Tag: cGAS-STING
Study illustrates conservation of immune system’s cell death mechanisms originating billions of years ago in single-celled organisms. — ScienceDaily
The human immune system, that marvel of complexity, subtlety, and sophistication, includes a billion-year-old family of proteins used by bacteria to defend themselves against viruses, scientists at Dana-Farber Cancer Institute and in Israel have discovered. The findings, published online today by the journal Science, are the latest in a growing…
Phospholipase A2 inhibitor and LY6/PLAUR domain-containing protein PINLYP regulates type I interferon innate immunity
Significance Interferon (IFN)-mediated antiviral responses serve as the first line of the host innate immune defense against viral infection. Here we identify a previously uncharacterized protein designated phospholipase A2 inhibitor and LY6/PLAUR domain-containing protein (PINLYP), which is essential for embryonic development and plays an important role in type I IFN…
How the Innate Immune DNA Sensing cGAS-STING Pathway Is Involved in Autophagy
The cGAS-STING pathway is a key component of the innate immune system and exerts crucial roles in the detection of cytosolic DNA and invading pathogens. Accumulating evidence suggests that the intrinsic cGAS-STING pathway not only facilitates the production of type I interferons (IFN-I) and inflammatory responses but also triggers autophagy….
Study reveals the role of intracellular receptor PQBP1 in response to Tau protein
Just as a home security system can alert a homeowner to the presence of an intruder, a protein called polyglutamine binding protein-1 (PQBP1) found in brain cells can alert the body to the presence of “intruding” viruses like human immunodeficiency virus (HIV). Now, researchers in Japan have shed new light…
Frontiers | The cGAS-STING Pathway: A Promising Immunotherapy Target
Introduction Invaded by exogenous or endogenous pathogens, the host immune system will be activated accordingly to resist harm and maintain homeostasis, which includes innate immunity and adaptive immunity. As the first line of host immune defense, innate immunity plays a critical role in recognizing extracellular and intracellular pathogens (1, 2)….
Tau and PQBP1: Protein Interaction Induces In
image: PQBP1 functions in brain microglia, which corresponds to dendritic cells or a part of macrophage regulating innate immune system, as an intracellular receptor for HIV cDNA and Tau proteins similarly. view more Credit: Department of Neuropathology, TMDU Researchers from Tokyo Medical and Dental University clarify the role of cell receptor…
Protein interaction induces inflammation in the brain — ScienceDaily
Just as a home security system can alert a homeowner to the presence of an intruder, a protein called polyglutamine binding protein-1 (PQBP1) found in brain cells can alert the body to the presence of “intruding” viruses like human immunodeficiency virus (HIV). Now, researchers in Japan have shed new light…
mitochondrial dna damage triggers an ifn mediated immune response
2.6 Mitochondrial Damage-Induced Mitochondrial DNA Release is Central to Chronic Kidney Disease-Induced Type-I-Interferon Response in Vascular Smooth Muscle Cells DNA released from nuclear or mitochondria is the main source of endogenous DNA that activates cGAS-STING pathway. This is thought to be mediated by the presence 75 of leaked mitochondrial DNA…
