Tag: cfDNA

Among individuals who have received COVID-19 vaccines, younger people, females, and those who got the second dose of the Moderna COVID-19 vaccine report more side effects from COVID-19 vaccines that may have led to moderate and severe limitations, according to a recent paper (Front Public Health 2022; doi: 10.3389/fpubh.2022.975781). These…

NEW YORK – A Chinese research team has shown that their method for profiling mutation and DNA methylation patterns in circulating cell-free DNA (cfDNA) can detect hepatocellular carcinoma (HCC) liver cancer cases. “[W]e developed the Mutation Capsule Plus (MCP) technology, supporting parallel profiling of mutations and methylation changes (MCP profiling)…

First Pediatric Study to Evaluate Use of AlloSure dd-cfDNA as Biomarker for Allograft BK Infection Findings Add to Growing Body of Evidence Showing Clinical Value of AlloSure for Surveillance in Pediatric Kidney Transplant Patients BRISBANE, Calif.–(BUSINESS WIRE)– CareDx, Inc. (Nasdaq: CDNA) – The Transplant Company™ focused on the discovery, development, and…

A blood-based multicancer early detection (MCED) test using cell-free DNA (cfDNA) is feasible for outpatients and has a positive predictive value of about 40%, according to a study presented at the 2022 annual meeting of the European Society for Medical Oncology. Deb Schrag, MD, MPH, and colleagues examined the clinical…

At the time of writing, Natera Inc. [NTRA] stock is trading at $47.91, up up 8.71%. It is a good measure of the stock’s recent performance to check whether the stock’s short-term value is rising or falling. The NTRA shares have gain 11.11% over the last week, with a monthly…

Physician’s Briefing Staff FRIDAY, Sept. 16, 2022 (HealthDay News) — Patients with pulmonary arterial hypertension (PAH) have elevated cell-free DNA (cfDNA), which increases with disease severity, according to a study published online Aug. 25 in Circulation. Samuel B. Brusca, M.D., from the U.S. National Institutes of Health Clinical Center in…

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Share Tweet Share Share Email According to the recent milestone development of the National Institute of Health in California, a new blood test has been identified. The purpose of the test is to assess the gravity of the disease in patients with pulmonary…

NEW YORK – Molecular testing company Predicine said on Tuesday that its blood and urine cell-free DNA (cfDNA) assay, PredicineCare, has secured a CE-IVD mark. The targeted next-generation sequencing (NGS) assay is developed to detect single nucleotide variants (SNVs), insertions and deletions (indels), DNA rearrangements (fusions), and copy number variations…

Cell-free DNA-based next-general sequencing (NGS) yielded low detection rates in patients with metastatic clear cell renal cell carcinoma (ccRCC), according to an analysis published in JCO Precision Oncology. Researchers performed NGS of tumor DNA and plasma DNA using the MSK-IMPACT platform in 110 patients with metastatic ccRCC. They explored detection…

The Magnetic Bead Purification Kits market report provides detailed competitive landscape of the global market. It includes company, market share analysis, product portfolio of the major industry participants. The report provides detailed segmentation of the Global Magnetic Bead Purification Kits industry based on product segment,…

When a person who has received an organ transplant experiences rejection, DNA from the transplanted organ is released into the bloodstream as the organ’s cells are attacked by the person’s immune system. The circulating DNA from the transplanted organ — referred to as cell-free DNA (cfDNA) — can be distinguished…

Within analysis, low-coverage whole-genome sequencing out of cfDNA was held to examine blood plasma away from patients with spine metastasis An analysis pipe is made and you will verified to evaluate the brand new CNV condition within the cfDNA, in order to determine whether brand new CIN score, that has…

SHANGHAI, June 1, 2022 /PRNewswire/ — Burning Rock Biotech Limited (NASDAQ: BNR, the “Company” or “Burning Rock”) announced that it has received CE marking for its OverC™ Multi-Cancer Detection Blood Test manufactured in both the US and China facilities (Identification Number: DE/CA20/01-IVD-Luxuslebenswelt-523/22, DE/CA20/01-IVD-Luxuslebenswelt-524/22). OverC™ Multi-Cancer Detection Blood Test is a…

For a study, researchers sought to present the breast cancer cohort. In a previous study, they reported on safety. They recommended a phase 2 dose (RP2D) of olaparib combined with the PI3Kα-specific inhibitor alpelisib in patients with high-grade serous ovarian cancer as studied in a phase 1b trial (NCT01623349). Investigators…

Plasma cfDNA predictors of established bacteraemic infection | Microbiology Society 1887 This is a required field Please enter a valid email address Approval was a Success Invalid data An Error Occurred Approval was partially successful, following selected items could not be processed due to error Microbiology…

Get inside Wall Street with StreetInsider Premium. Claim your 1-week free trial here. Natera, Inc. (NASDAQ: NTRA) today announced that it has presented data on the clinical utility of the company’s Prospera™ and Renasight™ tests in 14 sessions at the American Transplant Congress (ATC) 2022 meeting. This expands on the…

Circulating cell-free DNA (cfDNA) is fragmented extracellular DNA, which is released from apoptotic and necrotic cells in small fragments of <200 bp [1]. cfDNA is typically isolated from the blood stream; however, it is also possible to detect cfDNA in other biological fluids such as urine or cerebrospinal fluid [2, 3,…

This article was originally published here Curr Oncol Rep. 2022 May 16. doi: 10.1007/s11912-022-01278-0. Online ahead of print. ABSTRACT PURPOSE OF REVIEW: The field of liquid biopsies is constantly evolving through novel technologies. This review outlines current data on liquid biopsies and application to clinical management of metastatic prostate cancer….

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Cell-free DNA (cfDNA) exists in various types of bodily fluids, including plasma, urine, bile, and others. Bile cfDNA could serve as a promising liquid biopsy for biliary tract cancer (BTC) patients, as bile directly contacts tumors in the biliary tract system. However, there is no commercial kit or widely acknowledged…

CareDx, Inc. Data Highlights Clinical Utility of CareDx Solutions, Including Findings from Surveillance HeartCare Outcomes Registry (SHORE) Demonstrating Power of Multimodality Assessment for More Precise Interventions CareDx Symposia Feature Latest Advancements Including XenoSure and XenoMap SOUTH SAN FRANCISCO, Calif., April 20, 2022 (GLOBE NEWSWIRE) — CareDx, Inc. (Nasdaq: CDNA) –…

Background: Allograft biopsy is the gold standard for diagnosing graft rejection following simultaneous pancreas and kidney (SPK) transplant. Intraperitoneal biopsies are technically challenging and can be burdensome to patients and the healthcare system. Donor-derived cell-free DNA (dd-cfDNA) is well-studied in kidney transplant recipients; however, it has not yet been studied…

1  array comparative genomic hybridization(1473 times) Neoplasms(306 times) FISH (238 times)CNVs (135 times)MLPA (72 times) 2003 1-Mb resolution array-based comparative genomic hybridization using a BAC clone set optimized for cancer gene analysis. 2  array CGH(43 times) Neoplasms(12 times) CNVs (7 times)FISH (3 times)ID (3 times) 2003 Combined array comparative genomic hybridization and…

Circulating cfDNA as a Prognostic Biomarker in Patients With Advanced ALK+ NSCLC | PracticeUpdate …

By Dr Niranjan Nayak, Consultant pathologist zonal technical chief west, Apollo diagnostic Pune Are you aware? Non-invasive Prenatal Testing (NIPT) means a screening test that can be done commonly in the first 3 months of pregnancy to detect chromosomal abnormalities in the baby. This test detects the 3 commonly occuring…

This article was originally published here Comput Biol Med. 2022 Feb 3;143:105283. doi: 10.1016/j.compbiomed.2022.105283. Online ahead of print. ABSTRACT As a kind of novel non-invasive marker for molecular detection, cell-free DNA (cfDNA) has potential value for the early diagnosis of diseases, prognosis assessment, and efficacy monitoring. The constant developments in…

The diagnosis of vitreoretinal lymphoma (VRL), a rare subtype of primary central nervous system lymphoma (PCNSL), is challenging. We aimed to investigate the mutational landscape of VRL by sequencing circulating tumor DNA (ctDNA) from aqueous humor (AH) and/or vitreous fluid (VF), as well as the application of ctDNA sequencing to…

. 2021 Dec 31;33(6):708-718. doi: 10.21147/j.issn.1000-9604.2021.06.07. Affiliations Expand Affiliations 1 Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China. 2 Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100730, China. 3 Department of Medical…

With the modernization of the Chinese people’s eating habits and lifestyles, the incidence of inflammatory bowel disease (IBD) has shown a sustained and rapid growth trend. The pathogenesis of IBD is complex, and clinical treatment is often dominated by anti-inflammatory drugs such as salicylic acid, glucocorticoids, and immunosuppressants, which have…

This article was originally published here Ann Hematol. 2022 Feb 1. doi: 10.1007/s00277-022-04771-5. Online ahead of print. ABSTRACT With the advent of novel, highly effective therapies for multiple myeloma (MM), classical serologic monitoring appears insufficient for response assessment and prediction of relapse. Moreover, serologic studies in MM are hampered by…

Context: Circulating free DNA (cfDNA) analysis has emerged as novel noninvasive diagnostic biomarker in several solid tumors. Raised levels have been reported in several malignancies and may correlate with clinicopathological and treatment response. The current study was designed to assess the diagnostics of cfDNA in different tumor types of malignancies…

This article was originally published here J Heart Lung Transplant. 2021 Dec 26:S1053-2498(21)02630-9. doi: 10.1016/j.healun.2021.12.009. Online ahead of print. ABSTRACT BACKGROUND: As a marker of underlying lung allograft injury, donor-derived cell-free DNA (dd-cfDNA) may be used to identify episodes of acute allograft injury in lung transplant recipients. We investigated the…

A huge NHS unit is on Nuneaton’s Asda car park as a trail-blazing trial of a new cancer-detecting blood test is under way. As we reported in our newsletter, the town was just one of a handful of areas across the Midlands to be picked as part of the pilot….

Interrogation of cell-free DNA (cfDNA) represents an emerging approach to non-invasively estimate disease burden in multiple myeloma (MM). Here, we examined low-pass whole genome sequencing (LPWGS) of cfDNA for its predictive value in relapsed/ refractory MM (RRMM). We observed that cfDNA positivity, defined as ≥10% tumor fraction by LPWGS, was…

SOUTH SAN FRANCISCO, Calif., Jan. 07, 2022 (GLOBE NEWSWIRE) — CareDx, Inc.,  (Nasdaq: CDNA) – The Transplant Company™ focused on the discovery, development, and commercialization of clinically differentiated, high-value healthcare solutions for transplant patients and caregivers – today announced the results of a study led by the National Institutes of…

doi.org/10.1038/gim.2017.56Get rights and content Abstract Purpose Invasive diagnostic prenatal testing can provide the most comprehensive information about the genetic status of a fetus. Noninvasive prenatal screening methods, especially when using cell-free DNA (cfDNA), are often limited to reporting only on trisomies 21, 18, and 13 and sex chromosome aneuploidies. This…

cfDNA ultra-deep sequencing with UMIs 1 Dear all, I am analyzing sequencing data from a capture panel which uses UMIs. I did ultra-deep sequencing to detect variants in a very low VAF (less than 1%). This is an already fragmented DNA coming from plasma. After doing my pipeline using fgbio,…

QIAseq cfDNA Library Kit, 96 reactions   For 96 reactions on Illumina® sequencers: enzymes and buffers for cfDNA library prep, Illumina Adapter Plate 96-plex, Illumina Library Amplification Primer and PCR Master Mix   Features • Optimal conversion of cfDNA at every step from plasma to NGS library through highly efficient…

Natera has announced the launch of Prospera with quantification, the only cell-free DNA (cfDNA) test for kidney rejection that provides three values—the quantity of donor-derived cfDNA (dd-cfDNA), fraction of dd-cfDNA, and total cfDNA—on every report. Combining these three metrics has been shown to improve sensitivity when evaluating transplant rejection, compared…

Cell-free circulating tumor DNA (cfDNA)–based tumor genotyping was found to be noninferior to standard-of-care tissue-based genotyping for detection of guideline-recommended biomarkers and therapeutic outcomes in patients with advanced nonsquamous non–small cell lung cancer (NSCLC). Cell-free circulating tumor DNA (cfDNA)–based tumor genotyping is noninferior to tissue-based genotyping for detection of guideline-recommended…

We’re hiring Bioinformatics Scientists with strong backgrounds in database development, management and analysis as they relate to human health and disease biomarkers, with the goal of improving disease prediction and prevention. With ICR, you’ll get to: Design, build, test and refine multiple large biomarker databases in collaboration with multiple ICR…

Oral and Poster Abstracts 617. Acute Myeloid Leukemias: Biomarkers, Molecular Markers and Minimal Residual Disease in Diagnosis and Prognosis: Poster III Translational Research Maher Albitar, MD1*, Andrew Ip, MD, MSc2, Andre H. Goy, MD3*, Jeffrey Justin Estella, BS, MS1*, Ivan De Dios, BS1*,…

The discovery of a large population of long, cell-free DNA (cfDNA) molecules in maternal plasma, along with a method to identify the molecules’ tissues of origin, is reported in this week Proceedings of the National Academy of Sciences. To date, studies of circulating cfDNA have focused on short molecules of…

Non–small cell lung carcinoma is the most prevalent kind of lung cancer, and it is also the disease that causes the most fatalities globally each year. The liquid biopsy is the most recent step forward in personalized medicine in cancer therapy, allowing treatment depending on driver mutations found within a…

Data were taken from a prospective, multi-center, observational study (NCT02889978), which evaluated cell-free DNA multi-omics in prototype cfDNA-based multi-cancer early detection tests. In the study, researchers collected plasma and matched white blood cells before sequencing them from CCGA study participants (n = 2,800). Tumor biopsies were also sequenced when available….

Clinical limit of detection may be a reasonable metric for evaluating cell-free DNA for multi-cancer early detection. Clinical limit of detection (cLOD) may be a reasonable metric for evaluating cell-free DNA (cfDNA) for multi-cancer early detection, according to recent data from the Circulating Cell-Free Genome Atlas (CCGA) study (NCT02889978). In…

We’re hiringBioinformatics Scientists with strong backgrounds in database development, management and analysis as they relate to human health and disease biomarkers, with the goal of improving disease prediction and prevention. With ICR, You’ll Get To Design, build, test and refine multiple large biomarker databases in collaboration with multiple ICR teams…

Natera™ is a global leader in cell-free DNA (cfDNA) testing with a focus on women’s health, oncology, and organ health. To bolster our oncology products, we are looking for a Senior Bioinformatics Engineer to provide technical leadership and process guidance. Through collaboration between the product and development teams, the Senior…

HAYWARD, Calif., Sept. 16, 2021 /PRNewswire-PRWeb/ — Predicine, Inc. announced today results from a liquid biopsy study demonstrating the clinical application of utilizing the PredicineCARE liquid biopsy NGS assay to serially monitor changes in ctDNA levels in patients with metastatic castration-resistant prostate cancer (mCRPC). The European Urology study evaluated the effects…

Next-Generation Sequencing Utilizing Tumor Tissue and/or Blood The identification of actionable genomic alterations in tumors such as mCRC was once performed by Sanger DNA sequencing of tumor DNA that was extracted from fixed paraffin-embedded tumor tissue, but this has now been replaced by next-generation sequencing (NGS), which allows for larger-scale…

A novel liquid biopsy test has been shown to distinguish between patients with neurofibromatosis type 1 (NF1) who have benign plexiform neurofibroma (PN) precursor lesions from patients who have malignant peripheral nerve sheath tumors (MPNST), say authors of a multi-institutional cross-sectional study. “Transformation from PN to MPNST is challenging to…

Using a temporal multi-omics approach, a team led by scientists from Heidelberg University has identified a protein involved in tumor metastasis that could serve as a new therapeutic cancer target. Metastasis is the leading cause of cancer-related mortality and the mechanistically least well-understood step of the tumor progression cascade. However,…

Date posted: Aug 28, 2021 Natera™ is a global leader in cell-free DNA (cfDNA) testing with a focus on women’s health, oncology, and organ health. To bolster our oncology solutions, we are looking for a Bioinformatics Engineer to provide analytical and data management support for Natera’s oncology product. The Bioinformatics…

A novel artificial intelligence (AI) blood testing technology developed by researchers at the Johns Hopkins Kimmel Cancer Center has been shown to detect over 90% of lung cancers in samples from nearly 800 individuals with and without cancer. The test approach, called DELFI (DNA evaluation of fragments for early interception), spots unique…

Job Title; Bioinformatics Scientist, DNA Sequencing Position Location: South San Francisco, CA As a bioinformatics scientist / engineer developing applications in oncology, personalized medicine, inherited disease, and viral/microbial genetics, you will play a key role in developing, improving, and expanding analysis solutions for next-generation DNA sequencing products. Primary responsibilities will…