Tag: ATTR

SHANGHAI, Dec. 17, 2023 /PRNewswire/ — Yoltech Therapeutics today announced that the first patient has been administered a dose of YOLT-201, the company’s first in vivo genome editing candidate being developed as a single dose, Which is a potentially curative therapy for hereditary transthyretin amyloidosis. With cardiomyopathy (ATTR-CM). The study…

SHANGHAI, Dec. 17, 2023 /PRNewswire/ — YolTech Therapeutics today announced that the first patient has been dosed with YOLT-201, the company’s first in vivo genome editing candidate being developed as a single dose, potentially curative therapy for hereditary transthyretin amyloidosis with cardiomyopathy (ATTR-CM). The study by YolTech is a single-arm,…

A little more than a year of treatment with eplontersen was found to stabilize or even improve the heart’s structure and function in people with familial amyloid polyneuropathy (FAP) who also were experiencing symptoms of heart disease, known as cardiomyopathy. That’s according to an exploratory analysis of data from the…

In this tutorial we walk through a typical single-cell RNA-seq analysis using Bioconductor packages. We will try to cover data from different protocols, but some of the EDA/QC steps will be focused on the 10X Genomics Chromium protocol. We start from the output of the Cell Ranger preprocessing software. This…

In this tutorial we learn how to install slurm-doc on Rocky Linux 8. slurm-doc is Slurm documentation Introduction In this tutorial we learn how to install slurm-doc on Rocky Linux 8. What is slurm-doc Documentation package for Slurm. Includes documentation and html-based configuration tools for Slurm. We can use yum…

Recently, bluebird bio, Inc. BLUE obtained FDA approval for its third gene therapy, lovotibeglogene autotemcel (lovo-cel), for the treatment of sickle cell disease (“SCD”) in patients aged 12 and older who have a history of vaso-occlusive events (“VOEs”). The FDA approved lovo-cel under the brand name Lyfgenia. Concurrently, it also…

Intellia Therapeutics (NASDAQ: NTLA) and CRISPR Therapeutics (NASDAQ: CRSP) have one big thing in common: They both specialize in the hot area of gene editing, or the repairing of faulty genes responsible for disease. But CRISPR Therapeutics is farther along on the path to commercialization, recently scoring its first product…

So I made this script to automatically download the picture of a species from the general info box on Wikipedia. I have this data frame containing all the (latin) names of the species where I then want to automatically download the Wikipedia species picture and put them on a map….

Pictured: A collage of medical notes and anatomy/Nicole Bean for BioSpace With all the recent headlines being made in genetic medicine, a presentation from Turn Biotechnologies announcing the first successful in vivo delivery of messenger RNA to the skin with no off-target effects flew largely under the radar. While Turn…

Thanks for helping me out. I am using a pre-trained ViT-b/16 model with pretrained CLIP. def load_clip_to_cpu(backbone_name): url = clip._MODELS[backbone_name] model_path = clip._download(url) try: model = torch.jit.load(model_path, map_location=”cpu”).eval() state_dict = None except RuntimeError: state_dict = torch.load(model_path, map_location=”cpu”) pretrained_dict = state_dict or model.state_dict() model = clip.build_model(pretrained_dict) return model The strucutre of…

Limitations of siRNA as a proprietary drug Naked siRNA is easily degraded by nucleases in blood, and its relatively high molecular weight, negative charge, and hydrophilicity make it difficult to penetrate cell membranes. siRNA tends to accumulate in the kidney and be excreted in urine or is captured by the…

News Home Tuesday, November 14, 2023 10:04 AM | InvestorsObserver Analysts Mentioned in this article The market has been down on Intellia Therapeutics Inc (NTLA) stock recently. NTLA gets a Bearish score from InvestorsObserver Stock Sentiment Indicator. Intellia Therapeutics Inc has a Bearish sentiment reading. Find out what this means…

Hi all, I am trying to save my Seurat object to h5ad to use it as Anndata, I did it before using MuDataSeurat, with Seurat_4.3.0.1. `seurat_object = CreateSeuratObject(counts = out, project=”sample_name”) str(seurat_object) 1st str: Formal class ‘Seurat’ [package “SeuratObject”] with 13 slots ..@ assays :List of 1 .. ..$ RNA:Formal…

BridgeBio Pharma, Inc. (Nasdaq: BBIO) (“BridgeBio” or the “Company”), a commercial-stage biopharmaceutical company focused on genetic diseases and cancers, today presented additional Phase 3 data from ATTRibute-CM, its study of acoramidis in transthyretin amyloid cardiomyopathy, or ATTR-CM, at the American Heart Association (AHA) Scientific Sessions 2023. ATTRibute-CM was designed to…

– As previously announced, the primary endpoint (a hierarchical analysis inclusive of all-cause mortality and frequency of cardiovascular-related hospitalization) was met (Win Ratio of 1.8) with a highly statistically significant p-value (p<0.0001) – The placebo and acoramidis time-to-first event Kaplan-Meier (K-M) curves for a composite of all-cause mortality (ACM) and…

PALO ALTO, Calif., Nov. 09, 2023 (GLOBE NEWSWIRE) — BridgeBio Pharma, Inc. (Nasdaq: BBIO) (“BridgeBio” or the “Company”), a commercial-stage biopharmaceutical company focused on genetic diseases and cancers, announced today that additional Phase 3 data on clinical outcomes from ATTRibute-CM, its study of acoramidis in ATTR-CM will be presented at the…

PALO ALTO, Calif., Nov. 09, 2023 (GLOBE NEWSWIRE) — BridgeBio Pharma, Inc. (Nasdaq: BBIO) (“BridgeBio” or the “Company”), a commercial-stage biopharmaceutical company focused on genetic diseases and cancers, announced today that additional Phase 3 data on clinical outcomes from ATTRibute-CM, its study of acoramidis in ATTR-CM will be presented at the…

PALO ALTO, Calif., Nov. 09, 2023 (GLOBE NEWSWIRE) — BridgeBio Pharma, Inc. (Nasdaq: BBIO) (“BridgeBio” or the “Company”), a commercial-stage biopharmaceutical company focused on genetic diseases and cancers, announced today that additional Phase 3 data on clinical outcomes from ATTRibute-CM, its study of acoramidis in ATTR-CM will be presented at the…

I have an .exe that’s meant to be called from the terminal/command line, and I want to use R to generate the program calls, iterate over different arguments, measure timings, capture output, and so forth. The executable is whisper-standalone-win. From windows command line (cmd.exe), after cd‘ing to the executable, we…

A single infusion of NTLA-2001, an experimental gene editing therapy, generally is safe and leads to a marked reduction in blood levels of the harmful transthyretin (TTR) protein in people with familial amyloid polyneuropathy (FAP) and ATTR amyloidosis with cardiomyopathy (ATTR-CM). These updated, interim data cover 65 of 72 patients…

Closed. This question needs to be more focused. It is not currently accepting answers. Want to improve this question? Update the question so it focuses on one problem only by editing this post. This post was edited and submitted for review 1 hour ago. I’m interested in plotting a polygon/convex…

Hello everyone, I’ve been having the same question for a while now. I’m also conducting my own analysis of differential expression on a microarray dataset in R. However, the data is different from the results obtained using GEO2R. Here’s my line of code: my_id <- “GSE80178” gse <- getGEO(my_id, GSEMatrix…

I’ve noticed that there may be a new feature on the latest version of R Studio on Ubuntu 22.04, but I can’t seem to find any news about it and I don’t know what to search on Google to understand it more. Here is my R Studio Version RStudio 2023.09.1+494…

In a new post-hoc analysis of the phase 3 HELIOS-A study (NCT03759379) assessing vutrisiran (Amvuttra; Alnylam), an FDA-approved RNA interference therapeutic, the therapy demonstrated benefit in key measures, compared with external placebo, across all baseline polyneuropathy severities among patients with hereditary transthyretin-mediated (hATTR) amyloidosis. These results suggest patients who initiate…

BridgeBio Pharma, Inc. – Presented detailed positive results from the ATTRibute-CM Phase 3 study of acoramidis at the European Society of Cardiology (ESC) Congress, demonstrating that patients survived more and were hospitalized less than has been seen in other interventional studies of transthyretin amyloid cardiomyopathy (ATTR-CM) to the Company’s knowledge,…

Updated data from over 60 patients showed consistent, deep and durable serum TTR reduction achieved with a single dose of NTLA-2001, including in 29 patients who have now reached 12 months or more of follow-up NTLA-2001 was generally well-tolerated across both polyneuropathy and cardiomyopathy arms at all dose levels tested…

I am doing ML analysis for feature selection of my data I am using Boruta analysis. But I am getting error when i pass my array into boruta fit. Can any one help me resolve the issue. <h6>###############The code is</h6> from boruta import BorutaPy from sklearn.ensemble import RandomForestClassifier X1 =…

I want to learn how to convert pytorch model into TorchScript. To do that I have to define a torch.nn.Module class that wraps the model first. I use HuggingFace Diffusers or Transformers class to wrap the models and convert into TorchScript before. I want to know how to define the…

Hi, I was trying to install pymc3 v3.11.4 on Anaconda 23.9.0 with Python v3.8.10 on Ubuntu 22.04.3 LTS.Therefore I am using the module theano-pymc but when trying to import pymc3, I’m getting the error >>> import pymc3 /home/julian/anaconda3/envs/python3.8.10_/lib/python3.8/site-packages/theano/scalar/basic.py:2412: FutureWarning: In the future `np.bool` will be defined as the corresponding NumPy…

By Jonathan D. Grinstein, PhD Fyodor Urnov, PhD, is a pioneer in the field of genome editing and one of the scientists most invested in expanding the availability and utility of CRISPR-based therapies to the broadest possible population. He envisions a world in which genome editing can treat the nearly…

How to find OS duration, status information of patients in GSE1159 or GSE6891 (Microarray data analysis) 0 Hello. I want to analyze the survival of AML patients in GSE1159 and GSE6891. However, the datasets for these series do not have survival data (OS, status). Many papers have shown survival curves…

Home Bioconductor 3.18 Released October 25, 2023 Bioconductors: We are pleased to announce Bioconductor 3.18, consisting of 2266 software packages, 429 experiment data packages, 920 annotation packages, 30 workflows and 4 books. There are 69 new software packages, 10 new data experiment packages, 8 new annotation packages, no new workflows,…

I have a Graph Neural Network that operates on directed multigraph where the Data class is from torch_geometric. The data is under this following form: Data(x=[420, 13], edge_index=[2, 1248], edge_attr=[1248, 2, 718], y=[420], train_mask=[420], test_mask=[420], val_mask=[420]) where both nodes and edges have attributes. I tried to convert the following training…

Alnylam Pharmaceuticals, Inc. announced that results from the APOLLO-B Phase 3 study of investigational patisiran in patients with the cardiomyopathy of transthyretin-mediated (ATTR) amyloidosis were published online in the New England Journal of Medicine (NEJM). The data reported in the APOLLO-B Phase 3 study publication demonstrate that patisiran, an RNAi therapeutic targeting transthyretin (TTR), preserved…

Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), the leading RNAi therapeutics company, announced today that results from the APOLLO-B Phase 3 study of investigational patisiran in patients with the cardiomyopathy of transthyretin-mediated (ATTR) amyloidosis were published online in the New England Journal of Medicine (NEJM). The data reported in the APOLLO-B Phase…

– Treatment with an RNAi Therapeutic Preserved Functional Capacity and Health Status and Quality of Life Compared with Placebo at 12 Months – – Patisiran Demonstrated an Encouraging Safety and Tolerability Profile in Patients with the Cardiomyopathy of ATTR Amyloidosis – Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), the leading RNAi therapeutics…

– Treatment with an RNAi Therapeutic Preserved Functional Capacity and Health Status and Quality of Life Compared with Placebo at 12 Months – – Patisiran Demonstrated an Encouraging Safety and Tolerability Profile in Patients with the Cardiomyopathy of ATTR Amyloidosis – Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), the leading RNAi therapeutics…

Introduction Proteins are responsible for carrying out a multitude of biological tasks, implementing cellular functionality and determining phenotype. Mass spectrometry (MS)-based expression proteomics allows protein abundance to be quantified and compared between samples. In turn, differential protein abundance can be used to explore how biological systems respond to a perturbation….

Intellia Therapeutics is launching a pivotal Phase 3 clinical trial in the U.S. to evaluate the safety and effectiveness of its investigational gene-editing therapy NTLA-2001 in people with ATTR amyloidosis with cardiomyopathy (ATTR-CM). The study, which is expected to start by the end of the year, follows the recent approval…

Intellia Therapeutics, Inc. NTLA is a clinical-stage genome editing company focused on developing CRISPR/Cas9-based therapeutics. The company is evaluating its leading in vivo genome-editing candidates — NTLA-2001 for the treatment of transthyretin (ATTR) amyloidosis and NTLA-2002 for the treatment of hereditary angioedema (HAE). Earlier this week, the FDA cleared an…

Intellia Therapeutics, Inc. (NTLA Quick QuoteNTLA – Free Report) is a clinical-stage genome editing company focused on developing CRISPR/Cas9-based therapeutics. The company is evaluating its leading in vivo genome-editing candidates — NTLA-2001 for the treatment of transthyretin (ATTR) amyloidosis and NTLA-2002 for the treatment of hereditary angioedema (HAE). Earlier this…

The world’s first investigational in vivo CRISPR-based gene editing therapy cleared for late-stage clinical development is expected to enter Phase III in late 2023. The Investigational New Drug (IND) application for Intellia Therapeutics’ in vivo CRISPR-based candidate NTLA-2001, has been cleared as a gene editing therapy for transthyretin (ATTR) amyloidosis…

How to find OS duration, status information of patients in GSE1159 (Microarray data analysis) 0 Hello, many papers showed survival analysis using GSE1159 (N Engl J Med 2004; 350:1617-1628 and etc…). Although I got pData in GSE1159 in R, I didn’t find OS, status of patient infromation. how to get…

Intellia Therapeutics, Inc. (NASDAQ: NTLA), a leading clinical-stage genome editing company focused on developing potentially curative therapies leveraging CRISPR-based technologies, today announced that the U.S. Food and Drug Administration (FDA) has cleared the company’s Investigational New Drug (IND) application for NTLA-2001 for the treatment of transthyretin (ATTR) amyloidosis with cardiomyopathy….

Intellia Therapeutics, Inc. announced that the U.S. Food and Drug Administration (FDA) has cleared the company?s Investigational New Drug (IND) application for NTLA-2001 for the treatment of transthyretin (ATTR) amyloidosis with cardiomyopathy. The global Phase 3 study of NTLA-2001, an in vivo CRISPR-based gene editing candidate, is expected to initiate…

I have experienced installation issue with qiime2-shotgun-2023.9please help me to resolve this issue.Collecting package metadata (repodata.json): doneSolving environment: failed ResolvePackageNotFound: gxx_impl_linux-64=13.2.0 libgomp=13.2.0 bracken=2.9 xcb-util-image=0.4.0 keyutils=1.6.1 xkeyboard-config=2.38 jack=1.9.22 libcups=2.3.3 alsa-lib=1.2.8 libsanitizer=13.2.0 libgcc-devel_linux-64=13.2.0 gfortran_impl_linux-64=13.2.0 attr=2.5.1 libstdcxx-ng=13.2.0 xcb-util=0.4.0 gcc_impl_linux-64=13.2.0 libnsl=2.0.0 libstdcxx-devel_linux-64=13.2.0 xcb-util-wm=0.4.1 libcap=2.66 xcb-util-keysyms=0.4.0 pulseaudio=16.1 libsystemd0=252 xcb-util-renderutil=0.3.9 libxkbcommon=1.5.0 _openmp_mutex=4.5 libgfortran-ng=13.2.0 libgcc-ng=13.2.0 libudev1=253 gridss=2.13.2…

Cardiac amyloidosis OGphoto Alnylam logo We rate Alnylam Pharmaceuticals, Inc. (NASDAQ:ALNY) a Buy on the dip after the complete response letter, CRL for Patisiran. The investment thesis is based on the high probability of success for Vutrisiran, the company’s next-generation inverse RNA or RNAi candidate, in treating cardiac amyloidosis in…

I have installed z2jh on a local k8s cluster. Sometimes I get 500 error, other times it works fine.I’m using jupyterhub Version 3.0.0, helm chart 2.0.0 500 : Internal Server ErrorThe error was:Failed to connect to Hub API at ‘hub:8081/hub/api’. Is the Hub accessible at this URL (from host: jupyter-hammad-20ali-20baig)?…

The US Food and Drug Administration (FDA) has declined to approve the RNA interference (RNAi) therapeutic agent patisiran (Onpattro, Alnylam Pharmaceuticals) for treatment of transthyretin-mediated (ATTR) amyloidosis with cardiomyopathy, the company has announced. ATTR amyloidosis is an underdiagnosed, rapidly progressive, debilitating, fatal disease caused by misfolded TTR proteins, which accumulate…

Plotting gene Expression per pathway 0 Good morning, I am trying to recreate for my data an image I saw in a journal, as I find it very intuitive. The image is attached below. For my data I have for each GO category a list of named vectors containing the…

An Alnylam Pharmaceuticals drug developed to treat a rare disease’s potentially fatal effects on the heart has fallen short in its bid for FDA approval, costing the company a chance to immediately challenge a Pfizer product that has become a blockbuster seller in the indication. But the biotech still has…

I am building a GAT using PyTorch Geometric. I’ve manually built a GAT layer that uses only 1 attention head. However, I am stuck on figuring out how to get the predictions from the output of the final GAT layer. I have batches of size 32 graphs, and each graph…

Name Last modified Size Description Parent Directory   –   2anova1.jpg 2011-09-09 05:55 121K   4.3.1.jpg 2011-09-09 05:55 117K   4.4.1.jpg 2011-09-09 05:55 63K   4.6.1.jpg 2011-09-09 05:55 38K   4.7.1.jpg 2011-09-09 05:55 56K   4.10.1.jpg 2011-09-09 05:55 63K   4.11.1.jpg 2011-09-09 05:55 112K   4.12.1.jpg 2011-09-09 05:55 55K  …

Regenereon and Intellia Therapeutics expanded a long-running research pact to develop additional CRISPR-based gene editing therapies focused on neurological and muscular diseases. Terms call for the companies to research two in vivo non-liver targets, according to a company press release issued Tuesday. Intellia will lead the design of the editing methodology…

Intellia Therapeutics NTLA announced that it has expanded its existing collaboration with Regeneron Pharmaceuticals, Inc. REGN to develop additional in vivo CRISPR-based gene-editing therapies focused on neurological and muscular diseases. Under the expanded collaboration, Regeneron will supply its proprietary antibody-targeted adeno-associated virus vectors and delivery systems, while Intellia will bring its proprietary Nme2…

sam435 (Sam) October 1, 2023, 6:28pm 1 I am using integrated gradients for feature attributions on a model trained using DP-SGD with opacus library. However, calling attribute() throws the exception below. Calling the same on a non-private model works without any issues. Any hints on why captum throws this error…

Hello, I am attempting to use the DEICODE plugin, but I am getting what appears to be an incompatibility error. I am running the qiime2-2023.7 version that was installed in a conda environment for the new (M2) mac. I haven’t had any issues running this version of QIIME2 for other…

Gene therapy and gene editing are on the cutting edge of modern biotechnology. Gene therapies are used to correct genetic abnormalities by introducing genetic material at a cellular level and can often take the form of adding a functioning copy of a gene. Gene editing takes the science to the…

GROMACS version: 2023.1 Hello. I am trying to compile gromacs-2023.1 with cp2k-2023.2, but I am not being able to link the fftwf3 library. So when I run the following command: cmake … -DBUILD_SHARED_LIBS=OFF -DGMXAPI=OFF -DGMX_INSTALL_NBLIB_API=OFF -DGMX_DOUBLE=ON -DGMX_FFT_LIBRARY=fftw3 -DFFTWF_LIBRARY=/home/edivaldo/cp2k/tools/toolchain/install/fftw-3.3.10/lib -DFFTWF_INCLUDE_DIR=/home/edivaldo/cp2k/tools/toolchain/install/fftw-3.3.10/include -DGMX_BLAS_USER=/home/edivaldo/cp2k/tools/toolchain/install/openblas-0.3.23/lib/libopenblas.a -DGMX_LAPACK_USER=/home/edivaldo/cp2k/tools/toolchain/install/scalapack-2.2.1/lib/libscalapack.a -DGMX_CP2K=ON -DCP2K_DIR=“/home/edivaldo/cp2k/lib/local/psmp” -DGMX_MPI=on I keep getting this warning:– The…

GROMACS version: 2023.2GROMACS modification: Yes/NoHi,I’ve just install GROMACS with SYCL enabled, however, it seems like GROMACS cannot detect my GPU. My GPU is Intel Iris Xe Graphics, I’m using Ubuntu 22.04, CMake 3.27.4, and Intel oneAPI DPC++/C++ Compiler with MKL library 2023.2 for SYCL. Here it says SYCL is enabled:…

I’m trying to convert a model I finetuned using (the model is here: Salesforce/blip-image-captioning-base · Hugging Face). I’m trying to convert it to TorchScript so I can use it for an android app I used two techniques to try this but I always get a shape error on both. from…

Convert gene id’s to gene symbol preserving gene id’s in deseq2 0 Good evening, I have a dds object with gene id’s, and I need to convert them into gene symbols. The point is that some genes do not have a match and I don’t want to lose them in…

The global gene-editing market is projected to skyrocket from US$5 billion in 2021 to US$21.4 billion in 2030, growing 17.3% annually. The increasing prevalence of genetic disorders, leading to a range of diseases, is fuelling demand for personalized medicine and is the driving force behind the sharp rise of the…

Grandbrothers The U.S. Food and Drug Administration (FDA) said Monday that patisiran, a RNAi therapeutic developed by Alnylam Pharmaceuticals (NASDAQ:ALNY) for amyloidosis, caused only a “small” clinical benefit in a Phase 3 trial. The FDA’s views came in briefing documents released ahead of an advisory committee meeting on Alnylam’s (ALNY)…

Perceived wisdom goes that the way to outperform the market this year has been by leaning into the Magnificent Seven stocks (AAPL, AMZN, GOOGL, META, MSFT, NVDA, TSLA). These market leaders – all tech giants – are seen as being responsible for the market’s rally, but hold that thought, says…

BridgeBio Pharma, Inc. is a commercial-stage biopharmaceutical company. The Company is focused on discovering, creating, testing and delivering transformative medicines to treat patients who suffer from genetic diseases and cancers with clear genetic drivers. The Company’s pipeline of development programs ranges from early science to advanced clinical trials, which include…

BridgeBio Pharma, Inc. – The primary endpoint was met (Win Ratio of 1.8) with a highly statistically significant p-value (p<0.0001); this primary endpoint result consistently favored acoramidis treatment across key subgroups, including across both variant and wild-type ATTR patients as well as across New York Heart Association (NYHA) Class I, II,…

BridgeBio Pharma, Inc. announced the presentation of detailed positive results from its Phase 3 ATTRibute-CM study of acoramidis for patients with ATTR-CM by Julian Gillmore, MBBS, M.D., Ph.D., FRCP, FRCPath, in a Hot Line session at the European Society of Cardiology Congress 2023. In July, BridgeBio announced positive topline results…

– The primary endpoint was met (Win Ratio of 1.8) with a highly statistically significant p-value (p<0.0001); this primary endpoint result consistently favored acoramidis treatment across key subgroups, including across both variant and wild-type ATTR patients as well as across New York Heart Association (NYHA) Class I, II, and III patients….

PALO ALTO, Calif., Aug. 24, 2023 (GLOBE NEWSWIRE) — BridgeBio Pharma, Inc. (Nasdaq: BBIO) (“BridgeBio” or the “Company”), a commercial-stage biopharmaceutical company focused on genetic diseases and cancers, announced today that detailed Phase 3 results from ATTRibute-CM, its study of acoramidis in transthyretin amyloid cardiomyopathy, or ATTR-CM, will be presented at…

BridgeBio Pharma, a leading biopharmaceutical company, is set to unveil groundbreaking findings from its Phase 3 study, ATTRibute-CM, at the highly anticipated European Society of Cardiology (ESC) Congress 2023 in Amsterdam, Netherlands. The event, taking place from August 25 to August 28, 2023, will serve as a platform for BridgeBio…

When I attempt to install solo in conda environment lately, I have been encountering the following error. pip install solo-sc Collecting solo-sc Using cached solo-sc-1.3.tar.gz (18 kB) Preparing metadata (setup.py) … done Collecting ConfigArgParse (from solo-sc) Obtaining dependency information for ConfigArgParse from files.pythonhosted.org/packages/6f/b3/b4ac838711fd74a2b4e6f746703cf9dd2cf5462d17dac07e349234e21b97/ConfigArgParse-1.7-py3-none-any.whl.metadata Using cached ConfigArgParse-1.7-py3-none-any.whl.metadata (23 kB) Collecting pandas…

PCA percent variance DESeq2 0 @6d1ed6fa Last seen 14 hours ago United States I saved ‘pcaData’ as a data frame for future use. I ran the following to get vector ‘percentVar’, however, it is empty. Do I need the data in a different format to extract percent variance? > pcaData…

Ionis Pharmaceuticals, Inc. has announced its second-quarter 2023 financial results, surpassing earnings expectations. The reported earnings per share (EPS) is $-0.6, while expectations were $-0.94. The company’s leadership team, including the Chief Executive Officer, Chief Development Officer, and Chief Financial Officer, discussed the financial results during a conference call. During…

Ionis Pharmaceuticals recorded $188 million in quarterly revenue, a 40% increase year-over-year, according to its latest earnings report released Wednesday morning. For the first half of 2023, Ionis generated $319 million in revenue, well above the $276 million in revenue reported this time last year.  Ionis attributed the rise in…

Hello everyone! I am a beginner with bioinformatics but at the company I work at we have a genome assembly of one of our crops. I wanted to annotate the genome and to do so I used a piece of python code in ubuntu. I used the Augustus Arabidopsis database…

Ionis Pharmaceuticals, Inc. announced the completion of enrollment in the Phase 3 CARDIO-TTRansform cardiovascular outcomes study of eplontersen in patients with transthyretin-mediated amyloid cardiomyopathy (ATTR-CM), a large and growing patient population at risk of life-threatening cardiovascular (CV) events. The study enrolled more than 1,400 patients. Eplontersen is an investigational antisense…

CARDIO-TTRansform is the largest, most comprehensive ATTR-CM study with more than 1,400 patients enrolled Eplontersen is currently under U.S. FDA review for ATTRv-polyneuropathy, with ATTR-CM representing a second, larger potential patient population CARLSBAD, Calif., July 31, 2023 /PRNewswire/ — Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced the completion of enrollment in…

Hello, I would like your suggestions for this error with rma() function, for analysing microRNA-affymetrix data. I downloaded the package cdf (miRNA-4_0-st-v1_CDF) (provided below), created the package with make.cdf.package, installed it with R CMD INSTALL. library(makecdfenv) make.cdf.package(filename = “miRNA-4_0-st-v1.cdf”, packagename = “miRNA-4_0-st-v1.cdf”, cdf.path = “./miRNA_4_0_CDF/”, package.path= “/shared/home/mkondili/Tools_Packages/”, compress = FALSE,…

Recently reported findings from the phase 3 ATTRibute-CM study (NCT03860935) showed that acoramidis (BridgeBio), an investigational small molecule stabilizer of transthyretin (TTR), was effective in the treatment of TTR amyloid cardiomyopathy (ATTR-CM). BridgeBio plans on submitting a new drug application to the FDA by the end of this year, with…

(RTTNews) – BridgeBio Pharma, Inc. (BBIO) reported positive results from ATTRibute-CM, a Phase 3 study of acoramidis in transthyretin amyloid cardiomyopathy, or ATTR-CM. Key findings from the trial include: a highly statistically significant improvement in the primary endpoint; an 81% on-treatment survival rate; a highly statistically significant relative risk reduction…

GreenApple78/iStock via Getty Images Shares of BridgeBio (NASDAQ:BBIO) shot up 80% in midday trading Monday after the biotech company said it plans to file for US regulatory approval of its drug acoramidis by the end of the year after releasing positive Phase 3 data for the drug in the treatment…

Source/Disclosures Published by: Disclosures: Finkel is president of Amyloidosis Support Groups. Fox is an employee of BridgeBio Cardiorenal. Judge is co-chair of the steering committee for a trial sponsored by BridgeBio Pharma. ADD TOPIC TO EMAIL ALERTS Receive an email when…

PALO ALTO, Calif., July 14, 2023 (GLOBE NEWSWIRE) — BridgeBio Pharma, Inc. (Nasdaq: BBIO) (BridgeBio), a commercial-stage biopharmaceutical company focused on genetic diseases and cancers, today announced that members of its management team will host an investor call on Monday, July 17 at 8:00 am ET to share topline results…

PALO ALTO, Calif., July 14, 2023 (GLOBE NEWSWIRE) — BridgeBio Pharma, Inc. BBIO (BridgeBio), a commercial-stage biopharmaceutical company focused on genetic diseases and cancers, today announced that members of its management team will host an investor call on Monday, July 17 at 8:00 am ET to share topline results from…

BridgeBio to Host Investor Call to Share Topline 30-month Results from the Phase 3 ATTRibute-CM Study in Patients with Transthyretin Amyloid Cardiomyopathy on July 17, 2023 PALO ALTO, Calif., July 14, 2023 (GLOBE NEWSWIRE) — BridgeBio Pharma, Inc. (Nasdaq: BBIO) (BridgeBio), a commercial-stage biopharmaceutical company focused on genetic diseases and…

Subject: Need help with Qiime2 installation: ResolvePackageNotFound error Dear Qiime2 Community, I hope this message finds you well. I am currently facing an issue during the installation of Qiime2 and would greatly appreciate your assistance in resolving it. During the installation process, after following the Qiime2 instructions, I encountered the…

Someone’s famous uncle once said, “With great power comes great responsibility.” Genome editing is an incredibly powerful technique with huge promise and potential for medicine, as well as many other fields including agriculture and the environment. But those wielding the power must cut through the hype, evaluate the potential, and…

BFC Partners to Bring 464 Affordable Units to Coney Island – Multi-Housing News of your html page when using the responsive table generator code on sites not in UNLcms or the UNL.edu framework –>:root {–bg-table-stripe: #f6f6f5;–b-table: #e3e3e2;–caption: #242423;}table {background-color: transparent;border-collapse:collapse;font-family: Arial, Helvetica, sans-serif}th {text-align:left}.dcf-txt-center {text-align: center!important}.dcf-txt-left {text-align: left!important}.dcf-txt-right {text-align: right!important}.dcf-table…

odbtpcli.c odbtpcli.c /* ODBTPCLI is a general purpose ODBTP client that demonstrates how to execute a query and fetch rows if the query generates a result set. ODBTPCLI requires a file containing 3 or more lines of the following format to be specified on the command line when running the…

Hello, I have a question about the complex study design in the R ALDEx2 package (bioconductor.org/packages/devel/bioc/vignettes/ALDEx2/inst/doc/ALDEx2_vignette.html#46_Complex_study_designs_and_the_aldexglm_module). My goal is to compare more than two groups (e.g. two or more treatments vs control). In a simple case with two groups, we use a vector with two groups: data(selex) #subset only the…

I am using wandb as my logger and I am implementing the lr finder with lighting 2.0.4. When I check the saved hyperparameters in wandb after running my code, the saved lr is not the one that was selected by the lr finder. How can should I modify my code…

I am looking at differential genes between disease cases and controls (35 sample in total). I ran DESEQ2 with the raw counts of protein coding genes from my total RNA sequencing experiment to identify my DEGs. I understand that when doing PCA, its better to transform the normalized data to…

Fei_Liu (Fei Liu) June 28, 2023, 3:28am 1 I’m looking at the DDP source code train() function (reference): def train(self, mode=True): super().train(mode) if self._use_replicated_tensor_module: self._replicated_tensor_module.train(mode) # type: ignore[union-attr] return self What is the _replicated_tensor_module for? Context: I’m trying to understand the difference between ddp_model.train() and ddp_model.module.train(). Read more here: Source…

First time published in a peer-reviewed journal: birtamimab is the only investigational drug that has shown a significant survival benefit in patients with Mayo Stage IV AL amyloidosis in a double-blind placebo-controlled clinical trial A significant improvement in time to all-cause mortality at month 9 was observed with birtamimab versus…

Three elderly men diagnosed with an until-now irreversible heart condition, transthyretin cardiac amyloidosis, experienced an unprecedented spontaneous recovery confirmed by medical scans, leading researchers at UCL and the Royal Free Hospital to identify a unique amyloid-targeting immune response in these patients. This breakthrough raises the potential for new treatments and…

Intellia Therapeutics, Inc. is a clinical-stage genome editing company, which is focused on developing curative therapeutics using Clustered, Regularly Interspaced Short Palindromic Repeats/CRISPR associated 9 (CRISPR/Cas9) technology. CRISPR/Cas9 is a technology for genome editing, the process of altering selected sequences of genomic deoxyribonucleic acid. It is focused on leveraging its…

read.genbank <- function (locus) { X <- character() URL <- paste(“http://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=nucleotide&id=”,paste(locus, collapse = “,”), “&rettype=gb&retmode=text”,sep = “”) X <- c(X, scan(file = URL, what = “”, sep = “\n”, quiet = TRUE)) prin <- grep(“^ {0,}ORIGIN”, X) + 1 fin<- which(X == “//”) – 1 res <- list() code <-…

Hi all, I am working with the RNA-seq data on humans (24patients-20controls). I used DESeq2 to find differentially expressed genes. here is the code that I used: It is corrected for cell-type composition (using cibersort and PCA on the estimated cell-type proportions) dds <- DESeqDataSetFromHTSeqCount(sampleTable=sampleTable, directory=folder, design=~Plate+RIN+Sex+Age+condition+PC2+PC1) #considering PC1,PC2 as…

Text size Other gene editors pursuing sickle cell include Beam Therapeutics. Dreamstime Gene-editing stocks are regaining favor on Wall Street this year as evidence builds for their treatments of deadly diseases such as sickle cell. Shares of Crispr Therapeutics (ticker: CRSP) are up 45% this year, compared with the Nasdaq…