Tag: CircRNA

Rostral ventrolateral medulla (RVLM) is thought to serve as a major vasomotor center that participates in controlling the progression of stress-induced hypertension (SIH). Circular RNAs (circRNAs) perform important functions in the regulation of diverse physiological and pathological processes. However, information concerning the functions of RVLM circRNAs on SIH remains limited….

Objective: To investigate the effect of titanium dioxide nanoparticles (TiO2 NPs) on the expression profile of circular ribonucleic acid (circRNA) in human hepatocytes through in vitro cell experiments, and to attempt to understand the potential mechanism of hepatotoxicity through bioinformatics analysis. Methods: TiO2 NPs were characterized from the aspects of…

Introduction and objectives: The development of hepatocellular carcinoma (HCC) is a multi-step process that accumulates genetic and epigenetic alterations, including changes in circular RNA (circRNA). This study aimed to understand the alterations in circRNA expression in HCC development and metastasis and to explore the biological functions of circRNA. Materials and…

An unusual genetic quirk has been found as a cause of critical genetic mutations that could eventually lead to the onset of cancer and other diseases. And it’s not something related to the outside world, nor perhaps inherited from one’s parents. Instead, it’s a problem that simply happens within the…

Behavioral testing After undergoing a four-day training program, the mice were subjected to a positioning cruise experiment on the fifth day. The experiment involved comparing the escape latency and swimming distance in the quadrant opposite to the platform between the WD group and the control group. The findings indicated that…

doi: 10.1055/a-2051-8693. Online ahead of print. Affiliations Expand Affiliations 1 Department of Proctology, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan, China. 2 Department of Anesthesiology, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan, China. Item in Clipboard Zhong Li et al. Horm Metab Res. 2023. Show details Display…

NEW YORK – Molecular diagnostics startup Circular Genomics sees a more direct way to predict patient response to psychiatric medications by analyzing circular RNA (circRNA) molecules that brain cells shed into the bloodstream. The University of New Mexico spinout is focusing its efforts first on major depressive disorder (MDD), then…

Review . 2023 May 18;14:1123448. doi: 10.3389/fmicb.2023.1123448. eCollection 2023. Affiliations Expand Affiliation 1 School of Life Sciences, Jiangsu University, Zhenjiang, China. Item in Clipboard Review Yi-Xuan Fan et al. Front Microbiol. 2023. Show details Display options Display options Format AbstractPubMedPMID . 2023 May 18;14:1123448. doi: 10.3389/fmicb.2023.1123448. eCollection 2023. Affiliation 1 School…

[1] Greene NDE, Copp AJ. Neural tube defects. Annu Rev Neurosci, 2014; 37, 221−42. [2] Marean A, Graf A, Zhang Y, et al. Folic acid supplementation can adversely affect murine neural tube closure and embryonic survival. Hum Mol Genet, 2011; 20, 3678−83. …

RNAseq (HiSeq, Gene level, Tumor) Download RNAseq data RSEM upper-quartile normalized (Illumina HiSeq platform, Gene-level) gene Expression (RSEM-UQ, Log2(Val+1)) 140 28057 cct RNAseq (HiSeq, Gene level, Normal) Download RNAseq data RSEM upper-quartile normalized (Illumina HiSeq platform, Gene-level) gene Expression (RSEM-UQ, Log2(Val+1)) 21 28057 cct RNAseq (HiSeq, Gene level, Duct) Download…

Int J Biol Sci 2023; 19(9):2879-2896. doi:10.7150/ijbs.84994 This issue Cite Review Wujun Chen1#, Jiazhen Xu1#, Yudong Wu1, Bing Liang1, Mingzhe Yan1, Chuandong Sun1,2, Dong Wang1,2, Xiaokun Hu1,3, Li Liu1,4, Wenchao Hu1,5, Yingchun Shao1✉, Dongming Xing1,6✉ 1. Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao Cancer…

Background: Lysosomal cathepsin D (CTSD) can degrade internalized advanced glycation end products (AGEs) in dermal fibroblasts. CTSD expression is decreased in photoaged fibroblasts, which contributes to intracellular AGEs deposition and further plays a role in AGEs accumulation of photoaged skin. The mechanism under downregulated CTSD expression is unclear. Objective: To…

1Medical Research Center, the Second Affiliated Hospital of Zhengzhou University, China 2Department of Reproductive Medicine, Second Affiliated Hospital of Zhengzhou University, China 3Department of Clinical Laboratory, Second Affiliated Hospital of Zhengzhou University, China The final, formatted version of the article will be…

***Special callout as one of the lead researchers who performed this work, Piotr Kowalski, has an open position at his lab in ireland! LINK Explain Like I’m Five | ELI5 To my friends and family not in the biopharma industry: This article talks about circular RNA, which is a special…

Datasets To verify the effectiveness of the CircSSNN, we adopted 37 circRNA datasets as benchmark datasets following the baselines we compared [15, 16]. We first downloaded the datasets from the circRNA interactome database (circinteractome.nia.nih.gov/). Subsequently, we obtained 335,976 positive samples and 335,976 negative samples following the process of iCircRBP-DHN [17]….

1 Introduction Stroke is the leading cause of permanent disability (Diener and Hankey, 2020). The latest global burden of disease (GBD) study (GBD 2019 Diseases and Injuries Collaborators, 2020) indicated that stroke is the leading cause of death in the Chinese population. The overall lifetime risk of stroke in China…

SINGAPORE – A vaccine for the Nipah virus could be on the horizon, thanks to research on a new vaccine technology. Vaccine research organisation Hilleman Laboratories has announced a collaboration with the Agency for Science, Technology and Research (A*Star) to study the use of novel circular ribonucleic acid (circRNA) technology…

foreword Since the circRNA molecule was discovered in the plant virus genome in 1976, after more than 30 years of silence, it finally became a blockbuster in 2012, and quickly became a new generation of star molecules in the following years. In the past ten years, as scientific researchers have…

Osteoarthritis (OA) is the most common joint disease globally, and its progression is irreversible. The mechanism of osteoarthritis is not fully understood. Research on the molecular biological mechanism of OA is deepening, among which epigenetics, especially noncoding RNA, is an emerging hotspot. CircRNA is a unique circular noncoding RNA not…

Received: 19 January 2023 / Revised: 2 May 2023 / Accepted: 16 May 2023 / Published: 19 May 2023 Round 1 Reviewer 1 Report Terrazan and coworkers presented the manuscript entitled “ Inverse impact of cancer drugs on circular and linear RNAs in 2 breast cancer cell lines ”. The…

Background. Calcific aortic valve disease (CAVD) is the most common native valve disease. Valvular interstitial cell (VIC) osteogenic differentiation and valvular endothelial cell (VEC) dysfunction are key steps in CAVD progression. Circular RNA (circRNAs) is involved in regulating osteogenic differentiation with mesenchymal cells and is associated with multiple disease progression,…

Oslo – Circio Holding ASA (formerly Targovax ASA) (OSE: TRVX) Circio’s management and Board of Directors today held a live webcast. In the webcast, CEO Erik D. Wiklund provided a brief company presentation, together with an update on the circRNA-platform, followed by a Q&A session with representatives from the Compensation…

These plasmids were created by your colleagues. Please acknowledge the Principal Investigator, cite the article in which the plasmids were described, and include Addgene in the Materials and Methods of your future publications. For your Materials & Methods section: circRNA-synIRES-R25-mNeonGreen was a gift from Howard Chang (Addgene plasmid # 188115…

Oslo, Norway, 16 May 2023 – Circio Holding ASA (formerly Targovax ASA*) (OSE: TRVX) Circio’s management and Board of Directors today held a live webcast. In the webcast, CEO Erik D. Wiklund provided a brief company presentation, together with an update on the circRNA-platform, followed by a Q&A session with…

Some mitochondrial mRNA are circularized CircTAIL-seq is a technique used to Illumina sequence individual transcript PCR libraries of mitochondrial mRNA tails. The approach captures enough of each molecule’s 5′ and 3′ termini that the presence of editing can be confirmed if necessary17. Library preparation first requires circularizing total RNA with…

Oslo, Norway, 12 May 2023 – Circio Holding ASA (formerly Targovax ASA*) (OSE: TRVX): Circio’s management and Board of Directors invite to a live webcast on Tuesday 16 May at 10am CEST. In the webcast, CEO Erik D. Wiklund will provide a brief company update, followed by a Q&A session…

. 2023 Feb 23;20(5):7957-7980. doi: 10.3934/mbe.2023345. Affiliations Expand Affiliation 1 College of Information and Computer, Taiyuan University of Technology, Taiyuan 030024, China. Item in Clipboard Huiqing Wang et al. Math Biosci Eng. 2023. Show details Display options Display options Format AbstractPubMedPMID . 2023 Feb 23;20(5):7957-7980. doi: 10.3934/mbe.2023345. Affiliation 1 College of…

Meningioma is most common non-malignant brain tumor with more than 170,000 diagnosed in U.S. annually INDIANAPOLIS, May 4, 2023 /PRNewswire/ — NICO Corporation, an Indianapolis-based pioneer and leader in minimally invasive neurosurgery, has awarded a $40,000 grant to Daniel Prevedello, MD, vice chair for Academic Affairs and director of Skull…

Circular RNAs (circRNAs) play important roles in the regulation of cancer. However, the clinical implications and regulatory networks of circRNAs in cancer patients receiving immune checkpoint blockades (ICB) have not been fully elucidated. Here, we characterize circRNA expression profiles in two independent cohorts of 157 ICB-treated advanced melanoma patients and…

Oslo – Circio Holding ASA (formerly Targovax ASA) (OSE: TRVX) today announces that an abstract describing its circular RNA platform has been accepted for poster presentation at the 2023 American Society of Gene + Cell Therapy (ASGCT) Annual Meeting in Los Angeles, USA. The abstract describes the development of Circio’s…

Oslo, Norway, 3 May 2023 – Circio Holding ASA (formerly Targovax ASA*) (OSE: TRVX) today announces that an abstract describing its circular RNA platform has been accepted for poster presentation at the 2023 American Society of Gene + Cell Therapy (ASGCT) Annual Meeting in Los Angeles, USA. The abstract describes…

Organ fibrosis is the final common pathological pathway of many chronic diseases and is characterized by various injuries and insults with maladaptive tissue repair, followed by excessive collagen deposition into the extracellular matrix (ECM). Structural alterations lead to tissue stiffness, vascular rarefaction, hypoxia, proliferation, differentiation and activation of fibroblasts and…

CircRNA expression profiles in GC progression plus bioinformatics prediction analysis High-throughput individual circRNA microarray was conducted using plasma sample free 10 GC patients, containing 5 patients with T1-3N0M0 (case1) and the other 5 sufferers with T3 N1-3 M0 (case2), and 5 normal individuals (control) up judgment circRNA expressing profiles in GC progression….

33 news-img” onclick=”openPopup(myItems);”> news-txt”> (ANSA) – ROME, APRIL 26 – Italian scientists have discovered small circular RNA molecules (so called because they have a ring structure) that could play a role in rhabdomyosarcoma, a highly prevalent pediatric cancer. Announced in Nature Communications, the results of this research pave the way…

Norwegian biotech Targovax recently said it’s planning to rebrand as Circio, marking its shift from clinical stage immuno-oncology company to one focused on circular RNA (circRNA) therapeutics. The name change is subject to approval by Targovax’s shareholders, who are set to vote at the company’s annual general meeting on May…

Ren J, Yan X, Ai H, Zhang Z, Huang X, Ouyang J, Yang M, Yang H, Han P, Zeng W, et al. Susceptibility towards enterotoxigenic Escherichia coli F4ac diarrhea is governed by the MUC13 gene in pigs. PLoS ONE. 2012;7(9):e44573. Article  CAS  PubMed  PubMed Central  Google Scholar  Guinée P, Jansen…

Circio will focus on expediting the development of its innovative circular RNA (circRNA) platform. Credit: Herney Gómez from Pixabay. Targovax has unveiled plans to rebrand as Circio, reflecting its strategic shift to focus on expediting the development of its innovative circular RNA (circRNA) platform. Initially reported in 2011, CircRNA is…

Circular RNAs (circRNAs) have been shown to play a crucial role in cancer occurrence and progression. This present work investigated the link between hsa_circ_0008234 and colon cancer. Data retrieved from GSE172229 was used to compare the circRNA profiles of colon cancer and surrounding non-tumorous tissues. The amount of RNA and…

· The name Circio encapsulates the strategic shift to focus on the innovative, proprietary circular RNA (circRNA) platform · circRNA has the potential to outperform mRNA, and Circio’s pipeline is initially targeting cancer, with plans to rapidly expand into vaccines and gene therapy · International patent applications covering Circio’s vector…

Introduction Gout is an inflammatory disease caused by the deposition of monosodium urate (MSU) crystals in joints and other non-joint tissues. The main clinical manifestations of gout include recurrent joint redness, swelling, heat and pain, and even joint mutilation, urinary acid nephropathy and renal failure.1,2 The incidence and prevalence of…

A Novel CircRNA Circ_0001722 Regulates Proliferation and Invasion of Osteosarcoma Cells Through Targeting miR-204-5p/RUNX2 Axis Abstract Osteosarcoma (OS) is the most prevalent primary fatal bone neoplasm in adolescents and children owing to limited therapeutic methods. Circular RNAs (circRNAs) are identified as vital regulators in a variety of cancers. However, the…

With the rapid development of next-generation sequencing technology, several studies have shown that ncRNAs can act as competitive endogenous RNAs (ceRNAs) and are involved in various biological processes, such as proliferation, differentiation, apoptosis, and migration of breast cancer (BC) cells, and plays an important role in BC progression as a…

CircRNA, the latest research hotspot in the field of RNA, is a special non-coding RNA molecule, which is unable to encode proteins and bind polyribosomes. As a regulatory molecule, circRNA participates in cancer cell generation and progression mainly through the mechanism of competitive endogenous RNA. In numerous regulated cancer organs,…

Circular RNAs (circRNAs) are a novel type of endogenous non-coding RNAs, which are covalently closed loop structures formed by precursor mRNAs (pre-mRNAs) through back-splicing. CircRNAs are abnormally expressed in many tumors, and play critical roles in a variety of tumors as oncogenes or tumor suppressor genes by sponging miRNAs, regulating…

. 2023 Apr 13;18(4):e0283589. doi: 10.1371/journal.pone.0283589. eCollection 2023. Hassan Ayaz  1 , Nouman Aslam  1 , Faryal Mehwish Awan  1 , Rabea Basri  1 , Bisma Rauff  2 , Badr Alzahrani  3 , Muhammad Arif  1 , Aqsa Ikram  4 , Ayesha Obaid  1 , Anam Naz  4 , Sadiq Noor Khan  1 , Burton B Yang  5   6  …

Introduction Cervical cancer (CC) is one of the most widespread gynaecological cancers that threatens women’s health in developing countries.Citation1 CC progresses through a long stage of precancerous lesions, called cervical intraepithelial neoplasia (CIN), which is classified into three grades: CIN 1, CIN 2 and CIN 3.Citation2 Human papillomaviruses (HPVs) have…

Introduction Breast cancer is the second most common cancer and is the leading cause of cancer-related death among females worldwide with over 2 million newly diagnosed cases and more than 60 thousand deaths every year.Citation1 Despite advances in treatment, the mortality rate of breast cancer remains high, mainly due to…

Comput Struct Biotechnol J. 2023; 21: 2276–2285. ,a,1 ,a,1 ,a ,b,c and a,b,⁎ Leiming Jiang aComputational Systems Biology Laboratory, Department of Bioinformatics, Shantou University Medical College (SUMC), 515041 Shantou, China Shijia Hao aComputational Systems Biology Laboratory, Department of Bioinformatics, Shantou University Medical College (SUMC), 515041 Shantou, China Lirui Lin aComputational…

Abstract The detection of circular RNA molecules (circRNAs) is typically based on short-read RNA sequencing data processed by computational detection tools. During the last decade, a plethora of such tools have been developed, but a systematic comparison with orthogonal validation is missing. Here, we set up a circRNA detection tool…

1. Introduction Many studies have identified some non-coding RNAs (ncRNAs) with abnormal expressions in several diseases and/or disorders [1]. Among them, circular RNAs (circRNAs) are a special type of endogenous ncRNAs, probably formed by back-splicing events, which have attracted more and more interest nowadays. CircRNAs are closed loop structures [2],…

Good quality ZnO films have been accomplished soon after mindful optimisation associated with essential growth circumstances: the sequence associated with Zn along with A supply wooden shutters, expansion temp for both the ZnO nucleation as well as development covering, as well as Zn/O percentage. O2 plasma televisions pretreatment wasn’t applied…

Emerging studies have shown that circular RNAs (circRNAs) are involved in a variety of biological processes and play a key role in disease diagnosing, treating and inferring. Although many methods, including traditional machine learning and deep learning, have been developed to predict associations between circRNAs and diseases, the biological function…

Figure 1. Identification and validation of hsa_circ_0008234 in colon cancer Notes: (A): The highest five increased and decreased circRNAs between the normal and colon cancer tissue obtained from the GSE172229. (B): Volcano plot of the differentially expressed circRNAs with the threshold of |logFC| > 1 and p < 0.05. (C):…

Abstract Circular RNA and long noncoding RNA function as efficient miRNA sponges that regulate gene expression in eukaryotes. However, the sponges of functional miRNAs in glioblastoma remain largely unknown. Here, we identify a subset of circRNAs and lncRNAs that are specifically increased in miR-422a–downregulated glioblastoma tissues. We characterized a novel…

Cancer Breast cancer (BC) is a prevalent form of cancer among women globally. Recent studies suggest that circular RNA (circRNA) plays a significant role in BC progression, but the biological functions and underlying mechanisms remain unexplored. According to a recent study published in the Journal of Translational Medicine, the interaction…

In the past few years, our company absorbed and digested advanced technologies both at home and abroad. Meanwhile, our company staffs a team of experts devoted to the development of Bioinformatics Companies , Otu , Competing Endogenous Rna , Sincerely hope we are growing up together with our customers all…

Background: Exosomal circRNAs played critical roles in tumor development and progression and might be novel biomarkers in the diagnosis and treatment of various cancers. However, the biological functions and clinical implications of exosomal circRNAs in breast cancer are unclear. Methods: Expression profiles of exosomal circRNAs in exoRBase 2.0 database were…

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. At present, the mechanism of non-coding RNA in renal injury in SLE patients is still unclear. A total of 64 DEcircRNAs, 75 DEmiRNAs, and 249 DEmRNAs were identified. We integrated 10 circRNAs, 10 miRNAs, and 88 target mRNAs into a circRNA-miRNA-mRNA…

FOR IMMEDIATE RELEASE Research from Johns Hopkins Kimmel Cancer Center experts revealed a type of RNA, previously considered to be “junk,”  that may help doctors distinguish and treat a subgroup of patients with medulloblastoma. Medulloblastoma is the most common malignant brain tumor in children, accounting for about 20% of all…

Introduction Coronary heart disease (CHD) is the most common heart condition worldwide and the leading cause of death of elderly men and women (1). Despite recent declines in developed countries, both CHD morbidity and mortality continue to increase rapidly in developing countries. Various factors are involved in CHD pathogenesis, including…

Oslo, Norway, 15 March 2023 – Targovax ASA (OSE: TRVX) today announces that an abstract describing its circular RNA platform has been accepted for poster presentation at the 2023 American Association for Cancer Research (AACR) Annual Meeting in Orlando, USA. The abstract describes the advantage of protein expression utilizing Targovax´proprietary…

Objects To evaluate the hsa_circ_0001445 level in peripheral blood leukocytes of patients with coronary heart disease (CHD) and its related clinical factors, and predict its circRNA-miRNA-mRNA regulatory network in CHD pathogenesis via bioinformatics analysis. Methods Peripheral blood leukocytes were isolated from the whole blood samples of 94 CHD patients (aged…

Grabowski P, Zaug A, Cech T. The intervening sequence of the ribosomal RNA precursor is converted to a circular RNA in isolated nuclei of Tetrahymena. Cell. 1981;23(2):467–76. Article  CAS  PubMed  Google Scholar  Ye C, Chen L, Liu C, Zhu Q, Fan L. Widespread noncoding circular RNAs in plants. New Phytol….

In molecular biology, Circular RNAs (circRNAs) refer to a class of circular RNA molecules found across all kingdoms of life.[1][2][3] Studies in 2013 have suggested that circRNAs play important regulatory roles in miRNA activity. Researchers found that CDR1as circRNA acts as a miR-7 super-sponge that contains about 70 target sites…

Sci-Hub | Comprehensive circRNA-microRNA-mRNA network analysis revealed the novel regulatory mechanism of Trichosporon asahii infection. Military Medical Research, 8(1) | 10.1186/s40779-021-00311-w ◂ ↓ save Zhang, M.-W., Zhu, Z.-H., Xia, Z.-K., Yang, X., Luo, W.-T., Ao, J.-H., & Yang, R.-Y. (2021). Comprehensive circRNA-microRNA-mRNA network analysis revealed the novel regulatory mechanism of…

General Questions What information should I know before I do the RIP-Seq? Before doing a RIP-SEQ you generally need to specify • The type of sample to be done • What RBPs are of interest • Whether IP-level antibodies are available for these RBPs • The type…

Abstract Accumulating evidence indicates more and more circular RNAs (i.e. circRNAs) have played a vital role in regulating gene expression and are related to diseases through different biological procedures. Predicting circRNA-disease associations helps to conjecture possible disease related circRNA and facilitate human disease diagnosis and downstream treatment. Nevertheless, little effort…

Introduction Osteoporosis is a frequently diagnosed disease of the bone featured by reduced bone tissue quality as well as a reduced mass of bone tissues. It was determined that > 20 million people suffer from various degrees of osteoporosis at any moment.1,2 Although various therapeutic approaches and agents, such as…

In this study, we identified that a conserved circular RNA (circRNA) DICAR, which was downregulated in diabetic mouse hearts. DICAR had an inhibitory effect on diabetic cardiomyopathy (DCM), as the spontaneous cardiac dysfunction, cardiac cell hypertrophy, and cardiac fibrosis occurred in DICAR deficiency (DICAR+/-) mice, whereas the DCM was alleviated…

· Targovax has an early-mover advantage in circRNA, a novel area of RNA therapeutics attracting substantial interest from pharma and investors internationally · Targovax remains confident in the significant potential of ONCOS-102, but due to the currently challenging market conditions phase 2 development will only proceed once a partnership or…

Press Release Summary: Provides quality assessment for purified exosomal RNAs utilizing real-time PCR and electrophoresis Supports exoLR characterization and the development of companion diagnostics and other applications Ideal for analysis of mRNA, circRNA and lncRNA in exosomes Original Press Release: CD Genomics’ RNA-Solutions Platform Now Supports Exosomal RNA Research CD Genomics’…

Please use this identifier to cite or link to this item: hdl.handle.net/2445/184005 Title:  Role of the epithelial-mesenchymal transition-related circular RNA, circ-10720, in non-small-cell lung cancer Author:  Martín, JaraCastellano, Joan JosepMarrades Sicart, Ramon Ma.Canals, JordiViñolas Segarra, NúriaDíaz Sánchez, TaniaMolins López-Rodó, LaureanoMartinez, DanielHan, BingMoisés, JorgeHe, YangyiMonzó Planella, MarianoNavarro Ponz, Alfons Keywords:  Càncer…

Hello, I’m currently trying to analyze an RNA-seq data set of about 10500 samples (including biological replicates) and initially noticed some strange outputs in my differential expression output file. I am using the CIRIquant pipeline with the built-in differential expression function which uses the edgeR module to calculate DE circular…

Institute of Life Sciences (ILS) was established in the year 1989 as an autonomous institute under the administrative control of Govt. of Odisha. In 2002, it was taken over by the Department of Biotechnology, Govt. of India. The Prime Minister of India Shri Atal Bihari Vajpayee dedicated the institute to…

CD Genomics’ RNA-Solutions is a platform for revolutionary research in RNA, targeting coding and non-coding RNAs with different physiological functions. Based on rich RNA project experience and leading bioinformatics analytical capabilities, CD Genomics has launched a systematic solution for exosomal RNA research that assists in in-depth identification and functional analysis…

Cerebral ischaemiareperfusion injury is an important pathological process in nervous system diseases during which neurons undergo oxygenglucose deprivation and reoxygenation (OGD/R) injury. No study has used epitranscriptomics to explore the characteristics and mechanism of injury. N6methyladenosine (m6A) is the most abundant epitranscriptomic RNA modification. However, little is known about m6A…

This Retraction follows an Expression of Concern relating to this article previously published by Portland Press. This article is being retracted from Bioscience Reports at the request of the Editor-in-Chief and the Editorial Board following receipt of a notification from a reader, alerting the Editorial Board to repeated images in…

Circular RNAs (circRNAs) are crucially involved in cancers as competing endogenous RNA (ceRNA) or microRNA (miRNA) sponges. However, the function and mechanism of circRNAs in liver fibrosis remain unknown and are the focus of this study. Murine fibrotic models were induced by thioacetamide (TAA) or carbon tetrachloride (CCl4 ). Increased…

doi: 10.1007/s11011-023-01194-7. Online ahead of print. Affiliations Expand Affiliations 1 Department of Neurosurgery, Lanzhou University Second Hospital, No.82, Cuiyingmen, Chengguan District, Lanzhou City, 730030, Gansu Province, China. 2 Department of Anesthesia Operation, Gansu provincial hospital, No.204, Donggang West Road, Lanzhou City, 730000, Gansu Province, China. 3 Department of Neurosurgery, Lanzhou…

Sci-Hub | circRNA-miRNA cross-talk in the transition from paroxysmal to permanent atrial fibrillation. International Journal of Cardiology | 10.1016/j.ijcard.2019.04.072 ◂ ↓ save Costa, M. C., Cortez-Dias, N., Gabriel, A., de Sousa, J., Fiúza, M., Gallego, J., … Enguita, F. J. (2019). circRNA-miRNA cross-talk in the transition from paroxysmal to permanent…

. 2023 Dec;18(1):2178802. doi: 10.1080/15592294.2023.2178802. Affiliations Expand Affiliations 1 Department of Urology, Huashan Hospital, Fudan University, Shanghai, China. 2 Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, China. 3 National Clinical Research Center for Aging and Medicine, Fudan University, Shanghai, China. Item in Clipboard Xiyu Dai et al. Epigenetics. 2023…

Background: Circular RNA circPRKCI is a critical player in cell injury induced by Lipopolysaccharide (LPS), which promotes osteoporosis (OP). However, the function of circPRKCI in OP is unclear. We predicted that circPRKCI could bind to miR-103, which participates in OP, suggesting the potential involvement of circPRKCI in OP. Objective: This…

There was Three females and 2 males with a indicate chronilogical age of Six decades and a mean body mass index associated with 32.Eight. Intraoperatively, your suggest operative time was Nine hours Forty-eight moments, using a mean blood loss regarding 136 cubic centimeters. Postoperatively, there was absolutely no complications as…

All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of…

Human cartilage and chondrocytes Collections of human cartilage samples were according to protocols approved by the Ethics Committee of Sir Run Run Shaw Hospital (Hangzhou, China), and the methods were carried out in accordance with the approved guidelines. All subjects signed a written informed consent. Human cartilage samples were obtained…

Front Genet. 2022; 13: 964840. , 1 , 1 , 1 , 2 , 2 , 2 , 2 , 2 , 3 ,* and 4 ,* Yun Zhu 1 Department of Dermatology, The People’s Hospital of Yuxi City, Yuxi, China Weimin Yan 1 Department of Dermatology, The People’s Hospital…

Oslo – Targovax ASA (OSE: TRVX), a clinical stage biotechnology company developing immune activators to target hard-to-treat solid tumors, today announces its fourth quarter 2022 results. Members of Targovax’s executive management team will give an online presentation to investors, analysts and the press at 10:00 CET today. FOURTH QUARTER 2022…

Patient samples and ethics statement Peripheral blood samples from 10 OA patients and 7 healthy people were collected from the Second Affiliated Hospital of Kunming Medical University. The characteristics of the subjects enrolled in the OA study are shown in Table 1. The diagnosis of patients with OA was based…

· The financing will support initiation of the ONCOS-102 melanoma phase 2 and TG01 mutant RAS clinical trials and in vivo PoC studies for the ground-breaking circRNA program · The convertible bond facility with London-based Atlas Capital Markets provides a secured and flexible source of capital to advance all of…

Schematic illustrations of circRNA switches and circuits. (A) Design of miRNA or protein-responsive circRNA switch. miRNA-responsive circRNA has the antisense of target miRNA sequence at the UTR. Protein-responsive circRNA has a protein-binding motif in IRES region. In both systems, gene expression from circRNA is repressed if the target miRNA or…

Radiation-induced heart disease (RIHD) is one of the most common and serious long-term adverse effect after thoracic radiotherapy. Our aim was to investigate the potential molecular mechanism underlying RIHD using RNA-sequencing (RNA-seq) and bioinformatics methods. An RIHD rat model was established and transcription profiles were identified using RNA-seq. Differentially expressed…

Emerging evidence indicates the critical roles of N6-methyladenosine (m6A) modification in human cancers. Herein, our work reported that a novel m6A-modified circRNA from the MYO1C gene, circMYO1C, upregulated in the pancreatic ductal adenocarcinoma (PDAC). Our findings demonstrated that circMYO1C is highly expressed in PDAC tissues. Functionally, circMYO1C promoted the proliferation…

Sci-Hub | iCDA-CMG: identifying circRNA-disease associations by federating multi-similarity fusion and collective matrix completion. Molecular Genetics and Genomics | 10.1007/s00438-020-01741-2 ◂ ↓ save Xiao, Q., Zhong, J., Tang, X., & Luo, J. (2020). iCDA-CMG: identifying circRNA-disease associations by federating multi-similarity fusion and collective matrix completion. Molecular Genetics and Genomics. doi:10.1007/s00438-020-01741-2 …

Introduction The excessive accumulation of adipose tissue is one of the leading factors of obesity.Citation1,Citation2 Adipose tissues are typed as white adipose tissue (WAT), brown adipose tissue (BAT) and beige adipose tissue.Citation3 The primary function of WAT is storing triglyceride, while BAT, in contrast to WAT, dissipates the energy of…

Author Response Reviewer #1 (Public Review): N1-methyladenosine (m1A) is a rather intriguing RNA modification that can affect gene expression and RNA stability etc. The manuscript presented the exploration of RNAs m1A modification in normal and OGD/R-treated neurons and the effects of m1A on diverse RNAs. The authors showed that m1…

The Chen Lab at Washington University in St Louis (WUSTL) is hiring! We are looking for postdoctoral fellows to join us to investigate the regulation and function of a special class of non-canonical RNA – circular RNA (circRNA). The Chen Lab utilizes multi-omic and high-throughput screening approaches to uncover the genomic…

Non-coding RNA (ncRNA) is a special type of RNA transcript that makes up more than 90 % of the human genome. Although ncRNA typically does not encode proteins, it indirectly controls a wide range of biological processes, including cellular metabolism, development, proliferation, transcription, and post-transcriptional modification. NcRNAs include small interfering…

International Archives of Allergy and Immunology Experimental Allergy – Research Article Xu C.a,b,c · Du L.a,b · Guo Y.a,b · Liang Y.a,b Author affiliations aDepartment of Pulmonary and Critical Care Medicine,…

Figure 1. The AOM-DSS model recapitulated “inflammation -CRA-CRC” progression. (A) Schematic representation of the study design. The intestinal conditions and disease progression of mice were evaluated at baseline and 3 weeks, 6 weeks and 12 weeks after intervention. (B) Representative images and H&E staining images (original × magnification 200) of…

Ou A, Yung WKA, Majd N. Molecular mechanisms of treatment resistance in glioblastoma. Int J Mol Sci. 2021;22(1):351. CAS  Google Scholar  Wang G-M, Cioffi G, Patil N, Waite KA, Lanese R, Ostrom QT, et al. Importance of the intersection of age and sex to understand variation in incidence and survival…