Tag: cGAS-STING

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon (STING) pathway is a key mediator of innate immunity involved in cancer development and treatment. The roles of mitochondrial DNA (mtDNA) in cancer immunotherapy have been gradually emerged. Herein, we reported a highly emissive rhodium(III) complex (Rh-Mito) as the mtDNA intercalator. Rh-Mito can…

Published Erratum . 2023 May 19;14:1216456. doi: 10.3389/fimmu.2023.1216456. eCollection 2023. Affiliations Expand Affiliations 1 Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. 2 Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. 3 Department of Laboratory Medicine, Huadong Hospital, Fudan University, Shanghai,…

Wasti S, Sah N, Mishra B. Impact of heat stress on poultry health and performances, and potential mitigation strategies. Animals. 2020;10:1266. doi.org/10.3390/ani10081266. Article  PubMed  PubMed Central  Google Scholar  Lara LJ, Rostagno MH. Impact of heat stress on poultry production. Animals. 2013;3:356–69. Article  PubMed  PubMed Central  Google Scholar  Al-Saffar AA, Rose…

Jerby-Arnon, L.; Shah, P.; Cuoco, M. S.; Rodman, C.; Su, M. J.; Melms, J. C.; Leeson, R.; Kanodia, A.; Mei, S. L.; Lin, J. R. et al. A cancer cell program promotes T cell exclusion and resistance to checkpoint blockade. Cell 2018, 175, 984–997.e24. Article  CAS  Google Scholar  Li, X….

Purpose: Radiation therapy (RT) is indispensable for managing thoracic carcinomas. However, its application is limited by radiation-induced lung injury (RILI), one of the most common and fatal complications of thoracic RT. Nonetheless, the exact molecular mechanisms of RILI remain poorly understood. Methods and materials: To elucidate the underlying mechanisms, various…

Review doi: 10.1016/j.jbc.2023.104866. Online ahead of print. Affiliations Expand Affiliations 1 Departments of Medicine and Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104. 2 Departments of Medicine and Microbiology, Departments of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, 63110. 3 Departments of Medicine…

Results Add to Growing Body of Evidence that Inhibiting PP2A with LB–100 May Be a General Method for Enhancing the Effectiveness of Immunotherapy in Refractory Cancers  PASADENA, CA, May 30, 2023 (GLOBE NEWSWIRE) — LIXTE Biotechnology Holdings, Inc. (“LIXTE” or the “Company”) (Nasdaq: LIXT) today announced that a recently published article in the…

The recognition of foreign nucleic acids inside the cell is a crucial element of the innate immune response. This is accomplished by pattern recognition receptors (PRRs), such as cyclic GMP–AMP synthase (cGAS). cGAS senses intracytoplasmic double-stranded DNA (dsDNA), triggering a cascade that involves the synthesis of the second messenger 2′,3′-cyclic…

doi: 10.1021/acs.nanolett.3c01008. Online ahead of print. Affiliations Expand Affiliations 1 PCFM Lab of Ministry of Education, School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou 510275, China. 2 Department of Radiology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, Guangdong, China. 3 Department of Minimally Invasive Interventional Radiology,…

Preprints with The Lancet is part of SSRN´s First Look, a place where journals identify content of interest prior to publication. Authors have opted in at submission to The Lancet family of journals to post their preprints on Preprints with The Lancet. The usual SSRN checks and a Lancet-specific check…

Pain is a common clinical condition. However, the mechanisms underlying pain are not yet fully understood. It is known that the neuroimmune system plays a critical role in the pathogenesis of pain. Recent studies indicated that the cyclic-GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway can activate the innate immune system…

Vemuri, P. et al. Evaluation of amyloid protective factors and Alzheimer disease neurodegeneration protective factors in elderly individuals. JAMA Neurol. 74(6), 718–726. doi.org/10.1001/jamaneurol.2017.0244 (2017) (Epub 2017/04/19). Article  PubMed  PubMed Central  Google Scholar  Soheili-Nezhad, S., van der Linden, R. J., Olde Rikkert, M., Sprooten, E. & Poelmans, G. Long genes are…

Introduction Liver cancer is the third most common cause of cancer death globally with hepatocellular carcinoma (HCC) accounting for the majority of liver cancer.1,2 Early HCC (stage I/II) treatment mainly includes radical surgical resection, radiofrequency ablation and liver transplantation.3,4 However, there is a lack of typical clinical symptoms with early-stage…

The human immune system is responsible for differentiating between self and non-self, and protects the body from attacks by pathogens and damaged or abnormal cells [1]. Although immunotherapy including immune checkpoint blockade therapy and CAR T cell adoptive immunotherapy has been established as a promising approach for tumor treatment, a…

doi: 10.1080/01902148.2023.2211663. Online ahead of print. Affiliations Expand Affiliations 1 Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 2 Department of Pathology, College of Basic Medicine, Chongqing Medical University, Chongqing, China. 3 Department of Laboratory Medicine, the First Affiliated Hospital of…

Bergmann, O. et al. Evidence for cardiomyocyte renewal in humans. Science 324, 98–102 (2009). Article  CAS  PubMed  PubMed Central  Google Scholar  Senyo, S. E. et al. Mammalian heart renewal by pre-existing cardiomyocytes. Nature 493, 433–436 (2013). Article  CAS  PubMed  Google Scholar  Bergmann, O. et al. Dynamics of cell generation and…

Proteins associated with inflammation and immune system function were identified as potential blood biomarkers for the diagnosis and monitoring of ankylosing spondylitis (AS). “Better biomarkers would address a significant unmet need both in clinic, where earlier diagnosis and referral might be improved, as well as in bettering our understanding of…

Author links open overlay panelErminia Donnarumma, Elodie Vimont, Timothy Wai Show more doi.org/10.1016/j.acvdsp.2023.03.070Get rights and content Introduction Mitochondrial integrity is paramount to heart homeostasis. Under certain stress conditions, mitochondrial DNA (mtDNA) can leak into the cytosol and trigger type I innate immunity via the DNA sensing cGAS-STING pathway, the downstream…

Review doi: 10.4155/fmc-2022-0301. Online ahead of print. Affiliations Expand Affiliations 1 Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, MN 55414, USA. 2 Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27101, USA. Item in Clipboard Review Bo Hu et al. Future Med Chem. 2023….

Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1 – Fingerprint — University of Texas Southwestern Medical Center Sort by Weight Alphabetically Medicine & Life Sciences Autophagy 57% DNA 33% cyclic guanosine monophosphate-adenosine monophosphate 18% Autophagosomes 14% Second Messenger Systems 13% Inflammation 7% Read more…

Cyclic GMP-AMP synthase (cGAS) recognizes viral DNA and synthesizes cyclic GMP-AMP (cGAMP), which activates stimulator of interferon genes (STING/MITA) and downstream mediators to elicit an innate immune response. African swine fever virus (ASFV) proteins can antagonize host immune responses to promote its infection. Here, we identified ASFV protein QP383R as…

doi: 10.1002/bies.202300045. Online ahead of print. Affiliations Expand Affiliation 1 IGMM, Université de Montpellier, CNRS, Montpellier, France. Item in Clipboard Clara Taffoni et al. Bioessays. 2023. Show details Display options Display options Format AbstractPubMedPMID doi: 10.1002/bies.202300045. Online ahead of print. Affiliation 1 IGMM, Université de Montpellier, CNRS, Montpellier, France. Item in…

5-Azacytidine pretreatment resensitizes cisplatin-resistant DLBCL cell lines to cisplatin to varying degrees A platinum-based anti-neoplastic agent is an essential component of salvage regimens for aggressive lymphomas, for example, rituximab, gemcitabine, dexamethasone, and cisplatin (R-GDP) for relapsed/refractory DLBCL and Hodgkin lymphoma [21]. As a single agent in humans, cisplatin is administered…

Credit: matejmo/Getty Images Researchers have identified broad-spectrum antivirals that can act against several families of RNA viruses with pandemic potential. While it is difficult to determine what will cause the next pandemic, the team states in Cell Reports Medicine that viruses born by arthropods are some of the lead candidates….

The detection of extranuclear DNA (self or foreign) by Cyclic GMP-AMP synthase (cGAS) is crucial for human health. cGAS triggers the production of the second messenger cyclic guanosine monophosphate (cGMP) upon binding to extranuclear DNA. This, in turn, activates the stimulator of interferon genes (STING) – producing a range…

26 Apr 2023 Springing a leak is rarely good news, but when microglial mitochondria start oozing, it can be particularly bad in situations of tauopathy. So conclude scientists led by Li Gan and Sadaf Amin, Weill Cornell Medicine, New York, in the April 24 Nature Neuroscience. Tau fibrils damage microglial…

SARS-CoV-2 infection induces mtDNA release and recognition by cGAS Recent studies revealed that SARS-CoV-2 stimulation could cause the accumulation of intracellular and intercellular DNA due to cell fusion, cell death and even tissue damage.17,19,27 To detect SARS-CoV-2-triggered release of DNA during infection, we first detected the cytosolic dsDNA pattern by…

The Paul Martini Foundation promotes drug research and therapy, and facilitates scientific dialogue between medical scientists, research institutions, and health policy representatives. It is named after the renowned scientist and physician, Professor Paul Martini (1889-1964), for his significant contributions to clinical-therapeutic research. Each year, the Foundation awards the Paul Martini…

Activation of the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway could effectively initiate antitumor immunity, but specific acti­vation of STING pathway is still an enormous challenge. The research team led by Prof. Xian-Zheng Zhang from Wuhan University elaborately developed a ferroptosis-induced mitochondrial DNA (mtDNA)-guided tumor immunotherapy nanoplatform (designated as…

doi: 10.3389/fphar.2023.1160445. eCollection 2023. Affiliations Expand Affiliations 1 School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China. 2 Department of Hepatology, The Fifth Medical Center of PLA General Hospital, Beijing, China. 3 Military Institute of Chinese Materia, Fifth Medical Center of Chinese PLA General Hospital, Beijing, China. 4…

A research team led by Gary Ying Wai Chan from the School of Biological Sciences at The University of Hong Kong (HKU), has revealed the function of a unique enzyme, ANKLE1.  ANKLE1 acts on chromatin bridges trapped in the midzone of dividing cells. By cutting these bridges, ANKLE1 prevents damage…

Hay, R.J., N.E. Johns, H.C. Williams, et al. 2014. The global burden of skin disease in 2010: an analysis of the prevalence and impact of skin conditions. The Journal of Investigative Dermatology 134 (6): 1527–1534. Article  CAS  PubMed  Google Scholar  Karimkhani, C., R.P. Dellavalle, L.E. Coffeng, et al. 2017. Global…

20 Apr 2023 Retroviruses lurking in the human genome aren’t the only potential troublemakers in neurodegenerative diseases (see Part 5 of this series). Herpes simplex virus type 1 (HSV-1) integrates into the genome of trigeminal ganglia nerves, can lie dormant for decades, and flare up as cold sores throughout a person’s…

The National Scleroderma Foundation has awarded a $200,000 research grant to a University of Minnesota scientist to study how immune system responses drive the emergence of scleroderma — the cause of which remains unknown. The funding for researcher Rafael Contreras-Galindo, PhD, comes in the form of the two-year Marta Marx…

Contreras-Galindo receives grant for research rare diseases treatment Published 6:21 pm Tuesday, April 18, 2023 Rafael Contreras-Galindo, PhD. Photo provided The Hormel Institute, University of Minnesota’s, Rafael Contreras-Galindo, PhD, has been awarded the Marta Marx Fund for the Eradication of Scleroderma Award from the National Scleroderma Foundation.  Scleroderma is a…

Apr. 18—The Hormel Institute, University of Minnesota’s, Rafael Contreras-Galindo, PhD, has been awarded the Marta Marx Fund for the Eradication of Scleroderma Award from the National Scleroderma Foundation. Scleroderma is a group of rare diseases with fewer than 200,000 cases per year and is a serious condition that can be…

Knockout of ANKLE1 induces excessive accumulation of cytosolic DNA, leading to activation of immune responses. Credit: Dr Gary Ying Wai Chan and Dr Huadong Jiang A research team led by Dr. Gary Ying Wai Chan from the School of Biological Sciences at The University of Hong Kong (HKU), has revealed…

Borrelia burgdorferi, the etiologic agent of Lyme disease, is a spirochete that modulates numerous host pathways to cause a chronic, multisystem inflammatory disease in humans. B. burgdorferi infection can lead to Lyme carditis, neurologic complications, and arthritis because of the ability of specific borrelial strains to disseminate, invade, and drive…

CITE THIS COLLECTION DataCite3 Biotech3D Printing in Medicine3D Research3D-Printed Materials and Systems4ORAAPG BulletinAAPS OpenAAPS PharmSciTechAbhandlungen aus dem Mathematischen Seminar der Universität HamburgABI Technik (German)Academic MedicineAcademic PediatricsAcademic PsychiatryAcademic QuestionsAcademy of Management DiscoveriesAcademy of Management JournalAcademy of Management Learning and EducationAcademy of Management PerspectivesAcademy of Management ProceedingsAcademy of Management Review He, Qingbin;…

Abstract The recognition that cytosolic mtDNA activates cGAS-STING innate immune signaling has unlocked novel disease mechanisms. Here, an uncharacterized variant predicted to affect TOP1MT function, P193L, was discovered in a family with multiple early-onset autoimmune diseases, including Systemic Lupus Erythematosus (SLE). Although there was no previous genetic association between TOP1MT…

PXD024088 is an original dataset announced via ProteomeXchange. Dataset Summary Title Neddylation modification on cGAS of human and mouse Description The cytosolic DNA sensor cyclic GMP-AMP (cGAMP) synthetase (cGAS) has emerged as a fundamental component fueling the anti-pathogen immunity. Because of its pivotal role in initiating innate immune response, the…

. 2023 Apr 11;e202300147. doi: 10.1002/cbic.202300147. Online ahead of print. Affiliations Expand Affiliations 1 East China University of Science and Technology, School of Pharmacy, CHINA. 2 Chinese Center for Disease Control and Prevention, National Institute of Parasitic Diseases, CHINA. 3 East China University of Science and Technology, School of Pharmacy,…

doi: 10.1080/15548627.2023.2202108. Online ahead of print. Affiliations Expand Affiliation 1 Department of Biochemistry, and Department of Thoracic Surgery of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. Item in Clipboard Wei Wan et al. Autophagy. 2023. Show details Display options Display options Format AbstractPubMedPMID doi: 10.1080/15548627.2023.2202108. Online…

ABSTRACT Borrelia burgdorferi, the etiologic agent of Lyme disease, is a spirochete that modulates numerous host pathways to cause a chronic, multi-system inflammatory disease in humans. B. burgdorferi infection can lead to Lyme carditis, neurologic complications, and arthritis, due to the ability of specific borrelial strains to disseminate, invade, and…

Background: Inflammation and fibrosis are typical symptoms of non-alcoholic steatohepatitis (NASH), which is one of the most common chronic liver diseases. The cGAS-STING signaling pathway has been implicated in the progression of NASH, and targeting this pathway may represent a new therapeutic strategy. Licorice is a widely used herb with…

Domizio, Jeremy Di; Gulen, Muhammet F; Saidoune, Fanny; Thacker, Vivek V; Yatim, Ahmad; Sharma, Kunal; Nass, Théo; Guenova, Emmanuella; Schaller, Martin; Conrad, Curdin; Goepfert, Christine; de Leval, Laurence; Garnier, Christophe von; Berezowska, Sabina; Dubois, Anaëlle; Gilliet, Michel; Ablasser, Andrea (2022). The cGAS-STING pathway drives type I IFN immunopathology in COVID-19….

reticulatum, H. spinifera as well as L. polyedrum, displaying anatomical as well as toxic traits; (two) Adriatic ranges associated with Alexandrium minutum, Alexandrium ostenfeldii along with Prorocentrum lima as their dangerous profiles are usually weighed against that relating to strains of various geographical sources; (iii) F. japonica and Ostreopsis cf….

cGAS-STING signaling is a central component in the therapeutic action of most existing cancer therapies. The accumulated knowledge of tumor immunoregulatory network in recent years has spurred the development of cGAS-STING agonists for tumor treatment as an effective immunotherapeutic strategy. However, the clinical translation of these agonists is thus far…

Ethnopharmacological relevance: Schisandra Chinensis (Turcz.) Baill. is a long-term used traditional Chinese medicine with the functions of tonifying the kidney and calming the heart, tonifying qi and engendering fluid. It can be used to treat insomnia and dreaminess, spermatorrhea, coughs, as well as liver and kidney deficiency of Yin or…

Review . 2023 Mar 30;S1525-0016(23)00159-4. doi: 10.1016/j.ymthe.2023.03.026. Online ahead of print. Affiliations Expand Affiliations 1 School of Life Science, Chongqing University, Chongqing 400044, P. R. China. 2 School of Life Science, Chongqing University, Chongqing 400044, P. R. China. Electronic address: luozhong918@cqu.edu.cn. Item in Clipboard Review Yingqi Liu et al. Mol Ther….

Review doi: 10.1016/j.biopha.2022.113680. Epub 2022 Sep 7. Affiliations Expand Affiliations 1 Department of Toxicology, School of Public Health, Lanzhou University, Lanzhou, Gansu, China. 2 Department of Toxicology, School of Public Health, Lanzhou University, Lanzhou, Gansu, China. Electronic address: huiwang@lzu.edu.cn. Item in Clipboard Review Jingjing Liu et al. Biomed Pharmacother. 2022 Oct….

Activating cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway is a promising immunotherapeutic strategy for cancer treatment. Manganese(II) complexes MnPC and MnPVA (P = 1,10-phenanthroline, C = chlorine, VA = valproic acid) were found to activate the cGAS-STING pathway. The complexes not only damaged DNA, but also inhibited histone deacetylases…

Review doi: 10.1038/s12276-023-00965-7. Online ahead of print. Affiliations Expand Affiliations 1 Department of Biochemistry, The Catholic University of Korea College of Medicine, Seoul, 06591, South Korea. jhk@catholic.ac.kr. 2 Department of Biochemistry, The Catholic University of Korea College of Medicine, Seoul, 06591, South Korea. 3 Laboratory of Obesity and Aging Research,…

Figure 1 cGAS-STING pathway. Loss of Lamin B1, increased oxidative stress, genomic instability, mitochondrial dysfunction,… Figure 1 cGAS-STING pathway. Loss of Lamin B1, increased oxidative stress, genomic instability, mitochondrial dysfunction, as well as reduced expression of nucleases, lead to dsDNA break and accumulation in cytosol. Cytoplasmic cGAS recognizes dsDNA and synthetizes…

The cGAS-STING pathway serves a critical role in anticancer therapy. Particularly, response to immunotherapy is likely driven by both active cGAS-STING signaling that attracts immune cells, and by the presence of cancer neoantigens that presents as targets for cytotoxic T cells. Chromosomal instability (CIN) is a hallmark of cancer, but…

Cytoplasmic nucleic acids alert the immune system to invading pathogens and trigger a robust type I interferon (IFN) response via activation of the STING (stimulator of interferon genes) receptor. The sensor for cytoplasmic nucleic acids was recently discovered to be cyclic GMP-AMP synthase, an enzyme that produces a unique cyclic…

Efficacy of POLθ inhibition in HR-deficient cancers requires CD8+ T cells. a, b K14-Cre-Brca1f/f;Trp53f/f TNBC tumors from syngeneic FVB/129P2 mice (VEH, n = 5; NVB, n = 7) (a), or Brca2 KO KPC PDAC tumors from syngeneic C57BL/6 mice (VEH, n = 7; NVB, n = 6) (b) were subjected to IHC for CD3, CD4, and CD8 expression….

. 2023 Feb 23;S2095-9273(23)00131-7. doi: 10.1016/j.scib.2023.02.027. Online ahead of print. Affiliations Expand Affiliations 1 Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, China. 2 Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072,…

. 2023 Mar 6;24(3):e55536. doi: 10.15252/embr.202255536. Epub 2023 Jan 27. Niklas Kuhl #  1   2 , Andreas Linder #  1   2 , Nora Philipp  1   3 , Daniel Nixdorf  1   3 , Hannah Fischer  1 , Simon Veth  4 , Gunnar Kuut  1 , Teng Teng Xu  1   3 , Sebastian Theurich  1   3…

. 2023 Mar;11(3):e006648. doi: 10.1136/jitc-2022-006648. Affiliations Expand Affiliations 1 Department of Hepatic Surgery and Liver Transplantation Center, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China. 2 Department of Biotherapy Center, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China. 3 Department of Hepatic Surgery and Liver Transplantation…

Review doi: 10.1038/s41594-023-00933-9. Online ahead of print. Affiliations Expand Affiliations 1 Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. pateld@mskcc.org. 2 Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. 3 College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China. Item in Clipboard Review Dinshaw…

Introduction In recent years, CIN has gained great importance due to its implications for both, the diagnosis and prognosis of cancer. Recent studies have suggested that both CIN and clonal heterogeneity, influence cancer progression, aggressiveness, prognosis, and response to therapy.1–4 The above because both, CIN and clonal heterogeneity, lead to…

The cGAS-STING pathway plays an important role in host defense by sensing pathogen DNA, inducing type I IFNs, and initiating autophagy. However, the molecular mechanism of autophagosome formation in cGAS-STING pathway-induced autophagy is still unclear. Here, we report that STING directly interacts with WIPI2, which is the key protein for…

Figure 1 Intercellular communication in cGAS-STING signaling. (A) Schematic diagram of canonical cGAS-STING signaling. The… Figure 1 Intercellular communication in cGAS-STING signaling. (A) Schematic diagram of canonical cGAS-STING signaling. The DNA sensor cyclic GMP-AMP synthase (cGAS) recognizes a wide range of double-strand DNA (dsDNA) and is activated, thus generating the…

Keywords SARS-CoV-2, COVID-19, cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway, lung damage, interferon, cytokines Introduction Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) caused the coronavirus disease 2019 (COVID-19) pandemic with origin in Wuhan, China [1]. With confirmed 522 million infections and death of 6.27 million until May…

Received: 4 February 2023 / Revised: 25 February 2023 / Accepted: 27 February 2023 / Published: 28 February 2023 Round 1 Reviewer 1 Report Authors demonstrated that Mn2+ exhibits antiviral effects and inhibits RNA and DNA viruses replications in a cGAS-STING independent manner. Their results reveal that Mn2+ may harbor…

Usage: hover your mouse-pointer anywhere on the image above to see an enlarged portion of the image. You can also just click the image to see the original-sized version. Description: STAT6 is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family…

1 Introduction Cancer is one of the world’s most serious threats to human health, with high morbidity and mortality rates, and according to the latest global data, 9.96 million patients will die from cancer in 2020 (1). Cancer is a genetic abnormal disease triggered by a long-term combination of multiple…

doi: 10.3389/fimmu.2023.1092824. eCollection 2023. Luhao Zhang  1 , Xin Zhang  1 , Jiaming Liao  1 , Linting Xu  1 , Shaozhu Kang  1 , Hong Chen  1 , Mengshi Sun  1 , Siting Wu  1 , Zhuqing Xu  1 , Shina Wei  1   2 , Qiwei Qin  1   3   4   5 , Jingguang Wei  1   6…

Apoptosis is divided into extrinsic and intrinsic apoptotic cell death depending on the origin of cell death ligand. Activation of apoptosis from the cell exterior — extrinsic apoptosis — is induced upon binding of cognate ligands to death receptors [4–7], as well as the assembly of intracellular death complexes such…

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Recent studies already confirmed that placenta mitochondrial dysfunction is associated with the progression of gestational diabetes mellitus (GDM). Besides, a possible relationship between adipokine chemerin and disulfide-bond A oxidoreductase-like protein (DsbA-L) had been revealed, whereas the potential interaction remains unclear. In addition, very little is still known about the cyclic…

African swine fever (ASF) is a devastating infectious disease of pigs caused by the African swine fever virus (ASFV), which poses a great danger to the global pig industry. Many viral proteins can suppress with interferon signaling to evade the host’s innate immune responses. Therefore, the development of an effective…

Citation Jahun, A. S., Sorgeloos, F., Chaudhry, Y., Arthur, S. E., Hosmillo, M., Georgana, I., Izuagbe, R., & et al. Leaked genomic and mitochondrial DNA contribute to the host response to noroviruses in a STING-dependent manner. Cell Reports doi.org/10.17863/CAM.93870 Abstract The cGAS-STING pathway is central to the interferon response against…

Thompson S, James M, Wiebe N, Hemmelgarn B, Manns B, Klarenbach S, Tonelli M. Cause of death in patients with Reduced Kidney Function. J Am Soc Nephrol. 2015;26(10):2504–11. Article  Google Scholar  Matsushita K, Coresh J, Sang Y, Chalmers J, Fox C, Guallar E, Jafar T, Jassal SK, Landman GW, Muntner…

Credit: xfzsy/Getty Images Viruses have evolved with humans for millions of years, so it’s no surprise they’ve evolved tricks to evade our natural, or innate, immune responses. Unfortunately, it’s often unclear what these tricks are. But now, thanks to researchers at the University of North Carolina (UNC) School of Medicine,…

The human stories behind rare rheumatic diseases illustrate how genetic information can benefit patients. In 1988, a team of physicians met a patient with a unique disease of multiple organs, including the kidneys, liver, brain and eyes7. No immunosuppressive therapy was effective, and the patient and several of his family…

Preprint Article Version 1 This version is not peer-reviewed , , , , , , , , , , * , * Sun, S.; Xu, X.; Qiu, M.; Jiang, S.; Cao, Q.; Luo, J.; Zhang, T.; Chen, N.; Zheng, W.; Meurens, F.; Liu, Z.; Zhu, J. Manganese Mediates its Antiviral…

(A) HEK-293T cells were transfected with 1 μg of empty vector or the indicated FLAG-2C-expressing plasmids, along with 1 μg of empty vector or HA-cGAS plus HA-STING expressing plasmids. At 24 hpt, the IFN-β protein amount in the supernatant was determined by ELISA, and the expression of 2C was confirmed…

Cyclic GMP-AMP synthase (cGAS) plays a key role in the innate immune responses to both DNA and RNA virus infection. Here, we found that enterovirus 71 (EV-A71), Seneca Valley virus (SVV), and foot-and-mouth disease virus (FMDV) infection triggered mitochondria damage and mitochondrial DNA (mtDNA) release in vitro and vivo. These…

Melatonin supplementation has been shown to delay age-related hearing loss (ARHL) progression. Previously, melatonin was found to inhibit neuronal mitochondrial DNA (mtDNA) release, as well as inhibit cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling, thereby delaying the onset of central nervous system diseases. Therefore, we hypothesized that melatonin…

The accrual of cytosolic DNA leads to transcription of type I IFNs, proteolytic maturation of the IL-1 family of cytokines, and pyroptotic cell death. Caspase-1 cleaves pro-IL1β to generate mature bioactive cytokine and gasdermin D which facilitates IL-1 release and pyroptotic cell death. Absent in melanoma-2 (AIM2) is a sensor…

Causes and consequences of replication stress. Nat. Cell Biol. 2014; 16: 2-9doi.org/10.1038/ncb2897 Tomasetti C. Li L. Vogelstein B. Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention. Science. 2017; 355: 1330-1334doi.org/10.1126/science.aaf9011 Endogenous DNA damage as a source of genomic instability in cancer. Cell. 2017; 168: 644-656doi.org/10.1016/j.cell.2017.01.002 Halazonetis T.D. Gorgoulis…

Review doi: 10.1007/s12032-022-01908-4. Affiliations Expand Affiliations 1 Department of Vascular and Endocrine Surgery, Xijing Hospital, The Air Force Medical University, Xi’an, 710000, China. 2 Department of Vascular and Endocrine Surgery, Xijing Hospital, The Air Force Medical University, Xi’an, 710000, China. vascularzhang@outlook.com. Item in Clipboard Review Yue Jiang et al. Med Oncol….

Langlois JA, Rutland-Brown W, Wald MM. The epidemiology and impact of traumatic brain injury: a brief overview. J Head Trauma Rehabil. 2006;21:375–8. doi.org/10.1097/00001199-200609000-00001. Article  PubMed  Google Scholar  Cao HQ, Dong ED. An update on spinal cord injury research. Neurosci Bull. 2013;29:94–102. doi.org/10.1007/s12264-012-1277-8. Article  PubMed  Google Scholar  O’Donnell MJ, Xavier D,…

Expression landscape of the cGAS-STING sensor across human cancers. (a) The expression score of the cGAS-STING signal in paired tumor and nontumor tissues. (b) Significant difference of the cGAS-STING score between tumor and normal samples. BLCA: bladder urothelial carcinoma; BRCA: breast invasive carcinoma; CESC: cervical squamous cell carcinoma and endocervical…

Although it is an essential nutrient, high choline intake directly or indirectly via its metabolite is associated with increased risk of cardiovascular disease, the mechanism of which remains to be elucidated. The present study was performed to investigate whether hydrogen sulfide (H2S) was involved in high choline-induced cardiac dysfunction and…

Affiliation Wang C(1), Sun Z(1), Zhao C(1), Zhang Z(1), Wang H(1), Liu Y(1), Guo Y(1), Zhang B(1), Gu L(2), Yu Y(2), Hu Y(3), Wu J(4).Author information: (1)State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University, School of Life Sciences, Nanjing University, Nanjing 210093, PR China. (2)State…

Researchers at The University of Texas MD Anderson Cancer Center have developed an ultrasound-guided cancer immunotherapy platform that generates systemic antitumor immunity and improves the therapeutic efficacy of immune checkpoint blockade. The findings from the preclinical study were published today in Nature Nanotechnology. As the first-of-its-kind platform, the Microbubble-assisted UltraSound-guided…

Graphical abstract. Credit: Cell Reports (2022). DOI: 10.1016/j.celrep.2022.110856 The body’s innate immune system, active from birth, is the first line of defense against viruses and other pathogens that cause disease. Using vaccination as an example, after receiving a vaccine, pain, redness, or swelling may occur at the injection site. This…

The gut microbiota is crucial for health. However, how these non-invasive microbes communicate with the rest of the body to improve host physiology is not fully understood. Researchers from Stockholm, Umea, and Gothenburg Universities, Sweden, claim that the gut microbiota is essential for natural resistance to viral infections. This evidence…

This article was originally published here Nat Cell Biol. 2022 May 2. doi: 10.1038/s41556-022-00894-z. Online ahead of print. ABSTRACT Innate DNA sensing via the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) mechanism surveys microbial invasion and cellular damage and thus participates in various human infectious diseases, autoimmune diseases and cancers….

Craven L, Alston C, Taylor R, Turnbull D (2017) Recent advances in mitochondrial disease. Annu Rev Genomics Hum Genet 18:257–275. doi.org/10.1146/annurev-genom-091416-035426 CAS  Article  PubMed  Google Scholar  El-Hattab AW, Adesina AM, Jones J, Scaglia F (2015) MELAS syndrome: clinical manifestations, pathogenesis, and treatment options. Mol Genet Metab 116(1–2):4–12. doi.org/10.1016/j.ymgme.2015.06.004 CAS  Article …

Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that led to the coronavirus disease 2019 (COVID-19) pandemic can cause various clinical presentations ranging from asymptomatic and mild disease to critical and even deadly outcomes. The pathogenesis of COVID-19 is directly associated with the destruction of lung epithelial cells,…

Zhang, X., Bai, XC & Chen, ZJ Structures and mechanisms of the cGAS-STING innate immunity pathway. Immunity 5343–53 (2020). CAS PubMed Google Scholar Article Ishikawa, H. & Barber, GN STING is an endoplasmic reticulum adapter that facilitates innate immune signaling. Nature 455674–678 (2008). ADS CAS PubMed PubMed Central Article Google…

Atrophic (“dry”) form of age-related macular degeneration (AMD) is a leading cause of vision loss characterized by macular retinal pigment epithelium (RPE) and the ensuing photoreceptor degeneration. cGAS-STING signaling is a key cytosolic DNA sensor system in innate immunity and have recently been shown promotes RPE degeneration. However, expression regulation…

Sam50 is a key component of the sorting and assembly machinery (SAM) complex and is also involved in bridging mitochondrial outer and inner membrane contacts. However, the physiological and pathological functions of Sam50 remain largely unknown. On March 21, 2022, Wuhan University Song Zhiyin and Meng Qingtao jointly published a…

doi: 10.3389/fnmol.2022.852243. eCollection 2022. Lauren E Fritsch  1 , Jing Ju  2 , Erwin Kristobal Gudenschwager Basso  3 , Eman Soliman  3 , Swagatika Paul  4 , Jiang Chen  2 , Alexandra M Kaloss  3 , Elizabeth A Kowalski  3 , Taylor C Tuhy  5 , Rachana Deven Somaiya  1 , Xia Wang  3 , Irving Coy Allen  3 , Michelle H…

dc.identifier.citation Lepelley , A , Della Mina , E , Van Nieuwenhove , E , Waumans , L , Fraitag , S , Rice , G I , Dhir , A , Fremond , M-L , Rodero , M P , Seabra , L , Carter , E , Bodemer…