Tag: cGAS-STING

The formation of inflammation in the inflammatory pathways is caused by the defective DNA dispensing system during mitochondrial stress

Scientists have discovered a new way in which misplaced mitochondrial DNA (mtDNA) can be a cause of inflammation, which may equip clinicians with the tools to use these diseases as therapeutic interventions against inflammation associated with aging and other diseases. Credit: SciTechDaily.com. Salk scientists show a pathway for mouse cell…

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Scientists Discover Novel Mechanism for Mitochondrial DNA Disposal, Offering Potential for Targeted Therapeutics

In a groundbreaking study, researchers from the Salk Institute and the University of California San Diego have identified a new pathway used by cells to remove dysfunctional mitochondrial DNA (mtDNA) from within mitochondria. The discovery sheds light on how misplaced mtDNA triggers an immune response that promotes inflammation, opening up…

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Faulty DNA Disposal System Causes Inflammation

Endosomes (magenta) collect around mitochondria (blue) after infection with virus HSV-1, which attacks mtDNA (green) and causes its release. Credit: Salk Institute One of the ways our cells respond to damage and infection is with what’s known as the innate immune system. While the innate immune response is the first…

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Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal

Mitochondrial DNA (mtDNA) encodes essential subunits of the oxidative phosphorylation system, but is also a major damage-associated molecular pattern (DAMP) that engages innate immune sensors when released into the cytoplasm, outside of cells or into circulation. As a DAMP, mtDNA not only contributes to anti-viral resistance, but also causes pathogenic…

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Innovative Mechanism for Removal of Malfunctioning Mitochondrial DNA Triggers Inflammation

A breakthrough study by scientists at the Salk Institute and UC San Diego has discovered an innovative mechanism related to the removal of malfunctioning mitochondrial DNA (mtDNA) from mitochondria, which triggers an innate immune response leading to inflammation. This mechanism is now understood to play a critical role in aging…

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Faulty DNA disposal system causes inflammatio

image:  Endosomes (magenta) collect around mitochondria (blue) after infection with virus HSV-1, which attacks mtDNA (green) and causes its release. view more  Credit: Salk Institute LA JOLLA (February 8, 2024)—Cells in the human body contain power-generating mitochondria, each with their own mtDNA—a unique set of genetic instructions entirely separate from…

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[The I226R protein of African swine fever virus inhibits the cGAS-STING-mediated innate immune response]

This study aimed to explore the mechanism of how African swine fever virus (ASFV) I226R protein inhibits the cGAS-STING signaling pathway. We observed that I226R protein (pI226R) significantly inhibited the cGAS-STING-mediated type Ⅰ interferons and the interferon-stimulated genes production by dual-luciferase reporter assay system and real-time quantitative PCR. The results…

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[PDF] At the Crossroads of the cGAS-cGAMP-STING Pathway and the DNA Damage Response: Implications for Cancer Progression and Treatment

The evolutionary conserved DNA-sensing cGAS-STING innate immunity pathway represents one of the most important cytosolic DNA-sensing systems that is activated in response to viral invasion and/or damage to the integrity of the nuclear envelope. The key outcome of this pathway is the production of interferon, which subsequently stimulates the transcription…

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A STING Operation in neuroendocrine neoplasms | NANETS2023 | NANETS 2023

1Huntsman Cancer Institute, University of Utah, Salt Lake City, UT; 2University of Minnesota, Minneapolis, MN; 3Caris Life Sciences, Phoenix, AZ; 4The Ohio State University, Columbus, OH; 5Fox Chase Cancer Center, Philadelphia, PA; 6Sylvester Cancer Center, University of Miami, Miami, FL; 7Brown University, Providence, RI Background: Significant advances have been made…

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Gadolinium Oxide Nanoparticles reinforce immune response

Boyi Yu,1– 4 Xuanyi Lu,5 Xianglong Feng,1– 4 Ting Zhao,1– 4 Jiaxin Li,1– 4 Yudie Lu,5 Fei Ye,1– 4 Xiongxiong Liu,1– 4 Xiaogang Zheng,1– 4 Zheyu Shen,5 Xiaodong Jin,1– 4 Weiqiang Chen,1– 4 Qiang Li1– 4 1Biomedical Center, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, People’s Republic of…

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Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway

Abstract The O-GlcNAc transferase (OGT) is an essential enzyme that mediates protein O-GlcNAcylation, a unique form of posttranslational modification of many nuclear and cytosolic proteins. Recent studies observed increased OGT and O-GlcNAcylation levels in a broad range of human cancer tissues compared to adjacent normal tissues, indicating a universal effect…

Continue Reading Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway

cGAS-STING signalling regulates microglial chemotaxis in genome instability

doi: 10.1093/nar/gkad1184. Online ahead of print. Affiliations Expand Affiliations 1 Department of Biochemistry, University of Cambridge, Cambridge, UK. 2 Neuroscience, R&D BioPharmaceuticals, AstraZeneca, Cambridge, UK. 3 Translational Genomics, Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Mölndal, Gothenburg, Sweden. 4 Department of Data Sciences & Quantitative Biology, AstraZeneca, Cambridge, UK. Item…

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Cas9-induced targeted integration of large DNA payloads in primary human T cells via homology-mediated end-joining DNA repair

Khan, S. et al. Role of recombinant DNA technology to improve life. Int. J. Genomics Proteomics 2016, 2405954 (2016). Google Scholar  Spolski, R., Li, P. & Leonard, W. J. Biology and regulation of IL-2: from molecular mechanisms to human therapy. Nat. Rev. Immunol. 18, 648–659 (2018). Article  CAS  PubMed  Google…

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Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production | Molecular Medicine

Bustin SA, Benes V, Garson JA, Hellemans J, Huggett J, Kubista M, Mueller R, Nolan T, Pfaffl MW, Shipley GL, Vandesompele J, Wittwer CT. The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin Chem. 2009;55:611–22. Article  CAS  PubMed  Google Scholar  Chen Q, Sun L, Chen ZJ….

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Inhibition of ACLY overcomes cancer immunotherapy resistance via polyunsaturated fatty acids peroxidation and cGAS-STING activation

Adenosine 5′-triphosphate citrate lyase (ACLY) is a cytosolic enzyme that converts citrate into acetyl-coenzyme A for fatty acid and cholesterol biosynthesis. ACLY is up-regulated or activated in many cancers, and targeting ACLY by inhibitors holds promise as potential cancer therapy. However, the role of ACLY in cancer immunity regulation remains…

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Phages could help to tackle antimicrobial resistance

Researchers have found what triggers bacteria to start the CBASS immune response to counter infections by phages. Predatory viruses called phages pose a great threat to bacteria, as they can infiltrate their cells to replicate and take over. Phage have been of interest to scientists as tools to understand fundamental…

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Bioinformatics analysis of immune characteristics in tumors with alternative carcinogenesis pathways induced by human papillomaviruses | Virology Journal

de Martel C, Georges D, Bray F, Ferlay J, Clifford GM. Global burden of cancer attributable to infections in 2018: a worldwide incidence analysis. Lancet Glob Health. 2020;8:e180–90. Article  PubMed  Google Scholar  McKaig RG, Baric RS, Olshan AF. Human papillomavirus and head and neck cancer: epidemiology and molecular biology. Head…

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cGAS-STING pathway targeted therapies and their applications in the treatment of high-grade glioma.

cGAS-STING pathway targeted therapies and their applications in the treatment of high-grade glioma. Publication ,  Journal Article Tripathi, S; Najem, H; Mahajan, AS; Zhang, P; Low, JT; Stegh, AH; Curran, MA; Ashley, DM; James, CD; Heimberger, AB Published in: F1000Res Median survival of patients with glioblastoma (GBM) treated with standard of…

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How does JAK2 interact with cGAS?

What is the role of RNASEH2C in the cGAS pathway?5 answersRNASEH2C is not mentioned in any of the provided abstracts. What is the role of TLR7 in the cGAS pathway?3 answersTLR7 does not have a direct role in the cGAS pathway according to the abstracts provided. The abstracts discuss the…

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What is the role of RNASEH2C in the cGAS pathway?

What is a endoglycosidase H?3 answersEndoglycosidase H (Endo H) is a glycosidase enzyme that cleaves N-linked glycans from glycoproteins. It is commonly used in research to analyze protein glycosylation and to study glycoprotein trafficking. Endo H specifically cleaves high mannose and some hybrid N-glycans, but not complex N-glycans. It is…

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A Nanoinhibitor Targeting cGAS-STING Pathway to Reverse the Homeostatic Imbalance of Inflammation in Psoriasis

. 2023 Nov 28:e202316007. doi: 10.1002/anie.202316007. Online ahead of print. Affiliations Expand Affiliations 1 Nanjing University, College of Engineering and Applied Sciences, CHINA. 2 Nanjing University, Medical School, CHINA. 3 Nanjing University of Chinese Medicine, School of medicine, CHINA. 4 Nanjing University, Biomedical Engineering, 22 Hankou Road, 210023, Nanjing, CHINA….

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Trafficking and effect of released DNA in cGAS-STING signaling pathway activation and cardiovascular disease

1Hubei Key Laboratory of Diabetes and Angiopathy, Hubei University of Science and Technology, China 2Army Medical University, China 3Xianning Medical College, Hubei University of Science and Technology, China The final, formatted version of the article will be published soon. Notify me …

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Pharmaceuticals | Free Full-Text | At the Crossroads of the cGAS-cGAMP-STING Pathway and the DNA Damage Response: Implications for Cancer Progression and Treatment

Received: 30 September 2023 / Revised: 21 November 2023 / Accepted: 21 November 2023 / Published: 1 December 2023 Round 1 Reviewer 1 Report Comments and Suggestions for Authors The review article written by Korneenko et al., is well structured and of great importance to the readers. A minor comment…

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Cytoplasmic Escape of Mitochondrial DNA Mediated by Mfn2 Downregulation Promotes Microglial Activation via cGas-Sting Axis in Spinal Cord Injury

doi: 10.1002/advs.202305442. Online ahead of print. Fei-Long Wei  1 , Tian-Fu Wang  1 , Chao-Li Wang  2 , Zhen-Peng Zhang  3 , Jing-Wei Zhao  1 , Wei Heng  1 , Zhen Tang  1 , Ming-Rui Du  1 , Xiao-Dong Yan  1 , Xiao-Xiang Li  1 , Zheng Guo  1 , Ji-Xian Qian  1 , Cheng-Pei Zhou  1 Affiliations Expand Affiliations 1 Department…

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Adipose cDC1s contribute to obesity-associated inflammation through STING-dependent IL-12 production

Ward, Z. J. et al. Projected U.S. state-level prevalence of adult obesity and severe obesity. N. Engl. J. Med. 381, 2440–2450 (2019). Article  PubMed  Google Scholar  Khaodhiar, L., McCowen, K. C. & Blackburn, G. L. Obesity and its comorbid conditions. Clin. Cornerstone 2, 17–31 (1999). Article  CAS  PubMed  Google Scholar …

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New insights into how SARS-CoV-2 evades our immune system

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 2019 (COVID-19), possesses a positive-sense ribonucleic acid (RNA) genome and various proteins. Severe cases of COVID-19 involve cytokine release syndrome and acute respiratory distress. In a recent review published in the journal Cellular and Molecular Immunology,…

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Advances in structure-guided mechanisms impacting on the cGAS-STING innate immune pathway

doi: 10.1016/bs.ai.2023.08.001. Epub 2023 Sep 12. Affiliations Expand Affiliations 1 College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, P.R. China. 2 College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, P.R. China; School of Biomedical Engineering, Hubei University of Medicine, Shiyan, Hubei, P.R. China. 3 Structural Biology Program, Memorial Sloan-Kettering Cancer…

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Megakaryocytes possess a STING pathway that is transferred to platelets to potentiate activation

Introduction Host defence against infection relies on two important systems: the immune and the coagulation systems. Platelets are anucleate cells produced by megakaryocytes and are responsible for blood clotting and haemostasis (Lefrancais et al, 2017). They are also very abundant and play unexpected roles in immune responses (Maouia et al,…

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Iron derived from NCOA4-mediated ferritinophagy causes cellular senescence via the cGAS-STING pathway

Materials and reagents Tert-butyl hydroperoxide (TBH) were purchased from Sigma-Aldrich (St. Louis, USA). Ferric ammonium citrate (FAC) and D-galactose (D-gal) was obtained from Selleck (Shanghai, China) and Aladdin (Shanghai, China), respectively. Deferoxamine (DFO), Mito-TEMPO (Mito-T), 3-Methyladenine (3-MA), Chloroquine (CQ), Bafilomycin A1 (Baf-A1), and H-151 were purchased from MedChemExpress (NJ, USA)….

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How bacteria recognize viral invasion and activate immune defenses

A viral RNA produced during Φ80α-vir infection activates Ssc-CdnE03 in vitro. a, Detection of phage propagation after spotting tenfold dilutions of the lytic DNA phages Φ80α-vir, ΦNM1γ6, ΦNM4γ4 and Φ12γ3 onto lawns of S. aureus RN4220 harbouring a plasmid expressing an incomplete (Ssc-CdnE03 alone) or intact Ssc-CBASS operon. b, Thin-layer…

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Inflammation In The Brain Linked To Aging And Cognitive Decline

Neurons and Microglia – 3d rendered image of Neuron cell network on black background. Microglial … [+] cells are the most prominent immune cells of the central nervous system (CNS). Hologram view interconnected neurons cells with electrical pulses. Conceptual medical image. Glowing synapse. Healthcare concept. getty This article is part…

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Ginsenoside Rg3 enriches SCFA-producing commensal bacteria to confer protection against enteric viral infection via the cGAS-STING-type I IFN axis

Rg3 elicits protection against local and systemic enteric virus infection by regulating the intestinal microbiome To assess the antiviral effects of Rg3 in vivo, groups of C57BL/6J mice (referred to as WT B6 hereafter) were orally administered Rg3 for 3 consecutive days, inoculated with MNV-1 by the peroral route, and…

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Biotechs step on cGAS for autoimmune diseases

Ventus has overcome medicinal chemistry challenges to advance a first inhibitor of cGAS-STING into the clinic, as drug developers build the case for novel anti-inflammatory agents in autoimmune diseases including lupus. In late 2012, researchers showed how the cGAS-STING pathway detects pathogenic DNA to guard against viral and bacterial invaders….

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HDAC3 deacetylates H3K27ac and H3K9ac on the TrkC promoter to exacerbate sevoflurane-induced neurotoxicity

Apai C, Shah R, Tran K, Pandya Shah S (2021) Anesthesia and the developing brain: a review of sevoflurane-induced neurotoxicity in pediatric populations. Clin Ther 43:762–778 Article  CAS  PubMed  Google Scholar  Chai G et al (2022) Sevoflurane inhibits histone acetylation and contributes to cognitive dysfunction by enhancing the expression of…

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DUSP1 protects against ischemic acute kidney injury through stabilizing mtDNA via interaction with JNK

The mechanism underlying acute kidney injury (AKI) and AKI-to-Chronic kidney disease (CKD) transition remains unclear, but mitochondrial dysfunction may be a key driving factor. Literature reports suggest that dual-specificity phosphatase 1 (DUSP1) plays a critical role in maintaining mitochondrial function and structural integrity. In this study, ischemic Acute Kidney Injury…

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Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders | Molecular Neurodegeneration

Hemmi H, et al. A toll-like receptor recognizes bacterial DNA. Nature. 2000;408(6813):740–5. Article  CAS  PubMed  Google Scholar  Unterholzner L, et al. IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol. 2010;11(11):997–1004. Article  CAS  PubMed  PubMed Central  Google Scholar  Chiu YH, Macmillan JB, Chen ZJ. RNA polymerase III detects…

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from Signalling Networks to Targeted Intervention [Abstract]

Int J Biol Sci 2024; 20(1):152-174. doi:10.7150/ijbs.84890 This issue Cite Review Jiahui Gong1, Xilong Gao2, Shaoyang Ge3, Hongliang Li4, Ran Wang2,5, Liang Zhao1,2,6✉ 1. College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.2. Key Laboratory of Functional Dairy, Department of Nutrition and Health, China…

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STING agonists activate multiple regulated cell death mechanisms in monocytes

dc.contributor.author Pimková Polidarová, Markéta dc.contributor.author Hirsch, Ivan dc.contributor.author Brázdová, Andrea dc.contributor.author Grantz Šašková, Klára dc.contributor.editor Šímová, Šárka dc.date.accessioned 2023-11-03T13:10:36Z dc.date.available 2023-11-03T13:10:36Z dc.date.issued 2023 dc.identifier.uri hdl.handle.net/20.500.14178/2064 dc.description.abstract Stimulation of the innate immune responses using agonist of pattern recognition receptors is one of the investigated therapeutic approaches for treatment of chronic diseases,…

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GAS-STING: a classical DNA recognition pathways to tumor therapy

Review . 2023 Oct 18:14:1200245. doi: 10.3389/fimmu.2023.1200245. eCollection 2023. Affiliations Expand Affiliations 1 National Health Commission (NHC), Key Laboratory of Technical Evaluation of Fertility Regulation for Non-Human Primate, Fujian Maternity and Child Health Hospital, Fuzhou, Fujian, China. 2 College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical…

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Synergistic effects of Azithromycin and DMXAA

Kanoktip Petcharat,1 Narongsuk Munkong,2 Rungthip Thongboontho,1 Widsanusan Chartarrayawadee,3 Arthid Thim-Uam1 1Division of Biochemistry, School of Medical Sciences, University of Phayao, Phayao, 56000, Thailand; 2Department of Pathology, School of Medicine, University of Phayao, Phayao, 56000, Thailand; 3Division of Chemistry, School of Science, University of Phayao, Phayao, 56000, Thailand Correspondence: Arthid Thim-Uam,…

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DNA damage response(DDR): a link between cellular senescence and human cytomegalovirus | Virology Journal

Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res. 1961;25:585–621. Article  CAS  PubMed  Google Scholar  Hayflick L. THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS. Exp Cell Res. 1965;37:614–36. Article  CAS  PubMed  Google Scholar  Schmitt CA, Tchkonia T, Niedernhofer LJ, Robbins PD,…

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Which interferon-stimulated genes are induced by the cGAS STING pathway?

The cGAS-STING pathway induces the expression of interferon-stimulated genes (ISGs) with diverse antiviral functions. Activation of the cGAS-STING pathway leads to the production of type I interferon (IFN-I), which in turn induces the expression of ISGs. The exact ISGs induced by the cGAS-STING pathway were not specified in the abstracts…

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Phase separation in cGAS-STING signaling

Sun L, Wu J, Du F, Chen X, Chen ZJ. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 2013; 339(6121): 786–791 Article  CAS  PubMed  Google Scholar  Wu J, Sun L, Chen X, Du F, Shi H, Chen C, Chen ZJ. Cyclic GMP-AMP…

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HDAC3 improves intestinal function of mice by regulating cGAS-Sting pathway of intestinal glial cells

doi: 10.1016/j.molimm.2023.08.012. Epub 2023 Sep 2. Affiliations Expand Affiliations 1 Department of Critical Care Medicine, The Second Affiliated Hospital of Air Force Medical University, Xi’an 710038, Shaanxi, China. 2 Department of Neurosurgery, The Second Affiliated Hospital of Air Force Medical University, Xi’an 710038, Shaanxi, China. 3 Department of Experiential Surgery,…

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Bacteriophages Enhance Cellular Growth and Survival for Mammalian Cells

Phage interactions with bacteria are well known, and interactions between bacteria and their mammalian host can lead to a range of symbioses. However, the impact of bacteriophages on mammalian cellular and immunological processes is not well understood. Now, a new study by researchers at Monash University suggests that mammalian cells…

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Unlocking the Hidden Benefits of Bacteriophages for Mammalian Cells

Phage interactions with bacteria have long been studied, but their impact on mammalian cells remained a mystery until now. Researchers at Monash University have discovered that mammalian cells not only internalize bacteriophages but also utilize them as a resource to enhance cellular growth and survival. This groundbreaking study sheds new…

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cGAS-STING signaling pathway promotes hypoxia-induced renal fibrosis by regulating PFKFB3-mediated glycolysis

Hypoxia has long been considered to play an active role in the progression of fibrosis in chronic kidney disease, but its specific mechanism is not fully understood. The stimulator of interferon genes (STING) has been a research hotspot in the fields of tumor, immunity, and infection in recent years, and…

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Nsp1 facilitates SARS-CoV-2 replication through calcium-calcineurin-NFATc2 signaling pathway

DC Field Value Language dc.contributor.advisor Jin, D – dc.contributor.advisor Sridhar, S – dc.contributor.advisor To, KKW – dc.contributor.author Lui, Wai Yin – dc.contributor.author 雷瑋硏 – dc.date.accessioned 2023-10-24T08:59:07Z – dc.date.available 2023-10-24T08:59:07Z – dc.date.issued 2023 – dc.identifier.citation Lui, W. Y. [雷瑋硏]. (2023). Nsp1 facilitates SARS-CoV-2 replication through calcium-calcineurin-NFATc2 signaling pathway. (Thesis). University of…

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cGAS-STING triggers inflammaging-associated neurodegeneration | Molecular Neurodegeneration

cGAS-STING triggers inflammaging-associated neurodegeneration In their recent article in Nature, Gulen et al. [1] established the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway as a regulatory driver of inflammaging-associated neurodegeneration in mice. Pharmacological blockade of this pathway in aged mice prevented inflammaging and improved cognitive and motor performance….

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SIRT2 negatively regulates the cGAS-STING pathway by deacetylating G3BP1

SIRT2, a cytoplasmic member of the Sirtuin family, has important roles in immunity and inflammation. However, its function in regulating the response to DNA virus infection remains elusive. Here, we find that SIRT2 is a unique regulator among the Sirtuin family that negatively modulates the cGAS-STING-signaling pathway. SIRT2 is down-regulated…

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Micronucleus Is Not a Potent Inducer of cGAS-STING Pathway

Abstract Micronucleus (MN) has been associated with the innate immune response. The abrupt rupture of MN membranes results in the accumulation of cGAS, potentially activating STING and downstream interferon-responsive genes. However, direct evidence connecting MN and cGAS activation has been lacking. We have developed the FuVis2 reporter system, which enables…

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TLR9 regulates the autophagy-lysosome pathway to promote dendritic cell maturation and activation by activating the TRAF6-cGAS-STING pathway

doi: 10.1002/kjm2.12769. Online ahead of print. Affiliations Expand Affiliations 1 Department of Rheumatology & Immunology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province, People’s Republic of China. 2 Traditional Chinese Medicine Department, Boao Yiling Life Care Center, Qionghai, Hainan Province, People’s Republic of China. 3…

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2-BFI Protects Against Cerebral Ischemia-Reperfusion Injury by Inhibiting the cGAS-STING Pathway by Lu Xu, Meiqi Zhao, Ye Xu, Chunfei Xu, Lili Ma, Tong Xu, Yungang Cao, Zhao Han :: SSRN

28 Pages Posted: 17 Oct 2023 See all articles by Lu Xu Wenzhou Medical University – Department of Neurology Wenzhou Medical University – Department of Neurology Wenzhou Medical University – Department of Neurology Wenzhou Medical University – Department of Neurology Wenzhou…

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Progress in understanding the role of cGAS-STING pathway associated with programmed cell death in intervertebral disc degeneration

Fig. 2. Schematic of association between cGAS-STING signaling pathway and cell death. Fig. 2. Schematic of association between cGAS-STING signaling pathway and cell death. Herein, impacts of hyperactivated cGAS–STING signaling pathway were summarized, especial its relation with various cell death. A Apoptosis is a non-inflammatory process mediated by caspase enzymes,…

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STING Cyclic Dinucleotide Sensing Originated in Bacteria

dc.identifier.citation Morehouse, Benjamin R, Govande, Apurva A, Millman, Adi, Keszei, Alexander F. A, Lowey, Brianna, Ofir, Gal, Shao, Sichen, Sorek, Rotem, and Kranzusch, Philip J. “STING Cyclic Dinucleotide Sensing Originated in Bacteria.” Nature (London) 586, no. 7829 (2020): 429-33. en_US dc.description.abstract Stimulator of interferon genes (STING) is a receptor in…

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STING in tumors: a focus on non-innate immune pathways

The final, formatted version of the article will be published soon. Notify me Receive an email when it is updated You just subscribed to receive the final version of the article Cyclic GMP-AMP synthase (cGAS) and downstream stimulator of interferon genes (STING) are involved in mediating…

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DNA damage induced by CDK4 and CDK6 blockade triggers anti-tumor immune responses through cGAS-STING pathway

Patients’ tumor tissues and clinical data This study recruited 125 breast cancer patients for immunohistochemical (IHC) analysis and 10 breast cancer patients for RNA-seq analysis from the Affiliated Tumor Hospital of Nantong University. Tumor tissues collected from surgical patients were fixed with formalin and embedded with paraffin and then examined….

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The role of cGAS-STING signaling in pulmonary fibrosis and its therapeutic potential

1West China Second University Hospital, Sichuan University, China 2Fujian Provincial Hospital, China 3West China Hospital, Sichuan University, China The final, formatted version of the article will be published soon. Notify me Receive an email when it is updated You just…

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The activation of cGAS-STING in acute kidney injury

Introduction AKI, which is characterised by necroinflammation due to damage and necrosis of the kidney’s intrinsic cells,1 is a common clinical syndrome, occurring in 10–15% of hospitalized patients, whereas in the ICU this percentage is as high as 50%.2 The development of AKI is involved in the production of reactive…

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Manganese Exacerbates ConA-Induced Liver Inflammation via the cGAS-STING Signaling Pathway

Horning, K.J., S.W. Caito, K.G. Tipps, A.B. Bowman, and M. Aschner. 2015. Manganese is essential for neuronal health. Annual Review of Nutrition 35: 71–108. CAS  PubMed  PubMed Central  Google Scholar  Keen, C.L., J.L. Ensunsa, M.H. Watson, D.L. Baly, S.M. Donovan, M.H. Monaco, et al. 1999. Nutritional aspects of manganese from…

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[The Potential of a Novel Therapeutic Strategy for Colorectal Cancer Targeting the cGAS-STING Pathway]

The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)pathway is one of the important intracellular signaling pathways responsible for the recognition of exogenous DNA and subsequent induction of type Ⅰ interferon responses. Interestingly, in recent years, the importance of the cGAS-STING pathway in promoting anti-tumor immune responses has been highlighted. Decreased expression…

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Simultaneous Activation of Pyroptosis and cGAS-STING Pathway with Epigenetic/ Photodynamic Nanotheranostic for Enhanced Tumor Photoimmunotherapy

doi: 10.1002/adma.202306419. Online ahead of print. Affiliations Expand Affiliations 1 Department of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, and National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China. 2 Institute of Clinical Pharmacology, Engineering Research Center for Applied Technology of Pharmacogenomics of Ministry…

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GSDMD promotes neutrophil extracellular traps via mtDNA-cGAS-STING pathway during lung ischemia/reperfusion

doi: 10.1038/s41420-023-01663-z. Affiliations Expand Affiliations 1 Department of Anesthesiology, Guangxi Medical University Cancer Hospital, Nanning, China. 2 Guangxi Clinical Research Center for Anesthesiology, Nanning, China. 3 Guangxi Engineering Research Center for Tissue & Organ Injury and Repair Medicine, Nanning, China. 4 Guangxi Health Commission Key Laboratory of Basic Science and…

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DNAJA2 deficiency activates cGAS-STING pathway via the induction of aberrant mitosis and chromosome instability

Author Listed: Yaping Huang (University of Texas Southwestern Medical Center) Changzheng Lu (University of Texas Southwestern Medical CenterShenzhen Bay Laboratory) Hanzhi Wang (University of Texas Southwestern Medical Center) Liya Gu (University of Texas Southwestern Medical Center) Yang-Xin Fu (University of Texas Southwestern Medical CenterTsinghua University School of Medicine) Guo-Min Li…

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Frontiers | Novel Insight into cGAS-STING Pathway in Ischemic Stroke: From Pre

1Hunan University of Chinese Medicine, China 2Shandong University of Traditional Chinese Medicine, China 3Hunan Academy of Chinese Medicine, Hunan University of Chinese Medicine, China The final, formatted version of the article will be published soon. Notify me Receive an email when…

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The role of cGAS-STING signaling in ischemic stroke: From immune response to therapeutic targeting

Review doi: 10.1016/j.drudis.2023.103792. Online ahead of print. Affiliations Expand Affiliations 1 Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Raebareli (NIPER-R), Transit Campus, Bijnor-Sisendi Road, Sarojini Nagar, Near CRPF Base Camp, Lucknow (UP) 226002, India. 2 Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education…

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Epstein-Barr virus infection: the micro and macro worlds | Virology Journal

Epstein MA, Achong BG, Barr YM. VIRUS PARTICLES IN CULTURED LYMPHOBLASTS FROM BURKITT’S LYMPHOMA. Lancet. 1964;1(7335):702–3. Article  CAS  PubMed  Google Scholar  Cohen JI, Jaffe ES, Dale JK, Pittaluga S, Heslop HE, Rooney CM, et al. Characterization and treatment of chronic active Epstein-Barr virus disease: a 28-year experience in the United…

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Metformin Antagonizes Radiotherapy-Induced Anti-Tumor Effects via Inhibition of cGAS-STING Pathway Mediated Immune Responses

Author links open overlay panelM. Wu, D. Chen, Z. Liu, M. Chen, R. Liu, J. Wang, X. Li, Q. Tao, J. Yu Show more doi.org/10.1016/j.ijrobp.2023.06.1230Get rights and content Purpose/Objective(s) Radiotherapy induced anti-tumor effects depend on both direct tumor cell death caused by radiation and immune activation mediated by cGAS-STING pathway….

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Chitosan-based nano-micelles for potential anti-tumor immunotherapy: Synergistic effect of cGAS-STING signaling pathway activation and tumor antigen absorption

doi: 10.1016/j.carbpol.2023.121346. Epub 2023 Aug 29. Affiliations Expand Affiliations 1 College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China. 2 College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China; Jinhua Institute of Zhejiang University, Jinhua 321299, China. 3 College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China; Jinhua Institute of…

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Inhibition of PLK4 remodels histone methylation and activates immune response via cGAS-STING pathway in TP53 mutated AML | Blood

Citation Cheuk Him Man, Wing Lam, Chee Chean Dang, Xiao-yuan Zeng, Li-Chuan Zheng, Natalie Nok-Man Chan, Nelson K. L. Ng, Koon-Chuen Chan, Tsz-Ho Kwok, Timothy Chi-Chun Ng, Wing Yan Leung, Michael Huen, Carmen Chak-Lui Wong, Chi Wai Eric So, Zhixun Dou, Susumu Goyama, Mark Robert Bray, Tak Wah Mak, Anskar…

Continue Reading Inhibition of PLK4 remodels histone methylation and activates immune response via cGAS-STING pathway in TP53 mutated AML | Blood

New function for “STING” signal! Shanghai Jiao Tong University team reveals STING signaling drives new development of NK cell anti-tumor immunity

Introduction: Natural killer (NK) cells are cytotoxic innate lymphocytes that eradicate tumor cells. The induction of durable anti-tumor immune responses by NK cells is a priority for cancer immunotherapy. Although cytosolic DNA sensing plays a crucial role in initiating anti-tumor immunity, the role of NK cell-intrinsic STING signaling is unclear….

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Spinal TAOK2 contributes to neuropathic pain via cGAS-STING…

Abstract Thousand and one amino acid kinase 2 (TAOK2) is a member of the mammalian sterile 20 kinase family and is implicated in neurodevelopmental disorders; however, its role in neuropathic pain remains unknown. Here, we found that TAOK2 was enriched and activated after chronic constriction injury (CCI) in the rat…

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Zhijian ‘James’ Chen and Glen Barber Awarded Horwitz Prize for Discovering the cGAS-STING Pathway

2023 Horwitz Prize Columbia University will award the 2023 Louisa Gross Horwitz Prize to: Zhijian ‘James’ ChenHoward Hughes Medical Institute and University of Texas Southwestern Medical Center, USA Glen BarberUniversity of Miami, USA​​​​​​ for “discovering the cGAS-STING pathway.” The award ceremony and honorary lectures will take place Feb. 12, 2024….

Continue Reading Zhijian ‘James’ Chen and Glen Barber Awarded Horwitz Prize for Discovering the cGAS-STING Pathway

Role of cGAS-STING signaling pathway in cardiometabolic diseases

Zhong Nan Da Xue Xue Bao Yi Xue Ban . 2023 Jul 28;48(7):1086-1097. doi: 10.11817/j.issn.1672-7347.2023.230028. [Article in English, Chinese] Affiliations Expand Affiliations 1 Department of Cardiovascular Medicine, Second Xiangya Hospital, Central South University, Changsha 410011. dhq0827@163.com. 2 Department of Cardiovascular Medicine, Xiangtan Central Hospital, Xiangtan Hunan 411199. 3 Department of…

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Ambra1+ Myo-sEVsI/R enriched with mitochondri

image: Ambra1+-MYO-SEVS WERE INTERNALIZED BY FIBROBLASTS AND THE DELIVERED mtDNA COMPONENTS TO ACTIVATE THE FIBROBLAST cGAS-STING PATHWAY TO PROMOTE FIBROBLAST ACTIVATION AND PROLIFERATION. view more  Credit: ©Science China Press This study is led by Prof. Heng Ma (School of Basic Medicine, Fourth Military Medical University), Prof. Alex Chia Yu Chang (Ninth…

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Chen, Barber Win Horwitz Prize for cGAS-STING Pathway Discovery

NEW YORK, NY (September 20, 2023)-Columbia University will award the 2023 Louisa Gross Horwitz Prize to Zhijian ‘James’ Chen and Glen Barber for discovering the cGAS-STING pathway, a key component of one of the body’s first line of defenses, the innate immune system. When pathogens infiltrate our cells, they leave…

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UT Southwestern biochemist Zhijian ‘James’ Chen to receive prestigious Horwitz Prize : Newsroom

Zhijian “James” Chen, Ph.D., Professor of Molecular Biology who holds the George L. MacGregor Distinguished Chair in Biomedical Science at UT Southwestern, is one of the world’s top researchers on innate immunity. DALLAS – Sept. 20, 2023 – Zhijian “James” Chen, Ph.D., Professor of Molecular Biology at UT Southwestern Medical Center, has been…

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A new communication medium between cardiomyocytes and fibroblasts

Ambra1+-Myo-sEVs were internalized by fibroblasts and the delivered mtDNA components to activate the fibroblast cgas-sting pathway to promote fibroblast activation and proliferation. Credit: Science China Press Myocardial fibrosis is major pathological outcome after myocardial ischemia/reperfusion (MI/R) injury and a major risk factor for heart failure. MI/R injury induces cardiomyocyte damage…

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Sonodynamic amplification of cGAS-STING activation by cobalt-based nanoagonist against bone and metastatic tumor

Immunotherapy, a promising antitumor modality consisting of a series of therapeutic strategies that mobilize the endogenous immune system to execute an antitumor response, has drawn substantial attention in recent years [1]. However, hyporesponsiveness among patients, which is attributed to a category of immunosuppressive ‘cold’ tumors, hinders the further clinical application…

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Low-dose metronomic chemotherapy triggers oxidized mtDNA sensing inside tumor cells to potentiate CD8+T anti-tumor immunity

Low-dose metronomic (LDM) chemotherapy, the frequent and continuous use of low doses of conventional chemotherapeutics, is emerging as a promising form of chemotherapy utilization. LDM chemotherapy exerts immunomodulatory effects. However, the underlying mechanism is not fully understood. Here we found that suppressing tumor growth by LDM chemotherapy was dependent on…

Continue Reading Low-dose metronomic chemotherapy triggers oxidized mtDNA sensing inside tumor cells to potentiate CD8+T anti-tumor immunity

TET2 inhibits the proliferation and metastasis of lung adenocarcinoma cells via activation of the cGAS-STING signalling pathway

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ, He J. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66(2):115–32. Article  PubMed  Google Scholar  Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. Cancer J Clin. 2020;70(1):7–30. Article  Google Scholar  Thai AA,…

Continue Reading TET2 inhibits the proliferation and metastasis of lung adenocarcinoma cells via activation of the cGAS-STING signalling pathway

Precise RNA Editing: Cascade Self-Uncloaking Dual-Prodrug Nanoassemblies Based on CRISPR/Cas13a for Pleiotropic Immunotherapy of PD-L1-Resistant Colorectal Cancer,Advanced Functional Materials

CRISPR/Cas13a is a powerful genome editing system for RNA knockdown that holds enormous potential for cancer treatment by targeting currently undruggable oncogenes or immune checkpoints. However, the precise intratumoral activation of CRISPR/Cas13a to maximize the therapeutic efficiency while guaranteeing biosafety remains a daunting challenge. Here, a cascade self-uncloaking nanoassembly (SRC)…

Continue Reading Precise RNA Editing: Cascade Self-Uncloaking Dual-Prodrug Nanoassemblies Based on CRISPR/Cas13a for Pleiotropic Immunotherapy of PD-L1-Resistant Colorectal Cancer,Advanced Functional Materials

Role of the cGAS-STING pathway in radiotherapy for non-small cell lung cancer | Radiation Oncology

Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and Mortality Worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49. doi.org/10.3322/caac.21660 Article  PubMed  Google Scholar  Duma N, Santana-Davila R, Molina JR. Non-Small Cell Lung Cancer: Epidemiology, Screening, diagnosis, and treatment….

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Ficolin B secreted by alveolar macrophage exosomes exacerbates bleomycin-induced lung injury via ferroptosis through the cGAS-STING signaling pathway

Pathogenesis exploration and timely intervention of lung injury is quite necessary as it has harmed human health worldwide for years. Ficolin B (Fcn B) is a recognition molecule that can recognize a variety of ligands and play an important role in mediating the cell cycle, immune response, and tissue homeostasis…

Continue Reading Ficolin B secreted by alveolar macrophage exosomes exacerbates bleomycin-induced lung injury via ferroptosis through the cGAS-STING signaling pathway

Yin Hang’s research group from Tsinghua University School of Pharmacy found that 4-octylitaconic acid blocks STING palmitoylation and inhibits STING activation

Cell Reports | Yin Hang’s research group from Tsinghua University School of Pharmacy found that 4-octylitaconic acid blocks STING palmitoylation and inhibits STING activation On August 24, 2023, Yin Hang’s research group from the School of Pharmacy, Tsinghua University published a research article entitled “4-Octyl itaconate restricts STING activation by…

Continue Reading Yin Hang’s research group from Tsinghua University School of Pharmacy found that 4-octylitaconic acid blocks STING palmitoylation and inhibits STING activation

KRTA6A and FA2H Are Hub Genes Associated With Cgas-STING-related Immunogenic Cell Death in Lung Adenocarcinoma

Abstract Background/Aim: The immunogenic cell death (ICD) pathway plays a crucial prognostic role in lung adenocarcinoma (LUAD) therapy. The cyclic GMP–AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is an upstream mechanism that drives ICD activation, but the interaction of hub genes remains unclear. The present study aimed to investigate…

Continue Reading KRTA6A and FA2H Are Hub Genes Associated With Cgas-STING-related Immunogenic Cell Death in Lung Adenocarcinoma

The cGAS-STING pathway is dispensable in a mouse model of LMNA-cardiomyopathy despite nuclear envelope rupture

Abstract Mutations in the nuclear Lamin A/C gene (LMNA) cause diverse degenerative disorders, including malignant dilated cardiomyopathy in adults. A prevailing hypothesis postulates that LMNA mutations cause nuclear envelope ruptures that trigger pathogenic inflammatory signaling via the cGAS-STING cytosolic DNA-sensing pathway. Here, we provide evidence against this hypothesis, using a…

Continue Reading The cGAS-STING pathway is dispensable in a mouse model of LMNA-cardiomyopathy despite nuclear envelope rupture

Updated Roles of cGAS-STING Signaling in Autoimmune Diseases

1Department of Rheumatology and Immunology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, China 2Department of Orthopedics, Wuhan Hospital of Traditional Chinese and Western Medicine, Tongji Medical College, Huazhong University of Science and Technology, China The…

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The cGAS-STING pathway regulates microglial chemotaxis in genome instability

Abstract Defective DNA damage signalling and repair is a hallmark of age-related and genetic neurodegenerative disease. One mechanism implicated in disease progression is DNA damage-driven neuroinflammation, which is largely mediated by tissue-resident immune cells, microglia. Here, we utilise human microglia-like cell models of persistent DNA damage and ATM kinase deficiency…

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The cGAS-STING-YY1 axis accelerates progression of neurodegeneration in a mouse model of Parkinson’s disease via LCN2-dependent astrocyte senescence

doi: 10.1038/s41418-023-01216-y. Online ahead of print. Affiliations Expand Affiliations 1 Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, 101 Longmian Avenue, Nanjing, Jiangsu, 211166, PR China. 2 Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, 101 Longmian Avenue, Nanjing, Jiangsu, 211166, PR China. drh@njmu.edu.cn….

Continue Reading The cGAS-STING-YY1 axis accelerates progression of neurodegeneration in a mouse model of Parkinson’s disease via LCN2-dependent astrocyte senescence

ARF1 prevents aberrant type I IFN induction by regulating STING activation and recycling

Abstract Type I interferon (IFN) signalling is tightly controlled. Upon recognition of DNA by cyclic GMP AMP synthase (cGAS), stimulator of interferon genes (STING) translocates along the endoplasmic reticulum (ER)-Golgi axis to induce IFN signalling. Termination is achieved through autophagic degradation or recycling of STING by retrograde Golgi-to-ER transport. Here,…

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Inhibition of tumor intrinsic BANF1 activates antitumor immune responses via cGAS-STING and enhances the efficacy of PD-1 blockade

Introduction Immune checkpoint inhibitors (ICIs) have revolutionized the treatment pattern of various cancers, including melanoma and non-small cell lung cancer (NSCLC).1–3 However, there are still a considerable proportion (40%–60%) of patients who do not respond or do not achieve durable responses to these drugs.4 Thus, it is urgent clinical need…

Continue Reading Inhibition of tumor intrinsic BANF1 activates antitumor immune responses via cGAS-STING and enhances the efficacy of PD-1 blockade

IQGAP1 promotes mitochondrial damage and activation of the mtDNA sensor cGAS-STING pathway to induce endothelial cell pyroptosis leading to atherosclerosis

Atherosclerosis (AS) is currently the fastest-growing public health emergency and is characterized by lipid deposition, inflammatory infiltration, foam cell formation, and narrowing of the internal diameter of blood vessels [1]. Compared with previous decades, AS has progressively affected younger people [2]. Lipid deposition leads to oxidative stress, endothelial cell dysfunction,…

Continue Reading IQGAP1 promotes mitochondrial damage and activation of the mtDNA sensor cGAS-STING pathway to induce endothelial cell pyroptosis leading to atherosclerosis

Gut Microbiota Metabolites Mediate Bax to Reduce Neuronal Apoptosis via cGAS/STING Axis in Epilepsy

Zack MM, Kobau R (2017) National and state estimates of the numbers of adults and children with active epilepsy – United States, 2015. MMWR Morb Mortal Wkly Rep 66:821–825. doi.org/10.15585/mmwr.mm6631a1 Article  PubMed  PubMed Central  Google Scholar  Pottoo F et al (2020) Impact of adherence to antiepileptic medications on quality of…

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Plant-derived nanovesicles facilitate tumor therapy

Introduction Tumors are the second leading cause of death worldwide, with approximately 1670 deaths per day in the United States and 7700 deaths per day in China.1,2 The fundamental reason why cancers are still considered “frightening” is the difficulty of early tumor detection and the variety of issues present in…

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With Age, Microglia Pump cGAS, Revving Harmful Inflammation

18 Aug 2023 As people age, chronic inflammation can ensue. What drives this so-called “inflammaging”? A study published August 2 in Nature may have identified a primary cause, at least in the mouse brain. Scientists led by Andrea Ablasser at the Swiss Federal Institute of Technology in Lausanne, report that…

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cGAS-STING signaling pathway in intestinal homeostasis and diseases

1University Medical Center Groningen, Netherlands The final, formatted version of the article will be published soon. Notify me Receive an email when it is updated You just subscribed to receive the final version of the article The intestinal mucosa is constantly exposed to…

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New study reveals potential of molecular signaling pathway in suppressing aging-associated inflammation

As we age, the presence of low-grade inflammation in the body plays an important role in the decline and damage that occurs during aging, however, the exact pathways that lead to this inflammation and its impact on natural aging have long been a mystery . A study led by researchers…

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