Tag: AZ

A Benchmark of Genetic Variant Calling Pipelines Using Metagenomic Short-Read Sequencing

Introduction Short-read metagenomic sequencing is the technique most widely used to explore the natural habitat of millions of bacteria. In comparison with 16S rRNA sequencing, shotgun metagenomic sequencing (MGS) provides sequence information of the whole genomes, which can be used to identify different genes present in an individual bacterium and…

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Catlett-Votca Family History

Catlett-Votca Family History Sorted By Name.com Catlett-Votca Family History Page Public information, by definition, is not private. In December 2023, 1,657,853 entries were added from Maryland death indices, part of the “MOTHERLODE” released by the Maryland State Archives. Special thanks to Reclaim The Records for acquiring this information. Please consider…

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Iterate & Deploy OpenAPI spec files in a repository path. (Github Action)

So I’m trying to iterate through a list of files within a specific path in my repository. Currently using matrix as a for loop but when it iterates through the path, it uses the wildcard ‘*’ when running az import command. Below is my code. name: API Azure Deployment on:…

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A STING Operation in neuroendocrine neoplasms | NANETS2023 | NANETS 2023

1Huntsman Cancer Institute, University of Utah, Salt Lake City, UT; 2University of Minnesota, Minneapolis, MN; 3Caris Life Sciences, Phoenix, AZ; 4The Ohio State University, Columbus, OH; 5Fox Chase Cancer Center, Philadelphia, PA; 6Sylvester Cancer Center, University of Miami, Miami, FL; 7Brown University, Providence, RI Background: Significant advances have been made…

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SOCS3 inhibiting JAK-STAT pathway enhances oncolytic adenovirus efficacy by potentiating viral replication and T-cell activation

Kaufman HL, Kohlhapp FJ, Zloza A. Oncolytic viruses: a new class of immunotherapy drugs. Nat Rev Drug Discov. 2015;14:642–62. Article  CAS  PubMed  PubMed Central  Google Scholar  Kessler T, Wick W. Oncolytic virotherapy: potentially a game-changing tumor treatment. Cancer Cell. 2021;39:753–5. Article  CAS  PubMed  Google Scholar  Koch J, Schober SJ, Hindupur…

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theano – How to resolve Input Dimension Mis-match Error in Hierarchical Bayesian Inference with PyMC3

I am trying to implement a slightly peculiar model using hierarchical bayesian inference with and have been encountering a ‘ValueError’ due to input dimension mis-match in Pymc3. The model has two levels of hierarchy with the entire distributions of parameters inferred in the first level being carried over to the…

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Disease signatures in the gut metagenome of a prospective family cohort of inflammatory bowel disease

Abstract Inflammatory bowel disease (IBD) is associated with dysbiotic microbiomes. However, whether microbiomes of family members of IBD patients harbour microbial disease signatures of IBD is unknown. Here, we generate shotgun metagenomic data of an IBD family cohort and treatment-naive IBD cases, which we combine with published IBD metagenomes, to…

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Endometrial cancer PDX-derived organoids (PDXOs) and PDXs with FGFR2c isoform expression are sensitive to FGFR inhibition

Patients, tumour Implantation, PDX expansion and characterization The study was conducted according to the Declaration of Helsinki. Tumours were collected from EC patients following Human Research Ethics Committee (HREC) approval (HREC/15/MHS/127) and QUT HREC (#1500000169, 1500000323). All participants provided written informed consent that their excess tissue could be used for…

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Psychological impact of additional findings detected by genome-wide Non-Invasive Prenatal Testing (NIPT): TRIDENT-2 study

Lo YMD, Corbetta N, Chamberlain PF, Rai V, Sargent IL, Redman CWG, et al. Presence of fetal DNA in maternal plasma and serum. Lancet. 1997;350:485–7. Article  CAS  PubMed  Google Scholar  Warsof SL, Larion S, Abuhamad AZ. Overview of the impact of noninvasive prenatal testing on diagnostic procedures. Prenat Diagn. 2015;35:972–9….

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A genomic mutational constraint map using variation in 76,156 human genomes

Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA Siwei Chen, Laurent C. Francioli, Julia K. Goodrich, Ryan L. Collins, Masahiro Kanai, Qingbo Wang, Jessica Alföldi, Nicholas A. Watts, Christopher Vittal, Timothy Poterba, Michael W. Wilson, Yekaterina Tarasova, William Phu, Riley Grant, Mary T. Yohannes, Namrata Gupta, Irina M. Armean, Samantha M. Baxter, Sarah E. Calvo, Katherine R. Chao, Sinéad Chapman, Beryl B. Cummings, Phil Darnowsky, Patrick…

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Inferring compound heterozygosity from large-scale exome sequencing data

Department of Neurology, Hospital of the University of the Pennsylvania, Philadelphia, PA, USA Michael H. Guo Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA Michael H. Guo, Laurent C. Francioli, Sarah L. Stenton, Julia K. Goodrich, Nicholas A. Watts, Moriel Singer-Berk, Emily Groopman, Philip W. Darnowsky, Matthew Solomonson, Samantha Baxter, Jessica Alföldi, Irina M….

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Azure Docker image build cache past attempts?

Closed. This question is seeking recommendations for books, tools, software libraries, and more. It does not meet Stack Overflow guidelines. It is not currently accepting answers. We don’t allow questions seeking recommendations for books, tools, software libraries, and more. You can edit the question so it can be answered with…

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Fine-tuned AlphaFold for Precise MHC-Peptide Complex Prediction

%PDF-1.5 % 48 0 obj <> endobj 324 0 obj <>stream application/pdf MHC-Fine: Fine-tuned AlphaFold for Precise MHC-Peptide Complex Prediction 2023-11-29T23:31:03Z LaTeX with hyperref 2023-12-02T10:15:33-08:00 2023-12-02T10:15:33-08:00 pdfTeX-1.40.25 False This is pdfTeX, Version 3.141592653-2.6-1.40.25 (TeX Live 2023) kpathsea version 6.3.5 uuid:29cb78a7-1dd2-11b2-0a00-4008271d5700 uuid:29cb78ab-1dd2-11b2-0a00-bf0000000000 endstream endobj 49 0 obj <> endobj 51 0 obj…

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S3 Express One Zone set to power generative AI workloads

AWS’ S3 object storage is shifting from being a data repository to a vital part of the stack for generative AI and machine learning development. That’s the idea behind S3 Express One Zone (EOZ), the public cloud’s latest S3 object storage service, according to Andy Warfield, vice president and…

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MSL2 ensures biallelic gene expression in mammals

Materials Animals All of the mice were kept in the animal facility of the Max Planck Institute of Immunobiology and Epigenetics. The mice were maintained under specific-pathogen-free conditions, with 2 to 5 mice housed in individually ventilated cages (Techniplast). The cages were equipped with bedding material, nesting material, a paper…

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Population-specific distribution of TPMT deficiency variants

Introduction Thiopurine S-methyltransferase (TPMT) is a cytoplasmic enzyme that catalyzes the S-methylation of purine analogs, including azathioprine, 6-mercaptopurine (6-MP), and thioguanine.1 The metabolism of these drugs results in two types of metabolites: S-methylmercaptopurine and S-methylthioguanine, which are generally described as inactive metabolites, and S-methyl-thioinosine monophosphate, an inhibitor of de novo…

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Solved Using a correlation matrix and the churn dataset

Transcribed image text: File Edit Format View Help Charge, Intl Mins, Intl Calls, Intl Charge, CustServ Calls, Churn? KS, 128,415, 382-4657, no, yes, 25,265.100000,110,45.070000,197.400000,99,16.780000,244.700000,91,11.010000,10.000000,3,2.700000,1, False. OH,107,415,371−7191, no, yes, 26,161.600000,123,27.470000,195.500000,103,16.620000,254.400000,103,11.450000,13.700000,3,3.700000,1, False. NJ,137,415,358−1921, no, no, θ,243.400000,114,41.380000,121.200000,110,10.300000,162.600000,104,7.320000,12.200000,5,3.290000,0, False. OH,84,408,375−9999, yes, no, θ,299.400000,71,50.900000,61.900000,88,5.260000,196.900000,89,8.860000,6.600000,7,1.780000,2, False. OK, 75,415,330-6626, yes, no, θ,166.700000,113,28.340000,148.300000,122,12.610000,186.900000,121,8.410000,10.100000,3,2.730000,3, False. AL,118,510,391−8027, yes, no, 0,223.400000,98,37.980000,220.600000,101,18.750000,203.900000,118,9.180000,6.300000,6,1.700000,0,…

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Serial Next Generation Sequencing and the Role of PARP Inhibitor Therapy in 2024

(UroToday.com) The 2023 Society of Urologic Oncology (SUO) annual meeting held in Washington, D.C. between November 28th and December 1st, 2023, was host to a prostate cancer course. Dr. Alan Bryce provided an overview of the use and application of serial next generation sequencing (NGS) in the castrate-resistant prostate cancer disease…

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Biophysical properties of NaV1.5 channels from atrial-like and ventricular-like cardiomyocytes derived from human induced pluripotent stem cells

hiPSC cultures and cardiomyocyte differentiation The hiPSC lines CBRCULi001-A54 and CBRCULi008-A55 were generated from a 44-year-old male and 75-year-old female control lymphoblastoids, respectively, and they were reprogramed at the LOEX core facility (Quebec City, QC, Canada). All the work with hiPSCs were approved by CIUSSS de la Capitale-Nationale ethics committee (Project…

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Erros when calling a function when using pymc3 – v3

I’m using pymc3 .I use normal likelihood, my parameters are mu1 sigma1 and a. When I’m using pm.Normal as my likelihood,I need to make mu=Ft(mu1,sigma1,a).The function of Ft is to convolve array ft1 and array nor_resp, I defined it by myself, like this: def Ft(A,sigma2,mu2,a): t_min=0 t_max=(t4_s.shape[0]-nor_resp.shape[0]+1)*(t4_s[1]-t4_s[0]) num=t4_s.shape[0]-nor_resp.shape[0]+1 t=np.linspace(t_min,t_max,num) tau=1/sigma2**2…

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CG Oncology Announces Presentation of the First Phase 3 Monotherapy Data for Cretostimogene Grenadenorepvec in BCG-Unresponsive NMIBC Patients at SUO 2023 | DNA RNA and Cells

CG Oncology Announces Presentation of the First Phase 3 Monotherapy Data for Cretostimogene Grenadenorepvec in BCG-Unresponsive NMIBC Patients at SUO 2023 Details Category: DNA RNA and Cells Published on Wednesday, 15 November 2023 12:31 Hits: 91 IRVINE, CA, USA I November 14, 2023 ICG Oncology, Inc. announced today that interim…

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AstraZeneca shares positive phase 3 results for Imfinzi combination in liver cancer

AstraZeneca (AZ) has shared positive results from a late-stage study of its immunotherapy Imfinzi (durvalumab) when used as part of a combination treatment in a subset of patients with hepatocellular carcinoma (HCC), the most common type of liver cancer. The phase 3 EMERALD-1 trial has been evaluating Imfinzi plus transarterial…

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Senior Director, Head of Bioinformatics (TDE)

At AstraZeneca, we are committed to advancing the science of oncology to deliver life-changing medicines to patients most in need. With a combination-focused pipeline that exploits the power of six scientific platforms (Immuno-Oncology, Tumor Drivers and Resistance, DNA Damage Response, Antibody-drug Conjugates, Cell Therapy and Epigenetics) to help address…

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Molecular-based classification of endometrial carcinoma in Northern Thailand: impact on prognosis and potential for implementation in resource-limited settings | BMC Women’s Health

Study population The study cohort included women diagnosed with endometrial carcinoma at Chiang Mai University Hospital during January 2015 to December 2017. Inclusion criteria were patients with informed consent, available hysterectomy specimens for evaluation, and available clinical information and pathological results. We excluded individual without histologic materials and formalin-fixed paraffin-embedded…

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Senior Director, Head of Bioinformatics (TDE) – Oncology R&D in Gaithersburg, Maryland

At AstraZeneca, we are committed to advancing the science of oncology to deliver life-changing medicines to patients most in need. With a combination-focused pipeline that exploits the power of six scientific platforms (Immuno-Oncology, Tumor Drivers and Resistance, DNA Damage Response, Antibody-drug Conjugates, Cell Therapy and Epigenetics) to help address unmet…

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python – pymc3 sampling chain 0 failed error

Closed. This question is off-topic. It is not currently accepting answers. Code not implemented or not working as intended: Code Review is a community where programmers peer-review your working code to address issues such as security, maintainability, performance, and scalability. We require that the code be working correctly, to the…

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Characterization of intrinsic and effective fitness changes caused by temporarily fixed mutations in the SARS-CoV-2 spike E484 epitope and identification of an epistatic precondition for the evolution of E484A in variant Omicron | Virology Journal

Cele S, Gazy I, Jackson L, Hwa SH, Tegally H, Lustig G, et al. Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma. Nature. 2021;593(7857):142–6. Article  CAS  PubMed  PubMed Central  Google Scholar  Planas D, Bruel T, Grzelak L, Guivel-Benhassine F, Staropoli I, Porrot F, et al. Sensitivity of infectious SARS-CoV-2…

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Final Highlights from the 2023 ASHG Annual Meeting

When it comes to covering a conference as large as the annual meeting of the American Society of Human Genetics (ASHG), one of the biggest challenges is capturing the full breadth of content in a handful of stories. Last week, GEN’s editorial team published three special edition newsletters covering the…

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Integrative transcriptome- and DNA methylation analysis of brain tissue from the temporal pole in suicide decedents and their controls

World Health Organization. Facts sheet: suicide. www.who.int/news-room/fact-sheets/detail/suicide. National Institute of Mental Health. Suicide. www.nimh.nih.gov/health/statistics/suicide. Nock MK, Hwang I, Sampson N, Kessler RC, Angermeyer M, Beautrais A, et al. Cross-national analysis of the associations among mental disorders and suicidal behavior: findings from the WHO world mental health surveys. PLoS Med. 2009;6:e1000123….

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Majority of Patients With Generalized Myasthenia Gravis Fail to Meet Clinical Trial Criteria

In a new retrospective study presented at the American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) meeting, held November 1-4, in Phoenix, Arizona, a majority of patients with anti-acetylcholine receptor (AChR) antibody-positive generalized myasthenia gravis (gMG) treated in routine care did not meet criteria for a potential phase 3 clinical trial….

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Sub-Analysis of CHAMPION MG Study Reveals No Differences in Ravulizumab Treatment Based on Prior Immunoglobulin Use

In a new post hoc sub-analysis of the phase 3 CHAMPION MG study (NCT03920293), findings showed no statistically significantly differences in outcomes among patients with anti-acetylcholine receptor antibody-positive (AChR Ab+) generalized myasthenia gravis (gMG) who on intravenous immunoglobulin (IVIg) after starting treatment with ravulizumab (Ultomiris; AstraZeneca), an FDA-approved agent.1 Among…

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Molecular diagnosis, phylogenetic analysis, and antifungal susceptibility profiles of Candida species isolated from neutropenic oncological patients | BMC Infectious Diseases

Eissa S, Khedr R, Romeih M, Halaby L, Elanany M, Madney Y. Clinical characteristics and outcome of invasive fungal sinusitis in children with hematological malignancies. Med Mycol. 2022;60(4):myac010. Article  PubMed  Google Scholar  Lin G-L, Chang H-H, Lu C-Y, Chen C-M, Lu M-Y, Lee P-I, Jou S-T, Yang Y-L, Huang L-M,…

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Figure S12 – compa WG

%PDF-1.7 % 1 0 obj <>/OCGs[9 0 R 59 0 R 108 0 R 158 0 R 207 0 R 256 0 R 305 0 R]>>/Pages 3 0 R/Type/Catalog>> endobj 2 0 obj <>stream 2018-07-03T11:32:26+02:00 Adobe Illustrator CC 22.1 (Macintosh) 2019-05-14T19:51:08+02:00 2019-05-14T19:51:08+02:00 184 256 JPEG /9j/4AAQSkZJRgABAgEASABIAAD/7QAsUGhvdG9zaG9wIDMuMAA4QklNA+0AAAAAABAASAAAAAEA AQBIAAAAAQAB/+4ADkFkb2JlAGTAAAAAAf/bAIQABgQEBAUEBgUFBgkGBQYJCwgGBggLDAoKCwoK DBAMDAwMDAwQDA4PEA8ODBMTFBQTExwbGxscHx8fHx8fHx8fHwEHBwcNDA0YEBAYGhURFRofHx8f Hx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8f/8AAEQgBAAC4AwER AAIRAQMRAf/EAaIAAAAHAQEBAQEAAAAAAAAAAAQFAwIGAQAHCAkKCwEAAgIDAQEBAQEAAAAAAAAA AQACAwQFBgcICQoLEAACAQMDAgQCBgcDBAIGAnMBAgMRBAAFIRIxQVEGE2EicYEUMpGhBxWxQiPB UtHhMxZi8CRygvElQzRTkqKyY3PCNUQnk6OzNhdUZHTD0uIIJoMJChgZhJRFRqS0VtNVKBry4/PE 1OT0ZXWFlaW1xdXl9WZ2hpamtsbW5vY3R1dnd4eXp7fH1+f3OEhYaHiImKi4yNjo+Ck5SVlpeYmZ qbnJ2en5KjpKWmp6ipqqusra6voRAAICAQIDBQUEBQYECAMDbQEAAhEDBCESMUEFURNhIgZxgZEy obHwFMHR4SNCFVJicvEzJDRDghaSUyWiY7LCB3PSNeJEgxdUkwgJChgZJjZFGidkdFU38qOzwygp…

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Zilucoplan Shows Reduction in MG Worsening in Phase 3 RAISE Study for Generalized Myasthenia Gravis

Angela Genge, MD, FRCPC, eMBA In a new post hoc analysis of the phase 3 RAISE study (NCT04115293) assessing zilucoplan (Zilbrysq; UCB Pharma), an FDA-approved complement C5 inhibitor, findings showed a significantly lower proportion of patients who experienced myasthenia gravis (MG) worsening when treated with the therapy than placebo. Additionally,…

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Vutrisiran Shows Benefit Across Baseline Severities in Phase 3 HELIOS-A Study

In a new post-hoc analysis of the phase 3 HELIOS-A study (NCT03759379) assessing vutrisiran (Amvuttra; Alnylam), an FDA-approved RNA interference therapeutic, the therapy demonstrated benefit in key measures, compared with external placebo, across all baseline polyneuropathy severities among patients with hereditary transthyretin-mediated (hATTR) amyloidosis. These results suggest patients who initiate…

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Understanding the ADAPT-SC Results of Subcutaneous Efgartigimod: Tuan Vu, MD

WATCH TIME: 3 minutes “There was no new signal in terms of safety events. I think it’s [subcutaneous efgartigimod] a good option for patients who want to have the flexibility of having a subcutaneous injection at home or elsewhere.” Over the years, the treatment options for patients with generalized myasthenia…

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Open-Label PROPEL Study Results Highlight Longterm Impact of Cipaglucosidase Alfa and Miglustat in Late-Onset Pompe Disease

New data from the phase 3 PROPEL study (NCT04138277) showed that treatment with cipaglucosidase alfa (Pombiliti)/miglustat (Opfolda), a recently approved 2-component agent, was effective in patients with late-onset pompe disease (LOPD) for up to 104 weeks. These data, presented at the 2023 American Association of Neuromuscular and Electrodiagnostic Medicine (AANEM)…

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How to define likelihood by myself in Pymc3

majf October 29, 2023, 4:26am 1 I’m using pymc3 to process some experimental data.I need to define a likelihood by myself to remove background signal.But I don’t know how.For example ,I define a normal likelihood,but it dose’t work well .Compared to pm.Normal, it creates larger standard deviation and less accuracy.When…

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Modeling SHANK3-associated autism spectrum disorder in Beagle dogs via CRISPR/Cas9 gene editing

De Rubeis S, He X, Goldberg AP, Poultney CS, Samocha K, Cicek AE, et al. Synaptic, transcriptional and chromatin genes disrupted in autism. Nature. 2014;515:209–15. Article  PubMed  PubMed Central  Google Scholar  Iossifov I, O’Roak BJ, Sanders SJ, Ronemus M, Krumm N, Levy D, et al. The contribution of de novo…

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The landscape of cell-free mitochondrial DNA in liquid biopsy for cancer detection | Genome Biology

Dawson SJ, Tsui DWY, Murtaza M, Biggs H, Rueda OM, Chin SF, et al. Analysis of circulating tumor DNA to monitor metastatic breast cancer. N Engl J Med. 2013;368:1199–209. Massachusetts Medical Society. Article  CAS  PubMed  Google Scholar  van der Pol Y, Mouliere F. Toward the early detection of cancer by…

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Ralph Cram – File 770

(1) WAYS IN WHICH PRATCHETT IS STILL WITH US. Sam Jordison discusses “Pratchett power: from lost stories to new adaptations, how the late Discworld author lives on” in the Guardian. “Of all the dead authors in the world, Terry Pratchett is the most alive,” said John Lloyd at the author’s memorial in…

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Wide diagnostic and genotypic spectrum in patients with suspected mitochondrial disease | Orphanet Journal of Rare Diseases

Macken WL, Vandrovcova J, Hanna MG, Pitceathly RDS. Applying genomic and transcriptomic advances to mitochondrial medicine. Nat Rev Neurol. 2021;17(4):215–30. doi.org/10.1038/s41582-021-00455-2 Article  PubMed  Google Scholar  Gorman GS, Chinnery PF, DiMauro S, Hirano M, Koga Y, McFarland R, et al. Mitochondrial diseases. Nat Rev Dis Primers. 2016;2(1). doi.org/10.1038/nrdp.2016.80 Barcia G, Assouline…

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Species-specific responses of marine bacteria to environmental perturbation

Worden AZ, Follows MJ, Giovannoni SJ, Wilken S, Zimmerman AE, Keeling PJ. Rethinking the marine carbon cycle: Factoring in the multifarious lifestyles of microbes. Science. 2015;347:1257594–1257594. PubMed  Google Scholar  Moran MA. The global ocean microbiome. Science. 2015;350:aac8455–aac8455. PubMed  Google Scholar  Sunagawa S, Coelho LP, Chaffron S, Kultima JR, Labadie K,…

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Postdoctoral Fellow – EAZPOD 2023 at European Molecular Biology Laboratory (EMBL)

About the team/job EMBL-EBI and AstraZeneca are located nearby in Cambridge which will allow fellows to spend time at both sites and take advantage of the complementary expertise and opportunities this offers. Fellows will have easy access to scientific expertise, well-equipped computational facilities and an active seminar programme. Your role…

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Translation from PyMC3 to PyMC – v5

Hello, I am porting an old PyMC3 model (written in 2019, so I assume it was v3.7 or similar) to the PyMC and am struggling. Does there exist a vocabulary from ‘old’ to ‘new’ way of doing things? For example, what should I use instead of theano.shared .astype(floatX) in an…

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Data Import Issue detectRUNS R

I am running into an issue when importing data with detectRUNS in R. The following commands to import PLINK files have not been successful, and result in blank data frames. genotypeFilePath <- system.file(“extdata”, “genome.ped”,package=”detectRUNS”) mapFilePath <- system.file(“extdata”, “genome.map”, package=”detectRUNS”) head(genotypeFilePath) [1] “” The PLINK data are correctly formatted. OR I…

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AstraZeneca shares positive phase 3 results for Tagrisso combination in lung cancer

AstraZeneca (AZ) has shared positive results from a late-stage study evaluating Tagrisso (osimertinib) in combination with chemotherapy for certain lung cancer patients. The phase 3 FLAURA2 randomised more than 500 patients with locally advanced (stage 2B to 3C) or metastatic (stage 5) epidermal growth factor receptor-mutated (EGFRm) non-small cell lung…

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expanding the toolbox of molecular degraders through systematic degron discovery

Job:AstraZeneca funded PhD studentship: expanding the toolbox of molecular degraders through systematic degron discovery 0 Dear all, (Please circulate the following PhD project opportunity within your network) Applications are invited for a fully funded, four-year PhD studentship based at the Cambridge Institute for Therapeutic Immunology and Infectious Disease (CITIID) in…

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Microsoft Fabric to RStudio Desktop – RStudio IDE

Similar to this reddit user, I’m looking to connect data stored in Microsoft Fabric (either as a lakehouse or as a SQL endpoint) from my local RStudio Desktop (free) application. Note: I do not want to use SparkR notebooks in fabric as this link suggests, because 1) tidyverse doesn’t work…

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DeepMind partners with Google Cloud to watermark AI-generated images

In partnership with Google Cloud, Google DeepMind (Google’s AI research division) is launching a tool for watermarking and identifying AI-generated images — but only images created by Google’s image-generating model. The tool, called SynthID and available in beta for select users of Vertex AI (Google’s platform for building AI apps…

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Q&A: How the Henrietta Lacks settlement challenges biotech’s view on ethics

Pharmaceutical Technology spoke with bioethicist Robert Klitzman on the recent Henrietta Lacks lawsuits. Image Credit: Shutterstock / HappySloth Earlier this month, the family of Henrietta Lacks reached a settlement with the biotech company Thermo Fisher Scientific over the company’s use of Lacks’s “immortal cells”. Lacks was an African American woman…

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Mechanical stimuli activate gene expression via a cell envelope stress sensing pathway

Microfluidic device manufacturing The methods for microfluidic device manufacturing used here are similar to what is described in our previously published works18,32 except the etch depth was reduced to accommodate the smaller cell dimensions of Vibrio cholerae as compared to E. coli examined in prior work. Fused silica wafers (100 mm…

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Native diversity buffers against severity of non-native tree invasions

Institute of Integrative Biology, ETH Zurich (Swiss Federal Institute of Technology), Zurich, Switzerland Camille S. Delavaux, Thomas W. Crowther, Constantin M. Zohner, Niamh M. Robmann, Thomas Lauber, Johan van den Hoogen, Chelsea Chisholm & Daniel S. Maynard The Forest School at The Yale School of the Environment, Yale University, New Haven, CT, USA Sara Kuebbing Department of Forestry…

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Potential pathogenicity of Non-O1, Non-O139 V. cholerae

Introduction Vibrio cholerae is a Gram-negative bacterium that can be classified into different serotypes based on the O surface antigen, with O1 and O139 being responsible for causing cholera in humans. Cholera is a highly infectious and severe diarrheal disease that is prevalent worldwide, particularly in Africa, South Asia, and…

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Senior Informatician, Proteogenomics, Oncology Data Science Platforms Job

Job Description Oncology Data Science Platforms The Oncology Data Science – Data, Analytics, and AI Platforms (ODSP) team comprises multiple groups across the Cambridge UK, Boston MA, Gaithersburg MD, and Munich DE sites. ODSP develops technology, software, and data infrastructure to advance our Oncology data science. Our vision is to…

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2 men arrested in connection to body wrapped in tarp found near Kingman

YUCCA, AZ (3TV/CBS 5) — The Mohave County Sheriff’s Office says two people have been arrested in connection to a man’s murder near Kingman. Deputies said early Tuesday that Bryan Keith Gibson, 52, and Shannon Allen Powell, 29, both of Yucca, are facing murder, conspiracy, and body abandonment charges after…

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Traffic Signs | Regulatory Signs | Traffic Signs

Why Traffic Sign Corporation We offer municipal grade, professional MUTCD regulatory traffic signs that do not rust and can easily withstand harsh weather conditions for many years. We do accept government purchase orders. No order is too big or small. We proudly serve the traffic sign needs of states, counties,…

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Skeletal remains found in 2021 in Mohave County identified

GOLDEN VALLEY, AZ (3TV/CBS 5) — The Mohave County Sheriff’s Office teamed up with a forensic genealogy company in Texas to identify the skeletal remains found in 2021. According to a post made on Wednesday, hikers discovered the remains in a remote desert area of Golden Valley in October 2021….

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lamplighter mobile homes for rent

{{people.phone_number}} {{people.phone_number}} If you love it, buy it. NOW COMPLETE BRAND NEW 3 BED 2 BATH ALL AGE FAMILY PARK! . CHINO ALL AGE – REMODELE INSIDE & OUT 3 BEDRMS – 2 SMALL PETS-YARD. This form is intended for legitimate inquiries from individuals who are considering Lamplighter On The…

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AstraZeneca hiring Director of Bioinformatics – Oncology R&D in Cambridge, England, United Kingdom

Location: Granta Park, Cambridge with relocation to the Cambridge Biomedical Campus.Do you have expertise in, and passion for Bioinformatics? Would you like to play a pivotal leading role that impacts the delivery of novel biologics drugs for oncology, respiratory and cardiovascular diseases in a company that follows the science and…

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Mitogenomes revealed the history of bison colonization of Northern Plains after the Last Glacial Maximum

Shapiro, B. et al. Rise and fall of the Beringian steppe bison. Science 306, 1561–1565 (2004). Article  ADS  CAS  PubMed  Google Scholar  Zver, L., Toškan, B. & Bužan, E. Phylogeny of Late Pleistocene and Holocene Bison species in Europe and North America. Quat. Int. 595, 30–38 (2021). Article  Google Scholar …

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PR News | On the Move: CLYDE Ups Dashevsky to SVP-PA

Lilia Dashevsky CLYDE promotes Lilia Dashevsky to senior VP of public affairs. Dashevsky has been with the firm since March 2020, most recently serving as a VP. Before joining CLYDE, she was an account manager at event marketing and digital acquisition agency mdg, and senior coordinator, social and digital content…

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DNA identifies remains as man missing since 2019: AZ cops

Jordan Victor Carvalho, 30, disappeared in 2019, deputies said. Human remains found in 2022 in Golden Valley, Arizona, were recently identified as belonging to the missing man. Mohave County Sheriff’s Office Human remains found after flooding were identified through DNA evidence as an Arizona man who disappeared in 2019, authorities…

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Guidelines for public database submission of uncultivated virus genome sequences for taxonomic classification

Quadram Institute Bioscience, Norwich Research Park, Rosalind Franklin Road, Norwich, UK Evelien M. Adriaenssens United States Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA Simon Roux National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA J. Rodney Brister & Ilene…

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Create a compute instance – Azure Machine Learning

Article 07/06/2023 2 contributors Feedback In this article APPLIES TO: Azure CLI ml extension v2 (current) Python SDK azure-ai-ml v2 (current) Learn how to create a compute instance in your Azure Machine…

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AstraZeneca and Daiichi Sankyo share positive results from phase 3 lung cancer study

AstraZeneca (AZ) and Daiichi Sankyo have announced positive results from a late-stage study of their investigational TROP2-targeting antibody drug conjugate, datopotamab deruxtecan, in certain lung cancer patients. The phase 3 TROPION-Lung01 trial has been evaluating the drug versus docetaxel, the current standard of care chemotherapy, in patients with locally advanced…

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University of Oklahoma Associate Director Jobs July, 2023 (Hiring Now!)

University of Oklahoma Associate Director Jobs July, 2023 (Hiring Now!) – Zippia – 125 Jobs Course Developer Associate Director Job At University of Oklahoma ***This position will be located in Norman with a flexible and/or remote option possible for experienced candidates. Special Instructions: If you are selected as a final…

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AstraZeneca’s phase 3 liver cancer study shows continued survival benefit

AstraZeneca (AZ) has shared updated results from a late-stage study of its Imfinzi (durvalumab) plus Imjudo (tremelimumab) treatment plan in certain patients with hepatocellular carcinoma (HCC), the most common type of liver cancer. The dosing schedule of the combination is referred to as the STRIDE (single tremelimumab regular interval durvalumab)…

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CAR T cells as micropharmacies against solid cancers: Combining effector T-cell mediated cell death with vascular targeting in a one-step engineering process

General Lab Operation The assays were performed by experienced individuals throughout the course of the study. The study was performed using established laboratory protocols covering the processing, freezing, storage and thawing of cells as well as the staining procedure, data acquisition and gating strategy. Additional data beyond the data found…

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NeoGenomics Expands Board of Directors with Appointments of Three Independent Directors

FT. MYERS, FL / ACCESSWIRE / June 29, 2023 / NeoGenomics, Inc. (NASDAQ:NEO), a leading provider of oncology testing and global contract research services, today announced the appointment of Elizabeth Floegel, Neil Gunn, and Tony Zook to its Board of Directors. The Board has elected three new independent board members…

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Elevated cell-free mitochondria DNA level of patients with premature ovarian insufficiency | BMC Pregnancy and Childbirth

European Society for Human Reproduction and Embryology Guideline Group on POI, Webber L, Davies M, Anderson R, Bartlett J, Braat D, et al. ESHRE Guideline: management of women with premature ovarian insufficiency. Hum Reprod. 2016; 31(5): 926–37. Welt CK. Primary ovarian insufficiency: a more accurate term for premature ovarian failure….

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AstraZeneca hiring Senior Scientist, Bioinformatics, Oncology R&D in Gaithersburg, Maryland, United States

Gaithersburg, MD or Waltham, MAAstraZeneca is a global, science-led, patient-focused biopharmaceutical company. It is dedicated to discovering, developing, and delivering innovative, meaningful medicines and healthcare solutions for some of the world’s most serious diseases. At AstraZeneca Oncology, we are leading a revolution to redefine cancer care by pushing the boundaries…

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Pulsuz Video Yukle, Mp3 Yukle, Shekil Yukle, Klipler Yukle

Pulsuz Video Yukle, Mp3 Yukle, Shekil Yukle, Klipler Yukle Uzr isteyirik. Axatarilan sehife tapilmadi. Yeqin ki, axtaridiginiz sehifede deyshiklik edilib ve ya silinibBuyurun axtaridginiz melumati saytimizda yeniden axtarin.Son Xeberler PULSUZ ANDROID PROGRAMLARI YUKLE EYLENCELER MARAQLI XIDMETLER QADIN DUNYASI QADIN ALEMI SAGLAMLIQ TIBBI MELUMAT REKLAMLAR SERVISLER BIZIMLE ELAQE VASITELERI Anarim.Az Sayt…

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How long until effective Helicobacter pylori vaccine – human

Introduction Helicobacter pylori became a concern in 1979 when John Warren, a pathologist in Perth, Western Australia, discovered that the inflamed gastric mucosa was covered with bacteria that looked like Campylobacter.1 Warren and his colleague Barry Marshall cultured the first batch of these bacteria, newly named Helicobacter pylori, subsequently from…

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bioinformatics jobs work from home

Lamentamos pelo inconveniente. University of Arizona Tucson, AZ (Onsite) Full-Time. Experience in conducting laboratory work by utilizing tools in molecular biology and microbiology. Sie weiterhin diese Meldung erhalten, informieren Sie uns darber bitte per E-Mail Se continui a visualizzare The Bioinformatics Analyst position will work closely with the PI and…

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Azafaros Announces Enrollment of First Patient in Phase 2 RAINBOW Study Evaluating AZ-3102 in GM2 and NP-C Patients

RAINBOW study design enables rapid advancement into the company’s planned Phase 3 efficacy trial LEIDEN, The Netherlands–(BUSINESS WIRE)–Azafaros B.V. today announced that the first patient has been enrolled into its Phase 2 RAINBOW study (NCT05758922). The clinical trial is being conducted in Brazil and the US and will evaluate the…

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AstraZeneca shares positive phase 3 results for Tagrisso in lung cancer

AstraZeneca (AZ) has shared positive results from a late-stage study evaluating Tagrisso (osimertinib) as an additional treatment for certain lung cancer patients. The phase 3 ADAURA trial enrolled 682 patients with early-stage epidermal growth factor receptor-mutated (EGFRm) non-small cell lung cancer (NSCLC) who had undergone surgery to remove their primary…

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Data Engineer / Bioinformatician- AZ-Crick-Imperial College: Molecular Glue Discovery Partnership

Hi all, We seek a talented, highly motivated candidate with experience modelling and analysing complex data sets with a strong knowledge of programming language(s) for the newly funded Molecular Glue Discovery Partnership – an exciting new research partnership between the Francis Crick Institute and Imperial College working in close collaboration…

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Pneumonia caused by Chlamydia abortus in a male patient

Fan Gong,1 Zhikui Chen,2 Jianyuan Chang,1 Jinlong Liu,2 Xiaobin Wang,1 Weisong Mo,1 Mengqin Tan,1 Tao Jiang1 1Department of Emergency Medicine, Hunan University of Medicine General Hospital, Huaihua, 418000, People’s Republic of China; 2Department of Respiratory Medicine, Hunan University of Medicine General Hospital, Huaihua, 418000, People’s Republic of China Correspondence: Tao…

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Ageing restructures the transcriptome of the hypothalamic supraoptic nucleus and alters the response to dehydration

Hooper, L. et al. Which frail older people are dehydrated? The UK DRIE study. J. Gerontol. A Biol. Sci. Med. Sci. 71, 1341–1347 (2015). Article  PubMed  PubMed Central  Google Scholar  Cowen, L. E., Hodak, S. P. & Verbalis, J. G. Age-associated abnormalities of water homeostasis. Endocrinol. Metab. Clin. North Am….

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After 53 years, “Trunk Lady” is Identified

Summary On October 31st, 1969, two St. Petersburg Police officers found a black steamer trunk in a wooded area behind a restaurant at 4200 34th Street South. When they opened the trunk, they discovered a woman’s body wrapped in a large plastic bag. The victim had visible injuries to her…

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Import a swagger file with bicep

I am using bicep templates to deploy an APIM instance and then running a module block to run the following provider, Microsoft.ApiManagement/service/apis to import an API with Operations into the APIM instance. When I use the property of value and use the value loadTextContent(‘{pathToFile}/swagger.json’) I am able to load the…

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AstraZeneca hiring Associate Director, Bioinformatics, Oncology R&D in Gaithersburg, Maryland, United States

Gaithersburg, MD or Waltham, MAAstraZeneca is a global, science-led, patient-focused biopharmaceutical company. It is dedicated to discovering, developing, and delivering innovative, meaningful medicines and healthcare solutions for some of the world’s most serious diseases. At AstraZeneca Oncology, we are leading a revolution to redefine cancer care by pushing the boundaries…

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6 biotech companies in Luxembourg making waves in the industry

One of the wealthiest countries in the world, Luxembourg is renowned for its gromperekichelcher (potato pancakes), fine wines and medieval castles. An economic powerhouse in Europe, the country’s healthtec sector is mainly focused on the manufacture of diagnostic and medical devices, while the biopharma industry, which accounts for 29 per…

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Wilton Library Presents ‘Art/Place Artists’ in June Exhibition

**News Release Submitted by Wilton Library** May 18, 2023 Wilton Library is pleased to present the diverse works of “Art/Place Artists” in its June art exhibition, opening on Friday, June 2 with a reception from 6 to 7:30 p.m. Art/Place Gallery is celebrating 42 years as a not-for-profit artist run…

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Bioinformatics Scientist Job Opening in Phoenix, AZ at Phoenix Childrens Hospital

EMAIL* UPLOAD YOUR RESUME By clicking Agree, I consent to our data usage policies as stated here By agreeing to submit your resume, you consent (in accordance with our Terms of Use and Privacy Policy) to: A) Salary.com storing your resume for purposes of providing you with the job posting…

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AstraZeneca announces positive phase 3 results for Tagrisso combination in lung cancer

AstraZeneca (AZ) has announced positive results from a phase 3 trial evaluating Tagrisso (osimertinib) in combination with chemotherapy in certain lung cancer patients. The late-stage FLAURA2 trial enrolled 586 patients with locally advanced or metastatic epidermal growth factor receptor-mutated (EGFRm) non-small cell lung cancer (NSCLC). Patients were treated with Tagrisso…

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r – coloring in ggplot2 for US map

Using ggplot2 in R I want to assign colors to the 48 contiguous states based on their rankings, which range from -2 to 2. States with negative rankings will be colored red, while those with positive rankings will be colored green. States with a ranking of 0 will be given…

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Assessing the biogeography of marine giant viruses in four oceanic transects

Koonin EV, Dolja VV, Krupovic M, Varsani A, Wolf YI, Yutin N, et al. Global organization and proposed megataxonomy of the virus world. Microbiol Mol Biol Rev. 2020;84:e00061–19. Article  CAS  PubMed  PubMed Central  Google Scholar  Wilhelm S, Bird J, Bonifer K, Calfee B, Chen T, Coy S, et al. A…

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MvNormal much slower in pymc5 than pymc3? – v5

Hi there! I have a 30-member ensemble of simulations at nt=100 time steps. Each ensemble member is assumed to be the combination of some central response \mu and underlying noise. The noise is uncorrelated across ensemble members and has temporal covariance matrix \Sigma. In this example, I assume AR(1) noise,…

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python – KeyError while printing trace in pymc3

I’m tring to perform the spectral unmixing technique with the MCMC algorithm. But I encountered a problem while I ran it. This is the part of the code I’m running: import pymc3 as pm import theano.tensor as tt import arviz as az “”” Perform the spectral unmixing through a MCMC…

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AZ, Ionis hail phase 3 data for ATTR drug eplontersen

AstraZeneca have broken out the data they teased last month for transthyretin amyloidosis (ATTR) therapy eplontersen, showing that the drug was effective at slowing down disease progression in patients with polyneuropathy caused by the disease. The results of the NEURO-TTRansform trial were presented at the American Academy of Neurology (AAN)…

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How Whole Exome Sequencing Improves Identification of People With Cancer Predisposition Syndromes

Among individuals who consented to whole-exome sequencing (WES) and were identified as carriers of predisposition genes for hereditary breast and ovarian cancer (HBOC) or Lynch syndrome (also known as hereditary nonpolyposis colorectal cancer or HNPCC), 39.2% would not have qualified for genetic screening under current guidelines. This conclusion is based…

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AstraZeneca presents positive phase 3 results for Imfinzi regimen in lung cancer

AstraZeneca’s (AZ) Imfinzi has shown promising results when used before and after surgery in resectable early-stage non-small cell lung cancer (NSCLC), according to new phase 3 data presented at the American Association for Cancer Research Annual Meeting. Interim results from the AEGEAN study, which is assessing the PD-1/L1 inhibitor in…

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PathogenDx Expands Reach of Its Multiplexed Molecular Testing Technology

SCOTTSDALE, AZ — PathogenDx (“PathogenDx” or “Company”), a leader in next-generation microarray technology for better health and safety, announced it has expanded the reach of its patented multiplexed molecular testing technology—Dynamic Dimensional Detection (D3 Array™)—beyond the cannabis and hemp sectors. The Company is bringing its D3 Array™, which addresses the challenges microarray…

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Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis

Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA Joshua S. Weinstock, Gonçalo R. Abecasis, Thomas W. Blackwell, Matthew Flickinger, Colin Gross, Hyun Min Kang, Jonathon LeFaive, Jacob Pleiness, Albert Vernon Smith, Daniel Taliun, Peter VandeHaar, Jiongming Wang, Joshua S. Weinstock, Sebastian Zoellner, Thomas W. Blackwell, Goncalo R. Abecasis, Albert V. Smith & Hyun M. Kang Department of Pathology,…

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Possible frequent multiple mitochondrial DNA copies in a single nucleoid in HeLa cells

Cells Human cervix epitheloid carcinoma HeLa cells (ECACC 93021013; RRID:CVCL_0030) were cultured at 37 °C in Dulbecco′s Modified Eagle′s Medium (DMEM) with 3 mM glutamine, 10% (v/v) fetal calf serum (FCS), 10 mM HEPES, 100 IU/ml penicillin, 100 μg/ml streptomycin, and 5 mM glucose in humidified air with 5% CO2. Human osteosarcoma 143B cells were purchased…

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Mesophilic and thermophilic viruses are associated with nutrient cycling during hyperthermophilic composting

Handa IT, Aerts R, Berendse F, Berg MP, Bruder A, Butenschoen O, et al. Consequences of biodiversity loss for litter decomposition across biomes. Nature. 2014;509:218–21. Article  CAS  PubMed  Google Scholar  Roux S, Adriaenssens EM, Dutilh BE, Koonin EV, Kropinski AM, Krupovic M, et al. Minimum information about an uncultivated virus…

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Health Sciences genome sequencers a leap forward for research

Finding when and where DNA changes as a disease progresses allows for better treatment of chronic, genetic-based diseases including cancer, diabetes, and neurological and developmental disorders. At the University of Arizona, genome sequencers are used across multiple disciplines. But the newest genome sequencer in the UArizona Health Sciences offers the…

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Sanger Sequencing Market is expected to undergo a CAGR of 18.50%

Data Bridge Market Research analyses that the sanger sequencing market which was USD 1.92 billion in 2021, would rocket up to USD 7.47 billion by 2029, and is expected to undergo a CAGR of 18.50% during the forecast period 2022 to 2029. In addition to the market insights such as…

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