Tag: crispr

CRISPR QC Developing Electronic Platform to Measure Gene Editing Performance

BALTIMORE – With $1.6 million of seed funding recently added to its balance sheet, CRISPR QC is advancing the commercial development of its data analytics platform for gene editing. The San Diego-based startup currently offers an in vitro CRISPR-based assay as a service to help customers gain insights into the…

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ADAMTS4 is involved in the production of the Alzheimer disease amyloid biomarker APP669-711

APP669-711 is proteolytically generated from various cells under physiological conditions Although γ-secretase-mediated C-terminal variations of Aβ have been extensively analyzed, the N-terminal variations of secreted Aβ have not been investigated to date. Importantly, several analyses of cell-based models and genetically modified animals harboring the APP mutant carrying the Swedish mutation…

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GenScript is increasing its capacity for producing cGMP sgRNA and non-viral DNA payloads in order to keep project wait times to a minimum.

Dr. Ray Chen of GenScript in interaction with BioPharma APAC, reveals an aim to help accelerate the development of these therapies from research to clinic by providing high-quality cGMP sgRNA, Cas9 nuclease, and non-viral DNA payloads (ssDNA/dsDNA/circular minimized dsDNA) with fast turnaround time How is GenScript planning to meet the…

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Visualize variants and percentage of variants from one sample of Amplicon Seq data?

Visualize variants and percentage of variants from one sample of Amplicon Seq data? 0 Hello, We are analyzing viral evolution by analyzing mutations present in a specific genomic location and how it evolves over time. We are performing amplicon sequencing of a specific region that is 222-228 bp at intervals….

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After a decade, CRISPR gene editing is a ‘revolution in progress.’ What does the future hold?

Credit: Pixabay/CC0 Public Domain Medical innovations typically take 17 years from the time a lightbulb goes off in a scientist’s head until the first person benefits. But every once in a while, an idea is so powerful and so profound its effects are felt much faster. That’s been the case…

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Bioinformatics Analyst Position In North Chicago, IL

Job Description Job Title: Bioinformatic Analyst III The Genomic Research Center Computational Oncology group (GRC-CO) at Company is seeking a highly motivated computational biologist/bioinformatics scientist to play an integral role in a multi-disciplinary team focused on developing new therapies for the treatment of cancer. Company’s GRC is a center of…

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Rapid clonal identification of biallelic CRISPR/Cas9 knock-ins using SNEAK PEEC

Here we provide a tool that directly selects biallelically edited knock-ins using cell-surface displays, thereby eliminating the need for extensive clonal verification. By doing so SNEAK PEEC greatly reduces the considerable effort currently expended to obtain biallelically edited clones. The ability to generate a clonal population with multiple edits is…

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We Could See The Return Of A Certain Prehistoric Creature In Our Lifetime

The proposed ice age creature is the woolly mammoth. Colossal hopes to revive it as soon as 2027, and it would be less of a clone and more of a genetic hybrid made possible with CRISPR-Cas9 DNA splicing technology, according to NPR. Theoretically, once mammoth DNA is genetically spliced with the…

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SG Americas Securities LLC sells 26,447 Editas Medicine, Inc. shares (NASDAQ:EDIT)

SG Americas Securities LLC decreased the number of Editas Medicine, Inc. (NASDAQ: EDIT) shares it owned during the third quarter, as stated in the most recent SEC filing that the company submitted. Mhe institutional investor now has 24,459 shares of the company’s stock in possession after selling 26,447 shares of…

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CRISPR/Cas12a-based assay for the rapid and high-sensitivity detection of Streptococcus agalactiae colonization in pregnant women with premature rupture of membrane

Background: Streptococcus agalactiae or group B Streptococcus (GBS) is a leading infectious cause of neonatal morbidity and mortality. It is essential to establish a robust method for the rapid and ultra-sensitive detection of GBS in pregnant women with premature rupture of membrane (PROM). Methods: This study developed a CRISPR-GBS assay…

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Screening of lymphoma radiotherapy-resistant genes

Introduction Lymphoma, a cancer characterized by a malignant tumor of the immune system that originates in the lymph nodes or lymphoid tissue, is one of the most common cancers worldwide. According to GLOBOCAN, the incidence of non-Hodgkin lymphoma (NHL) in both males and females ranked top ten among all cancers…

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What we know about oxytocin could be entirely wrong

The role of the ‘love hormone’ as a non-negotiable for social attachment is being questioned by research on the humble prairie vole. A study published on Friday has shown that prairie voles – which mate for life – can still form attachments with their mates and be a caring parent…

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LI’s Regeneron winners reflect humanity’s quest for knowledge

As founts of awe and inspiration, Long Island’s young scientists never disappoint. This month brought announcements of the 300 national semifinalists of the Regeneron Science Talent Search, the nation’s most prestigious such competition, and two weeks later, the 40 finalists who will travel to Washington in March for the last stage of the competition….

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Is it possible to recover from a severe heart attack?

Is it possible to fully recover from a severe heart attack? A recent study by scientists at UT Southwestern Medical Center in Texas, published in Science, suggests that with the help of gene editing, this may soon become reality. A heart attack happens when blood vessels are blocked and the…

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Principal/Associate Director Pre-clinical Bioinformatics – Repare Therapeutics

Repare Therapeutics provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal,…

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Fluorescent aptasensor based on the MNPs-CRISPR/Cas12a-TdT for the determination of nasopharyngeal carcinoma-derived exosomes

doi: 10.1007/s00604-023-05657-7. Affiliations Expand Affiliations 1 Department of Radiotherapy, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China. 2 Department of Pharmacy, Zigong Third People’s Hospital, Zigong, 643020, Sichuan, China. 3 Department of Otorhinolaryngology Head and Neck Surgery, Shenzhen Fuyong People’s Hospital, Shenzhen,…

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Monogamous Rodents Don’t Need “Love Molecule” To Pair Up

Prairie voles mate for life. Much like humans, once voles form a pair bond—typically with a member of the opposite sex—they cohabitate, coparent, and even prefer each other’s company over that of other voles. Decades of research on the monogamous rodents have led to a better understanding of the so-called…

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New Technology Developments in CRISPR and CAS Gene Market to Grow

CRISPR and CAS Gene Market The CRISPR and CAS Gene Market Report Overview 2022 Qualitative Research Study accomplished by Stratagem Market Insights research’s database of 350 pages, titled “Global CRISPR and CAS Gene Market Study” with 100+ market data Tables, Pie Charts, Graphs & Figures spread through Pages and easy-to-understand…

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Research Associate in Stem Cell Neurobiology job with KINGS COLLEGE LONDON

  Job description We are looking for a skilled research associate with a molecular biological background to join a vibrant group investigating amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD). You will be using CRISPR to gene edit human stem cells to introduce unpublished disease-linked mutations. This work will entail the use of…

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CRISPR Therapeutics AG (NASDAQ:CRSP) Receives Consensus Recommendation of “Hold” from Brokerages

Shares of CRISPR Therapeutics AG (NASDAQ:CRSP – Get Rating) have been given an average rating of “Moderate Buy” by the twenty analysts that are covering the firm, Marketbeat Ratings reports. Two analysts have rated the stock with a sell rating, three have given a hold rating and ten have assigned…

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Research Fellow, Bioinformatician, Cancer Science Institute job with NATIONAL UNIVERSITY OF SINGAPORE

Job Description The position of Postdoctoral Fellow (PDF) in computational cancer genomics is immediately available at The Cancer Science Institute of Singapore (The National University of Singapore). This PDF will lead a newly funded project in the laboratory of Dr. Jason Pitt that will explore how germline genetics and cell-of-origin…

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DekaBank Deutsche Girozentrale reduces its holdings in CRISPR Therapeutics AG (NASDAQ:CRSP)

The most recent report that DekaBank Deutsche Girozentrale submitted to the Securities and Exchange Commission (SEC) indicates that during the third quarter, the financial institution’s holdings in CRISPR Therapeutics AG (NASDAQ: CRSP) were reduced by 56.2%. The institutional investor was left with 20,000 shares after selling 25,660 shares over the…

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Scientist II, Bioinformatics Job Opening in South Plainfield, NJ at PTC Therapeutics, Inc.

Job Posting for Scientist II, Bioinformatics at PTC Therapeutics, Inc. Job Description Summary: The Scientist II, Bioinformatics is responsible for planning and performing scientific experiments that contribute to PTC’s research and drug discovery activities. The Scientist II is also responsible for communicating experimental results to his/her supervisor and…

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This home use kit makes CRISPR accessible to all

CRISPR therapies could cause cancer Even if CRISPR technology is a kind of revolution in genetic engineering, some experts emphasize CRISPR therapies could cause cancer or have unintended consequences. Some critics are concerned about environmental degradation, eugenics, and bioterrorism. But what exactly is CRISPR? Acronym for “clustered regularly interspaced short palindromic repeats,”…

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Cellinfinity Bio Announces Publication and Licensing of Key Technology for Directed Evolution of Cells That Allows for More Effective Adoptive Cell Therapy

WEST HAVEN, Conn. & SAN FRANCISCO–(BUSINESS WIRE)–Cellinfinity Bio, a privately held pioneer biotechnology company developing first/best-in-class cell therapy products against solid tumors and other diseases, today announced the publication of CLASH (CRISPR-based Library-scale AAV perturbation with Simultaneous HDR knock-in), a platform that for the first time enables massively parallel genomic…

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Bioinformatics Analyst III

× Job Title:  Bioinformatics Analyst III # of Openings:  1 Contract Length: 6 mos Key Responsibilities• Evaluate, develop, and implement computational methods, pipelines and tools for data analysis and visualization. Interpret results and contribute to hypothesis generation.• Implement our existing analytical workflows and establish new workflows as needed for analysis…

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I Edited Human DNA at Home With a DIY CRISPR Kit

I never thought I’d order live human kidney cells to my address, but that all changed when I found out about biohacker Jo Zayner’s at-home genetic engineering class.  You may know Jo Zayner, a “biohacker” who has been in the vanguard of scientific self-experimentation for years, from their role in…

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Gene Editing Technology Market to See Booming Growth

Gene Editing Technology The latest study released on the Global Gene Editing Technology Market by AMA Research evaluates market size, trend, and forecast to 2027. The Gene Editing Technology market study covers significant research data and proofs to be a handy resource document for managers, analysts, industry experts and other…

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Research Associate, Cancer Science Institute job with NATIONAL UNIVERSITY OF SINGAPORE

Job Description A research associate position is available immediately in Prof Daniel Tenen’s lab for a highly motivated Master or Ph.D. graduate with background in molecular or cellular biology, and bioinformatics to develop a novel, fully automated analysis pipeline for the newly emerging ChIP sequencing methods: “Cut and Run” and…

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Establishment and Methodological Evaluation of a Method for Rapid Detection of Helicobacter pylori and Virulence Genes Based on CRISPR-Cas12a,Infection and Drug Resistance

Introduction: More than half of the world’s people are infected or have been infected with Helicobacter pylori. This infection is related to many diseases, with its pathogenicity related to virulence factors. Therefore, the rapid diagnosis of H. pylori and genotyping of virulence genes play an extremely important role in the…

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SVB Leerink Brokers Lower Earnings Estimates for Intellia Therapeutics, Inc. (NASDAQ:NTLA)

Intellia Therapeutics, Inc. (NASDAQ:NTLA – Get Rating) – Equities research analysts at SVB Leerink dropped their FY2022 earnings per share estimates for shares of Intellia Therapeutics in a research note issued on Monday, January 23rd. SVB Leerink analyst M. Foroohar now anticipates that the company will earn ($5.72) per share…

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Cancer Vaccine Created via CRISPR Prevents and Stops Brain Tumors

Nluepke/Pixabay Innovative technologies such as the gene-editing tool CRISPR-Cas9 enable pioneering scientists to develop novel treatments for diseases such as cancer. A new study published in Science Translational Medicine funded by the National Institutes of Health unveils an innovative cancer vaccine developed with CRISPR-Cas9 that both terminates and prevents tumors…

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The Future of Science: Humanity Takes a Front Seat

Over the last few years, we saw breakthroughs and discoveries that scientists had only dreamed of. From the development of the life-saving COVID-19 vaccines to NASA crashing a spacecraft into an asteroid in a successful attempt to alter its orbit, clearly a lot can happen in a short period of…

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This New AI Tool Could Accelerate the Development of Gene-Editing on a Large-Scale

A new artificial intelligence program may just be the driving force behind the first simple production of modifiable proteins called zinc fingers that would treat diseases by switching genes on and off. The technique, which was developed by scientists from the University of Toronto and NYU Grossman School of Medicine, seeks to…

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Bioinformatics Analyst III (W2 Only) – SPECTRAFORCE TECHNOLOGIES Inc. – Remote

Job Title: Bioinformatics Analyst III Location: Remote Duration: 6 Months Pay Range : $52 – $57/hr on W2   Description: Key Responsibilities Evaluate, develop, and implement computational methods, pipelines and tools for data analysis and visualization. Interpret results and contribute to hypothesis generation. Implement our existing analytical workflows and establish…

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Cryo-EM structure and protease activity of the type III-E CRISPR-Cas effector

Hampton, H. G., Watson, B. N. J. & Fineran, P. C. The arms race between bacteria and their phage foes. Nature 577, 327–336 (2020). Article  CAS  Google Scholar  Makarova, K. S. et al. Evolution and classification of the CRISPR-Cas systems. Nat. Rev. Microbiol. 9, 467–477 (2011). Article  CAS  Google Scholar …

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Recursion Releases MolRec, a Compound Intelligence Tool for Drug Discovery, Alongside the Largest of Its Kind Open-Source Dataset During First R&D Day

For the first time ever, a demonstration version of one of Recursion’s Compound Intelligence tools to explore maps of biology and chemistry is open for anyone to use RxRx3, the underlying dataset released alongside MolRec™, spans almost the entire human genome and is 76 times larger than all previous datasets…

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AI tool makes speedy gene-editing possible, offers alternative to CRISPR

Researchers have designed an artificial intelligence (AI) program that may enable the production of customizable proteins called zinc fingers to treat diseases by turning genes on and off. The research published on Thursday in Nature Biotechnology may accelerate large-scale gene therapy development. Illnesses including cystic fibrosis, Tay-Sachs disease, and sickle…

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Vertex and CRISPR Therapeutics advance towards EMA approval for exa-cel

The therapy, exagamglogene autotemcel (exa-cel), has been developed for the treatment of sickle cell disease (SCD) and transfusion-dependent beta thalassemia (TDT). The submission is supported by two global Phase 3 studies. Vertex and CRISPR Therapeutics entered into a strategic research collaboration in 2015 focused on the use of CRISPR/Cas9 to…

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6 Undervalued Biotech Stocks for 2023

In the face of the bear market, biotechnology stocks have been performing better than the broader market, but Morningstar analysts say there are still plenty of undervalued stocks in this dynamic industry. That includes big names such as Moderna MRNA, which was in the spotlight for its coronavirus vaccine, and…

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A new AI-powered gene-editing technique could be set to replace CRISPR

Researchers would have to be able to figure out, out of a huge number of possible combinations, how each zinc finger interacts with its neighbor to make each desired genetic change. This is because these proteins connect to DNA in complex ways, so they would have to figure out how…

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What Is CRISPR-Cas12a2? & Why Does It Matter?

A Brief History of CRISPR CRISPR are genetic sequences found in bacteria, which use them as a defense mechanism against viruses called bacteriophages. It essentially targets the virus’s genetic material to stop its propagation. CRISPR molecules can be used together with the Cas9 protein (Cas mean CRISPR Associated Protein) to…

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Evolution of giant pandoravirus revealed by CRISPR/Cas9

Viral strains utilized in this work The following viral strains have been used in this study: Pandoravirus neocaledonia3, Pandoravirus macleodensis3, Pandoravirus kuranda (this study, ON887157), Mollivirus kamchatka26, Pithovirus sibericum27 and Mimivirus reunion28. Cloning of DNA constructs All primers used in this study are listed in Table S1. All vectors used in…

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3 Gene Editing Stocks to Buy Now OR You’ll Be Kicking Yourself Later

InvestorPlace – Stock Market News, Stock Advice & Trading Tips To many investors, gene editing sounds like the plot of a science fiction movie. The concept of being able to edit our DNA to cure genetic diseases is quite unbelievable, and the upside of gene editing to treat rare diseases…

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Global CRISPR Technology Research Report Report 2023-2027 Featuring Major Players

GlobeNewswire Meat, Poultry And Seafood Global Market Opportunities And Strategies To 2031 provides the strategists; marketers and senior management with the critical information they need to assess the global meat, poultry and seafood market as it emerges from the COVID 19 shut down.New York, Jan. 26, 2023 (GLOBE NEWSWIRE) —…

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The Read-Across to Graphite Bio’s CEDAR Sickle Cell Trial Suspension

Three weeks ago, on January 5, Graphite Bio announced a voluntary pause of their Phase I/II CEDAR clinical trial of nulabeglogene autogedtemcel (nula-cel) for sickle cell disease (SCD) after observing complications in the first dosed patient—prolonged low blood cell counts (pancytopenia) requiring ongoing transfusion and growth factor support. While the…

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Milestone for gene-edited therapy exa-cel for sickle cell disease

Vertex Pharmaceuticals (Europe) and CRISPR Therapeutics have announced that the European Medicines Agency (EMA) has validated the Marketing Authorization Application of exa-cel for the treatment of sickle cell disease (SCD) and transfusion-dependent beta thalassemia (TDT). The submission is supported by two global phase 3 studies investigating exa-cel as a potential…

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Inscripta Is Reimagining What The Synthetic Biology Company Of The Future Will Be

Inscripta’s team in Pleasanton, CA Inscripta Inscripta, a global leader in genome engineering, is reshaping the image of a synthetic biology company. Biomanufacturing is set to transform many industries by making the products that the world needs in a cleaner, more efficient, and sustainable way. But there is not a…

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First regulatory submission for a CRISPR-based medicine

The first regulatory submission for a CRISPR-based therapy has been validated by the European Medicines Agency, to treat sickle cell disease and transfusion-dependent beta thalassemia. The European Medicines Agency (EMA) has validated the Marketing Authorization Application (MAA) for exagamglogene autotemcel (exa-cel), the first regulatory submission for a CRISPR-based medicine. Through…

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3 Gene Editing Stocks With the Best Long-Term Potential

Source: vxhal/ShutterStock.com Gene editing stocks present themselves as one of the more lucrative investments in the healthcare sector. Gene editing, a revolutionary take on the science of genetic engineering, has the potential to countless lives around the globe. By introducing genetic material into cells, scientists can correct genetic abnormalities in…

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Beta thalassemia, towards a new gene therapy-breakinglatest.news-Breaking Latest News

People with beta thalassemia know that gene therapy can be effective in reducing, if not eliminating, the need for transfusions, so much so that a therapy of this kind has recently been authorized in the USA. The company that produces it, however, decided that it was not worth marketing in…

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Gene Therapy for Blood Disorders Market Size and Revenue Share

The newly published report titled “Global Gene Therapy for Blood Disorders Market- By Trends, Industry Competition Analysis, Pipeline Analysis/Clinical Trial, Revenue (US$ Billions) and Forecast Till 2030.” features in-depth analysis and an extensive market study, exploring its significant upcoming years industry factors. According to the latest gene therapy industry market…

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Nuclease-dead S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in patient-derived stem cell model of Parkinson’s disease

Abstract Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, but no disease-modifying therapies have been successful in clinical translation presenting a major unmet medical need. A promising target is alpha-synuclein or its aggregated form, which accumulates in the brain of PD patients as Lewy bodies. While it…

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Bioinformatician (Fixed Term) – Job Opportunities

Applications are invited for a talented research associate in bioinformatics/computational biology to lead an exciting project aiming to shed light on the fundamental biology of neurodegenerative diseases and mitochondrial dysfunction using a single cell data set and functional genomic screens including CRISPR and Perturb-seq. The post holder will join Professor…

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New Innovations That Could Change Dermatology

At Maui Derm Hawaii 2023, Rox Anderson, MD, FAAD, director of the Wellman Center for Photomedicine at Harvard Medical School in Boston, Massachusetts, highlighted the future of the dermatology field, as far as emerging therapies and technology in his session, “Innovations in Dermatology 2023: A Peek Into the Future”. Anderson…

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Cell Therapy Bioprocessing Market Predicted to Reach USD 30,052.61 Mn by 2028 Says, The Insight Partners

According to our new research study on “Cell Therapy Bioprocessing Market Forecast to 2028 – COVID-19 Impact and Global Analysis – by technology, cell type, end user,” the market is expected to reach US$ 30,052.61 million in 2028 from US$ 11,192.50 million in 2020. The market is estimated to grow…

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CRISPR Technology Global Markets Report 2023: A $9.2

Dublin, Jan. 25, 2023 (GLOBE NEWSWIRE) — The “CRISPR Technology: Global Markets” report has been added to ResearchAndMarkets.com‘s offering. The current report provides detailed exposure to the CRISPR technology market. This report highlights the current and future market potential of CRISPR technology, along with a detailed analysis of the drivers,…

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CRISPR’s Wild First Decade Only Scratches the Surface of Its Potential

Ten years ago, a little-known bacterial defense mechanism skyrocketed to fame as a powerful genome editor. In the decade since, CRISPR-Cas9 has spun off multiple variants, expanding into a comprehensive toolbox that can edit the genetic code of life. Far from an ivory tower pursuit, its practical uses in research,…

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Computational Postdoctoral Fellow – combinatorial CRISPR screening

About the Role: We are looking for a Computational Postdoctoral Fellow to help deliver Project Symphony, an OpenTargets-funded Project aiming to perform extensive combinatorial CRISPR screening of cancer cell lines at the Wellcome Sanger Institute. This position will be for a 3-year fixed term contract. You will join the Experimental…

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EMA clears barrier on road to landmark Vertex-CRISPR approval

Vertex and CRISPR Therapeutics have taken a small step toward a landmark approval, securing European Medicines Agency (EMA) validation of the approval application for their CRISPR-Cas9 candidate. The candidate, exagamglogene autotemcel (exa-cel), is an autologous cell therapy treatment for sickle cell disease and transfusion-dependent beta thalassemia. By using CRISPR-Cas9 to…

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Efficiency of CRISPR/Cas9 Gets a Boost

In the course of optimising key procedures of genome editing, researchers from the department of Developmental Biology / Physiology at the Centre for Organismal Studies of Heidelberg University have succeeded in substantially improving the efficiency of molecular genetic methods such as CRISPR/Cas9 and related systems, and in broadening their areas…

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Truist Financial Corp Raises Position in CRISPR Therapeutics AG (NASDAQ:CRSP)

Truist Financial Corp raised its stake in shares of CRISPR Therapeutics AG (NASDAQ:CRSP – Get Rating) by 81.9% during the third quarter, according to the company in its most recent Form 13F filing with the Securities and Exchange Commission (SEC). The firm owned 5,996 shares of the company’s stock after…

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CrisprBits develops India’s first CRISPR-based SARS-CoV-2 test with Omicron detection

OmiCrisp has been developed with support from Centre for Cellular And Molecular Platforms (C-CAMP)-InDx Programme CrisprBits, one of the first Indian companies using CRISPR, a breakthrough gene-editing technology, has developed OmiCrisp, a CRISPR- based test to detect SARS-CoV-2 and to determine whether it is an Omicron or non-omicron variant. The…

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Establishment and Methodological Evaluation of a Method for Rapid Dete

Introduction Helicobacter pylori (H. pylori) is a Gram-negative, spiral microaerophilic bacterium that infects more than half of the world’s population.1,2 Studies have shown that this bacterium is the main pathogenic factor in chronic gastritis and peptic ulcers, and is related to the occurrence and development of gastric cancer.3,4 For several…

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Seven technologies to watch in 2023

From protein sequencing to electron microscopy, and from archaeology to astronomy, here are seven technologies that are likely to shake up science in the year ahead. Single-molecule protein sequencing The proteome represents the complete set of proteins made by a cell or organism, and can be deeply informative about health…

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Single and multiplexed gene repression in solventogenic Clostridium via Cas12a-based CRISPR interference

. 2022 Dec 24;8(1):148-156. doi: 10.1016/j.synbio.2022.12.005. eCollection 2023 Mar. Affiliations Expand Affiliation 1 Department of Chemical and Biomolecular Engineering, Tulane University, New Orleans, LA, 70118, United States. Free PMC article Item in Clipboard Rochelle Carla Joseph et al. Synth Syst Biotechnol. 2022. Free PMC article Show details Display options Display options…

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TRIM24 controls induction of latent HIV-1 by stimulating transcriptional elongation

Finzi, D. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 278, 1295–1300 (1997). Article  CAS  Google Scholar  Wong, J. K. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. Science 278, 1291–1295 (1997). Article  CAS  Google Scholar  Joos, B. et al. HIV rebounds…

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Cascade DNA Circuits Mediated CRISPR-Cas12a Fluorescent Aptasensor based on Multifunctional Fe3 O4 @hollow-TiO2 @MoS2 Nanochains for Tetracycline Determination

Herein, for the first time, the CRISPR-Cas12a system is combined with aptamer, cascaded dynamic DNA network circuits, and Fe3 O4 @hollow-TiO2 @MoS2 nanochains (Fe3 O4 @h-TiO2 @MoS2 NCs) to construct an efficient sensing platform for tetracycline (TC) analysis. In this strategy, specific recognition of the target is transduced and amplified…

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New insights into the role of the NOTCH1 gene in congenital heart defects

Graphical abstract. Credit: Circulation Research (2022). DOI: 10.1161/CIRCRESAHA.122.321398 A new study published in Circulation Research provides novel insights into how mutations in the NOTCH1gene may lead to abnormal differentiation and proliferation of cardiomyocytes and contribute to ventricular hypoplasia and other structural anomalies found in congenital heart defects in humans. In…

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Human hg38 chr19:11,216,461-11,670,150 UCSC Genome Browser v442

     Custom Tracks 1806hidedensefull 468hidedensefull BT20hidedensefull BT474hidedensefull MCF7hidedensefull T47Dhidedensefull    Mapping and Sequencing Base Positionhidedensefull p13 Fix Patcheshidedensesquishpackfull p13 Alt Haplotypeshidedensesquishpackfull Assemblyhidedensesquishpackfull Centromereshidedensesquishpackfull Chromosome Bandhidedensesquishpackfull Clone Endshidedensesquishpackfull Exome Probesetshidedensesquishpackfull FISH Cloneshidedensesquishpackfull Gaphidedensesquishpackfull GC Percenthidedensefull GRC Contigshidedensefull GRC Incidenthidedensesquishpackfull Hg19 Diffhidedensesquishpackfull INSDChidedensesquishpackfull LiftOver & ReMaphidedensesquishpackfull LRG Regionshidedensesquishpackfull Mappabilityhideshow RefSeq Acchidedensesquishpackfull…

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CRISPR gene editing is in clinical trials to treat sickle cell disease, cancer, HIV/AIDS and some rare inherited diseases. Here’s what we can expect going forward

Examples of Crispr’s promise arrive frequently, as new clinical trials report their results. Most are still at an early stage, but the sheer breadth of diseases targeted, and the mainly positive results so far, mean it is easy to be optimistic about the future of this technique. Follow the latest…

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Female graduates surpass male in medal tally at School of Life Sciences, JSS AHER

Mysuru: School of Life Sciences, Mysuru and Life Sciences Departments of JSS Academy of Higher Education and Research (JSS AHER), Mysuru, had organised Graduates’ Reception for B.Sc and M.Sc graduates of the academic year 2021-22 at Sri Rajendra Auditorium, JSS Medical College, Mysuru recently. In his welcome address, Dr. K….

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Raymond James Financial Services Advisors Inc. increases its holdings of CRISPR Therapeutics AG (NASDAQ:CRSP)

Raymond James Financial Services Advisors Inc. disclosed to the Securities and Exchange Commission (SEC) in its most recent filing that during the third quarter of 2018, the company increased its holdings in CRISPR Therapeutics AG (NASDAQ: CRSP) by 26.5%. The institutional investor’s stock holdings in the company now total 26,280…

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CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Technology Global Markets Report 2023 – ResearchAndMarkets.com

DUBLIN–(BUSINESS WIRE)–The “CRISPR Technology: Global Markets” report has been added to ResearchAndMarkets.com‘s offering. A $9.2 Billion Market by 2027, from $3.3 Billion in 2022 The current report provides detailed exposure to the CRISPR technology market. This report highlights the current and future market potential of CRISPR technology, along with a…

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CRISPR Nano-Technology Market Estimated To Experience a Hike

CRISPR Nano-Technology Market The CRISPR Nano-Technology Market Report examines many facets of the industry including market size, market status, market trends, and forecasts. The report also provides brief information on specific growth opportunities by competitors and key market drivers. The Market Report provides In-depth analysis of the market status of…

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Genome editing procedures optimized — ScienceDaily

In the course of optimising key procedures of genome editing, researchers from the department of Developmental Biology / Physiology at the Centre for Organismal Studies of Heidelberg University have succeeded in substantially improving the efficiency of molecular genetic methods such as CRISPR/Cas9 and related systems, and in broadening their areas…

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CRISPR pioneer looks to tech’s past, future in new review

It took five years to sequence the first human genome. Today, it takes less than 24 hours. Rapid genome sequencing is one of the many advances indebted to CRISPR-Cas9, the powerful gene editing technology that has fundamentally changed research and biomedicine in the 10 years since its advent. In a…

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A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens

Abstract The ability to map genetic interactions has been essential for determining gene function and defining biological pathways. Therefore, a system to readily perform genome-wide genetic modifier screens in human cells is a powerful platform for dissecting complex processes in mammalian cells, where redundancy and adaptation commonly mask the phenotype…

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Sensitive and selective DNA detecting electrochemical sensor via double cleaving CRISPR Cas12a and dual polymerization on hyperbranched rolling circle amplification

Electrochemical sensors are widely used for nucleic acid detection. However, they exhibit low sensitivity and specificity. To overcome these limitations, DNA amplification method is necessary. In this study, we introduced CRISPR (Clustered regularly interspaced short palindromic repeats) Cas12a-dependent hyperbranched rolling circle amplification (HRCA) into an electrochemical sensor platform. By resolving…

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CRISPR Therapeutics (NASDAQ:CRSP) PT Lowered to $70.00

CRISPR Therapeutics (NASDAQ:CRSP – Get Rating) had its price objective lowered by stock analysts at JMP Securities from $100.00 to $70.00 in a research note issued to investors on Thursday, The Fly reports. The firm presently has a “market outperform” rating on the stock. JMP Securities’ target price points to…

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Basic research opens up new therapeutic opportunities for fighting leukemia

Genome-wide CRISPR/Cas9-based loss-of-function screen identifies genetic dependencies of STAT3Y640F-driven cells a) Schematic illustration of a competitive proliferation assay. b) Competitive proliferation assays of clonal Cas9-expressing STATY640F-driven HPC7 or c) clonal Cas9-HPC7 empty vector cells expressing IRF670 and sgRNAs targeting either Myb (positive control) or the Rosa26 locus (negative control). d)…

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CRISPR/Cas9 Market to Witness Huge Growth by Key Players:

The market report delivers an all-inclusive analysis of the market structure along with a forecast of the various segments and sub-segments of the CRISPR/Cas9 industry. This wide-ranging market research report acts as a backbone for the success of business in any niche. The CRISPR/Cas9 market survey report has been prepared…

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‘A magic wand’: World-first NZ gene-editing trial may offer cure for debilitating disorder

A new therapy involving revolutionary gene-editing tech CRISPR-Cas9 may have offered a permanent cure for the rare but debilitating genetic disorder, hereditary angioedema. Photo / 123RF One of the first human gene-editing trials ever held in New Zealand may have offered a permanent cure for a rare but potentially life-threatening…

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CRISPR Technology: Global Markets

ReportLinker Report Scope:. The current report provides detailed exposure to the CRISPR technology market.This report highlights the current and future market potential of CRISPR technology, along with a detailed analysis of the drivers, restraints, and challenges in the market. New York, Jan. 16, 2023 (GLOBE NEWSWIRE) — Reportlinker.com announces the…

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In Vitro CRISPR-Cas12a-Based Detection of Cancer-Associated TP53 Hotspot Mutations Beyond the crRNA Seed Region

Cost-effective and time-efficient detection of oncogenic mutations supports improved presymptomatic cancer diagnostics and post-treatment disease monitoring. Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas12a is an RNA-guided endonuclease that, upon protospacer adjacent motif (PAM)-dependent recognition of target DNA in cis, exhibits indiscriminate ssDNase activity in trans, which can be harnessed for…

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Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling

Childs, B. G. et al. Senescent cells: an emerging target for diseases of ageing. Nat. Rev. Drug Discov. 16, 718–735 (2017). Article  CAS  Google Scholar  Gil, J. Cellular senescence causes ageing. Nat. Rev. Mol. Cell Biol. 20, 388 (2019). Article  CAS  Google Scholar  van Deursen, J. M. The role of…

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Ensoma Raises $85M in Series B

Ensoma, a Boston, MA-based genomic medicines company developing one-time in vivo treatments that precisely engineer any cell of the hematopoietic system, raised $85M in Series B funding, and acquired Twelve Bio, a Copenhagen, Denmark-based CRISPR engineering company. The round was co-led by Arix Bioscience and 5AM Ventures with participation from F-Prime Capital,…

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CRISPR/Cas9-mediated genome editing in diploid and tetraploid potatoes

Ali A, Hassan S, Asad A (2002) Incidence of six potato virus es in spring, summer and autumn potato crops of the North West Frontier Province of Pakistan. Aust Plant Path 31:143–146 Article  Google Scholar  Andersson M, Turesson H, Nicolia A, Falt A, Samuelsson M, Hofvander P (2017) Efficient targeted…

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Hypersaline Lake Urmia: a potential hotspot for microbial genomic variation

Physico-chemical features of Lake Urmia Sampling was performed during the period of lowest rainfall and input volume in the year when the lake water reached the highest salt concentration (locations shown in Fig. 1, Supplementary Table S1). The measured ionic composition of the collected brine showed the typical composition of halite-dominated…

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Newly Discovered CRISPR Immune System Shuts Down Infected Cells To Thwart Infection

In a rare feat, Utah State University biochemists Thomson Hallmark and Ryan Jackson, along with collaborators, published not one, but two seminal papers in a top-tier, peer-reviewed journal this week. Their findings describe the structure and function of a newly discovered CRISPR immune system that — unlike better-known CRISPR systems…

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Comprehensive Report on CRISPR Cas9 Market 2022 Trends, Growth Demand, Opportunities & Forecast To 2031

A New Research on the CRISPR Cas9 Market was conducted across a variety of industries in various regions to produce more than 250+ page reports. This study is a perfect blend of qualitative and quantifiable information highlighting key market developments, industry and competitors’ challenges in gap analysis and new opportunities…

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Short Interest in CRISPR Therapeutics AG (NASDAQ:CRSP) Declines By 16.2%

CRISPR Therapeutics AG (NASDAQ:CRSP – Get Rating) was the target of a significant drop in short interest in December. As of December 15th, there was short interest totalling 9,340,000 shares, a drop of 16.2% from the November 30th total of 11,140,000 shares. Based on an average trading volume of 1,060,000…

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A minimally invasive fin scratching protocol for fast genotyping and early selection of zebrafish embryos

Aleström, P. et al. Zebrafish: Housing and husbandry recommendations. Lab. Anim. 54, 213–224 (2020). Article  Google Scholar  Hubrecht, R. C. & Carter, E. The 3Rs and humane experimental technique: Implementing change. Animal (Basel) 9, E754 (2019). Google Scholar  Russell, W. M. S. & Burch, R. L. The Principles of Humane…

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A multi-omics integrative network map of maize

Eisenstein, M. Big data: the power of petabytes. Nature 527, S2–S4 (2015). Article  CAS  Google Scholar  Trewavas, A. A brief history of systems biology: ‘Every object that biology studies is a system of systems’. Francois Jacob (1974). Plant Cell 18, 2420–2430 (2006). Article  CAS  Google Scholar  Dixon, S. J., Costanzo,…

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RCSB PDB – 8BD4: TniQ-capped Tns-ATP-dsDNA complex

CRISPR-Cas systems have been co-opted by Tn7-like transposable elements to direct RNA-guided transposition. Type V-K CRISPR-associated transposons rely on the concerted activities of the pseudonuclease Cas12k, the AAA+ ATPase TnsC, the Zn-finger protein TniQ, and the transposase TnsB … CRISPR-Cas systems have been co-opted by Tn7-like transposable elements to direct…

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Multistep diversification in spatiotemporal bacterial-phage coevolution

Marsh, P. & Wellington, E. M. H. Phage-host interactions in soil. FEMS Microbiol. Ecol. 15, 99–107 (1994). Article  Google Scholar  Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S. & Koskella, B. The impact of bacteriophages on phyllosphere bacterial abundance and composition. Mol. Ecol. 27, 2025–2038 (2018). Article …

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The 5 Most Anticipated Scientific Breakthroughs For 2023, According To The BBC

This year, many advances in science, medicine and space exploration were introduced to the world, leaving precedents and foundations for continuing development in 2023. this also includes For the Artemis program of the National Aeronautics and Space Administration (NASA), which brought the world’s attention back to the exploration of the…

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This Christmas, DNA engineering is giving the families of leukaemia sufferers hope

In May 2022, a clinical trial quietly got under way in London when a British teenager named Alyssa became the first patient to receive an experimental treatment generated using “base-editing”, an emerging form of DNA engineering. Alyssa, 13, had exhausted all conventional treatments for a difficult-to-treat blood cancer, and was…

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Systematic interrogation of tumor cell resistance to CAR T cell therapy in pancreatic cancer | Cancer Research

Chimeric antigen receptor (CAR) T cell therapy can lead to dramatic clinical responses in B cell malignancies. However, early clinical trials with CAR T cell therapy in non-B cell malignancies have been disappointing to date, suggesting that tumor intrinsic features contribute to resistance. To investigate tumor intrinsic modes of resistance,…

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Gene therapies raise difficult legal and ethical questions

Jessica Almqvist, professor of International Law and Human Rights. Photo Kennet Ruona. Credit: Lund University New advanced therapies can alleviate or cure chronic diseases. But medical progress raises the question of how rights should be protected and balanced, according to Jessica Almqvist, professor in international law and human rights, who…

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