Tag: CHO

Dyadic International : Presentation | MarketScreener

Dyadic International (NASDAQ: DYAI) Next Generation Proteins for World Health C1 Vaccine Technology Presentation Mark Emalfarb, Founder & CEO Vaccine Technology Summit September 15-16, 2022 London UK Safe Harbor Regarding Forward-looking Statements Certain statements contained in this presentation are forward-looking statements within…

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Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data

Visscher, P. M. et al. 10 years of GWAS discovery: biology, function, and translation. Am. J. Hum. Genet. 101, 5–22 (2017). CAS  PubMed  PubMed Central  Article  Google Scholar  Hekselman, I. & Yeger-Lotem, E. Mechanisms of tissue and cell-type specificity in heritable traits and diseases. Nat. Rev. Genet. 21, 137–150 (2020)….

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CLINICAL CHARACTERISTICS AND PROGNOSTIC FACTORS IN PRIMARY BREAST DIFFUSE LARGE B-CELL LYMPHOMA

Keywords Diffuse large B-cell lymphoma, Breast, Prognostic factors, Relapse, Central nervous system References [1] C. Wiseman, and K.T. Liao, Primary lymphoma of the breast. Cancer 29 (1972) 1705-12.www.ncbi.nlm.nih.gov/pubmed/4555557 [2] P.J. Hosein, J.C. Maragulia, M.P. Salzberg, O.W. Press, T.M. Habermann, J.M. Vose, M. Bast, R.H. Advani, R. Tibshirani, A.M. Evens, N….

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Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals

Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, US Usman A. Tahir, Daniel H. Katz, Jeremy M. Robbins, Zsu-Zsu Chen, Mark D. Benson, Daniel E. Cruz, Debby Ngo, Shuliang Deng, Xu Shi, Shuning Zheng, Aaron S. Eisman, Laurie Farrell, James G. Wilson & Robert E. Gerszten Broad Institute of Harvard and MIT, Cambridge, MA, US Julian Avila-Pachecho, Alexander G….

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“Increasing Production of Therapeutic mAbs in CHO Cells through Genetic” by Charles Barentine

Abstract Between 2014 and 2018, the global market for therapeutic monoclonal antibodies (mAbs) rose from $60 billion to $115.2 billion with a projected value of $300 billion by 2025. These molecules are used to effectively treat some of the most challenging illnesses from auto-immune diseases to cancer. While mAbs are…

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Recent Advances in 3D-Cultured Brain Tissue Models Derived from Human iPSCs

Heffernan, A.L., Hare, D.J.: Tracing environmental exposure from neurodevelopment to neurodegeneration. Trends Neurosci. 41, 496–501 (2018) CAS  PubMed  Article  Google Scholar  Pacitti, D., Privolizzi, R., Bax, B.E.: Organs to cells and cells to organoids: the evolution of in vitro central nervous system modelling. Front Cell Neurosci. 13, 129 (2019) CAS …

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SMAD4 rs10502913 | COPD

1Department of Pulmonary and Critical Care Medicine, Sinopharm Tongmei General Hospital, Datong, People’s Republic of China; 2China-Japan Friendship Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China; 3Department of Emergency, Chinese PLA General Hospital -Fourth Medical Center, Beijing, People’s Republic of China; 4School…

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The evolutionary origin of host association in the Rickettsiales

Salje, J. Cells within cells: Rickettsiales and the obligate intracellular bacterial lifestyle. Nat. Rev. Microbiol. 19, 375–390 (2021). CAS  PubMed  Article  Google Scholar  Wang, S. & Luo, H. Dating Alphaproteobacteria evolution with eukaryotic fossils. Nat. Commun. 12, 3324 (2021). CAS  PubMed  PubMed Central  Article  Google Scholar  Strassert, J. F. H.,…

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Plant-based Expression Systems are Gaining Mainstream Advantage

Industry adoption of plant-made biologics remains slow, but plant-based technology gains an advantage by mainstream exposure. While Chinese hamster ovary (CHO) cells are the workhorse of biologics production, other cell expression systems are starting to gain ground, such as plant-based expression systems. Though an older technology in and of itself,…

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Stabilizing and Anti-Repressor Elements Effectively Increases Transgene Expression in Transfected CHO Cells

doi: 10.3389/fbioe.2022.840600. eCollection 2022. Affiliations Expand Affiliations 1 School of Basic Medicine, Xinxiang Medical University, Xinxiang, China. 2 International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, China. Free PMC article Item in Clipboard Qin Li et al. Front Bioeng Biotechnol. 2022. Free PMC…

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Tramadol Therapy and CYP2D6 Genotype – Medical Genetics Summaries

Introduction Tramadol (brand names ConZip, Ultram, UltramER, Odolo) is an analgesic used to treat moderate to severe pain. It is used for a variety of pain conditions, including post-operative pain, cancer pain, and musculoskeletal pain. Tramadol is a centrally acting opioid analgesic with mu-opioid binding activity as well as weak…

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Roles of circRNAs | CMAR

Introduction Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, with an increasing global incidence, and a leading cause of cancer-related mortality.1 Although hepatitis B and C virus infections, cirrhosis, alcohol intake, and non-alcoholic fatty liver disease (NAFLD) are the main risk factors contributing to HCC.1,2 Approximately…

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Cells | Free Full-Text | Single-Cell Analysis of CHO Cells Reveals Clonal Heterogeneity in Hyperosmolality-Induced Stress Response

Hyperosmolality can occur during industrial fed-batch cultivation processes of Chinese hamster ovary (CHO) cells as highly concentrated feed and base solutions are added to replenish nutrients and regulate pH values. Some effects of hyperosmolality, such as increased cell size and growth inhibition, have been elucidated by previous research, but the…

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Bispecific antibodies | Scientist Live

Bispecific antibodies: rising stars in antibody therapeutics Monoclonal antibodies (mAbs) are important therapeutic agents for the treatment of many human diseases, such as cancer, autoimmune diseases, cardiovascular diseases, asthma, and viral infections. Unlike monospecific mAbs, bispecific antibodies (bsAbs) are antibodies containing two antigen-binding sites and therefore can simultaneously target two…

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MND1 Expression as a Predictor of Breast Cancer Survival

Introduction Breast cancer (BC) is the most commonly diagnosed cancer in women, and it is the main cause of cancer mortality in women around the world.1 Although standard treatments for breast cancer, including surgery, radiotherapy, chemotherapy, endocrine therapy, targeted therapy, and immunotherapy, have greatly improved during the last few decades.2,3…

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Recent developments in miRNA based recombinant protein expression in CHO

Aguiar TQ, Santos SB, Martins IM, Domingues L, Oliveira C (2019) Production and bioengineering of recombinant pharmaceuticals. Proteins: sustainable source, processing and applications. Elsevier, Amsterdam, pp 259–293 Chapter  Google Scholar  Amadi IM, Agrawal V, Christianson T, Bardliving C, Shamlou P, LeBowitz JH (2020) Inhibition of endogenous miR-23a/miR-377 in CHO cells…

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(PDF) Differential protein expression following low temperature culture of suspension CHO-K1 cells | Niraj Kumar

(PDF) Differential protein expression following low temperature culture of suspension CHO-K1 cells | Niraj Kumar – Academia.edu Academia.edu uses cookies to personalize content, tailor ads and improve the user experience. By using our site, you agree to our collection of information through the use of cookies. To learn more, view…

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Engineering and validation of a dual luciferase reporter system for quantitative and systematic assessment of regulatory sequences in Chinese hamster ovary cells

Experimental workflow and vector designs One way to validate the all-in-one reporter system is through transient or stable transfection of mammalian cells. Within this framework, the schematics in Fig. 1 illustrate the overall workflow of this study and feature the characteristics of promoters. To summarize, the study involves the engineering and…

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Indigenous Production of Industrially Important Recombinant Human Erythropoietin in Stable Huh-7 and CHO Cell Line

Recombinant human erythropoietin (rHuEPO) is one of the biopharmaceuticals that dominates the market due to the presence of large number of patients suffering from anemia associated with end-stage renal disease, cancer or AIDS. EPO is a glycoprotein mainly produced by kidney in adults and liver in fetus, involved in the…

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Innovative site-specific anti-HER2 antibody-drug conjugate

Introduction Antibody-drug conjugates (ADCs) have been studied for decades as a promising cancer treatment. As compared to conventional chemotherapy, ADCs have a larger therapeutic window because of their ability to target antigen-expressing tumor cells.1 As ADC drug development technology continues to evolve, several ADC drugs are being introduced to the…

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Gene variants of the SLC2A5 gene encoding GLUT5, the major fructose transporter, do not contribute to clinical presentation of acquired fructose malabsorption | BMC Gastroenterology

Fassio F, Facioni MS, Guagnini F. Lactose maldigestion, malabsorption, and intolerance: a comprehensive review with a focus on current management and future perspectives. Nutrients. 2018. doi.org/10.3390/nu10111599. Article  PubMed  PubMed Central  Google Scholar  Gibson PR, Newnham E, Barrett JS, et al. Review article: fructose malabsorption and the bigger picture. Aliment Pharmacol…

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An Introduction to the Biopharmaceutical Industry – Features

David Gemmell looks at key unit operations, and why chemical engineers are heavily involved in their design, troubleshooting or optimisation TO DATE, the Covid-19 pandemic has taken the lives of over 5.7m1 people and impacted global trade, travel, and the livelihoods of billions. It also sparked a vaccine…

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CRISPR-Cas13d for CHO Cell Engineering and Antibody Production

Abstract Chinese hamster ovary (CHO) cell is the predominant cell factory to produce biopharmaceuticals such as immunoglobulin G (IgG), but in CHO cells lactate accumulation and cell death compromise IgG production while fucosylation mitigates the antibody-dependent cellular cytotoxicity (ADCC) of IgG. To tackle these problems, we harnessed a burgeoning gene…

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Development of A Novel Anti-Epcam Monoclonal Antibody for Various Applications[v1]

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed Version 1 : Received: 28 March 2022 / Approved: 28 March 2022 / Online: 28 March 2022 (10:11:34 CEST) Li, G.; Suzuki, H.; Asano, T.; Tanaka, T.; Suzuki, H.; Kaneko, M.K.; Kato, Y. Development of A Novel Anti-Epcam…

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Hyperosmolality in CHO cell culture: effects on the proteome

Chinese hamster ovary (CHO) cells are the most commonly used host cell lines for therapeutic protein production. Exposure of these cells to highly concentrated feed solution during fed-batch cultivation can lead to a non-physiological increase in osmolality (> 300 mOsm/kg) that affects cell physiology, morphology, and proteome. As addressed in…

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Adapt Adherent CHO Cells To Suspension Culture

Chinese Hamster Ovary (CHO) cells are a popular workhorse for production of recombinant therapeutic proteins. Amenable to both adherent and suspension culture, CHO cells offer versatility in growth platform that is favorable to the end user’s requirements. So why the switch? Simply put, growing CHO cells in suspension will allow…

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Escherichia coli K-12 substr. MG1655 purA

BioCyc ID:TU00094 Synonyms: OP00133 Local Context (not to scale — see Genome Browser for correct scale) Transcription Unit Notes: Click on a binding site (if any) to navigate to the page for its transcription factor. Click on a gene to navigate to its gene page. Key to regulator colors: Green:…

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Cutting Edge Agriculture Gene Editing with Cas-CLOVER

Blog Agriculture Biotechnology Though CRISPR-Cas enabled targeted genome engineering across a vast array of organisms, the system features major disadvantages. Frequent off-target mutagenesis, licensing restrictions and non-ideal economic license terms have inhibited commercial crop-science product upscaling, and, in many cases, entirely disqualified CRISPR’s use by many commercial crop developers. Seeking…

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Cho Cell Line Development & Engineering: Impact On Biopharmaceutical Production: Essay Example, 2571 words

1. Introduction The approval of Chinese hamster ovary (CHO) cell cultures for the manufacturing of protein therapeutic products modernized conventional medicine. CHO cells remained the workhorse for the production of monoclonal antibodies (mAbs) for the last at least 20 years for different reasons. First, CHO cells are easily adapting and…

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BTG2 gene predicts poor outcome in PT-DLBCL

Introduction Primary testicular diffuse large B-cell lymphoma (PT-DLBCL) is a rare and aggressive form of mature B-cell lymphoma.1–3 PT-DLBCL was the most common type of testicular tumor in men aged over 60 and characterized by painless uni- or bilateral testicular masses with infrequent constitutional symptoms.4–6 PT-DLBCL shows significant extranodal tropism,…

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Wikswo and VIIBRE team on track to build third-generation ‘self-driving lab’ with $1M from National Science Foundation | News

John Wikswo, founder and director of the Vanderbilt Institute for Integrative Biosystems Research and Education and Gordon A. Cain University Professor, is the principal investigator of a $1 million award from the National Science Foundation. The object is to build a pathbreaking “robot scientist”—a fully automated microfluidic system for parallel,…

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Frontiers | Hair Graying Regulators Beyond Hair Follicle

Introduction Hair graying is one of the representative signs of aging. It has been considered to be triggered by a decreased number of follicular melanocyte stem cells (MeSCs; Nishimura et al., 2005; Iida et al., 2020) or dysfunction of MeSCs such as decreased oxidation resistance capacity with aging (Shi et…

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Fatty infiltration after rotator cuff tear

Introduction Rotator cuff tear (RCT) is a common shoulder disorder causing shoulder pain and disability. The prevalence of full-thickness RCT is 20.7% in the general population, and increased with age.1 Rotator cuff play essential roles in shoulder function and the treatment of proximal humeral fractures.2,3 It is important to repair…

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[Solved] ) What is the theoretical yield (in moles) of aluminum chloride (AlCl 3 -133.34 g/mol) if 0.385 mol of aluminum are reacted with 0.800 mol o…

1.) What is the theoretical yield (in moles) of aluminum chloride… – 133.34 g/mol) if 0.385 mol of aluminum are reacted with 0.800 mol of chlorine. (g) —> 2AlCl(s)   2.) A sample of impure potassium chloride weighing 0.4260 grams is dissolved in water and treated with an excess of silver…

Continue Reading [Solved] ) What is the theoretical yield (in moles) of aluminum chloride (AlCl 3 -133.34 g/mol) if 0.385 mol of aluminum are reacted with 0.800 mol o…

Translate chinese hamster ovary cells in Swedish

Computer translation Trying to learn how to translate from the human translation examples. English chinese hamster ovary cells Human contributions From professional translators, enterprises, web pages and freely available translation repositories. Add a translation English chinese hamster ovary cell Last Update: 2014-12-09 Usage Frequency: 1 Quality: English chinese hamster ovary…

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Radiosensitizing and cytotoxic effects of nitroimidazoles in CHO cells expressing elevated levels of glutathione-S-transferase

doi.org/10.1016/0360-3016(89)90304-0Get rights and content Abstract A cell line, CHO-Chlr, which has elevated levels of glutathione-S-transferase (GST), is resistant to damage caused by bi-functional nitrogen mustards. This cell line has a similar radiation sensitivity to and value of oxygen enhancement ratio as the wild type cells, CHO-KI, from which the mutant…

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Localization of small nuclear RNA by EM autoradiography in Chinese Hamster Ovary (CHO) cells

doi.org/10.1016/0014-4827(83)90345-2Get rights and content Abstract The ultrastructural localization of small nuclear RNA (snRNA) was studied by EM autoradiography in Chinese Hamster Ovary (CHO) cells. Conditions were set where most (>85 %) of the nuclear [3H]uridine label consisted of snRNA, the most abundant species being U1, U2 and the nucleolar species…

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Valine feeding reduces ammonia production through rearrangement of metabolic fluxes in central carbon metabolism of CHO cells

Aghamohseni H, Ohadi K, Spearman M, Krahn N, Moo-Young M, Scharer JM, Butler M, Budman HM (2014) Effects of nutrient levels and average culture pH on the glycosylation pattern of camelid-humanized monoclonal antibody. J Biotechnol 186:98–109. doi.org/10.1016/j.jbiotec.2014.05.024 CAS  Article  PubMed  Google Scholar  Altamirano C, Illanes A, Casablancas A, Gámez X,…

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WaiMasterClass Event 2 – [Kaggle for Data Scientists] Tickets, Sat, Jan 29, 2022 at 10:00 AM

Welcome from WaiMasterClass 2022 by Women in AI Myanmar! Women in AI Myanmar is hosting WaiMasterClass DataScience Series in 2022. There will be a total of 4 classes for this WaiMasterClass DataScience Series. This is our second event in Datascience series. In event 2, Aye Hninn Khine and Cho Zin…

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Establishment of serum-free adapted Chinese hamster ovary cells with double knockout of GDP-mannose-4,6-dehydratase and GDP-fucose transporter

Aggarwal RS (2014) What’s fueling the biotech engine-2012 to 2013. Nat Biotechnol 32:32–39. doi.org/10.1038/nbt.2794 CAS  Article  PubMed  Google Scholar  Becker DJ, Lowe JB (2003) Fucose: biosynthesis and biological function in mammals. Glycobiology 13:41–53. doi.org/10.1093/glycob/cwg054 CAS  Article  Google Scholar  Chan KF, Shahreel W, Wan C et al (2016) Inactivation of GDP-fucose…

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CHO Laboratory report – second draft.docx – Engineering of lipid-metabolism in CHO cells by overexpression of SCD1 Abstract Introduction Overall aim is

Engineering of lipid-metabolism in CHO cells by over-expression of SCD1AbstractIntroduction–Overall aim is to investigate how SCD1 over-expression influences target recombinant protein expression, as well as how temperature changes may add on to this influence in any capacity. Overexpression of the enzyme Stearoyl CoA desaturase 1 (SCD1) in Chinese Hamster Ovary…

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Molecular Basis for Retroviral Neuropathogenesis

Murine leukemia-inducing retroviruses (MuLVs) can undergo changes that allow them to cause neurological diseases in rodents, and understanding the molecular basis for these changes will give us insights into the genetic elements required for distinct disease phenotypes. We have been studying PVC-211 MuLV, a variant of the erythroleukemia-inducing Friend MuLV…

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The membrane structure of inner ear protein prestin is revealed

Force spectroscopy of prestin, the motor protein in the inner ear. Credit: Kanazawa University As mammals, we have very sensitive hearing, thanks to a process known as cochlear amplification. This amplification is down to sensory cells in the inner ear called outer hair cells (OHCs), and it is thought to…

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Low Glucose Cultivation of CHO cells by Advanced Control System,BR1000

Overview Low glucose cell cultivation (eg. ~1 g/L) for biopharmaceutical production requires frequent sampling and frequent glucose supplementation. The excessive sampling requirement not only reduces the volume of the culture medium, but also is an unnecessary burden on the operators when performed manually. Here, we demonstrated that the Advanced Control…

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High-Level Transient Recombinant Protein Production In CHO Suspension Cells Using Corning 5L Erlenmeyer Flasks

By Zhang Linyu, Xiao Hui, and Wang Xuebin, Corning Incorporated, Corning Life Sciences Asia Technology Center Mammalian cells are a well-established system for the expression of biologically active recombinant proteins and antibodies that possess appropriate post-translational modifications.1 Stable expression technologies have yielded kilograms of protein from mammalian cells.2 However, some…

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Dominant expression of multiple drug resistance after in vitro X-irradiation exposure in intraspecific Chinese hamster ovary hybrid cells | Health & Environmental Research Online (HERO)

BACKGROUND: Exposure of Chinese hamster ovary (CHO) cells to fractionated x irradiation in vitro has led to expression of a distinctive multiple-drug-resistant phenotype. This phenotype is characterized by overexpression of P-glycoprotein without an increase in P-glycoprotein messenger RNA or gene amplification; increased glutathione S-transferase (GST) activity; and resistance to vincristine,…

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GeneTonic: an R/Bioconductor package for streamlining the interpretation of RNA-seq data | BMC Bioinformatics

1. Van den Berge K, Hembach KM, Soneson C, Tiberi S, Clement L, Love MI, Patro R, Robinson MD. RNA sequencing data: Hitchhikers guide to expression analysis. Annu Rev Biomed Data Sci. 2019;2(1):139–73. doi.org/10.1146/annurev-biodatasci-072018-021255. Article  Google Scholar  2. Conesa A, Madrigal P, Tarazona S, Gomez-Cabrero D, Cervera A, McPherson A,…

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Zooplankton diversity monitoring strategy for the urban coastal region using metabarcoding analysis

1. Eyun, S. Phylogenomic analysis of Copepoda (Arthropoda, Crustacea) reveals unexpected similarities with earlier proposed morphological phylogenies. BMC Evol. Biol. 17, 23 (2017). PubMed  PubMed Central  Google Scholar  2. Eyun, S. et al. Evolutionary history of chemosensory-related gene families across the Arthropoda. Mol. Biol. Evol. 34, 1838–1862 (2017). CAS  PubMed …

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Identification of estrogen receptor beta expression in Chinese hamster ovary (CHO) cells and comparison of estrogen-responsive gene transcription in cells adapted to serum-free media

doi.org/10.1016/S0960-0760(03)00250-4Get rights and content Abstract Most cultured cell lines require addition of serum to the medium to maintain their proliferative capacity. For studies examining the cellular effects of estrogens serum is charcoal-stripped to remove steroids. Nonetheless, addition of the selective estrogen receptor modulator (SERM) 4-hydroxytamoxifen (4-OHT) inhibits the basal transcriptional…

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Reprogramming of Chinese hamster ovary cells towards enhanced protein secretion

Available online 17 December 2021 doi.org/10.1016/j.ymben.2021.12.004Get rights and content Highlights • Combined transcription factor engineering (BLIMP1 and XBP1s) reprogrammes CHO cell phenotype towards that of professional secretory cells. • Combinatorial transcription factor action generates additive responses (protein synthetic, secretory capacity, metabolic efficiency) towards a desirable phenotype. • Resultant new host…

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Sphere Fluidics Plans New Applications for Single-Cell Isolation, Assay Platform

NEW YORK – Sphere Fluidics is planning to use a recent fundraising round to build out new applications for its Cyto-Mine single-cell isolation and assay platform, with an eye toward gaining new customers in drug discovery and development. “There’s about 25 different things you’d like to prove in biopharma discovery,”…

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DNA damage and repair in CHO cells following hematoporphyrin photoradiation

doi.org/10.1016/0304-3835(80)90107-XGet rights and content Abstract The induction and repair of alkali labile lesions and single strand breaks in DNA of CHO cells following HpD photoradiation or X-irradiation has been examined. For treatments producing equal survival levels, the amount of DNA damage was less for HpD-photoradiated cells compared to X-irradiated cells….

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Mathematical model of the multi-amino acid multi-transporter system predicts uptake flux in CHO cells

Available online 9 December 2021 doi.org/10.1016/j.jbiotec.2021.12.003Get rights and content Highlights • First model for multi-amino acid multi-type-transporter system in CHO cells • Analytical expression for estimating amino acid uptake rates from concentration data • Predicts experimentally reported uptake rate from data not used in model formulation • Predicts change in…

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Frontiers | The cGAS-STING Pathway: A Promising Immunotherapy Target

Introduction Invaded by exogenous or endogenous pathogens, the host immune system will be activated accordingly to resist harm and maintain homeostasis, which includes innate immunity and adaptive immunity. As the first line of host immune defense, innate immunity plays a critical role in recognizing extracellular and intracellular pathogens (1, 2)….

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Ethnic Diversity of DPD activity and the DPYD Gene

Plain Language Summary Fluoropyrimidine (FP; 5-FU, capecitabine) is a common chemotherapy used to treat many different cancers, including cancer of the colon and rectum, upper digestive tract, breast and head and neck. Cancer patients who receive FP chemotherapy are at risk of developing severe side effects from their treatment. A…

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Official Pytorch Implementation of Relational Self-Attention, NeurIPS 2021

This repository is the official implementation of “Relational Self-Attention: What’s Missing in Attention for Video Understanding” by Manjin Kim*, Heeseung Kwon*, Chunyu Wang, Suha Kwak, and Minsu Cho (*equal contribution). Requirements Python: 3.7.9 Pytorch: 1.6.0 TorchVision: 0.2.1 Cuda: 10.1 Conda environment environment.yml To install requirements: conda env create -f environment.yml…

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Install pytorch in jetson nano

install pytorch in jetson nano Done! Getting Started with Jetson Nano In this tutorial, you will learn how to set up the NVIDIA ® Jetson ™ Nano and install everything you need to use the full power of the tiny embedded board. Git – Version Contol…

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miRNAs and mRNAs in intestinal ischemia-reperfusion injury

Introduction Intestinal ischemia-reperfusion (II/R) injury is a severe clinical complication common in the Intensive Care Unit (ICU). It is associated with high morbidity and mortality.1 Usually, this problem is followed by various causes, including sepsis, shock, trauma, and so on.2 Intestinal ischemia-reperfusion injury destroys intestinal tissue and impairs the function…

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Prognostic Biomarkers Identified for Pancreatic Ductal Adenocarcinoma Using Whole Genome Sequencing

Possible biomarkers for prognosis and clinical outcomes were identified, through the use whole exome sequencing and RNA sequencing, as therapeutic targets for patients with pancreatic ductal adenocarcinoma (PDAC), according to a recent study. The study, published in Therapeutic Advances in Medical Oncology, also reconfirmed genomic landscapes, major driver mutations, and…

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Comparative genomic analysis of Methanimicrococcus blatticola provides insights into host adaptation in archaea and the evolution of methanogenesis

1. Hackstein JH, Stumm CK. Methane production in terrestrial arthropods. Proc Natl Acad Sci USA. 1994;91:5441–5. CAS  PubMed  PubMed Central  Article  Google Scholar  2. Hackstein JHP, van Alen TA. Fecal methanogens and vertebrate evolution. Evolution. 1996;50:559–72. PubMed  Article  PubMed Central  Google Scholar  3. Borrel G, McCann A, Deane J, Neto…

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Antibiotic Resistance Genes | IDR

Witawat Tunyong,1 Weewan Arsheewa,2 Sirijan Santajit,3,4 Thida Kong-ngoen,1 Pornpan Pumirat,1 Nitat Sookrung,5,6 Wanpen Chaicumpa,6 Nitaya Indrawattana1 1Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand; 2Department of Microbiology, Phrapokklao Hospital, Chanthaburi, 22000, Thailand; 3School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, 80161, Thailand;…

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Nuclear protein in testis carcinoma

Introduction Nuclear protein in testis (NUT) carcinoma (NC) is defined by the rearrangement of the chromosomal region 15q14 harboring the NUTM1 gene. As a clinically aggressive neoplasm with poor differentiation, NC was previously believed to occur primarily in children and young adolescents. However, with an increasing number of reports, middle-aged…

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Infective endocarditis caused by ESBL-EC

Tsuneaki Kenzaka,1,2 Yuto Shinkura,1 Shizuo Kayama,3– 5 Liansheng Yu,3– 5 Sayoko Kawakami,3 Motoyuki Sugai,3– 5 Satoru Kawasaki1 1Department of Internal Medicine, Hyogo Prefectural Tamba Medical Center, Tanba, Japan; 2Division of Community Medicine and Career Development, Kobe University Graduate School of Medicine, Kobe, Japan; 3Antimicrobial Resistance Research Center, National Institute of…

Continue Reading Infective endocarditis caused by ESBL-EC