Tag: cGAS-STING

Maintaining manganese in tumor to activate cGAS-STING pathway evokes a robust abscopal anti-tumor effect.

Affiliation Wang C(1), Sun Z(1), Zhao C(1), Zhang Z(1), Wang H(1), Liu Y(1), Guo Y(1), Zhang B(1), Gu L(2), Yu Y(2), Hu Y(3), Wu J(4).Author information: (1)State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University, School of Life Sciences, Nanjing University, Nanjing 210093, PR China. (2)State…

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First-of-its-kind platform generates antitumor immunity and improves responses to checkpoint inhibitors

Researchers at The University of Texas MD Anderson Cancer Center have developed an ultrasound-guided cancer immunotherapy platform that generates systemic antitumor immunity and improves the therapeutic efficacy of immune checkpoint blockade. The findings from the preclinical study were published today in Nature Nanotechnology. As the first-of-its-kind platform, the Microbubble-assisted UltraSound-guided…

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How a genetic mutation affects the body’s immune system response to viruses, development of blood cancers

Graphical abstract. Credit: Cell Reports (2022). DOI: 10.1016/j.celrep.2022.110856 The body’s innate immune system, active from birth, is the first line of defense against viruses and other pathogens that cause disease. Using vaccination as an example, after receiving a vaccine, pain, redness, or swelling may occur at the injection site. This…

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By keeping the Immune System in good condition, Gut Microbiome protects us from viral infections

The gut microbiota is crucial for health. However, how these non-invasive microbes communicate with the rest of the body to improve host physiology is not fully understood. Researchers from Stockholm, Umea, and Gothenburg Universities, Sweden, claim that the gut microbiota is essential for natural resistance to viral infections. This evidence…

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A non-canonical cGAS-STING-PERK pathway facilitates the translational program critical for senescence and organ fibrosis

This article was originally published here Nat Cell Biol. 2022 May 2. doi: 10.1038/s41556-022-00894-z. Online ahead of print. ABSTRACT Innate DNA sensing via the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) mechanism surveys microbial invasion and cellular damage and thus participates in various human infectious diseases, autoimmune diseases and cancers….

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Circulating cell-free mtDNA release is associated with the activation of cGAS-STING pathway and inflammation in mitochondrial diseases

Craven L, Alston C, Taylor R, Turnbull D (2017) Recent advances in mitochondrial disease. Annu Rev Genomics Hum Genet 18:257–275. doi.org/10.1146/annurev-genom-091416-035426 CAS  Article  PubMed  Google Scholar  El-Hattab AW, Adesina AM, Jones J, Scaglia F (2015) MELAS syndrome: clinical manifestations, pathogenesis, and treatment options. Mol Genet Metab 116(1–2):4–12. doi.org/10.1016/j.ymgme.2015.06.004 CAS  Article …

Continue Reading Circulating cell-free mtDNA release is associated with the activation of cGAS-STING pathway and inflammation in mitochondrial diseases

Role of cGAS-STING in SARS-CoV-2 infection

Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that led to the coronavirus disease 2019 (COVID-19) pandemic can cause various clinical presentations ranging from asymptomatic and mild disease to critical and even deadly outcomes. The pathogenesis of COVID-19 is directly associated with the destruction of lung epithelial cells,…

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Activation of STING by targeting a pocket in the transmembrane domain

Zhang, X., Bai, XC & Chen, ZJ Structures and mechanisms of the cGAS-STING innate immunity pathway. Immunity 5343–53 (2020). CAS PubMed Google Scholar Article Ishikawa, H. & Barber, GN STING is an endoplasmic reticulum adapter that facilitates innate immune signaling. Nature 455674–678 (2008). ADS CAS PubMed PubMed Central Article Google…

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Inhibition of cGAS-STING by JQ1 alleviates oxidative stress-induced retina inflammation and degeneration

Atrophic (“dry”) form of age-related macular degeneration (AMD) is a leading cause of vision loss characterized by macular retinal pigment epithelium (RPE) and the ensuing photoreceptor degeneration. cGAS-STING signaling is a key cytosolic DNA sensor system in innate immunity and have recently been shown promotes RPE degeneration. However, expression regulation…

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Wuhan University Song Zhiyin and other teams discovered a new mechanism of mitochondrial DNA release

Sam50 is a key component of the sorting and assembly machinery (SAM) complex and is also involved in bridging mitochondrial outer and inner membrane contacts. However, the physiological and pathological functions of Sam50 remain largely unknown. On March 21, 2022, Wuhan University Song Zhiyin and Meng Qingtao jointly published a…

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Type I Interferon Response Is Mediated by NLRX1-cGAS-STING Signaling in Brain Injury

doi: 10.3389/fnmol.2022.852243. eCollection 2022. Lauren E Fritsch  1 , Jing Ju  2 , Erwin Kristobal Gudenschwager Basso  3 , Eman Soliman  3 , Swagatika Paul  4 , Jiang Chen  2 , Alexandra M Kaloss  3 , Elizabeth A Kowalski  3 , Taylor C Tuhy  5 , Rachana Deven Somaiya  1 , Xia Wang  3 , Irving Coy Allen  3 , Michelle H…

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Enhanced cGAS-STING-dependent interferon signaling associated with mutations in ATAD3A

dc.identifier.citation Lepelley , A , Della Mina , E , Van Nieuwenhove , E , Waumans , L , Fraitag , S , Rice , G I , Dhir , A , Fremond , M-L , Rodero , M P , Seabra , L , Carter , E , Bodemer…

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STING Agonist-Mediated Cytokine Secretion Is Accompanied by Monocyte Apoptosis

doi: 10.1021/acsinfecdis.1c00554. Online ahead of print. Affiliations Expand Affiliations 1 Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo namesti 2, Prague 16000, Czech Republic. 2 Faculty of Science, Charles University, Albertov 6, Prague 12800, Czech Republic. Item in Clipboard Marketa Pimkova Polidarova et al. ACS Infect…

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The cGAS-STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy

Abstract The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling exert essential regulatory function in microbial-and onco-immunology through the induction of cytokines, primarily type I interferons. Recently, the aberrant and deranged signaling of the cGAS-STING axis is closely implicated in multiple sterile inflammatory diseases, including heart failure, myocardial infarction,…

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cGAS-STING Pathway in Infectious and Non-Infectious Diseases

The innate immune system has a critical role in the recognition and response to extracellular and intracellular pathogens. Pattern recognition receptors including Toll-like receptors (TLRs), C-type lectin receptors (CLRs), RIG-I-like receptors (RLRs), NOD-like receptors (NLRs), and cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) are responsible for recognizing these pathogens. cGAS…

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Study illustrates conservation of immune system’s cell death mechanisms originating billions of years ago in single-celled organisms. — ScienceDaily

The human immune system, that marvel of complexity, subtlety, and sophistication, includes a billion-year-old family of proteins used by bacteria to defend themselves against viruses, scientists at Dana-Farber Cancer Institute and in Israel have discovered. The findings, published online today by the journal Science, are the latest in a growing…

Continue Reading Study illustrates conservation of immune system’s cell death mechanisms originating billions of years ago in single-celled organisms. — ScienceDaily

Phospholipase A2 inhibitor and LY6/PLAUR domain-containing protein PINLYP regulates type I interferon innate immunity

Significance Interferon (IFN)-mediated antiviral responses serve as the first line of the host innate immune defense against viral infection. Here we identify a previously uncharacterized protein designated phospholipase A2 inhibitor and LY6/PLAUR domain-containing protein (PINLYP), which is essential for embryonic development and plays an important role in type I IFN…

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How the Innate Immune DNA Sensing cGAS-STING Pathway Is Involved in Autophagy

The cGAS-STING pathway is a key component of the innate immune system and exerts crucial roles in the detection of cytosolic DNA and invading pathogens. Accumulating evidence suggests that the intrinsic cGAS-STING pathway not only facilitates the production of type I interferons (IFN-I) and inflammatory responses but also triggers autophagy….

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Study reveals the role of intracellular receptor PQBP1 in response to Tau protein

Just as a home security system can alert a homeowner to the presence of an intruder, a protein called polyglutamine binding protein-1 (PQBP1) found in brain cells can alert the body to the presence of “intruding” viruses like human immunodeficiency virus (HIV). Now, researchers in Japan have shed new light…

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Frontiers | The cGAS-STING Pathway: A Promising Immunotherapy Target

Introduction Invaded by exogenous or endogenous pathogens, the host immune system will be activated accordingly to resist harm and maintain homeostasis, which includes innate immunity and adaptive immunity. As the first line of host immune defense, innate immunity plays a critical role in recognizing extracellular and intracellular pathogens (1, 2)….

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Tau and PQBP1: Protein Interaction Induces In

image: PQBP1 functions in brain microglia, which corresponds to dendritic cells or a part of macrophage regulating innate immune system, as an intracellular receptor for HIV cDNA and Tau proteins similarly. view more  Credit: Department of Neuropathology, TMDU Researchers from Tokyo Medical and Dental University clarify the role of cell receptor…

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Protein interaction induces inflammation in the brain — ScienceDaily

Just as a home security system can alert a homeowner to the presence of an intruder, a protein called polyglutamine binding protein-1 (PQBP1) found in brain cells can alert the body to the presence of “intruding” viruses like human immunodeficiency virus (HIV). Now, researchers in Japan have shed new light…

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mitochondrial dna damage triggers an ifn mediated immune response

2.6 Mitochondrial Damage-Induced Mitochondrial DNA Release is Central to Chronic Kidney Disease-Induced Type-I-Interferon Response in Vascular Smooth Muscle Cells DNA released from nuclear or mitochondria is the main source of endogenous DNA that activates cGAS-STING pathway. This is thought to be mediated by the presence 75 of leaked mitochondrial DNA…

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