorates cardiotoxicity

Cyntia Gracesella Patintingan,1 Melva Louisa,2 Vetnizah Juniantito,3 Wawaimuli Arozal,2 Silmi Hanifah,1 Septelia Inawati Wanandi,4 Rajarajan Thandavarayan5 1Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; 2Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; 3Department of Veterinary Clinic Reproduction and Pathology, Faculty of Veterinary Medicine, Agriculture Institute of Bogor,…

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Loss of Nudt15 thiopurine detoxification increases direct DNA damage in hematopoietic stem cells

Karran, P. & Attard, N. Thiopurines in current medical practice: Molecular mechanisms and contributions to therapy-related cancer. Nat. Rev. Cancer 8, 24–36. doi.org/10.1038/nrc2292 (2008). Article  CAS  PubMed  Google Scholar  Toksvang, L. N., Lee, S. H. R., Yang, J. J. & Schmiegelow, K. Maintenance therapy for acute lymphoblastic leukemia: Basic science…

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Solution for pop-up problem with rsem-prepare-reference (RSEM can not recognize reference sequence name ATM…)

Solution for pop-up problem with rsem-prepare-reference (RSEM can not recognize reference sequence name ATM…) 0 Hello everyone, I was trying to use rsem-calculate-expression with the Aligned.toTranscriptome.out.bam file created by STAR. However, when I tried to run the code, I faced the error saying “RSEM can not recognize reference sequence name…

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The complementarity of DDR, nucleic acids and anti-tumour immunity

Decout, A., Katz, J. D., Venkatraman, S. & Ablasser, A. The cGAS–STING pathway as a therapeutic target in inflammatory diseases. Nat. Rev. Immunol. 21, 548–569 (2021). Article  CAS  PubMed  PubMed Central  Google Scholar  Martincorena, I. & Campbell, P. J. Somatic mutation in cancer and normal cells. Science 349, 1483–1489 (2015)….

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New method used to develop RNA therapy for the treatment of rare diseases

Taxonomy of ASO-amenable variants. Two-step logic for classifying the amenability of genetic variants to splice modulation rescue (probably, possibly or unlikely). First, each variant is evaluated for its damaging impact on either canonical splicing or protein-coding function, on the basis of SpliceAI, MaxEntScan, LaBranchoR and REVEL. Second, each variant is…

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Viridian: Despite Drop, Advancement Towards Phase 3 Continues (NASDAQ:VRDN)

Rasi Bhadramani/iStock via Getty Images Viridian Therapeutics, Inc. (NASDAQ:VRDN) recently reported results from its ongoing phase 1/2 study using its drug candidate known as VRDN-001 for the treatment of patients with chronic thyroid eye disease [TED]. The stock fell by as much as 20% after the announcement of such data,…

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A framework for individualized splice-switching oligonucleotide therapy

Patients The WGS and clinical data of 235 patients with A-T were provided by the Global A-T Family Data Platform of ATCP. Our access to the data was approved by the Data Access Committee of ATCP. Selected patients with A-T enrolled at the Manton Center for Orphan Disease Research under…

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Novel and Validated Inflammation-Based Prognosis Score

Introduction Diffuse large B-cell lymphoma (DLBCL) is a group of B cell-derived malignant tumors with obvious heterogeneity.1 After obtaining standardized treatment, a sizeable portion of DLBCL patients can be cured and survive for a long time. However, roughly one-third of DLBCL patients experience drug resistance and disease recurrence.2,3 Therefore, it…

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Genome Sequencing Study Reveals Targets for Splice-Switching Antisense Oligonucleotide Therapy

NEW YORK — Researchers in the US and South Korea have created a system to identify rare disease patients with certain genetic variants who may be best suited for splice-switching antisense oligonucleotide (ASO) therapy, using ataxia telangiectasia (A-T) as a model. Splice-switching ASOs are short, synthetic antisense nucleic acids that…

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PARP inhibitors: enhancing efficacy through rational combinations

Bai P. Biology of poly(ADP-Ribose) polymerases: the factotums of cell maintenance. Mol Cell. 2015;58:947–58. Article  CAS  PubMed  Google Scholar  Ray U, Raghavan SC. Understanding the DNA double-strand break repair and its therapeutic implications. DNA Repair. 2021;106:103177. Article  CAS  PubMed  Google Scholar  Wright WD, Shah SS, Heyer WD. Homologous recombination and…

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Shubhashree Residential, Phase 3 Akurdi Rent – WITHOUT BROKERAGE Semi-furnished 1 BHK Rental Flat in Shubhashree Residential, Phase 3, Akurdi, Pune for Rs. 15,500

Description Livability Score is a measure of proximity of the property to essential facilities and amenities on a scale of 0 to 10 8.6 Transit Score is a measure of how well a property is served by public transit on a scale from 0 to 10 7.7 Powered By: Smart…

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[Clinicopathologic characteristics and prognostic analysis of testicular diffuse large B-cell lymphoma]

Objective: To analyze the clinicopathologic characteristics and prognosis of testicular diffuse large B-cell lymphoma (DLBCL) . Methods: A retrospective analysis was performed on 68 patients with testicular DLBCL admitted to Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine from October 2001 to April 2020. The gene mutation…

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COMPASS Pathways Raises Up To $50 Million In Non-Dilutive Financing

Mental health psychedelics biotech company COMPASS Pathways CMPS received funding for its COMP360 Phase 3 program in Treatment-Resistant Depression (TRD). The company entered into a term loan agreement with Hercules Capital Inc. HTGC for up to $50 million, filed under the SEC’s Form 8-K on July 5.  This non-dilutive financing will go toward supporting the Phase 3 program,…

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Inconsistent results between GROMACS/2016.4 and GROMACS/2021.3 – User discussions

GROMACS version: 2016.4 and 2021.3GROMACS modification: No Dear GROMACS users and developers,I am simulating a crystal structure using both GROMACS/2016.4 and GROMACS/2021.3, adopting the GAFF2 force field, at 100 K and 1 atm. The results that I obtain using two different versions of GROMACS are remarkably different, more than one…

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Targeting cGAS/STING signaling-mediated myeloid immune cell dysfunction in TIME | Journal of Biomedical Science

Kennel KB, Greten FR. Immune cell-produced ROS and their impact on tumor growth and metastasis. Redox Biol. 2021;42: 101891. Article  CAS  PubMed  PubMed Central  Google Scholar  Kirtonia A, Sethi G, Garg M. The multifaceted role of reactive oxygen species in tumorigenesis. Cell Mol Life Sci. 2020;77:4459–83. Article  CAS  PubMed  Google…

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Simultaneous Delivery of Dual Inhibitors of DNA Damage Repair Sensitizes Pancreatic Cancer Response to Irreversible Electroporation

doi: 10.1021/acsnano.3c05009. Online ahead of print. Xin Long  1 , Anna Dai  2 , Teng Huang  2 , Wenhao Niu  3 , Luoxia Liu  4 , Hui Xu  5 , Tao Yin  6 , Tian’an Jiang  7 , Shuguo Sun  2 , Ping Lei  3 , Chun Li  8 , Xiaohua Zhu  4 , Jun Zhao  2   4   9 Affiliations…

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The effect of inhibition of receptor tyrosine kinase AXL on DNA damage response in ovarian cancer

Cell lines and culture conditions All media and supplements were purchased from Gibco unless otherwise stated. OC cell line SKOV3, OVCA429, CH1 and NSCLC cell line H1299 and A549 were maintained using Dulbecco’s Modified Eagle Medium (DMEM) media supplemented with 10% (v/v) foetal bovine serum (FBS). OC cell lines HeyA8,…

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FDA Approves Talazoparib In Combination With Enzalutamide for mCRPC

The FDA has approved talazoparib (Talzenna) in combination with enzalutamide (Xtandi) for the treatment of adult patients with homologous recombination repair (HRR)-mutated metastatic castration-resistant prostate cancer (mCRPC). The approval is based on data from the phase 3 TALAPRO-2 trial (NCT03395197).1,2 The median radiographic progression-free survival (rPFS) with talazoparib/enzalutamide was not…

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Please solve this problem ” requires numeric/complex matrix/vector arguments”

I am tring to run open source R code. (atm.amegroups.com/article/view/16442/17558) But when I tried, there was some error in this code. library(dummy) set.seed(666) n <- 1500 lac<- round(rnorm(n,mean=5,sd=1.1),1) age<- round(rnorm(n,mean=67,sd=10)) smoking<- as.factor(sample(x=c(“never”,”ever”,”smoking”), size=n, replace=TRUE, prob=c(0.5,0.3,0.2))) smoking<-relevel(smoking,ref=”never”) gender<- as.factor(sample(x = c(“male”,”female”), size = n, replace = TRUE, prob = c(60,40))) ##1##…

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The Fight to Take Back Our Genes

Should companies be able to patent human genes? For decades, the U.S. Patent and Trademark Office said yes, ultimately granting patents on thousands of genes. Two of the genes that were patented are BRCA1 and BRCA2. The patent office approved exclusive rights over the genes because Myriad Genetics was the…

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Germline ATM Mutations Detected by Somatic DNA Sequencing in Lethal Prostate Cancer

Background: Germline mutations in the ataxia telangiectasia mutated (ATM) gene occur in 0.5-1% of the overall population and are associated with tumour predisposition. The clinical and pathological features of ATM-mutated prostate cancer (PC) are poorly defined but have been associated with lethal PC. Objective: To report on the clinical characteristics…

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MD Anderson Research Highlights for June 7, 2023

Newswise — HOUSTON ― The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back. Recent…

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A case report of cutaneous anthrax diagnosed with mNGS

Yushan Liu,1,2 Gezhi Zheng,1,3 Jing Li,1,3 Nan Yang,1– 4 Juan Li,1,2 Zhengwen Liu,1– 4 Qunying Han,1– 4 Yingren Zhao,1– 4 Fenjing Du,1,3 Yingli He,1,&ast; Taotao Yan1,&ast; 1Department of Infectious Diseases, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2Institution of Hepatology, The First Affiliated…

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Genomic characteristics of ESBL-producing E. coli in China

Introduction Currently, the emergence of bacterial resistance poses a significant challenge to public health worldwide. With the widespread use of antimicrobial agents in recent years, the isolation of multidrug-resistant Escherichia coli has increased yearly, particularly among Extended Spectrum β-lactamases (ESBLs) producing strains, which can cause not only multi-site infections but…

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2 BHK / Bedroom Builder Floor for rent in DLF City Plots Phase 3 DLF Phase 3 Gurgaon – 1200 Sq. Ft.

Dlf phase 3 metro station Micromax moulsari avenue metro station Dlf phase 2 metro station Guru dronacharya metro station Indusind bank cyber city metro station Vodafone belvedere towers metro station Shri Shiv Shakthi Mandir Icici bank ATM Central bank ATM Central bank atm teste 001112 Abn amro bank ATM Citibank…

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MDRUN crash during gREST simulation under NVT ensemble – User discussions

GROMACS version: 2022.3GROMACS modification: No Hello everyone. I am currently using GROMACS ver. 2022.3 patched with PLUMED ver. 2.8.1., and I’ve been trying to replicate the gREST simulations from Oshima et al. (J. Chem. Inf. Model. 2020, 60, 11, 5382–5394) using GROMACS. In the paper, the authors perform gREST simulation…

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Residential land / Plot for sale in V Block DLF Phase 3 Gurgaon

Guru dronacharya metro station Dlf phase 3 metro station Micromax moulsari avenue metro station Dlf phase 2 metro station Indusind bank cyber city metro station Sikandarpur rmrg metro station Shri Shiv Shakthi Mandir Icici bank ATM Central bank ATM Central bank atm teste 001112 Abn amro bank ATM Citibank ATM…

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Pfizer’s antibiotic combination shows promise in treating multi-drug resistant infections

Pfizer has announced positive phase 3 results supporting the safety and efficacy of its investigational antibiotic combination, aztreonam-avibactam (ATM-AVI), in treating serious infections caused by multi-drug resistant, gram-negative bacteria. Declared by the World Health Organization as one of the top ten threats to global health, antimicrobial resistance occurs when bacteria,…

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Pneumonia caused by Chlamydia abortus in a male patient

Fan Gong,1 Zhikui Chen,2 Jianyuan Chang,1 Jinlong Liu,2 Xiaobin Wang,1 Weisong Mo,1 Mengqin Tan,1 Tao Jiang1 1Department of Emergency Medicine, Hunan University of Medicine General Hospital, Huaihua, 418000, People’s Republic of China; 2Department of Respiratory Medicine, Hunan University of Medicine General Hospital, Huaihua, 418000, People’s Republic of China Correspondence: Tao…

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Phase 3 Studies of Pfizer’s Novel Antibiotic Combination Offer New Treatment Hope for Patients with Multidrug-Resistant Infections and Limited Treatment Options

Data support that antibiotic aztreonam-avibactam (ATM-AVI) is effective and well-tolerated in treating infections caused by Gram-negative bacteria, with a similar safety profile to aztreonam alone NEW YORK–(BUSINESS WIRE)– Pfizer Inc. (NYSE: PFE) today announced positive results from the Phase 3 program comprising the REVISIT (NCT03329092) and ASSEMBLE (NCT03580044) studies evaluating…

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Pfizer’s Antibiotic Combo Offers Hope for Multidrug-Resistant Infections

Pfizer Inc. (NYSE: PFE) today announced positive results from the Phase 3 program comprising the REVISIT (NCT03329092) and ASSEMBLE (NCT03580044) studies evaluating the efficacy, safety, and tolerability of the novel investigational antibiotic combination aztreonam-avibactam (ATM-AVI) in treating serious bacterial infections due to Gram-negative bacteria, including metallo-β-lactamase (MBL)-producing multidrug-resistant pathogens for…

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Pfizer Reports Positive Phase 3 Results for Antibiotic Combination >PFE

By Colin Kellaher Pfizer on Thursday reported positive results from a pair of Phase 3 studies evaluating the efficacy, safety and tolerability of the novel investigational antibiotic combination aztreonam-avibactam, or ATM-AVI. The New York drugmaker, which is studying the combination in the treatment of serious bacterial infections due to antibiotic-resistant…

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Liquid Biopsy Holds Promise in Prostate Cancer Diagnosis

Given the shortcomings of conventional biopsy, liquid biopsy offers a different strategy as a cutting-edge diagnostic tool.1 By examining the circulating blood components, it is possible to assess the limiting factors more accurately for better treatment choices—clonal variations and heterogeneity. Additionally, liquid biopsy provides a more accurate representation of the…

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Human microglia show unique transcriptional changes in Alzheimer’s disease

Podlesny-Drabiniok, A., Marcora, E. & Goate, A. M. Microglial phagocytosis: a disease-associated process emerging from Alzheimer’s disease genetics. Trends Neurosci. 43, 965–979 (2020). Article  CAS  PubMed  PubMed Central  Google Scholar  Calsolaro, V. & Edison, P. Neuroinflammation in Alzheimer’s disease: current evidence and future directions. Alzheimers Dement. 12, 719–732 (2016). Article …

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Residential land / Plot for sale in DLF Phase 3 Gurgaon

Dlf phase 3 metro station Micromax moulsari avenue metro station Dlf phase 2 metro station Guru dronacharya metro station Indusind bank cyber city metro station Vodafone belvedere towers metro station Shri Shiv Shakthi Mandir Icici bank ATM Central bank ATM Central bank atm teste 001112 Abn amro bank ATM Citibank…

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Sting and p53 DNA repair pathways are compromised in Alzheimer’s disease

Vemuri, P. et al. Evaluation of amyloid protective factors and Alzheimer disease neurodegeneration protective factors in elderly individuals. JAMA Neurol. 74(6), 718–726. doi.org/10.1001/jamaneurol.2017.0244 (2017) (Epub 2017/04/19). Article  PubMed  PubMed Central  Google Scholar  Soheili-Nezhad, S., van der Linden, R. J., Olde Rikkert, M., Sprooten, E. & Poelmans, G. Long genes are…

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Generating mammalian stable cell lines by electroporation – PubMed – Neon NxT Electroporation System | Thermo Fisher Scientific

doi: 10.1016/B978-0-12-418687-3.00017-3. Affiliations Increase Affiliation 1 Johns Hopkins University School of Medicine, Baltimore, DOCTOR, AMERICA. Free PMC articles Item in Clipboard Patti A Longo et al. Methods Enzymol. 2013. Free PMC article Show details Display choices Display options Format AbstractPubMedPMID doi: 10.1016/B978-0-12-418687-3.00017-3. Affiliate 1 Johns Hopkins University School of Doctor, Baltimore,…

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Screening and verification of key ubiquitination genes

Introduction Liver cancer is the third most common cause of cancer death globally with hepatocellular carcinoma (HCC) accounting for the majority of liver cancer.1,2 Early HCC (stage I/II) treatment mainly includes radical surgical resection, radiofrequency ablation and liver transplantation.3,4 However, there is a lack of typical clinical symptoms with early-stage…

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Pinostrobin, a fingerroot compound, regulates miR-181b-5p and induces acute leukemic cell apoptosis

Leukemia cell culture The human acute promyelocytic leukemia cell line (NB4) and the human acute lymphocytic leukemia cell line (MOLT-4) were purchased from Cell Lines Service (Eppelheim, Germany). Leukemia cells were cultured in RPMI-1640 medium supplemented with 10% (v/v) FBS and 1% (v/v) penicillin–streptomycin (Gibco Life Technologies, Waltham, MA, USA)….

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COMPASS Pathways Reports Q1 2023: Financials, Commercial Groundwork And Ongoing Phase 3 Trials – Compass Pathways (NASDAQ:CMPS)

Mental healthcare biotech company advancing psilocybin therapy COMPASS Pathways plc CMPS reported its financial results for the first quarter 2023 ended March 31, 2023 and updated on recent business and clinical progresses. In numbers: Cash and cash equivalents totaled $117.1 million as of March 31, 2023 compared to…

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Postdoctoral Researcher with Bioinformatics background in Genome Stability at University of Oxford

Applications are invited from enthusiastic, motivated individuals for a CRUK-funded Postdoctoral Researcher position for Professor Madalena Tarsounas’s Group, within the Department of Oncology. You will join an exciting research programme which combines cell/molecular biology and microscopy approaches with high-throughput technologies and bioinformatics to understand how BRCA1 and BRCA2 facilitate DNA…

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Jaguar Health : Completes Enrollment in its Pivotal Phase 3 OnTarget Trial of Crofelemer for Prophylaxis of Cancer Therapy-Related Diarrhea – Form 8-K

Jaguar Completes Enrollment in its Pivotal Phase 3 OnTarget Trial of Crofelemer for Prophylaxis of Cancer Therapy-Related Diarrhea Primary endpoint based on patient reported outcomes from study expected in October 2023 With the completion of the PIPE financing of unregistered shares and 6-month lock up term, Jaguar has agreed, as…

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