Tag: Bioinformatic

Database Of Space Life Science Investigations And Bioinformatics Of Microbiology In Extreme Environments

Database Of Space Life Science Investigations And Bioinformatics Of Microbiology In Extreme Environments Biological experiments performed in space crafts like space stations, space shuttles, and recoverable satellites has enabled extensive spaceflight life investigations (SLIs). In particular, SLIs have revealed distinguished space effects on microbial growth, survival, metabolite production, biofilm formation,…

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Insight Global hiring Bioinformatics Software Engineer in Tennessee, United States

Job Description: 1) Use Nextflow to build bioinformatics pipelines that take FASTQ or BAM files as input and process them using bioinformatic tools. 2) Write Python/R scripts to process, summarize, and visualize outputs created by other tools. 3) Ensure that the pipeline is modular and flexible, with the ability to…

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2023 gene therapy research STAR Grant winners announced

At PacBio, enabling the promise of genomics to better human health cuts right to the core of everything we do.That’s why in 2023 we created the STAR (Student Travel Awarded Researcher) Grant program. This exciting funding opportunity is intended to assist up-and-coming researchers in genomics-aligned fields with sequencing services and…

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Gritstone bio hiring SENIOR BIOINFORMATICS ENGINEER in Boston, MA

DescriptionGritstone bio is a public, next-generation personalized cancer and infectious immunotherapy company. Gritstone brings together distinguished scientific founders, an experienced and diverse management team, a seasoned and successful board of directors and deep financial backing to tackle fundamental challenges at the intersection of cancer genomics, immunology, and immunotherapy design. The…

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Memorial Sloan Kettering Cancer Center hiring Bioinformatics Software Engineer III – Chan Lab in New York, NY

 The people of Memorial Sloan Kettering Cancer Center (MSK) are united by a singular mission: ending cancer for life. Our specialized care teams provide personalized, compassionate, expert care to patients of all ages. Informed by basic research done at our Sloan Kettering Institute, scientists across MSK collaborate to conduct innovative…

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What is 16s rRNA sequencing?

What are the limitations of using 16S sequencing for taxonomic identification?4 answers16S sequencing for taxonomic identification has several limitations. The most commonly used bioinformatics tools, such as Qiime 2 and Mothur, may underestimate the accuracy of species-level taxonomic assignments. Additionally, current analytical approaches lack the ability to formalize syntheses of…

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Data manager/Bioinformatics Scientist

For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance,…

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Data Scientist / Bioinformatician, Biologics R&D Job

Job Description 6000! This is the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on new technologies that have the potential to help produce therapeutic breakthroughs for patients. The Biologics Center (NBC) is accommodated within the Novartis Institutes…

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Accurate detection of identity-by-descent segments in human ancient DNA

Ethics No new aDNA data were generated for this study and we only analysed previously published and publicly available aDNA data. Identifying biological kin is a standard analysis in the aDNA field. Permission for aDNA work on the archaeological samples was granted by the respective excavators, archaeologists, curators and museum…

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Analysis of sepsis combined with pulmonary infection by mNGS

Introduction Sepsis is one of the major diseases that poses a serious threat to human health, and its incidence and in-hospital mortality rates remain high despite the continuous updating of sepsis guidelines.1 Its main clinical manifestations are elevated body temperature, chills, and rapid heart rate, and it is most common…

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Research Scientist Position – Genomic Basis of Marine Sponge Symbioses – GEOMAR

Research Scientist Position – Genomic Basis of Marine Sponge Symbioses GEOMAR – Helmholtz Centre for Ocean Research Kiel, Germany Project Description: The Hentschel lab at GEOMAR seeks to elucidate the physiological and metabolic functioning and mechanisms of interaction between marine sponges and their symbiotic microbial consortia. Our research covers fundamental…

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Senior Bioinformatics Scientist @ University of Chicago

Department BSD DFI – Translational Informatics About the Department The Duchossois Family Institute focuses on the role of commensal bacteria in enhancing disease resistance and is using genomic and metabolomic platforms to characterize the microbiome and its metabolites. Computational and bioinformatic expertise is required to understand how commensal bacteria impact…

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Multicenter evaluation of gut microbiome profiling by next-generation sequencing reveals major biases in partial-length metabarcoding approach

Bacterial profile variations in mock communities at the genus level While 16S rRNA metabarcoding only identified bacteria and archaea, Saccharomyces cerevisiae and Cryptosporidium were only identified by a shotgun metagenomics approach. Only three metabarcoding partners (P1, P4, and P5), out of six, detected all eight bacterial species present in the…

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MNCLCDA: predicting circRNA-drug sensitivity associations by using mixed neighbourhood information and contrastive learning | BMC Medical Informatics and Decision Making

circRNA-drug sensitivity associations We download the circRNA-drug sensitivity association dataset from reference [17], where Deng et al. [17] collected and organized the association data between circRNA and drug sensitivity from the circRic database [16]. Here, the drug sensitivity and circRNA data come from the GDSC database [19], which provides 80,076…

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Bioinformatics Analyst I-II in Seattle, WA for Fred Hutchinson Cancer Center

Details Posted: 17-Dec-23 Location: Seattle, Washington Type: Full-time Salary: Open Overview Fred Hutchinson Cancer Center is an independent, nonprofit organization providing adult cancer treatment and groundbreaking research focused on cancer and infectious diseases. Based in Seattle, Fred Hutch is the only National Cancer Institute-designated cancer center in Washington. With a…

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Molecular Weight Marker Market is Projected to grow at +12.1% CAGR from 2023 To 2030 by Exactitude Consultancy

Molecular Weight Marker Marke The molecular weight marker market is expected to grow at 12.1% CAGR from 2023 To 2030. It is expected to reach above USD 938.76 million by 2030. Molecular weight markers are reference standards used in gel electrophoresis and other molecular biology techniques to estimate the size…

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Senior Bioinformatics Engineer / Software Developer| Science, Engineering & Life Science Recruitment, Jobs & Staffing | SRG

A Bioinformatics Engineer is required to join a small but rapidly expanding company – by joining early in the journey you will gain exposure to the various facets of start-up life and have a unique chance to contribute to the technology and influence company culture. As the company expands this…

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Research Biologist (Computational/Bioinformatics)/Microbiologist (Research Associate) Job in Columbia, MO

Summary The Agricultural Research Service (ARS) is the United States Department of Agriculture’s chief scientific research agency and one of the world’s premiere scientific organizations. ARS Postdoctoral Research Associates are hired to supplement a lead scientist’s research on agricultural problems of high national priority affecting American agriculture. **ANNOUNCEMENT IS OPEN…

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PhD position at CiMUS (Santiago de Compostela, Spain)

1 PhD position is available at the Gene Regulatory Control in Disease group at CIMUS/University of Santiago de Compostela, Spain (International Campus of Excellence). Using both experimental and computational approaches, our laboratory aims to deconstruct the mechanistic basis for control of gene expression in developmental and pathological contexts at the…

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Artificial intelligence in drug discovery

Drug discovery — from original idea to the launch of a finished product — is a complex process that takes 12–15 years and over a billion dollar of investment. Yet, an alarmingly large number of drugs end up as ‘failures’ in one of the three phases of clinical trials. Something…

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abcam hiring Principal Bioinformatics Scientist in Cambridge, England, United Kingdom

Company DescriptionFor over 20 years, Abcam has been providing tools the scientific community needs to enable faster breakthroughs in critical areas like cancer, neurological disorders, infectious diseases, and metabolic disorders. We believe that to continue making progress, we need to work together in new ways. We need your own unique…

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Germany Shifts from Next Generation Sequencing Panels to Whole Genome Sequencing Coverage

Pilot Program for the Integration of Genomic Medicine into German Healthcare Today in Germany, patients are reimbursed for the cost of NGS analysis which uses gene panels to identify diseases. Starting on the first of January, whole genome sequencing (WGS) will be reimbursed for patients at selected reference center hospitals…

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Database size positively correlates with the loss of species-level taxonomic resolution for the 16S rRNA and other prokaryotic marker genes

Abstract For decades, the 16S rRNA gene has been used to taxonomically classify prokaryotic species and to taxonomically profile microbial communities. The 16S rRNA gene has been criticized for being too conserved to differentiate between distinct species. We argue that the inability to differentiate between species is not a unique…

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Global Bioinformatics Market Set to Hit $39.80 billion, Growing at 18.70% CAGR, Fueled by Increased Demand for Personalized Healthcare, Projects Kings Research

DUBAI, UAE, Dec. 13, 2023 /PRNewswire/ — As per the recent report released by Kings Research, the global Bioinformatics Market is anticipated to grow from USD 10.10 billion in 2022 to USD 39.80 billion by 2030, depicting an 18.70% CAGR over the forecast period of 2023-2030. The increasing need for personalized…

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Bioactive glycans in a microbiome-directed food for children with malnutrition

Collection and handling of biospecimens obtained from participants in the randomized controlled clinical study of the efficacy of MDCF-2 The human study entitled ‘Community-based clinical trial with microbiota-directed complementary foods (MDCFs) made of locally available food ingredients for the management of children with primary moderate acute malnutrition (MAM)’ was approved…

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Bioinformatics Analyst at Volta Labs, Inc.

Volta Labs is an MIT spin-off that has unlocked powerful new DNA sequencing capabilities by developing novel fluidic technology. Building off of this core technology, Volta has created a product that streamlines DNA sequencing sample prep. Volta is at the forefront of a sequencing revolution, driving sequencing towards seamless ease…

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Bioinformatics/Genomics Senior Consultant in , for The Ohio State University

Details Posted: 13-Dec-23 Type: Full-time Salary: Open Categories: Information Technology Staff/Administrative Scope of Position: The James Molecular Pathology Laboratory performs clinical molecular diagnostics testing and uniquely spans across the research and clinical missions of The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital (OSUCCC-James). The OSUCCC-James is committed…

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High-throughput sequencing of Diatoms using V4 region of 18S rRNA gene in Bayug Island, Iligan City, Philippines

Almarez DN, Almarez FJS, Baulete EM. 2014. Bayug Island Aquasilvi Program: An Eco-Governance Strategy for Climate Change Adaptation and Mitigation. J Govern Dev 10(2): 35-54. DOI: 10.32890/jgd. Alongi DM. 2014. Carbon cycling and storage in mangrove forests. Ann Rev Mar Sci 6: 195-219. DOI: 10.1146/annurev-marine-010213-135020. Balint M, Pfenninger M, Grossart…

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Methylation Analysis Tutorial in R_part1

The code and approaches that I share here are those I am using to analyze TCGA methylation data. At the bottom of the page, you can find references used to make this tutorial. If you are coming from a computer background, please bear with a geneticist who tried to code…

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Revolutionizing Water Safety with MinION Genome Sequencing

Revolutionizing Water Safety with MinION Genome Sequencing Introduction Microbiology Concepts and Detection Techniques 2.1. Concept of Microbial Water Quality 2.2. Limitations of Culture-Based Methods 2.3. Introduction to NEXt-Generation Sequencing (NGS) 2.4. Shotgun Sequencing: A Powerful DNA Sequencing Technique The Need for DNA Sequencing in Water Analysis 3.1. Application of DNA…

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The Biostar Herald for Monday, December 11, 2023

The Biostar Herald publishes user submitted links of bioinformatics relevance. It aims to provide a summary of interesting and relevant information you may have missed. You too can submit links here. This edition of the Herald was brought to you by contribution from Istvan Albert, cmdcolin, and was edited by…

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Next-generation sequencing emerges as innovative tool to detect orthopedic infections

December 11, 2023 6 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . “ data-action=”subscribe”> Subscribe We were unable to process…

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Scientist I, QTAS – Bioinformatics job with AbbVie

AbbVie is seeking a highly motivated scientist to join our Quantitative, Translation & ADME Sciences (QTAS) team in South San Francisco. The ideal candidate will have a strong background in immuno-oncology, bioinformatics and data science, ability to drive cutting-edge science and work a matrix environment. Applicants having experience in R and…

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Resin acids play key roles in shaping microbial communities during degradation of spruce bark

Bark preparation Spruce bark was obtained from the Iggesund pulp and paper mill (Iggesund, Holmen AB, Sweden), from a bark pile resulting from stripping of spruce logs at the mill after harvest, with the average age of trees at harvest being ~70 years. The bark was left to dry at…

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Freshwater Viral Metagenome Analyses Targeting dsDNA Viruses

doi: 10.1007/978-1-0716-3515-5_3. Affiliations Expand Affiliations 1 Division of Environmental Materials, Honam National Institute of Biological Resources, Mokpo, Republic of Korea. 2 Department of Biological Sciences and Bioengineering, Inha University, Incheon, Republic of Korea. chojc@inha.ac.kr. Item in Clipboard Kira Moon et al. Methods Mol Biol. 2024. Show details Display options Display options…

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Bioinformatics Analyst II in Seattle, WA for Fred Hutchinson Cancer Center

Details Posted: 08-Dec-23 Location: Seattle, Washington Type: Full-time Salary: Open Overview Fred Hutchinson Cancer Center is an independent, nonprofit organization providing adult cancer treatment and groundbreaking research focused on cancer and infectious diseases. Based in Seattle, Fred Hutch is the only National Cancer Institute-designated cancer center in Washington. With a…

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What are the factors that influence the bias of 16S rRNA gene ampicon sequencing?

What are the factors that contribute to coverage bias in amplicon sequencing?4 answersCoverage bias in amplicon sequencing can be influenced by several factors. These include differences in 3′-end stability, primer Tm, amplicon length, amplicon GC content, and GC content of amplicon flanking regions. The presence of a highly dominant taxon…

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Newcastle University hiring Research Assistant/Associate in Bioinformatics Biosciences Institute in Newcastle, England, United Kingdom

SalaryResearch Assistant: £31,396 to £32,982 per annum Research Associate: £33,996 per annum Newcastle University is a great place to work, with excellent benefits . We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a number of health and wellbeing initiatives to support you….

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Illumina RNA Sequencing – SeqCenter, LLC

RNA, the intermediate stage in the flow of genetic information from DNA to protein, contains many systems of expression and regulation that can be studied through RNA sequencing. While whole genome sequencing reveals information at the DNA level, next generation RNA sequencing (RNA-seq) characterizes the transcriptome and provides additional context…

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Nanoscale photobiotinylation, pulldown and sequencing of region-specific DNA from intact cells.

Abstract Femto-seq is a novel nanoscale optical method that can be used to obtain DNA sequence information from targeted regions around a specific locus or other nuclear regions of interest. Two-photon excitation is used to photobiotinylate femtoliter volumes of chromatin within the nucleus, allowing for subsequent isolation and sequencing of…

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Animal Microbiome Market Latest Updated Report 2023-2031

PRESS RELEASE Published December 5, 2023 Animal Microbiome Market Assessment worth $ 12.4 Billion by 2030 – Exclusive Report by InsightAce Analytic InsightAce Analytic Pvt. Ltd. announces the release of a market assessment report on the “Global Animal Microbiome Market– by Products (Phage Therapy Product, Functional Food (Probiotics, Prebiotics and…

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Bioinformatics Analyst in Proteomics – basel-jobs.ch

The Position In Roche’s Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity,…

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Vanderbilt Postdoctoral Researcher Reveals Genomic Secrets of Ocean Sponges – Evolution@Vanderbilt Evolution@Vanderbilt

Posted by flickaj on Monday, December 4, 2023 in featured. By: Sarah Ward Evolutionary Studies graduate communications assistant Picture a thriving marine environment. Perhaps you envision a community as colorful and lively as “Finding Nemo,” where massive schools of fish are flanked by sharks and sea turtles. What about sponges?…

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New discovery unveils an additional layer of the CRISPR-Cas antiviral defense system

The recent publication in Science by Mogila, Tamulaitiene et al. represents a continuation of the successful scientific research conducted by Gintautas Tamulaitis’ group. In this study, the Vilnius University researchers using bioinformatic analysis, biochemical, and structural studies characterized a novel family of effector proteins, named Cami1. They showed that when…

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Noncoding mutations cause super-enhancer retargeting resulting in protein synthesis dysregulation during B cell lymphoma progression

B cells undergo a series of programmed genomic alterations that enable the immunoglobulin light and heavy chain loci to generate high-affinity antibodies against invading pathogens. First, B cells undergo variability, diversity and joining (VDJ) recombination in the bone marrow with subsequent somatic hypermutation (SHM) and class switch recombination (CSR) occurring…

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The BAF chromatin remodeler synergizes with RNA polymerase II and transcription factors to evict nucleosomes

Kornberg, R. D. & Lorch, Y. Primary role of the nucleosome. Mol. Cell 79, 371–375 (2020). Article  CAS  PubMed  Google Scholar  Zhu, F. et al. The interaction landscape between transcription factors and the nucleosome. Nature 562, 76–81 (2018). Article  CAS  PubMed  PubMed Central  Google Scholar  Lee, C. K., Shibata, Y.,…

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Debian — Details of source package bbmap in bookworm

Links for bbmap Debian Resources: Maintainers: External Resources: The following binary packages are built from this source package: bbmap BBTools genomic aligner and other tools for short sequences bbmap-jni short read aligner and other bioinformatic tools – JNI library Other Packages Related to bbmap adep: debhelper-compat (= 13) Package not…

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Chapter 6 GGHH 2023 – notes – Chapter 6. Expression Quantitative Trait Loci (eQTL) Learning Outcomes

Chapter 6. Expression Quantitative Trait Loci (eQTL) Learning Outcomes Define an eQTL Summarise the methodology of RNAseq Understand the reason for expressing RNAseq outcomes as transcripts per million (TPM) Explain why patterns of H3K4me3 and H3K27ac can be used as markers of transcriptionally active genes Incorporate this data into a…

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Energy Jobline hiring Principal Bioinformatician – Structural Biology in London, England, United Kingdom

Newton Colmore is working with an AI Drug Discovery company, and we are assisting them with their search for a bioinformatician to join their research team. Because we are searching for a bioinformatician with highly specific skills, the role is open on seniority, and we are considering scientists that have…

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A genome assembly for Orinus kokonorica provides insights into the origin, adaptive evolution and further diversification of two closely related grass genera

Jiao, Y. N. et al. Ancestral polyploidy in seed plants and angiosperms. Nature 473, 97–100 (2011). Article  PubMed  Google Scholar  Levin, D. A. Polyploidy and novelty in flowering plants. Am. Nat. 122, 1–25 (1983). Article  Google Scholar  Soltis, P. S. & Soltis, D. E. Ancient WGD events as drivers of…

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m6A-related lncRNAs as potential biomarkers and the lncRNA ELFN1-AS1/miR-182-5p/BCL-2 regulatory axis in diffuse large B-cell lymphoma

doi: 10.1111/jcmm.18046. Online ahead of print. Affiliations Expand Affiliations 1 Department of General Surgery, Guizhou Provincial people’s Hospital, Guiyang, China. 2 Department of Infectious Diseases, Guizhou Provincial people’s Hospital, Guiyang, China. Item in Clipboard Qinglong Yang et al. J Cell Mol Med. 2023. Show details Display options Display options Format AbstractPubMedPMID…

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Post-doctoral researcher in bioinformatics, focusing on molecular sub-phenotyping of obstructive lung diseases including post-COVID and COPD – Karolinska Institute – job portal

Post-doctoral researcher in bioinformatics, focusing on molecular sub-phenotyping of obstructive lung diseases including post-COVID and COPD Login and apply Do you want to contribute to top quality medical research? We have an opening for a post-doctoral researcher in bioinformatics to join a multidisciplinary systems medicine team investigating the molecular mechanisms…

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Senior Bioinformatics Systems Analyst in Santa Cruz, CA for University of California Santa Cruz

Details Posted: 01-Dec-23 Location: Santa Cruz, California Salary: Open Categories: Information Technology Staff/Administrative Senior Bioinformatics Systems Analyst Location: Santa CruzJob ID: 61781 JOB POSTING NO VISA SPONSORSHIP IS AVAILABLE FOR THIS POSITION.THIS RECRUITMENT WILL REMAIN OPEN UNTIL FILLED. HOW TO APPLY For full consideration, applicants should attach their resume and…

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Alfalfa vein mottling virus, a novel potyvirid infecting Medicago sativa L. | Virology Journal

Plant material Five alfalfa plants (stems and leaves) were sampled from each of the four different fields, 10–15 acres in size, located in Yuma Country, Arizona, USA. Geographic coordinates of the alfalfa fields and the adjacent crops are shown in Table 1. Table 1 Geographic locations of alfalfa fields Total…

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Benchmarking of bioinformatics tools for NGS-based microRNA profiling with RT-qPCR method

MicroRNAs are vital gene expression regulators, extensively studied worldwide. The large-scale characterization of miRNAomes is possible using next-generation sequencing (NGS). This technology offers great opportunities, but these cannot be fully exploited without proper and comprehensive bioinformatics analysis. This may be achieved by the use of reliable dedicated software; however, different…

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Vacature Postdoc position in Bioinformatics

In this TKI-PPP funded project, our objective is to construct a comprehensive landscape of the tumor microenvironment in cervical cancer patients and investigate its potential clinical applications using cutting-edge bioinformatic and molecular profili… Cervical cancer ranks fourth leading causes of cancer death in women globally, with approximately 800-900 diagnosis annually…

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Identification of differentially expressed circRNAs in prostate cancer of different clinical stages by RNA sequencing

CircRNAs are widely found in eukaryotes and are a class of abundantly expressed, highly tissue-specific, and stable non-coding RNAs that have an essential role in regulating gene expression12. The abnormal expression of circRNAs has been reported in esophageal squamous cell carcinoma13, breast carcinoma14, gastric cancer15, and hepatocellular carcinoma16, which are…

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Guidance on Crucial Parameters for Bioinformatic Analysis of Metabolomic Data

Guidance on Crucial Parameters for Bioinformatic Analysis of Metabolomic Data 0 As part of a systematic review, I am conducting a bioinformatic analysis of metabolomic data. I would like to know which parameters are crucially relevant in this context, such as p-value and FDR. My lack of familiarity with metabolomics…

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ESRP1 controls biogenesis and function of a large abundant multiexon circRNA | Nucleic Acids Research

Abstract While the majority of circRNAs are formed from infrequent back-splicing of exons from protein coding genes, some can be produced at quite high level and in a regulated manner. We describe the regulation, biogenesis and function of circDOCK1(2–27), a large, abundant circular RNA that is highly regulated during epithelial-mesenchymal…

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Bioinformatics – Intern at Exact Sciences

Position Overview/Summary Exact Sciences is seeking a Bioinformatics intern to help optimize and improve the algorithms in the MRD program. Essential Duties Include, but are not limited to, the following: Assist with routine operation of our sequencing bioinformatic analysis pipeline. Create and optimize new and existing bioinformatics pipelines. Perform analysis…

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Senior Bioinformatics Software Engineer – Land A Remote Job From Top Employers

The Center for Applied Bioinformatics (CAB) at the St. Jude Children’s Research Hospital (SJCRH) is seeking a creative Software Engineer with a strong background in bioinformatics to join our development team to create and maintain our vital analytical infrastructure. The new hire will work closely with a team of computer…

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Python function to export the annotated records to genbank file using python and biopython

Python function to export the annotated records to genbank file using python and biopython 0 def export_annotated_data(annotated_records, output_file): Convert records to genbank format SeqIO.write(annotated_records, output_file, “genbank”) it throws an error of str ‘name’ missing biopython python bioinformatic programming • 20 views • link updated 1 minute ago by barslmn ★…

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ILRI Research Officer – Post-Doctoral Fellow – Genomic Epidemiology Analysis- Bioinformatics

ILRI Research Officer – Post-Doctoral Fellow – Genomic Epidemiology Analysis- Bioinformatics – Jobs in Nairobi International Livestock Research Institute (ILRI) seeks to recruit a Post-Doctoral Fellow to lead Bioinformatic analysis within ILRI genomic platform that conduct research on a range of topics including genomic epidemiology and surveillance of pathogens in…

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Head of the Medical Bioinformatics platform (m/f/d) – Kiel

Das Universitätsklinikum Schleswig-Holstein (UKSH) verbindet internationale Spitzenforschung mit interdisziplinärer Krankenversorgung. Wir sind einziger Maximalversorger und größter Arbeitgeber des Landes. Unsere mehr als 14.500 Mitarbeiter*innen stellen eine höchst individuelle Versorgung sicher – unverzichtbar für die Menschen in Schleswig-Holstein.The Institute of Clinical Molecular Biology (IKMB)The Medical Faculty together with the Institute of…

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Israel-based Fungit has a mission to feed billions of people around the world

“The global population is growing by a staggering 100 million per year,” explained Fungit Biosolutions. “By the year 2050, the world population is expected to grow by more than 3 billion and exceed 10 billion people. An increase in population directly translates into an immediate increase in demand for food.”…

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Genome wide analysis revealed conserved domains involved in the effector discrimination of bacterial type VI secretion system

Construction of the VgrG database Encoded as a stand-alone gene or fused at the N-terminus of the toxin, the MIX domains can assist the delivery of their cognate T6SS effector19,20. As the central component of the spike complex, VgrG is a good marker to explore the potential conserved domains involved…

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CSIRO hiring Research Scientist – Bioinformatics in Hobart, Tasmania, Australia

Acknowledgement of CountryCSIRO acknowledges the Traditional Owners of the land, sea and waters, of the area that we live and work on across Australia. We acknowledge their continuing connection to their culture and pay our respects to their Elders past and present. View our vision towards reconciliation Child Safety CSIRO…

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Functional filter for whole-genome sequencing data identifies HHT and stress-associated non-coding SMAD4 polyadenylation site variants >5 kb from coding DNA

Summary Despite whole-genome sequencing (WGS), many cases of single-gene disorders remain unsolved, impeding diagnosis and preventative care for people whose disease-causing variants escape detection. Since early WGS data analytic steps prioritize protein-coding sequences, to simultaneously prioritize variants in non-coding regions rich in transcribed and critical regulatory sequences, we developed GROFFFY,…

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Limma/DESeq2 for unbalanced nested design (paired samples)

I have an RNAseq dataset that I want to perform differential gene-expression analysis on. The dataset consists of 3 groups = macrophages deriving from adults (n=6), term-born infants (n=5), and preterm infants (n=3). Each sample has been treated with an immune-stimulus, or left untreated (paired samples). Group Treatment Sample_Nr Sample_within_group…

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2024 Summer Intern – Oncology Bioinformatics – GRED Job In California – Genentech

The Position 2024 Summer Intern – Oncology Bioinformatics – gRED Oncology Bioinformatics supports and expands oncology research within the larger gRED organization, with our team focusing on cancer immunogenomics and cell therapies. One aspect of these efforts is genomic sequence analysis and optimization, especially in the context of regulatory…

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Bioinformatics Scientist – Madison, Wisconsin, United States

Job Summary: The Bioinformatics Scientist will develop, adapt, and implement computational and bioinformatics pipelines for established and novel approaches, depending on the current demands of the service. The Bioinformatics Scientist will be responsible for project management, data delivery, and communication of results to clients as required. As we are a…

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ISOGenix Limited hiring Senior Bioinformatician in Oxford, England, United Kingdom

Senior Bioinformatician Are you driven by the potential of gene therapy to transform lives and eager to be at the forefront of this revolutionary field? Look no further! Our dynamic start-up is seeking a talented and motivated Senior Bioinformatician to join our growing team of brilliant minds. [Please note: For application, please…

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Cellular senescence triggers intracellular acidification and lysosomal pH alkalinized via ATP6AP2 attenuation in breast cancer cells

Doxo and Abe promote cellular senescence accompanied by an altered profile of senescence-related genes in breast cancer cells Doxo and Abe were used to treat breast cancer cells (human triple-negative breast cancer cell line MDA-MB-231 and human luminal A subtype breast cancer cell line MCF-7) for 24 h, without a robust…

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Job Application for Scientist I, Bioinformatics at Scribe Therapeutics

Scientist I, Bioinformatics Scribe Therapeutics is a molecular engineering company focused on creating best-in-class in vivo therapies that permanently treat the underlying cause of disease. Founded by CRISPR inventors and leading molecular engineers Benjamin Oakes, Brett Staahl, David Savage, and Jennifer Doudna, Scribe is overcoming the limitations of current genome…

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connecting co-expression networks to injury and pathology

Full vacancy here: www.universiteitleiden.nl/vacatures/2023/q4/14246-phd-researcher-in-systems-toxicology-connecting-co-expression-networks-to-injury-and-pathology Key responsibilities Systems toxicology is emerging as key methodology to analyze and interpret omics data in the chemical safety: it mimics the modular and multi-factorial nature of diseases and perturbational statuses. In particular, Dr. Callegaro and colleagues in the PI group of Bob van de Water…

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Bioinformatician in Systems Toxicology for Chemical Safety Assessment. Leiden, the Netherlands.

Full vacancy here: www.universiteitleiden.nl/vacatures/2023/q4/14202-postdoc-or-phd-researcher-bioinformatician-in-systems-toxicology-for-chemical-safety-assessment Key Responsibilities The research group of Prof. Bob van de Water aims to unravel cell signaling programs that underlie adverse xenobiotic-induced adverse responses. In particular, high throughput toxicogenomics analysis is applied with innovative gene co-expression network models thus contributing to a system toxicology approach in qualifying…

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Data_Sheet_3_First shotgun metagenomics study of Juan de Fuca deep-sea sediments reveals distinct microbial communities above, within, between, and below sulfate methane transition zones.xlsx

The marine deep subsurface is home to a vast microbial ecosystem, affecting biogeochemical cycles on a global scale. One of the better-studied deep biospheres is the Juan de Fuca (JdF) Ridge, where hydrothermal fluid introduces oxidants into the sediment from below, resulting in two sulfate methane transition zones (SMTZs). In…

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2024 Co-Op, Bioinformatics job with Moderna, Inc.

The Roles: Exciting opportunities to work with Ph.D.-level computational biologists advancing Modernas mRNA therapeutics platform. This application covers three roles. Candidates with interest and skills fitting one or more of these are encouraged to apply. Our co-op program goes from: January 16th to June 14th 2024. All applicants must be…

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Frederick National Laboratory for Cancer Research hiring Senior Bioinformatics Analyst (BA IV) in Frederick, MD

Job ID: req3821 Employee Type: exempt full-time Division: Bioinformatics and Computational Science Facility: Frederick: Ft Detrick Location: PO Box B, Frederick, MD 21702 USA The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research,…

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Knockdown of GNL3L alleviates the progression of COPD

Introduction Chronic obstructive pulmonary disease (COPD) is a common chronic bronchitis disease characterized by persistent airflow limitation, which can be prevented and treated. COPD is the third leading cause of death in the world reported in 2020.1 With the progression of the disease, COPD will lead to respiratory failure, pulmonary…

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Sr Scientist I, Bioinformatics Engineer job with AbbVie

The Genomics Research Center (GRC) is a center of excellence for genetics and genomics that supports both Discovery and Development. The GRC plays an integral role towards our goal of developing extraordinary genetics and genomics research, focusing on finding the right targets and helping us better understand not only human…

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International Livestock Research Institute (ILRI) Hiring Post-Doctoral Fellow – Genomic Epidemiology Analysis- Bioinformatics (R-A)

International Livestock Research Institute (ILRI) seeks to recruit a Post-Doctoral Fellow to lead Bioinformatic analysis within ILRI genomic platform that conduct research on a range of topics including genomic epidemiology and surveillance of pathogens in the context of one health, pandemic preparedness and climate change. The Fellow will work with…

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Amgen hiring Grad Intern – NGS Bioinformatics in United States

HOW MIGHT YOU DEFY IMAGINATION?Do more with the knowledge you’re working hard to acquire and the passion you already have. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies, reaching over 10 million patients worldwide….

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University of Michigan hiring Bioinformatics Specialist in Ann Arbor, MI

How to Apply Applications are welcomed and encouraged from all qualified individuals regardless of background and identity. To apply, please complete the application on the U-M Careers site. A one page cover letter is required for consideration for this position and should be attached as the first page of your…

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Grad Intern – NGS Bioinformatics job with Amgen

HOW MIGHT YOU DEFY IMAGINATION? Do more with the knowledge youre working hard to acquire and the passion you already have. At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology companies, reaching over 10 million patients…

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ILRI Hiring Post-Doctoral Fellow – Opportunities For Young Kenyans

 Nairobi, Kenya  Full-time  Animal and Human Health International Livestock Research Institute (ILRI) seeks to recruit a Post-Doctoral Fellow to lead Bioinformatic analysis within ILRI genomic platform that conduct research on a range of topics including genomic epidemiology and surveillance of pathogens in the context of one health, pandemic preparedness and…

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Senior Bioinformatics Research Scientist- Data Scientist job with St. Jude Children’s Research Hospital Careers

St. Jude Children’s Research Hospital has an exciting opportunity for a Senior Bioinformatic Research Scientist in the NeuroImage Analysis Core. The NeuroImage Analysis core is in the Department of Developmental Neurobiology (DNB)  is a team of computational scientists with a focus on turning image data into biological knowledge. We utilize computational…

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Chitin degradation by Synechococcus WH7803

Candidate chitinase genes have been previously identified with bioinformatic tools2. A putative chitinase gene in the Synechococcus WH7803 genome is WH7803_2068, which we refer to as chiA henceforth. ChiA contains a Beta-glycosidase of family GH18 listed as a possible chitinase and two N-terminal carbohydrate-binding domain of the CBM28 family (Fig….

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Senior Bioinformatician – Centogene, Berlin or Remote

Senior Bioinformatician – Centogene, Berlin or Remote Senior Bioinformatician Centogene Berlin or Remote, Germany Your tasks and responsibilities: We are looking for senior Bioinformatician to join in the R&D bioinformatics team in either Berlin or remotely from all over the world. You will be responsible for developing new bioinformatics pipelines…

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CCMB Bioinformatics Mol Bio & Bioinformatics Research

“Breaking News: Exciting Job Openings at CCMB for Bioinformatics and Mol Bio Research! Apply Now!” CCMB Bioinformatics Mol Bio & Bioinformatics Research CCMB Bioinformatics Mol Bio & Bioinformatics Research. Interested and eligible applicants can check out all of the details on the same below: A leading research institution, CSIR-CENTRE FOR…

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Volta Labs, Inc. hiring Senior Bioinformatics Engineer/Analyst in Boston, Massachusetts, United States

Volta Labs is an MIT spin-off that has unlocked powerful new DNA sequencing capabilities by developing novel fluidic technology. Building off of this core technology, Volta has created a product that streamlines DNA sequencing sample prep. Volta is at the forefront of a sequencing revolution, driving sequencing towards seamless ease…

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Predicting multiple conformations via sequence clustering and AlphaFold2

AlphaFold2 (AF2) 1 has revolutionized structural biology by accurately predicting single structures of proteins. However, a protein’s biological function often depends on multiple conformational substates2, and disease-causing point mutations often cause population changes within these substates3,4. We demonstrate that clustering a multiple sequence alignment (MSA) by sequence similarity enables AF2…

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Case of Spine Infection with Brucella melitensis

Introduction Brucellosis is a common zoonotic infection in most of the developing regions of the world, severely affecting livestock productivity and human health. It caused by a small, nonmotile gram-negative coccobacillus of the genus Brucella. Among reported human brucellosis cases, the pathogenic strain B. melitensis is the most frequently encountered.1,2…

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Forecasting the dynamics of a complex microbial community using integrated meta-omics

Characterization of the microbial community From the experimental period between 21 March 2011 and 3 May 2012 (ref. 27), we previously obtained and analysed 51 weekly samples, to which we added 21 samples collected in the month of June during the years 2012–2016. The 72 samples were submitted to the…

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STAFF SCIENTIST 1 -Deputy Program Head, Sequence Enhancements, Tools, and Delivery (SeqPlus) Program job with National Library of Medicine, National Center for Biotechnology Information

The National Library of Medicine (NLM), National Center for Biotechnology Information (NCBI),  Information Engineering Branch (IEB) is recruiting for a Staff Scientist 1 to support the Sequence  Enhancements, Tools, and Delivery (SeqPlus) Program, which includes eukaryotic, prokaryotic, and viral Reference Sequence (RefSeq) databases, the Basic Local Alignment Search Tool (BLAST), the Conserved…

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Tumor microenvironment heterogeneity in bladder cancer identifies biologically distinct subtypes predicting prognosis and anti-PD-L1 responses

Bladder cancer is the most prevalent cancer of the urological system and it is histologically and genomically heterogeneous, which results in highly variable outcomes. Although improved strategies, such as the introduction of Bacillus Calmette-Guerin (BCG) and cisplatin-based chemotherapy, have significantly improved prognosis, that of high-risk, advanced, and metastatic BCa remains…

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Job opening at the Copenhagen Center for Glycomics (Post-doc/bioinformatics/data science)

Ämne: Job opening at the Copenhagen Center for Glycomics (Post-doc/bioinformatics/data science)   Dear fellow Glyco-colleagues,   I would like to let you all know that I’ve got a position open for a post-doc to join my group and the Copenhagen Center for Glycomics, doing data science/bioinformatics (position closes 2nd April 2023).   The…

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St. Jude Children’s Research Hospital hiring Senior Bioinformatics Analyst/Bioinformatics Analyst in Memphis, Tennessee, United States

St. Jude Children’s Research Hospital is looking for a highly motivated Senior Bioinformatics Analyst/Bioinformatic Analyst to contribute to genetic research projects in the Department of Epidemiology and Cancer Control. Our research leverages comprehensive biomedical data from childhood cancer survivors participating in two world-leading cohort studies, CCSS (ccss.stjude.org/ ) and SJLIFE…

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Elimination of contamination in the published 16S rRNA gene sequence of Rothia amarae type strain J18T during phylogenetic studies of a bacterial isolate from a suspension cell culture of Arabidopsis thaliana (Heynh.)

Abstract In our phylogenetic studies of a bacterial strain isolated from an Arabidopsis suspension culture, we obtained convincing evidence for contamination of the published 16S rRNA gene sequence of Rothia amarae type strain J18T (GenBank AY043359.1). Correction of this sequence by deleting the contamination region eliminated contradictions in bioinformatic results…

Continue Reading Elimination of contamination in the published 16S rRNA gene sequence of Rothia amarae type strain J18T during phylogenetic studies of a bacterial isolate from a suspension cell culture of Arabidopsis thaliana (Heynh.)

Bioinformatician job with Proclinical Staffing

Proclinical is seeking a Bioinformatician for a digital IT and data science provider located in Cambridge, MA. Must be eligible to work in the US. Job Responsibilities: Deploy and optimize bioinformatic workflows for the integration and analysis of NGS data, including short and long read sequencing data. Interpret results from…

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