Tag: CircRNA

Overexpression of circRNA TCFL5 promotes proliferation, invasion, and migration of Eca109 and KYSE150. (a) qRT-PCR was used to detect whether the expression of circRNA TCFL5 is overexpressed or suppressed Eca109 and KYSE150 cells; (b) CCK-8 analysis was used to detect the proliferation of Eca109 and KYSE150 cells affected by circRNA…

Introduction Lung cancer is associated with high morbidity and mortality and continues to be a major public health problem worldwide (1). Lung adenocarcinoma (LUAD) is the most common histological type of lung cancer. While the 5-year survival rates of patients with lung cancer are still <15%, rates are closer to…

Introduction Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, with an increasing global incidence, and a leading cause of cancer-related mortality.1 Although hepatitis B and C virus infections, cirrhosis, alcohol intake, and non-alcoholic fatty liver disease (NAFLD) are the main risk factors contributing to HCC.1,2 Approximately…

Circular RNAs (circRNAs) are a novel class of regulatory RNA involved in many biological, physiological and pathological processes by functioning as a molecular sponge, transcriptional/epigenetic/splicing regulator, modulator of protein–protein interactions, and a template for encoding proteins. Cells are constantly dealing with stimuli from the microenvironment, and proper responses rely on…

The first sequenced genome of a person who died in Pompeii from the eruption of Mount Vesuvius is published in Scientific Reports this week. Pompeii, which was a major Roman port city in Italy, has been a major archeological site due to the well-preserved nature of both buildings and human…

This article was originally published here Autoimmunity. 2022 May 11:1-11. doi: 10.1080/08916934.2022.2073590. Online ahead of print. ABSTRACT BACKGROUND: Systemic lupus erythematosus (SLE) is defined as a multisystem autoimmune disease involving various organs, of which exact molecular mechanisms remain elusive. Here, we aimed to investigate a novel circular RNA (circRNA), circRACGAP1,…

Biogenesis, biology and characterization of circular RNAs Kristensen LS et al. The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet. (2019) Summary text Biogenesis and properties of circRNAs Biogenesis of cirRNA Characteristics of circRNAs Discover and analyze circRNAs circRNA genome-wide analysis CircRNA site-specific analysis circRNA visualization Biological functions…

The health of radiation workers has always been our focus. Epidemiological investigation shows that long-term exposure to low-dose ionizing radiation can affect human health, especially cancer and cardiovascular disease, and there are many studies on it. However, up to now, there have been few reports on the research of blood…

. 2022 Apr 19;S0361-9230(22)00098-3. doi: 10.1016/j.brainresbull.2022.04.006. Online ahead of print. Chun-Yan Li  1 , Wei Ma  2 , Kuang-Pin Liu  2 , Jin-Wei Yang  3 , Xian-Bin Wang  2 , Zhen Wu  3 , Tong Zhang  3 , Jia-Wei Wang  3 , Wei Liu  2 , Jie Liu  2 , Yu Liang  2 , Xing-Kui Zhang  2 , Jun-Jun Li  2 , Jian-Hui…

19 Pages Posted: 23 Mar 2022 See all articles by Pengfei Song University of Science and Technology Beijing University of Science and Technology Beijing University of Science and Technology Beijing University of Science and Technology Beijing University of Science and Technology…

Background: Aortic dissection (AD) is a rare and lethal disorder with its genetic basis remains largely unknown. Many studies have confirmed that circRNAs play important roles in various physiological and pathological processes. However, the roles of circRNAs in AD are still unclear and need further investigation. The present study aimed…

modern When Pfizer Made history with their mRNA COVID-19 vaccine. Vaccines have sent a new era of development of mRNA therapies, and after 11.4 billion doses, mRNA therapy is the future of treatments for many different conditions. Currently, other types of RNA therapies are also attracting attention, triggering exciting new…

image: rt-circRNA rtcisE2F is originated from two adjacent genes CYP2C18 and CYP2C19, involves in the binding between m6A E2F6/E2F3 mRNAs and m6A readers IGF2BP2/YTHDF2, and finally promotes the stability of E2F6/E2F3 mRNAs. E2F6 and E2F3 drive the activation of Wnt/β-catenin signaling and the self-renewal of liver TICs. view more  Credit: ©Science…

Rawla, P., Sunkara, T., Muralidharan, P. & Raj, J. P. Update in global trends and aetiology of hepatocellular carcinoma. Contemp. Oncol. (Poznan, Poland) 22, 141–150 (2018). CAS  Google Scholar  Kong, D. et al. Current statuses of molecular targeted and immune checkpoint therapies in hepatocellular carcinoma. Am. J. Cancer Res. 10,…

Background: Several types of RNA in the cell are usually involved in biological processes with multiple functions. Generally, coding RNAs translate to proteins, and non-coding ones regulate this translation in the gene regulatory networks. Some single-strand RNAs can create a circular shape via the back splicing process and convert into…

Sepsis patients and healthy controls A total of 62 sepsis patients (male/female: 32/30; mean age, 52.3±4.9 years) who were admitted to Minhang Hospital, Fudan University between March 2018 and March 2020 were enrolled in the study. In addition, 62 healthy controls (male/female: 32/30; mean age, 52.4±4.8 years) who were at…

Biochem Biophys Res Commun . 2022 Feb 23;601:137-145. doi: 10.1016/j.bbrc.2022.02.087. Online ahead of print. Affiliations Expand Affiliations 1 Fujian Institute of Hematology, Fujian Medical Center of Hematology, Clinical Research Center for Hematological Malignancies of Fujian Province, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian, 350001,…

Please use this url to cite or link to this publication: hdl.handle.net/1854/LU-8743723 MLA Vromman, Marieke, et al. “CIRCprimerXL: Convenient and High-Throughput PCR Primer Design for Circular RNA Quantification.” Frontiers in Bioinformatics, 2022, doi:10.3389/fbinf.2022.834655. APA Vromman, M., Anckaert, J., Vandesompele, J., & Volders, P.-J. (2022). CIRCprimerXL: Convenient and High-Throughput PCR Primer…

This article was originally published here Front Genet. 2022 Feb 10;12:793182. doi: 10.3389/fgene.2021.793182. eCollection 2021. ABSTRACT Background: Circular RNAs (circRNAs), which have broad posttranscriptional regulatory potencies, are involved in the pathogenesis of fibrotic diseases and are promising diagnostic biomarkers and therapeutic targets. However, their specific roles in renal fibrosis remain…

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circRNA quantification, differential expression analysis and miRNA target prediction of RNA-Seq data Introduction nf-core/circrna is a best-practice analysis pipeline for the quantification, miRNA target prediction and differential expression analysis of circular RNAs in paired-end RNA sequencing data. The pipeline is built using Nextflow, a workflow tool to run tasks across…

ABSTRACT Previous data have reported the high expression of circRNA paralemmin 2 (circPALM2) in mice with acute lung injury (ALI). However, the role of circPALM2 in ALI pathogenesis remains unclear. The study aims to reveal the function of circPALM2 in ALI and the underlying mechanism. C57BL/6 J mice and murine lung…

Circular RNAs (circRNAs) are a novel class of noncoding RNAs that play important roles in human diseases. However, the regulation of circRNAs in glucocorticoid-induced osteoporosis (GIOP) has not been reported. In this study, we performed high-throughput sequencing to identify altered circRNAs in the vertebrae from GIOP patients. A total of…

Graph Convolution Networks Using Message Passing and Multi-Source Similarity Features for Predicting circRNA-Disease Association | IEEE Conference Publication | IEEE Xplore Skip…

Regulatory RNAs involved in nerve cell signaling and structure were altered in cell and mouse models of Rett syndrome, with these changes also evident in tissue from deceased patients, a study reported. These findings aid in understanding the biological processes impaired in Rett and may reveal potential biomarkers to help…

Background: Circular RNAs (circRNAs) have been demonstrated to be closely related to the carcinogenesis of human cancer in recent years. However, the molecular mechanism of circRNAs in the pathogenesis of hepatocellular carcinoma (HCC) has not been fully elucidated. We aimed to identify critical circRNAs and explore their potential regulatory network…

This article was originally published here Int J Gen Med. 2021 Dec 29;14:10423-10428. doi: 10.2147/IJGM.S343889. eCollection 2021. ABSTRACT BACKGROUND: The role of circRNA circ_0071662 has been studied in bladder cancer. The present study aimed to analyze its involvement in esophageal squamous cell carcinoma (ESCC). METHODS: Patients with ESCC (n =…

LDLRAD3 activated the mTORC1 pathway to facilitate malignant behaviors of NSCLC cells via the miR-20a-5p-SLC7A5 axis. (a) The phosphorylation levels of proteins were analyzed by immunohistochemistry. Scale bars: 50 μm. (b) The expression levels and phosphorylation levels of proteins in cotransfected cells were analyzed by western blot. (c) The proliferation of…

Abstract The antisense non-coding RNA in the INK locus (ANRIL) is a hotspot for genetic variants associated with cardiometabolic disease. We recently found increased ANRIL abundance in human pancreatic islets from donors with certain Type II Diabetes (T2D) risk-SNPs, including a T2D risk-SNP located within ANRIL exon 2 associated with…

doi: 10.3389/fgene.2021.772557. eCollection 2021. Chun Huang  1 , Fei Ge  1 , Xiaoming Ma  1 , Rongfeng Dai  1 , Renqing Dingkao  2 , Zhuoma Zhaxi  3 , Getu Burenchao  3 , Pengjia Bao  1 , Xiaoyun Wu  1 , Xian Guo  1 , Min Chu  1 , Ping Yan  1 , Chunnian Liang  1 Affiliations Expand Affiliations 1 Key Laboratory of…

  Basic information Title: ciRS-7 is a prognostic biomarker and potential gene therapy target for renal cell carcinoma   Journal: Molecular Cancer     Impact factor: 27.401   Vazyme products:   HiScript® III 1st Strand cDNA Synthesis Kit (+gDNA wiper)（number: Vazyme #R312, for 1st Strand cDNA Synthesis） AceQ® qPCR SYBR Green Master Mix (High ROX Premixed)（number: Vazyme…

A brief introduction mRNA,miRNA,lncRNA And circRNA Principle of genome sequencing 、 Routine analysis of Shengxin . Catalog Introduction to transcriptome sequencing mRNA|miRNA|lncRNA|circRNA Introduction to analysis mRNA Group miRNA Group lncRNA Group circRNA Group mRNA|miRNA|lncRNA|circRNA Correlation analysis Reference Introduction to transcriptome sequencing Transcriptome （Transcriptome） Is a single or group of cells…

The circRNAs sequencing results vary due to the different enrichment methods and their performance is needed to systematic comparison. This study investigated the effects of different circRNA enrichment methods on sequencing results, including abundance and species of circRNAs, as well as the sensitivity and precision. This experiment was carried out…

Introduction Intestinal ischemia-reperfusion (II/R) injury is a severe clinical complication common in the Intensive Care Unit (ICU). It is associated with high morbidity and mortality.1 Usually, this problem is followed by various causes, including sepsis, shock, trauma, and so on.2 Intestinal ischemia-reperfusion injury destroys intestinal tissue and impairs the function…

How to construct circRNA-miRNA-mRNA network using cytoscape 1 Hi, If I have a selected set of circRNAs, miRNAs, mRNAs, then how can I construct an interaction network among them through Cytoscape. Is there any Cytoscape plugin for that and what should be the input file format? Please guide me to…