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Tag: CircRNA
Bhubaneswar ILS scientists discover direct interaction of circular RNAs with mRNAs in gene expression
In an extremely proud moment for Odisha, a team of researchers at the prestigious Institute of Life Sciences (ILS) in Bhubaneswar has made a groundbreaking discovery that suggests the role of direct interaction of circRNAs with mRNAs in gene expression regulation. The findings represent a novel method for illuminating the…
Exosomes From IgE-Stimulated Mast Cells Aggravate Asthma-Mediated Atherosclerosis Through circRNA CDR1as-Mediated Endothelial Cell Dysfunction in Mice
Background: IgE has been known for mediating endothelial cell dysfunction and mast cell (MC) activation to fuel asthma-aggravated high-fat diet-induced atherosclerosis. However, it remains unclear for the mechanism of asthma-mediated atherosclerosis, especially the potential involvement of IgE in the exacerbation of asthma-mediated atherosclerosis with a standard laboratory diet, and the…
Aal-circRNA-407 regulates ovarian development of Aedes albopictus, a major arbovirus vector, via the miR-9a-5p/Foxl axis
< Back to Article Fig 5 Spatial-temporal patterns of four high abundant circRNA candidates measured by real-time RT-PCR. (A) Temporal profiles of circRNA candidates at different developmental stages of Aedes albopictus determined by qRT-PCR. E = n hours post-oviposition embryo (n = 200 per replicate); 1st -2nd L = 1st…
About Us_ Geneseed Biotech
Guangzhou Geneseed Biotech. Co.,Ltd. founded in June 2010,is a high-tech enterprise focusing on circRNA technology research and industrialization development.Since 2014, Geneseed has been focusing on the circRNA segment, and continuously cultivating for nearly a decade, with a profound accumulation of original technologies. Our team has professionals in microbiology, molecular biology, bioinformatics,…
Progress of circRNA/lncRNA-miRNA-mRNA axis in atrial fibrillation [PeerJ]
Introduction The incidence and mortality rates of AF are continuously increasing, leading to serious complications such as heart failure and stroke (Fig. 1) (Sagris et al., 2021). The occurrence and development of AF involve different mechanisms and interactions (Kornej et al., 2020). AF often progresses from paroxysmal to persistent (Nattel…
LncRNA/circRNA-mRNA networks in CARAS | JIR
Introduction Combined allergic rhinitis and asthma syndrome (CARAS), a new terminology introduced by the World Allergy Organization (WAO) in 2004, is an allergic reaction that occurs in the respiratory tract, including upper respiratory tract allergy (allergic rhinitis, AR) and lower respiratory tract allergy (asthma, AS).1,2 The incidence of AS in…
MNCLCDA: predicting circRNA-drug sensitivity associations by using mixed neighbourhood information and contrastive learning | BMC Medical Informatics and Decision Making
circRNA-drug sensitivity associations We download the circRNA-drug sensitivity association dataset from reference [17], where Deng et al. [17] collected and organized the association data between circRNA and drug sensitivity from the circRic database [16]. Here, the drug sensitivity and circRNA data come from the GDSC database [19], which provides 80,076…
predicting circRNA-drug sensitivity associations by using mixed neighbourhood information and contrastive learning
%PDF-1.4 % 1 0 obj <> endobj 2 0 obj <>stream 2023-12-18T04:19:04 Adobe InDesign 15.1 (Windows) 2023-12-18T14:40:22+01:00 2023-12-18T14:40:22+01:00 Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) circRNA-drug sensitivity associations;Random walk with restart;Contrastive learning;Graph convolutional network False application/pdf doi.org/10.1186/s12911-023-02384-0 BioMed Central BMC Medical Informatics…
Circulating circRNA expression profile and its potential role in late recurrence of paroxysmal atrial fibrillation post catheter ablation
Background: Catheter-based pulmonary vein isolation (PVI) is an effective and well-established intervention for symptomatic paroxysmal atrial fibrillation (PAF). Nevertheless, late recurrences of atrial fibrillation (LRAF) occurring during 3 to 12 months are common, and the underlying mechanisms remain elusive. Circular RNAs (circRNAs) in atrial tissue have been linked to the…
Special Issue : Extracellular Vesicles and ncRNA
Dear Colleagues, Over the past two decades, the biological science arena has witnessed the emergence and rapid advancement of two distinct research domains: noncoding RNA (ncRNA) and extracellular vesicles. Presently, the significance of ncRNA in the biology of virtually all living organisms is beyond dispute, and our comprehension of its…
Their Roles and Interactome in Parkinson’s Disease Progression
Circular RNAs (circRNA) are products of alternative splicing that consist of a closed circular structure through a covalent 3′-5′ phosphodiester linkage. Their unique structure lends itself to a variety of physical properties and functions, including increased half-life within the cellular environment and the ability to sponge microRNA (miRNA) and RNA-binding…
“Regulation of mRNA and circRNA as a Cause and Consequence of Aging in” by Rebekah Napier-Jameson
Abstract A role for RNA binding proteins in regulating lifespan has emerged. We identified a pair of neuronal RBPs, exc-7 and mbl-1, which display synthetic lifespan defects. Such a strong synthetic phenotype represented an opportunity to use transcriptomics to search for potential causative targets that are synthetically regulated. We identified…
ncRNA | Free Full-Text | Regulation of Macrophage Polarization in Allergy by Noncoding RNAs
1. Introduction Allergies affect millions of people worldwide and are characterized by an excessive type 2 immune response to normally harmless substances, generally known as antigens or allergens, specifically [1,2]. Consequently, this response leads to the development of various allergic symptoms, including asthma, allergic rhinitis, and atopic dermatitis. In the…
Gene Therapy: Unlocking Innovations in Cancer Treatment, Detection, and Drug Development
The history of using genes as a tool to treat humans goes back nearly five decades, marking a pivotal moment in medical science. In 1972, the concept of gene therapy was first considered as a form of treatment. This groundbreaking idea was introduced in a paper titled “Gene therapy for…
CircRNA and Stroke: New Insight of Potential Biomarkers and Therapeutic Targets
Diener HC, Hankey GJ (2020) Primary and secondary Prevention of ischemic Stroke and Cerebral Hemorrhage: JACC Focus Seminar. J Am Coll Cardiol 75(15):1804–1818 Article PubMed Google Scholar Dou Z, Yu Q, Wang G, Wu S, Reis C, Ruan W, Yan F, Chen G (2020) Circular RNA expression profiles alter significantly…
DeepWalk-aware graph attention networks with CNN for circRNA-drug sensitivity association identification
doi: 10.1093/bfgp/elad053. Online ahead of print. Affiliations Expand Affiliations 1 School of Information Engineering, East China Jiaotong University, Nanchang, China. 2 School of Information Science and Engineering, Shandong Normal University, Jinan, China. 3 College of Computer Science and Electronic Engineering, Hunan University, Changsha, China. Item in Clipboard Guanghui Li et al….
Influence of FTDP-17 mutants on circular Tau RNAs
At least 53 mutations in the microtubule associated protein tau gene (MAPT) have been identified that cause frontotemporal dementia. 47 of these mutations are localized between exons 7 and 13. They could thus affect the formation of circular RNAs (circRNAs) from the MAPT gene that occur through backsplicing from exon…
Circular RNA Associated With Higher Risk and Poor Outcomes in MDS and AML
The circular RNA (circRNA) circZBTB46 was expressed at increasing levels among patients with higher risk myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) and was associated with shorter survival, according to the results of a study published in the journal Clinical and Experimental Medicine. A type of noncoding, stable RNA,…
In-depth analyses of lncRNA and circRNA expression in the hi… : NeuroReport
Zhang, Yongcanga,*; Tang, Liangb,c,*; Wang, Yanb; Zhu, Xiaoyana; Liu, Lana Author Information aMedical College, Tibet University, Lhasa, Tibet bDepartment of Basic Medicine, Changsha Medical University cHunan Provincial University Key Laboratory of the Fundamental and Clinical Research on Neurodegenerative Diseases, Changsha Medical University, Changsha, People’s Republic of China Received 19…
Research progress in the role of non-coding RNAs and embryo implantation
Non-coding RNA (ncRNA) refers to RNA that lack the ability to encode protein. Based on their distinct biological characteristics, ncRNA are mainly classified into microRNA (miRNA), long non-coding RNA (lncRNA), and circular RNA (circRNA). NcRNA plays a crucial regulatory role in various biological processes. Pregnancy is a highly intricate physiological…
Targeting the epigenome to reinvigorate T cells for cancer immunotherapy | Military Medical Research
Tsui C, Kretschmer L, Rapelius S, Gabriel SS, Chisanga D, Knöpper K, et al. MYB orchestrates T cell exhaustion and response to checkpoint inhibition. Nature. 2022;609(7926):354–60. Article CAS PubMed PubMed Central Google Scholar Zhu L, Zhou X, Gu M, Kim J, Li Y, Ko CJ, et al. Dapl1 controls NFATc2…
Biotechnology/Bioinformatics JRF Vacancy at Institute of Life Sciences (ILS), Bhubaneswar
Institute of Life Sciences (ILS), Bhubaneswar, an esteemed autonomous institute under the Department of Biotechnology, Ministry of Science & Technology, Government of India. Committed to advancing life sciences research, ILS invites applications from passionate individuals to join our dynamic team. Vacancies List Explore the exciting opportunity we have: Position Title:…
Transcriptome analysis reveals pituitary lncRNA, circRNA and mRNA affecting fertility in high-and low-yielding goats
1South China Agricultural University, China The final, formatted version of the article will be published soon. Notify me Receive an email when it is updated You just subscribed to receive the final version of the article The pituitary gland serves as the central…
Sci-Hub | Potential circRNA-disease association prediction using DeepWalk and network consistency projection. Journal of Biomedical Informatics, 112, 103624
Sci-Hub | Potential circRNA-disease association prediction using DeepWalk and network consistency projection. Journal of Biomedical Informatics, 112, 103624 | 10.1016/j.jbi.2020.103624 ◂ ↓ save Li, G., Luo, J., Wang, D., Liang, C., Xiao, Q., Ding, P., & Chen, H. (2020). Potential circRNA-disease association prediction using DeepWalk and network consistency projection. Journal…
WO2017055487A2 – A METHOD FOR DIAGNOSING A DISEASE BY DETECTION OF circRNA IN BODILY FLUIDS
“Current Protocols in Molecular Biology“, 1991, JOHN WILEY & SONS, pages: 6.3.1 – 6.3.6 “Quantitative monitoring of gene expression patterns with a complementary DNA microarray.“, SCIENCE, vol. 270, no. 5235, 1995, pages 467 – 70 ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 – 410 ALTSCHUL ET…
Functional relevance of circRNA aberrant expression in pediatric acute leukemia with KMT2A::AFF1 fusion
Circular RNAs (circRNAs) are emerging molecular players in leukemogenesis and promising therapeutic targets. In KMT2A::AFF1 (MLL::AF4) rearranged leukemia, an aggressive disease compared to other pediatric B-cell precursor (BCP) acute lymphoblastic leukemia (ALL), data about circRNAs are limited. Here we disclose the circRNA landscape of KMT2A::AFF1 translocated BCP-ALL infant patients, showing…
Identification of differentially expressed circRNAs in prostate cancer of different clinical stages by RNA sequencing
CircRNAs are widely found in eukaryotes and are a class of abundantly expressed, highly tissue-specific, and stable non-coding RNAs that have an essential role in regulating gene expression12. The abnormal expression of circRNAs has been reported in esophageal squamous cell carcinoma13, breast carcinoma14, gastric cancer15, and hepatocellular carcinoma16, which are…
The Role of circRNA-miRNA-mRNA Regulatory Network and its Potential Biomarker Function in Colorectal Cancer
Background: Revealing the process and mechanism of colorectal cancer will facilitate the discovery of new biomarkers and contribute to the development of targeted drugs. Objective: This study aimed to explore the potentially functional circRNA-miRNA-mRNA network in colorectal cancer (CRC), and further explore its mechanism. Methods: Bioinformatics analysis was used to…
ESRP1 controls biogenesis and function of a large abundant multiexon circRNA
doi: 10.1093/nar/gkad1138. Online ahead of print. Dawei Liu 1 , B Kate Dredge 1 , Andrew G Bert 1 , Katherine A Pillman 1 2 , John Toubia 1 3 , Wenting Guo 4 , Boris J A Dyakov 5 6 , Melodie M Migault 1 , Vanessa M Conn 1 7 , Simon J…
ESRP1 controls biogenesis and function of a large abundant multiexon circRNA | Nucleic Acids Research
Abstract While the majority of circRNAs are formed from infrequent back-splicing of exons from protein coding genes, some can be produced at quite high level and in a regulated manner. We describe the regulation, biogenesis and function of circDOCK1(2–27), a large, abundant circular RNA that is highly regulated during epithelial-mesenchymal…
Navigating the Frontier of Circular RNA Therapeutics: Insights from the Experts
Join our panel of experts as we explore the exciting field of circular RNA therapeutics. The landscape of therapeutic innovation is continually evolving, and one of the latest frontiers captivating the attention of analytical scientists is Circular RNA (circRNA). As we gear up for our expert discussion forum on exploring…
What is the physiological role of circRNA?
The paper does not explicitly mention the physiological role of circRNA. Open access•Journal Article•DOI The paper does not provide information about the physiological role of circRNA. The physiological role of circRNA is to participate in various pathophysiological processes by acting as a microRNA sponge, regulating protein transcription, and interacting with…
What is the physiological role of circRNA HNSCC?
Open access•Journal Article•DOI The provided paper does not mention the physiological role of circRNA HNSCC. The paper focuses on the role of circRNAs in cancer glycolysis and their potential as targets for cancer treatment. The provided paper does not mention the physiological role of circRNA HNSCC. Open access•Journal Article•DOI The…
Integrative lncRNA, circRNA, and mRNA analysis reveals expression profiles of six forensic body fluids/tissue
RNAs have attracted much attention in forensic body fluid/tissue identification (BFID) due to their tissue-specific expression characteristics. Among RNAs, long RNAs (e.g., mRNA) have a higher probability of containing more polymorphic sites that can be used to assign the specific donor of the body fluid/tissue. However, few studies have characterized…
Govt ILS Bioinformatics JRF Job
“Exciting Govt Job Alert: Apply for the Life Sciences JRF Position at Govt ILS – Apply Online Now!” Govt ILS Bioinformatics JRF Job – Life Sciences Apply Online INSTITUTE OF LIFE SCIENCES(An Autonomous Institute under the Dept. of Biotechnology, Ministry ofScience & Technology, Govt. of India)NALCO Square , Bhubaneswar 751023,…
ST Pharm Presented ‘100-Day Expedite Strategy’, Preparedness and Proactive Measures for Future Pandemic at Korea-CEPI R&D Workshop
SEOUL, South Korea, Nov. 20, 2023 /PRNewswire/ — Nov. 21, 2023 local time, ST Pharm announced ‘Rapid Preparedness of Pandemic Vaccine in 100 Days using ST Pharm’s own mRNA Platform Technology’ at the Korea-CEPI R&D Workshop in World Bio Summit 2023, organized by Korea Health Industry Development Institute (KHIDI) and Coalition…
Identification of Cuproptosis-related circRNA-miRNA-mRNA Network in Laser-induced Choroidal Neovascularization Models and in Peripheral Blood Mononuclear Cells of Patients with Neovascular Age-related Macular Degeneration | Ophthalmic Research
Introduction: To investigate the molecular alterations of cuproptosis-related genes and to construct the cuproptosis-related circRNA-miRNA-mRNA networks in neovascular age-related macular degeneration (nAMD). Methods: The transcriptional profiles of laser-induced choroid neovascularization (CNV) mouse models and nAMD patient samples were obtained from sequencing and from the GEO database (GSE146887), respectively. The expression…
CircRNA in ocular neovascular diseases: Fundamental mechanism and clinical potential
Review doi: 10.1016/j.phrs.2023.106946. Epub 2023 Oct 4. Affiliations Expand Affiliations 1 Department of Ophthalmology, 2nd Hospital of Jilin University, Changchun 130041, Jilin, China. 2 Department of Ophthalmology, 2nd Hospital of Jilin University, Changchun 130041, Jilin, China; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai…
Insects | Free Full-Text | Novel Insights into the circRNA-Modulated Developmental Mechanism of Western Honey Bee Larval Guts
1. Introduction As a representative social insect with crucial ecological, economic and scientific value, the western honey bee (Apis mellifera) is widely reared and applied in the apicultural industry in considerable countries around the world [1]. In addition, A. mellifera has been applied as a research model for development, social…
Exosome-delivered circRNA circSYT15 contributes to cisplatin resistance in cervical cancer cells through the miR-503-5p/RSF1 axis
The development of chemotherapy resistance is a major obstacle for cervical cancer (CC) patients. Exosome-mediated transfer of circular RNAs (circRNAs) was found to have relevance to the CC. This study is designed to explore the role and mechanism of exosomal circRNA synaptotagmin 15 (circSYT15) on cisplatin (DDP) resistance in CC….
Exploring the interplay between PARP1 and circRNA biogenesis and function
Review Wiley Interdiscip Rev RNA . 2023 Nov 13:e1823. doi: 10.1002/wrna.1823. Online ahead of print. Affiliations Expand Affiliations 1 Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA. 2 Department of Epigenetics, Van Andel Research Institute, Grand Rapids, Michigan, USA. Item in Clipboard Review Hejer Dhahri et al….
Predicting circRNA-disease association using heterogeneous network and meta-path
[1] H. L. Sanger, G. Klotz, D. Riesner, H. J. Gross, A. K. Kleinschmidt, Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures, Proc. Natl. Acad. Sci. USA, 73 (1976), 3852–3856. doi.org/10.1073/pnas.73.11.3852 doi: 10.1073/pnas.73.11.3852 …
Figure 2 | Bioinformatics-Based Identification of CircRNA-MicroRNA-mRNA Network for Calcific Aortic Valve Disease
Genetics Research/ 2023/ Article/ Fig 2 / Research Article Figure 2 Differentially expressed RNAs. (a) Volcano plot of DE-circRNAs. Green represents down-regulation and red represents up-regulation. (b) Heatmap of 32 DE-circRNAs, –value <0.001. (c) Heatmap of the DE-miRNAs with the most obvious up-regulation and down-regulation, –value <0.05. (d) It is…
Exploring the association between circRNA expression and pediatric obesity based on a case-control study and related bioinformatics analysis
Objective: Our present study utilized case-control research to explore the relationship between specific circRNAs and pediatric obesity through a literature review and bioinformatics and to predict their possible biological functions, providing ideas for epigenetic mechanism studies of pediatric obesity. Methods: CircRNAs related to pediatric obesity were preliminarily screened by a…
Reviewing the Importance of circRNA
In recent years following the COVID-19 pandemic, RNA has gained attention for its successes and potential use in vaccines and therapeutics. One avenue of interest in RNA research is a non-coding class of RNA first identified almost 50 years ago, circular RNA (circRNA). In 1976, Sanger et al. first identified…
Retracted: Integrated Analysis of Circular RNA-Associated ceRNA Network Reveals Potential circRNA Biomarkers in Human Breast Cancer
Retraction of Publication . 2023 Nov 1:2023:9780596. doi: 10.1155/2023/9780596. eCollection 2023. Item in Clipboard Retraction of Publication Computational And Mathematical Methods In Medicine. Comput Math Methods Med. 2023. Show details Display options Display options Format AbstractPubMedPMID . 2023 Nov 1:2023:9780596. doi: 10.1155/2023/9780596. eCollection 2023. Item in Clipboard Cite Display options…
A Comprehensive Resource for Exploring CircRNA in Cancer Immunotherapy
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New Vaccine Manufacturing Facility Opens in Singapore to Enhance Pandemic Preparedness
Amidst growing concerns about global health security, Singapore has inaugurated a cutting-edge facility aimed at bolstering pandemic preparedness. The state-of-the-art manufacturing facility, called Aces, was officially opened on Thursday, representing a significant step in the advancement of global public health. With a focus on developing affordable vaccines for common diseases,…
New Manufacturing Facility in Singapore Enhances Vaccine Production and Pandemic Response
Singapore has taken a significant step in strengthening its vaccine production capabilities with the inauguration of a state-of-the-art manufacturing facility. The modern facility, named Aces, is part of a comprehensive investment by Hilleman Laboratories totaling $80 million over five years. The facility, funded jointly by Merck & Co and the…
Meet circ2CBA: A Novel Deep Learning Model that Revolutionizes the Prediction of circRNA-RBP Binding Sites
In a recent development, a team of researchers from China have introduced a deep learning model, named circ2CBA, that promises to revolutionize the prediction of binding sites between circular RNAs (circRNAs) and RNA-binding proteins (RBPs). This development holds significant implications for understanding the intricate mechanisms underlying various diseases, particularly cancers….
The Bib Theorists: Exploring the Extensive Effects of SARS-CoV-2 Infection on Host Systems
Title: COVID-19’s Impact on the Cardiovascular System: Uncovering the Mechanisms The Bib Theorists As the world continues to grapple with the effects of the COVID-19 pandemic, researchers are uncovering more about the virus’s impact on various bodily systems. Among them, the cardiovascular system has emerged as a significant player in…
Advancing circRNA-RBP Interaction Prediction: circ2CBA Deep Learning Model
TL;DR: Chinese researchers introduced circ2CBA, a deep learning model for predicting circRNA-RBP binding sites. CircRNAs play a crucial role in disease mechanisms, especially cancer, making their interaction with RBPs significant. circ2CBA stands out for its ability to predict binding sites using only circRNA sequence information, simplifying the process. The model…
Expression profiles of circRNAs and biomarkers for COPD
Introduction Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease featured by airflow obstruction with high prevalence, morbidity, and mortality. It is reported that COPD is the third leading cause of death globally at present, and the incidence of COPD in adults over 40 years is more than…
What are the steps in oxford nanopore genetic sequencing
Oxford Nanopore genetic sequencing involves several steps. First, ribodepletion is performed using an RNaseH-based method to remove ribosomal RNA. Next, lowly abundant circRNAs are enriched through exonuclease treatment and negative selection of linear RNAs. Then, a cDNA library is created and amplified by PCR. Quality control is ensured through a…
Diagnostic value of circRNA in coronary heart disease: a meta-analysis
doi: 10.2217/bmm-2023-0369. Online ahead of print. Affiliations Expand Affiliations 1 Department of Cardiology, The First People’s Hospital of Lianyungang, Lianyungang, 222002, Jiangsu PR, China. 2 Department of Cardiology, Hainan General Hospital, Haikou, 570311, Hainan PR, China. Item in Clipboard Ming-Zhu Li et al. Biomark Med. 2023. Show details Display options Display…
CircRNA circ_0013339 Regulates the Progression of Colorectal Cancer Through miR-136-5p/SOX9 Axis
doi: 10.1007/s10528-023-10540-4. Online ahead of print. Affiliations Expand Affiliations 1 Department of Gastrointestinal Surgery, The Third Affiliated Hospital of Anhui Medical University (The First People’s Hospital of Hefei), Hefei, 230000, Anhui, China. ztcx9pc@163.com. 2 Department of Gastroenterology, The Second People’s Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University,…
Identification of circRNA-miRNA-mRNA network as biomarkers for interstitial cystitis/bladder pain syndrome
Research Paper Advance Articles Shi-Qin Yang1, *, , Liao Peng1, *, , Le-De Lin1, , Yuan-Zhuo Chen1, , Meng-Zhu Liu1, , Chi Zhang1, , Jia-Wei Chen1, , De-Yi Luo1, , 1 Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China * Equal contribution…
circexplorer2 output
circexplorer2 output 0 Hi all! I am desperately searching for information about the output of circexplorer2, namely “circularRNA_known”. I do not find any explanation about the columns exonCount and fragment for example. Could someone provide resources or, better, explain a bit more the following: Do the “exonCount” correspond to the…
Researchers develop curated and integrated biomarker knowledgebase for animals
Graphical Abstract. Credit: Nucleic Acids Research (2023). DOI: 10.1093/nar/gkad873 Biological markers, commonly referred to markers or biomarkers, serve as quantifiable and measurable indicators of certain biological states in normal and pathogenic processes, as well as potential pharmacologic responses to therapeutics. They serve as the foundation for diagnostic analysis, the identification…
A joint model for predicting circRNA-RBP binding sites based on deep learning
The flowchart of circ2CBA. Credit: Frontiers Journals The interaction between circRNAs and RBPs is related to many diseases, especially cancers. Understanding the mechanism of the interaction and predicting their binding sites is critical. New research published in Frontiers of Computer Science proposes a method to predict these binding sites using…
A joint model for predicting circRNA-RBP bind
image: The flowchart of circ2CBA view more Credit: Yajing GUO, Xiujuan LEI, Lian LIU, Yi PAN The interaction between circRNAs and RBPs is related to many diseases especially cancers. Understanding the mechanism of the interaction is critical and predicting the binding sites of them is helpful for this. Existing methods for…
Scientists train AI to illuminate drugs’ impact
An ideal medicine for one person may prove ineffective or harmful for someone else, and predicting who could benefit from a given drug has been difficult. Now, an international team led by neuroscientist Kirill Martemyanov, Ph.D., based at The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, is…
A Breakthrough in Predicting CircRNA-RBP Binding Sites using Deep Learning
New research published in Frontiers of Computer Science presents an innovative approach to predicting binding sites between circular RNAs (circRNAs) and RNA-binding proteins (RBPs). The study introduces a deep learning-based model named circ2CBA, which leverages sequence information of circRNAs to accurately predict their interaction with RBPs. Traditionally, understanding the complex…
The investigation of circRNA profiling reveals the regulatory role of the hsa_circ_0000375/miR-7706 pathway in breast cancer
Cardoso F, Paluch-Shimon S, Senkus E, Curigliano G, Aapro MS et al (2020) 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5). Ann Oncol 31:1623–1649 Article CAS PubMed Google Scholar Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J et al (2013) Circular RNAs are a large…
circRNADisease v2.0: an updated resource for high-quality experimentally supported circRNA-disease associations
circRNADisease v2.0 is an enhanced and reliable database that offers experimentally verified relationships between circular RNAs (circRNAs) and various diseases. It is accessible at cgga.org.cn/circRNADisease/ or cgga.org.cn:9091/circRNADisease/. The database currently includes 6998 circRNA-disease entries across multiple species, representing a remarkable 19.77-fold increase compared to the previous version. This expansion consists…
A circRNA therapy based on Rnf103 to inhibit Vibrio anguillarum infection
. 2023 Oct 23;42(11):113314. doi: 10.1016/j.celrep.2023.113314. Online ahead of print. Affiliations Expand Affiliations 1 Laboratory of Fish Molecular Immunology, College of Fisheries and Life Science, Shanghai Ocean University, Shanghai, China. 2 Laboratory of Fish Molecular Immunology, College of Fisheries and Life Science, Shanghai Ocean University, Shanghai, China; Laboratory of Marine…
Bioinformatic Analysis of circRNAs in Human ASO
Introduction Arteriosclerosis obliterans (ASO) is a chronic disorder with atherosclerosis involving lower extremity arteries leading to arterial stenosis or occlusion. The incidence continues to increase with age, affecting about 202 million people worldwide to varying degree.1–3 Despite the proposed theories of lipid infiltration, arterial intimal injury, and chronic inflammation, the…
circRNA poster to be presented at the 30th European Society for Gene and Cell Therapy (ESGCT)
Oslo, Norway, 19 October 2023 – Circio Holding ASA (OSE: CRNA) today announcesthat an abstract describing its circular RNA technology has been accepted forposter presentation at the 30th i European Society for Gene and Cell Therapy inBrussels, Belgium.The poster is scheduled for presentation 25-26 October 2023 and will beavailable on…
Researchers develop circRNA-based early-detection method for pancreatic cancer
A simple blood test may pick up the emergence of this silent killer — usually not diagnosed until its late stages In a significant breakthrough that could eventually extend the survival of patients with one of the deadliest of all malignancies, an international team of researchers has devised an investigational…
Circio: circRNA poster to be presented at the 30th European Society for Gene and Cell Therapy (ESGCT) -October 19, 2023 at 01:05 am EDT
Oslo, Norway, 19 October 2023 – Circio Holding ASA (OSE: CRNA) today announces that an abstract describing its circular RNA technology has been accepted for poster presentation at the 30th iEuropean Society for Gene and Cell Therapy in Brussels, Belgium. The poster is scheduled for presentation 25-26 October 2023 and…
HonorHealth Research Institute, City of Hope
SCOTTSDALE, Ariz. — Oct. 18, 2023 — In a significant breakthrough that could eventually extend the survival of patients with one of the deadliest of all malignancies, an international team of researchers have devised an investigational blood test that might one day help doctors detect pancreatic cancer earlier. The team…
Characteristics, Biogenesis and Functions of CircRNAs
Circular RNA (CircRNA), a single-stranded closed-loop RNA that lacks terminal 5′ caps and 3′ poly (A) tails, is more stable than linear RNA. CircRNA was first discovered in plant-infected viroids and was later observed in eukaryotes, although it was not produced via the back-splicing mechanism. 1. Characteristics Circular RNA (CircRNA),…
Pseudogene MAPK6P4-encoded functional peptide promotes glioblastoma vasculogenic mimicry development
Gusyatiner, O. & Hegi, M. E. Glioma epigenetics: from subclassification to novel treatment options. Semin. Cancer Biol. 51, 50–58 (2018). Article PubMed Google Scholar Kunnakkat, S. & Narayana, A. Bevacizumab in the treatment of high-grade gliomas: an overview. Angiogenesis 14, 423–430 (2011). Article PubMed Google Scholar Luo, Q. et al….
Identification of a lncRNA/circRNA-miRNA-mRNA ceRNA Network in Alzheimer’s Disease
Background: Alzheimer’s disease (AD) occurs in the elderly and pre-elderly, characterized by decline of memory, cognitive dysfunction, impairment of learning capacity, and motor dysfunction. Recently a competitive endogenous RNA (ceRNA) network has been found to be related to AD progression, but there is still little understanding of the ceRNA regulatory…
CeRNA Expression Profiling Identifies KIT-Related circRNA-miRNA-mRNA Networks in Gastrointestinal Stromal Tumour
CeRNA Expression Profiling Identifies KIT-Related circRNA-miRNA-mRNA Networks in Gastrointestinal Stromal Tumour – Fingerprint — Okayama University Sort by Weight Alphabetically Medicine & Life Sciences Circular RNAs 100% Gastrointestinal Stromal Tumors 87% MicroRNAs 61% Messenger RNA 41% Neoplasms 8% Sarcoma 8% Small Intestine 8% Genes 7% Carcinogenesis 7% Stomach 6% Biomarkers…
circAtlas
Introduction Welcome to circAtlas 3.0 (a gateway to consistently curated vertebrate circular RNAs). circAtlas 3.0 contains a compendium of 2,674 RNA-seq libraries from 33 normal tissues from human, macaque, mouse, rat, rabbit, cat, dog, pig, sheep and chicken. Main characteristics of circAtlas include: circAtlas uses the standardized nomenclature scheme proposed…
FL-circAS–Home
FL-circAS–Home Welcome to FL-circAS! Circular RNAs (circRNAs) are a class of functional RNA molecules with a continuous loop structure characterized by back-splice junctions (BSJs). Analyses of short-read RNA sequencing (RNA-seq) have identified millions of BSJ events in various species and developed numerous databases. However, it is inherently challenging for such…
LncRNA/CircRNA-miRNA-mRNA Axis in Atherosclerotic Inflammation: Research Progress
Title:LncRNA/CircRNA-miRNA-mRNA Axis in Atherosclerotic Inflammation: Research Progress Volume: 25 Author(s): Nuan Lv, Yilin Zhang, Luming Wang, Yanrong Suo, Wenyun Zeng, Qun Yu, Bin Yu and Xijuan Jiang* Affiliation: School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China Keywords: Atherosclerosis, Inflammation, LncRNA, CircRNA, miRNA, mRNA. Abstract: Atherosclerosis is…
Promising Modalities and Clinical Trials Fueling Growth in the RNA Market
Company Logo RNA Therapeutics Market and RNA Vaccines Market RNA Therapeutics Market and RNA Vaccines Market Dublin, Oct. 12, 2023 (GLOBE NEWSWIRE) — The “RNA Therapeutics Market and RNA Vaccines Market by Type of Modality, Type of Molecule, Therapeutic Areas, Route of Administration, Key Geographical Regions (North America, Europe and…
Rapid Growth Predicted for Global RNA Therapeutics and RNA Vaccines Market by 2035
The global market for RNA therapeutics and RNA vaccines is expected to witness significant growth, reaching a value of over USD 1.1 billion by 2035. This rapid expansion is anticipated to be driven by a compound annual growth rate (CAGR) of 50% from 2026 to 2035. RNA-based therapies have gained…
Urinary stem cell-derived exocrine circRNA ATG7 regulates the SOCS1/STAT3 signaling pathway through miR-4500, inhibits M1 macrophage polarization, and alleviates the progression of diabetes nephropathy
Objective: The etiopathogenesis of diabetes nephropathy (DN) has not yet been fully clarified. Finding effective treatments to prevent renal failure in DN patients has become the main focus of research in recent years. Circular RNA (circRNA) has been shown to play a momentous role in DN progression. Based on this,…
Circio Holding ASA and Neoregen Biotech Enter Collaboration for Delivery of Novel Circular Rna Therapeutics Using Nict Technology -October 10, 2023 at 01:06 am EDT
Circio Holding ASA and Neoregen Biotech announced the start of a research collaboration on novel circar RNA (circRNA) therapeutics s based on Circios’s proprietary circVec technology. The parties will test the ability of Neoregen’s NICT (Neoregen Intra-Cellular delivery Technology) delivery system to enhance cellular uptake and nuclear transfer of circVec…
Circio : and Neoregen Biotech enter collaboration for delivery of novel circular RNA therapeutics using NICT technology -October 10, 2023 at 01:04 am EDT
Circio and Neoregen Biotech today announce the start of a research collaboration on novel circular RNA (circRNA) therapeutics based on Circio´s proprietary circVec technology. The parties will test the ability of Neoregen´s NICT (Neoregen Intra-Cellular delivery Technology) delivery system to enhance cellular uptake and nuclear transfer of circVec vectors compared…
gkac1252.pdf – Published online 16 January 2023 Nucleic…
Published online 16 January 2023Nucleic Acids Research, 2023, Vol. 51, No. 4e24 Synthetic circular RNA switches and circuits that control protein expression in mammalian cells Shigetoshi Kameda1,2, Hirohisa Ohno1and Hirohide Saito 1,* 1 Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho,…
Exploring CircRNA N6-methyladenosine in human rheumatoid arthritis: Hyper-methylated hsa_circ_0007259 as a potential biomarker and its involvement in the hsa_circ_0007259/hsa_miR-21-5p/STAT3 axis
Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes inflammation. It often impacts the joints of the hands, wrists, and knees, causing long-lasting pain, swelling, dysfunction, and deformity [1]. The prevalence of RA in Europe and North America is estimated to be 0.5–1.0% [2], while in China, it affects…
Differentially expressed circRNAs in peripheral blood samples as potential biomarkers and therapeutic targets for acute angle-closure glaucoma
Study approval and patient consent The study protocol was approved by the Ethics Committee of Qinghai Provincial People’s Hospital (approval number: 2023-141) and conducted in accordance with the ethical principles for medical research involving human subjects described in the Declaration of Helsinki in addition to relevant Chinese laws and institutional…
Functional analysis of differentially expressed circular RNAs in sheep subcutaneous fat | BMC Genomics
Chikwanha, O. C., P. Vahmani, V. Muchenje, M. E. R. Dugan and C. Mapiye (2018). Nutritional enhancement of sheep meat fatty acid profile for human health and wellbeing. Food research international (Ottawa, Ont.) 104: 25–38. doi.org/10.1016/j.foodres.2017.05.005. Khan R, Raza SHA, Schreurs N, Xiaoyu W, Hongbao W, Ullah I, et al….
Why rings of RNA could be the next blockbuster drug
RNA-based vaccines were the heroes of the COVID-19 pandemic. They set records for the highest-grossing drug launches in history, and their development was recognized in this year’s Nobel Prize in Physiology or Medicine. But it was long known that this technology had a key shortcoming: RNA, in its usual linear…
Regulation of microRNA by circular RNA
Review Wiley Interdiscip Rev RNA . 2023 Oct 2;e1820. doi: 10.1002/wrna.1820. Online ahead of print. Affiliations Expand Affiliation 1 Institute of Life Sciences, Nalco Square, Bhubaneswar, Odisha, India. Item in Clipboard Review Suman Singh et al. Wiley Interdiscip Rev RNA. 2023. Show details Display options Display options Format AbstractPubMedPMID Wiley Interdiscip…
CircRNA itchy E3 ubiquitin protein ligase improves mitochondrial dysfunction in sepsis-induced acute kidney injury by targeting microRNA-214-3p/ATP-binding cassette A1 axis
Circular RNAs (circRNAs) are promising biomarkers and therapeutic targets for acute kidney injury (AKI). In this study, we investigated the mechanism by which circRNA itchy E3 ubiquitin protein ligase (circ-ITCH) regulates sepsis-induced AKI. A sepsis-induced AKI mouse model was created using LPS induction and circ-ITCH overexpression. Circ-ITCH levels were confirmed…
P 005 All data in this figure are presented as mean SD n 3 Downloaded from
PAGE13OF 15Nucleic Acids Research, 2023, Vol. 51, No. 4e24 miR-21-5p, respectively. In both cases, the circRNA cir- cuit showed better performance of duration than the linear RNA circuit with m1(1.5- to 137-fold duration) after ap- proximately 96 h of RNA transfection (Figure6C and D), indicating that our circRNA circuits improved…
Gene modules and genes associated with postoperative atrial fibrillation: weighted gene co-expression network analysis and circRNA-miRNA-mRNA regulatory network analysis – Chen
The PDF file you selected should load here if your Web browser has a PDF reader plug-in installed (for example, a recent version of Adobe Acrobat Reader). Alternatively, you can also download the PDF file directly to your computer, from where it can be opened using a PDF reader. To…
Targeting circular RNA for cardiovascular diseases
Abstract Circular RNAs (CircRNAs) are ubiquitous, and covalently closed loop structures. They are single-stranded molecules without free 3′ and 5 ′ ends. CircRNAs have been rapidly gaining momentum as a potential therapy option for a wide range of cardiovascular disorders, including coronary artery disease (CAD), Cerebrovascular disease (CVD), Peripheral artery…
Researchers made a discovery related to circular RNA (circRNA) UPSC
Copyright infringement not intended Picture Courtesy: iStock Context: The researchers at the Indian Institute of Science Education and Research (IISER) in Bhopal have made a significant discovery related to circular RNA (circRNA) and its role in HIV-1 replication. Key Highlights Identification of ciTRAN: The researchers used a specialized technique called…
Analysis of circRNA profiles and clinical value in Stevens-Johnson syndrome and toxic epidermal necrolysis
doi: 10.1111/exd.14939. Online ahead of print. Affiliations Expand Affiliations 1 Department of Dermatology, The Second Affiliated Hospital of Nanchang University, Nanchang, China. 2 Department of Dermatology, The First Affiliated Hospital of Nanchang University, Nanchang, China. Item in Clipboard Pan Lv et al. Exp Dermatol. 2023. Show details Display options Display options…
Scientists Discover Circrna That Plays A Crucial Role In Replication Of HIV 1 Virus
This breakthrough research by IISER Bhopal scientists reveals how ‘ciTRAN,’ a circular RNA molecule, influences the virus’s transcription process, which could potentially lead to novel therapeutic strategies against HIV-1 Scientists at the Indian Institute of Science Education and Research (IISER) Bhopal have discovered a specific circular RNA (circRNA) known as…
Newly Discovered RNA Plays Crucial Role in HIV-1 Multiplication
Researchers from the Indian Institute of Science Education and Research Bhopal (IISER Bhopal) have made a significant breakthrough in understanding how the AIDS-causing HIV-1 virus multiplies within the human body. Led by Dr. Ajit Chande, the team has identified a specific circular RNA (circRNA) called ‘ciTRAN’ that plays a crucial…
IISER scientists identify a circular RNA that plays a crucial role in the replication of HIV-1 virus
Researchers from Indian Institute of Science Education and Research Bhopal (IISER Bhopal) identified a specific circular RNA (circRNA) called ‘ciTRAN’, which plays a crucial role in multiplication of the AIDS-causing HIV-1 virus within the human body. Led by Dr. Ajit Chande from Department of Biological Sciences, IISER Bhopal, this research…
IISER Bhopal Scientists Uncover Game-Changing Circular RNA That Enhances HIV-1 Virus Replication
“Mind-Blowing Discovery: IISER Bhopal Scientists Uncover Game-Changing Circular RNA That Enhances HIV-1 Virus Replication” IISER Bhopal Scientists Discover Circular RNA That Plays Key Role in HIV-1 Virus Replication Scientists from the Indian Institute of Science Education and Research (IISER) Bhopal have made an exciting breakthrough in understanding the replication process…
circRNA poster to be presented at the 15th international adenovirus meeting
Oslo, Norway, 25 September 2023 – Circio Holding ASA (OSE: CRNA) today announcesthat an abstract describing its circular RNA platform has been accepted forposter presentation at the 15th international adenovirus meeting in Brac Island,Crotia.The abstract describes the development of Circio’s proprietary circAde vectorsystem for therapeutic protein expression. The abstract describes…