Tag: CAS

Seven technologies to watch in 2022

The Telomere-to-Telomere Consortium is sequencing whole chromosomes.Credit: Adrian T. Sumner/SPL From gene editing to protein-structure determination to quantum computing, here are seven technologies that are likely to have an impact on science in the year ahead. Fully finished genomes Roughly one-tenth of the human genome remained uncharted when genomics researchers…

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Newly discovered protein essential for CRISPR/Cas3 genome editing

24 January 2022 A hidden component of the CRISPR/Cas3 genome editing system, which is essential for it to work, has been discovered by scientists. The CRISPR/Cas3 family of genome editing systems is similar to other CRISPR families but can uniquely make larger and more accurate changes to DNA (see BioNews…

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Multi-organoid system to simulate human liver-islet axis in normal and type 2 diabetes

Schematic of hiPSCs derived multi-organoid-on-chip system to model human liver-pancreatic islet axis in vitro. Credit: Tao Tingting Type 2 diabetes (T2DM) is a systematic multi-organ metabolic disease, which is characterized by dynamic interplay among different organs. Pancreatic islet-liver axis is closely associated with normal glucose regulation and homeostasis maintenance. The…

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Xenotransplantation: Argentina is about to produce genetically modified animals for human transplants

While the international medical community celebrates the first successful xenotransplantation, in Argentina two research teams from public universities are preparing to produce genetically modified animals so that their organs are suitable for human transplants and the first pigs of this type would be obtained at the end of this year…

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CRISPR-Cas12a ribonucleoprotein-mediated gene editing in the plant pathogenic fungus Magnaporthe oryzae

. 2021 Dec 24;3(1):101072. doi: 10.1016/j.xpro.2021.101072. eCollection 2022 Mar 18. Affiliations Expand Affiliation 1 Department of Plant Pathology, Kansas State University, Manhattan, KS, USA. Free PMC article Item in Clipboard Jun Huang et al. STAR Protoc. 2021. Free PMC article Show details Display options Display options Format AbstractPubMedPMID . 2021 Dec…

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Nutritionally charged lettuce developed with CRISPR/Cas gene editing tech – CNW News – Breaking News & Top Stories – Latest World, US & Local News

The concept of genetic modification can be described as polarizing. Some people believe that both traditional and modern plant breeding techniques are unsafe and unnatural. Others see the potential for greater yields and better nutrition. Yarin LIVNEH, a PhD student at Hebrew University in Israel, is part of the second…

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UMass Chan Medical School hiring Research Lab Tech I – Neurogenerative Disease (CRISPR-Cas gene editing) in Worcester, Massachusetts, United States

OverviewGENERAL SUMMARY OF POSITION: We are seeking a Research Technician to work collaboratively on CRISPR-Cas gene editing of the Huntington’s Disease (HD) gene. HD is a devasting neurodegenerative disease that currently has no effective treatment. Our goal is to develop gene editing methods to inactivate or correct the disease-causing version…

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CRISPR/Cas12a-based biosensors for ultrasensitive tobramycin detection with single- and double-stranded DNA activators

Dawei Li received his Bachelor’s degree (2003) and Master’s degree (2006) from Lanzhou University and PhD (2013) from Nanyang Technological University. At present he is an associate professor in college of biology and the environment at Nanjing Forestry University. His current research interests mainly focus on the design and synthesis…

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The CRISPR-Cas toolbox and gene editing technologies

The emergence of CRISPR-Cas systems has accelerated the development of gene editing technologies, which are widely used in the life sciences. To improve the performance of these systems, workers have engineered and developed a variety of CRISPR-Cas tools with a broader range of targets, higher efficiency and specificity, and greater…

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A year of ToBRFV

Although 2021 was the year of viruses for the entire world population, it was even more so for growers, who were confronted with the infamous Tomato Brown Rugose Fruit Virus (ToBRFV). It has been quite a ride – which is, unfortunately, not over just yet. In order to give you…

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CRISPR/Cas12a Powered DNA Framework-Supported Electrochemical Biosensing Platform for Ultrasensitive Nucleic Acid Analysis

Nucleic acid analysis using ultrasensitive and simple methods is critically important for the early-stage diagnosis and treatment of diseases. The CRISPR/Cas proteins, guided by a single-stranded RNA have shown incredible capability for sequence-specific targeting and detection. Herein, in order to improve and expand the application of CRISPR/Cas technology to the…

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Sigma-Aldrich Joins the CRISPR Interference Fray | McDonnell Boehnen Hulbert & Berghoff LLP

On June 21st,* the Patent Trial and Appeal Board declared two new interferences involving CRISPR technology.  The first, Interference No. 106,132, named Sigma-Aldrich as Senior Party and the University of California/Berkeley, the University of Vienna, and Emmanuelle Charpentier (collectively, “CVC”) as Junior Party, while the second, Interference No. 106,133 named…

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“Bushy plant growth is not an invention”

No Patents on Seeds! is filing an opposition against a Nunhems (BASF) patent on watermelons (EP2814316) derived from conventional breeding. The bushy plants were originally discovered in a garden. They argue that the genetic predisposition to bushy growth occurred randomly. Nunhems has, in this case, simply used well-known methods to…

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DEFENCE THERAPEUTICS ACCUMTM BOOSTS BY 9-FOLD THE DELIVERY EFFECTIVENESS OF THE CRISPR/CAS9 PROTEIN TO TARGET CELLS

DGAP-News: Defence Therapeutics Inc. / Key word(s): Miscellaneous 13.12.2021 / 08:30 The issuer is solely responsible for the content of this announcement. CSE: DTC FSE: DTC USOTC: DTCFF PRESS RELEASE DEFENCE THERAPEUTICS ACCUMTM BOOSTS BY 9-FOLD THE DELIVERY EFFECTIVENESS OF THE CRISPR/CAS9 PROTEIN TO TARGET CELLS Vancouver, BC, Canada, December…

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ADVANCED ELECTROPORATION TECHNIQUES in Biology and – EUR 104,90

Vendeur: bookandchopine ✉️ (6.022) 97.6%, Lieu où se trouve: ÉTOILE-SUR-RHÔNE, FR, Lieu de livraison: EUROPE, Numéro de l’objet: 255274816286 Advanced Electroporation Techniques in Biology and. BookAndChopine exerce son activité sur le web depuis plus de douze années maintenant. Les envois standard ne sont pas remboursés en cas de perte, c’est…

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HIRA complex presets transcriptional potential through coordinating depositions of the histone variants H3.3 and H2A.Z on the poised genes in mESCs

doi: 10.1093/nar/gkab1221. Online ahead of print. Yang Yang  1   2 , Liwei Zhang  3 , Chaoyang Xiong  2 , Jun Chen  2   4   5 , Li Wang  6 , Zengqi Wen  2   5 , Juan Yu  2 , Ping Chen  4 , Yanhui Xu  6 , Jingji Jin  1   7   8 , Yong Cai …

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Targeted mutagenesis in plants using Beet curly top virus for efficient delivery of CRISPR/Cas12a components

Available online 8 December 2021 doi.org/10.1016/j.nbt.2021.12.002Get rights and content Highlights • An efficient geminiviral vector was developed from Beet curly top virus with a wide host range. • The geminiviral vector delivered CRISPR/Cas components efficiently into plant cells. • A high frequency of both mutagenesis and complete HDR in plant…

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An assessment of pH-sensitive cationic lipid nanoparticles for drug delivery

A recent review in the Chemical and Pharmaceutical Bulletin looks at the molecular design of pH-sensitive cationic lipids and their applications for various tissues and cell types. The researchers also describe the application of lipid nanoparticles (LNPs) for delivering various macromolecules including small interfering ribonucleic acid (siRNA), antisense oligonucleotide, messenger…

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CRISPR Pioneers Doudna and Banfield Introduce Microbiome Community Editing

CRISPR systems have been developed, to date, to edit the genes of one type of cell at a time. Now, a new technique has been characterized that can add or modify genes within a community of many different species simultaneously, opening the door to the idea of “community editing.” The…

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BRAIN Biotech AG: Additional Genome Editing Nuclease: BRAIN-Metagenome-Cas 01 (BMC01)

DGAP-News: BRAIN Biotech AG / Key word(s): Miscellaneous/Patent08.12.2021 / 15:00 The issuer is solely responsible for the content of this announcement. Zwingenberg, Germany, December 8th, 2021 Additional Genome Editing Nuclease: BRAIN-Metagenome-Cas 01 (BMC01) BRAIN Biotech AG has successfully extended its proprietary genome editing toolbox with the addition of BRAIN-Metagenome-Cas 01…

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BRAIN Biotech AG: Additional Differentiated Genome-Editing Nuclease: BRAIN-Metagenome-Cas 01 (BMC01)

DGAP-Ad-hoc: BRAIN Biotech AG / Key word(s): Miscellaneous/PatentBRAIN Biotech AG: Additional Differentiated Genome-Editing Nuclease: BRAIN-Metagenome-Cas 01 (BMC01) 08-Dec-2021 / 14:53 CET/CESTDisclosure of an inside information acc. to Article 17 MAR of the Regulation (EU) No 596/2014, transmitted by DGAP – a…

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CRISPR/Cas9 gene editing boosts effectiveness

image: Ultrasound irradiation of a tumor causes a lipid nanoparticle (drawing shown above) to release harmful ROS and a CRISPR/Cas9 gene-editing system. view more  Credit: Credit: Adapted from ACS Central Science 2021, DOI: 10.1021/acscentsci.1c01143 Sonodynamic therapy uses ultrasound in combination with drugs to release harmful reactive oxygen species (ROS) at the…

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RNA-targeting enzyme expands the CRISPR toolkit

McGovern Fellows Jonathan Gootenberg (left) and Omar Abudayyeh in their lab. Credit: Caitlin Cunningham Researchers at MIT’s McGovern Institute for Brain Research have discovered a bacterial enzyme that they say could expand scientists’ CRISPR toolkit, making it easy to cut and edit RNA with the kind of precision that, until…

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CVC Files Opposition to ToolGen Substantive Motion No. 1 | McDonnell Boehnen Hulbert & Berghoff LLP

On July 15th, Junior Party the University of California/Berkeley, the University of Vienna, and Emmanuelle Charpentier (collectively, “CVC”) filed its Opposition to Senior Party ToolGen’s Substantive Motion No. 1 for benefit of priority to U.S. Provisional Application No. 61/837,481, filed June 20, 2013 (“P3” or “ToolGen P3”), or alternatively, International…

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Researchers Engineer a Mini CRISPR Genetic Editing System That Could Be Easier To Deliver Into Cells

CRISPR illustration. Credit: National Institutes of Health A compact and efficient CRISPR-Cas system, named CasMINI, could be broadly useful for cell-engineering and gene-therapy applications because it is easier to deliver into cells. The findings appear in a study that was published on September 3, 2021, in the journal Molecular Cell….

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ToolGen Files Opposition to Broad Preliminary Motion No. 3 to De-Designate Claims as Corresponding to Either Interference Count | McDonnell Boehnen Hulbert & Berghoff LLP

On May 28th, Junior Party the Broad Institute, Harvard University, and MIT (collectively, “Broad”) filed its Substantive Preliminary Motion No. 3 in CRISPR Interference No. 106,126 (where ToolGen is the Senior Party).  This motion, pursuant to 37 C.F.R. §§ 41.121(a)(1)(iii) and 41.208(a)(1) requested that the Board de-designate Broad claims in these…

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Gene Therapy: Is RNA Better DNA?

Gene Therapy: Is RNA Better DNA? CRISPR / Cas 13 detects viruses and helps with cancer research Tipp-Ex for the RNA: ADAR rewrites letters RNA editing does not need CRISPR / Cas Read article in MIT Technology Review 5/2021 When he slashed the acronym CRISPR from “Clustered Regularly Interspaced Short…

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The CRISPR Family Tree Holds a Multitude of Untapped Gene Editing Tools

Thanks to CRISPR, gene therapy and “designer babies” are now a reality. The gene editing Swiss army knife is one of the most impactful biomedical discoveries of the last decade. Now a new study suggests we’ve just begun dipping our toes into the CRISPR pond. CRISPR-Cas9 comes from lowly origins….

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High tumor mutation burden and DNA repair gene mutations

Introduction Anaplastic lymphoma kinase (ALK)‑fusion genes represent a small but important part of oncogenic driver mutations in NSCLC, accounting for approximately 3%‑7% of all cases worldwide.1,2 Small molecule tyrosine kinase inhibitors (TKIs) are the standard therapy for ALK-rearranged NSCLC. Crizotinib, a first-generation TKI, is the most widely used targeted drug…

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A Campylobacter integrative and conjugative element with a CRISPR-Cas9 system targeting competing plasmids: a history of plasmid warfare?

Abstract Microbial genomes are highly adaptable, with mobile genetic elements (MGEs) such as integrative conjugative elements (ICE) mediating the dissemination of new genetic information throughout bacterial populations. This is countered by defence mechanism such as CRISPR-Cas systems, which limit invading MGEs by sequence-specific targeting. Here we report the distribution of…

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MIT study finds more than 1m potential genome-editing tools in microbes

While investigating the ancestry of Cas proteins, the researchers also found the first evidence of CRISPR activity in a eukaryotic cell. CRISPR gene editing is a field with many promises that has sometimes struggled to deliver. Now, a new study published in the journal Science has made a step towards…

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Scientists use gene editing tool to target mosquito-spread disease

CRISPR/Cas9 based kmo knock-in cassette. Representation of the kmo locus and HDR donor construct for integration. Grey arrows represent exons and the red vertical line indicates the sgRNA target site within exon 5. The dark gray lines indicate the left and right homology arm sequences (LHA and RHA, respectively). In…

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Researchers discover transposon-encoded RNA-guided nucleases with potential for genome editing

Researchers seeking to understand the origins of CRISPR-Cas9 systems have uncovered a class of transposon-encoded RNA-guided nucleases, which they dubbed “OMEGA,” that could be harnessed for genome editing in human cells. These systems hold strong potential for developing as biotechnologies, the authors say. CRISPR-Cas systems have transformed genome editing and…

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ToolGen Files Opposition to Broad Preliminary Motion No. 1 to Change Interference Count | McDonnell Boehnen Hulbert & Berghoff LLP

On May 28th, Junior Party the Broad Institute, Harvard University, and MIT (collectively, “Broad”) filed its Substantive Preliminary Motion No. 1 in CRISPR Interference No. 106,126, where ToolGen is the Senior Party.  This Motion shared many similarities to a similar motion filed in Broad’s Interference No. 106,115 against the University of…

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New Class of Transposon-Encoded RNA-Guided Nucleases May Add to Genome Editing Toolbox

NEW YORK – A team of US researchers led by the Broad Institute’s Feng Zhang has discovered a new class of transposon-encoded RNA-guided DNA nucleases, which they said could be used for genome editing in human cells and hold potential for biotechnology. In a paper published on Thursday in Science,…

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Breakout “CRISPR platform” company Mammoth Biosciences is officially a unicorn

The CRISPR-based biotech startup Mammoth Biosciences is officially a unicorn, the company says. The billion dollar valuation comes on the back of a $150 million series D round led by Redmile Group, with participation from Foresite Capital, Senator Investment Group, Sixth Street, Greenspring Associates, Mayfield, Decheng Capital, Plum Alley and…

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Mini CRISPR Genome Editing System Created

The common analogy for CRISPR gene editing is that it works like molecular scissors, cutting out select sections of DNA. Stanley Qi, assistant professor of bioengineering at Stanford University, likes that analogy, but he thinks it’s time to reimagine CRISPR as a Swiss Army knife. “CRISPR can be as simple as…

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Compact CasMINI CRISPR Tech Is Easier to Deliver to Cells, Could Have Broad Gene Therapy Potential

Scientists led by a team at Stanford University have developed a compact, efficient CRISPR-Cas system, called CasMINI, which is about half the size of existing CRISPR-Cas systems, and which could have broad utility for gene therapy applications as well as cell engineering. The researchers confirmed in experiments that CasMINI could,…

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Multipurpose Mini CRISPR System Easier to Deliver Into Human Cells for Gene Therapy, Treat Rheumatoid Arthritis, Diverse Ailments

Bioengineers reimagine the CRISPR system as a Swiss Army knife packed with many applications. They repurposed it to make a mini version, called CasMINI, that can easily be delivered into human cells for gene therapy and treat various ailments. The new technology, described in the study titled “Engineered Miniature CRISPR-Cas…

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Stanford researchers engineer an efficient, multi-purpose, mini CRISPR system

The common analogy for CRISPR gene editing is that it works like molecular scissors, cutting out select sections of DNA. Stanley Qi, assistant professor of bioengineering at Stanford University, likes that analogy, but he thinks it’s time to reimagine CRISPR as a Swiss Army knife. “CRISPR can be as simple…

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Researchers develop the smallest CRISPR to date for genome editing

A compact and efficient CRISPR-Cas system, named CasMINI, could be broadly useful for cell-engineering and gene-therapy applications because it is easier to deliver into cells. The findings appear in a study publishing September 3 in the journal Molecular Cell. This is a critical step forward for CRISPR genome-engineering applications….

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A mini-CRISPR system could be ‘Swiss knife’ in gene editing

Why grab just a pair of scissors when you could get more functionality with a Swiss knife? A team of researchers at Stanford University think they’ve built such a tool to apply to CRISPR gene editing, which could help advance the platform and make it easier to deliver into cells. the…

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ENHANCED GRAVITROPISM 2 encodes a STERILE ALPHA MOTIF–containing protein that controls root growth angle in barley and wheat

    Significance To date, the potential of utilizing root traits in plant breeding remains largely untapped. In this study, we cloned and characterized the ENHANCED GRAVITROPISM2 (EGT2) gene of barley that encodes a STERILE ALPHA MOTIF domain–containing protein. We demonstrated that EGT2 is a key gene of root growth…

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2020 Heritable Human Genome Editing – Genômica

  editing methodologies. It is possible that continuing research may yield new methodologies that rapidly supersede the safety and efficacy of current editing approaches. Non-Heritable Genome Editing: The Use of Genome Editing in Somatic Cells One potential alternative to HHGE for the treatment of genetic dis- eases is somatic genome…

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CRISPR-Based Therapeutics Blaze an In Vivo Path to the Clinic

Therapeutic applications of genome editing were envisioned at least as early as the mid-1990s, when the first sequence-specific genome editing technologies emerged. Initially, such applications were considered distant prospects, but by 2012, they suddenly seemed near to hand. It was at that time that CRISPR technologies emerged. CRISPR, which stands…

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Industrializing CRISPR

Sponsored content brought to you by Kevin Holden, PhD Kevin Holden, PhD, Head of Science at Synthego, discusses the importance of industrializing CRISPR as the technology matures and makes inroads in the clinic. GEN: What’s new and interesting to you in the world of CRISPR? HOLDEN: Some of the most…

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New Techniques and Complex Models

CRISPR systems that rely on inactivated Cas enzymes—that is, dead Cas (dCas) enzymes—never looked more alive. They harness the targeting power associated with CRISPR—but not the double-strand cuts. As such, they give researchers new ways to interrogate and manipulate gene function. Possibilities include CRISPR interference (CRISPRi) and CRISPR activation (CRISPRa)…

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ToolGen Files Opposition to CVC Substantive Preliminary Motion No. 3 to Add Claims in ToolGen Patent | McDonnell Boehnen Hulbert & Berghoff LLP

On May 20th, Junior Party the University of California, Berkeley; the University of Vienna; and Emmanuelle Charpentier (collectively, “CVC”) filed its Substantive Preliminary Motion No. 3 in Interference No. 106,127 (which names ToolGen as Senior Party), asking the Patent Trial and Appeal Board to add claims in ToolGen’s U.S. Patent…

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CRISPR Applications in Medicine Depend on Minimizing Off-Target Editing

By Rolf Turk, PhD Genome editing technologies, such as CRISPR, are being applied to better understand basic biological systems as well as to research new kinds of gene and cell therapies. The CRISPR-Cas9 system comprises a Cas9 endonuclease protein that forms a complex with a guide RNA (gRNA) molecule, which…

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Could gene editing be the solution to food shortage?

GMO tomato. [Courtesy: iStockphoto] The ageless debate on genetically modified organisms (GMOs) is getting a new twist as scientists make fresh discoveries. Experts from the International Institute of Tropical Agriculture (IITA) are now keen to extinguish a lingering assumption that genetic modification, and gene editing, are more or less the…

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Frontiers | DNA Methylation and RNA-Sequencing Analysis Show Epigenetic Function During Grain Filling in Foxtail Millet (Setaria italica L.)

Introduction Gene expression is not only controlled by DNA sequences but also by epigenetic marks in eukaryotes. DNA methylation as one of the important epigenetic modifications has been demonstrated as closely related to gene expression in biological processes, such as transcriptional activity, developmental regulation, and environmental responses (Maunakea et al.,…

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New CRISPR-Cas system cuts virus RNA

Credit: DOI: 10.1126/science.abk2718 Researchers from the group of Stan Brouns (Delft University of Technology) have discovered a new CRISPR-Cas system that cuts RNA. The study will be published on August 26 in Science and is expected to offer many opportunities for the development of new applications in genetic research and…

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Sparking Drug Discovery Efficiency with CRISPR-Cas9

The speed, targeting flexibility, and ease-of-use of the CRISPR-Cas system gives researchers the capability to create relevant experimental models for drug discovery screening and testing. To avoid creating bottlenecks, data acquisition and analysis must keep pace with this boom in model generation. Highly sensitive multimode plate readers support CRISPR-Cas applications…

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Industry Trends and Global Forecasts, 2021-2030

INTRODUCTION Clustered regularly interspaced short palindromic repeats (CRISPR) are a family of DNA sequences, which constitute a primitive immune system that is responsible for protecting prokaryotic cells from phage infections. New York, Aug. 24, 2021 (GLOBE NEWSWIRE) — Reportlinker.com announces the release of the report “CRISPR Based Therapeutics Market by…

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Controlling CRISPR | Optics & Photonics News

Light-based approaches for steering CRISPR–Cas9, the powerful Nobel Prize–winning genome-editing toolkit, promise to boost the technique’s precision and specificity—and might help bring it into clinical use. [Getty Images] In early 2011, two scientists walked the cobblestone streets of Old San Juan, the historic district of Puerto Rico’s capital. Recently introduced…

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Editas Medicine Presents Data on New SLEEK Gene Editing

SLEEK enables high efficiency, multi-transgene knock-in of induced Pluripotent Stem Cells (iPSCs), T cells, and Natural Killer (NK) cells Data support SLEEK as an optimized approach to develop next generation cell therapy medicines CAMBRIDGE, Mass., Aug. 20, 2021 (GLOBE NEWSWIRE) — Editas Medicine, Inc. (Nasdaq: EDIT), a leading genome editing company, today…

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Prevalence and Molecular Characteristics Based on Whole Genome Sequenc

Introduction Tuberculosis, caused by Mycobacterium tuberculosis, remains one of the top 10 causes of death worldwide and the leading cause of death from a single infectious agent (ranking above HIV/AIDS).1 In 2020, World Health Organization (WHO) reported that 7.1 million people with tuberculosis were newly diagnosed and notified in 2019,…

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CRISPR: Guide to gRNA design

Introduction to CRISPR in SnapGene Genome editing technology has been evolving for many years. The Holy Grail of genome engineering has always been to introduce a specific genetic change that affects only the genomic target and leaves no undesired changes in the DNA. The discovery and application of the bacterial…

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CRISPR/Cas9 That’s Out of This World

In space, someone can splice your genes Olivia Gaskill | 08/19/2021 | Quick Read CRISPR/Cas 9 in space: the final frontier? With more astronauts embarking on space explorations (and an obsession for commercial space travel in billionaire circles), there is a growing need to tackle the risk of DNA damage…

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ToolGen Files Opposition to CVC Substantive Preliminary Motion No. 1 for Priority Benefit | McDonnell Boehnen Hulbert & Berghoff LLP

On May 20th, Junior Party the University of California, Berkeley; the University of Vienna; and Emmanuelle Charpentier (collectively, “CVC”) filed its Substantive Preliminary Motion No. 1 in Interference No. 106,127 (which names ToolGen as Senior Party), asking the Patent Trial and Appeal Board for benefit of priority to U.S. Provisional…

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Another Milestone for CRISPR-Cas9 Technology: First Trial Data for Treatment Delivered Intravenously

Unlike most other CRISPR/Cas-9 therapies that are ex vivo treatments in which cells are modified outside the body, this study was successful with an in vivo treatment Use of CRISPR-Cas9 gene editing technology for therapeutic purposes can be a boon for clinical laboratories. Not only is this application a step…

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CRISPR-Based Tech Could Revolutionize Antibody-Based Diagnostics

Lead author, Karl Barber with a PICASSO microarray. [Karl Barber, Schmidt Science Fellows] Scientists have used an adaptation of the genome editing technology CRISPR to develop a new peptide display platform that can be used as a tool to identify antibodies in patient blood samples. Researchers from the Howard Hughes…

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Humanized Mice: Generation, Advantages and Applications

Mice are commonly used as models of human disease, helping scientists to understand the workings of complex pathologies and develop safe and efficacious drugs. It is now possible to create a range of genetically engineered mouse models, including humanized, knock-in and knock-out models, that can be used to further advance…

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Can These Three Gene Therapies Get Us Closer to an HIV Cure?

Three research teams investigating HIV cures received a total of nearly $600,000 in grants from amfAR, The Foundation for AIDS Research. All three groups are exploring cutting-edge gene therapies as a possible way to eradicate the HIV reservoir and cure HIV. The HIV reservoir is one of the main obstacles…

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