Tag: crispr

Molecular Mechanisms of Cereblon-Interacting Small Molecules in Multiple Myeloma Therapy

This article was originally published here J Pers Med. 2021 Nov 11;11(11):1185. doi: 10.3390/jpm11111185. ABSTRACT Thalidomide analogues (or immunomodulatory imide drugs, IMiDs) are cornerstones in the treatment of multiple myeloma (MM). These drugs bind Cereblon (CRBN), a receptor for the Cullin-ring 4 ubiquitin-ligase (CRL4) complex, to modify its substrate specificity….

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CRISPR-Created Model of Fabry Disease Sparks New Insights

Kidney organoids designed with the same mutation as that present in Fabry disease can help investigators better understand how the disease functions, authors suggested. A new report makes the case that stem-cell-derived kidney organoids can provide a meaningful model for understanding how Fabry disease affects the body and for developing…

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CRISPR AG (CRSP) falls 2.63% to Close at $78.79 on November 26

Last Price $ Last Trade Change $ Change Percent % Open $ Prev Close $ High $ low $ 52 Week High $ 52 Week Low $ Market Cap PE Ratio Volume Exchange CRSP – Market Data & News Trade CRISPR Therapeutics AG (NASDAQ: CRSP) shares fell 2.63%, or…

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A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program

This article was originally published here Nat Commun. 2021 Nov 25;12(1):6905. doi: 10.1038/s41467-021-27270-z. ABSTRACT Although 90% of children with acute lymphoblastic leukemia (ALL) are now cured, the prognosis for infant-ALL remains dismal. Infant-ALL is usually caused by a single genetic hit that arises in utero: an MLL/KMT2A gene rearrangement (MLL-r)….

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BHLH11: Active Repressor for Iron Toxicity in Arabidopsis

Iron (Fe) is an indispensable microelement for plant growth and development, but Fe excess can be toxic to plants. To maintain Fe homeostasis, plants must sense the environmental Fe concentration and fine-tune the expression of Fe uptake-associated genes accordingly. Previous studies have shown that bHLH11 is a negative transcription factor…

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New research details using gene editing to make stronger antibiotics

New research has been published in Nature Communications, describing how a team of scientists from the University of Manchester used gene editing to manufacture new antibiotics. The team used CRISPR-Cas9 gene editing to create new non-ribosomal peptide synthetase (NRPS) enzymes, critical in the natural production of antibiotics like penicillin. Previously,…

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An electrochemical protocol for CRISPR-mediated gene-editing of sheep embryonic fibroblast cells

Genetic engineering of farm animals is commonly carried out via cell-mediated transfection followed by somatic cell nuclear transfer. However, efficient transfer of exogenous DNA into ovine embryonic fibroblast (EF) cells without compromising cell viability have remained a challenging issue. Here, we aimed to develop a protocol for electrotransfection of sheep…

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Postdoctoral Researcher in Plant-Virus Interactions (nr 1)

Category Research / Academic Location Amsterdam Are you a skilled researcher in Plant biology, and intrigued by how plant viruses manipulate their host? We are now seeking a postdoctoral researcher for an ambitious proteomics project on plant viruses. At the University of Amsterdam (UvA), we study how RNA viruses interact with…

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Scientists produce new antibiotics by gene editing

Scientists have discovered a new route to produce complex antibiotics exploiting gene editing to re-programme pathways to future medicines urgently required to combat antimicrobial resistance, treat neglected diseases and tackle future pandemics. Researchers from The University of Manchester have discovered a new way of manipulating key assembly line enzymes in…

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Breeder Q&A: All about basil

While basil is popular with consumers and economically important for the industry, the culinary herb has yet to benefit from the intensive research treatment enjoyed by crops such as corn, wheat, and soy. It is also no secret that the pipeline of new degreed or experienced talent simply is not…

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In Situ Hand-in-Hand DNA Tile Assembly and CRISPR/Cas12a-based Ultrasensitive Detection for Leukemia Diagnosis,Sensors and Actuators B: Chemical

CRISPR/Cas technology has attracted increasing attention for use in accurate and sensitive nucleic acid detection, and has innovated the field of molecular diagnostics. Because it is programmability and shows high fidelity and effective signal amplification capabilities. Specifically, Cas12a has been evaluated through in-depth research because it triggers collateral trans-cleavage activity…

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Protein Barcodes Enable High-Dimensional Single-Cell CRISPR Screens.

158232 pLKO_HA.AU1.VSVg_NGFR Protein Barcode (Pro-Code) for vector/cell tracking. Contains U6 trRNA cassette for sgRNA cloning. Enables phenotypic CRISPR screens at a single cell resolution (using cytometry). Loading… 158233 pLKO_NWS.FLAG.VSVg_NGFR Protein Barcode (Pro-Code) for vector/cell tracking. Contains U6 trRNA cassette for sgRNA cloning. Enables phenotypic CRISPR screens at a single cell…

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ecDNA hubs drive cooperative intermolecular oncogene expression

1. Wu, S. et al. Circular ecDNA promotes accessible chromatin and high oncogene expression. Nature 575, 699–703 (2019). 2. Gorkin, D. U., Leung, D. & Ren, B. The 3D genome in transcriptional regulation and pluripotency. Cell Stem Cell 14, 762–775 (2014). CAS  PubMed  PubMed Central  Google Scholar  3. Zheng, H….

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Infecting Gut Microbes with CRISPR-loaded Virus Demonstrates Potential for Microbiome Gene Editing

Escherichia coli (E. Coli) bacteria. In a first, researchers at the UC San Francisco have successfully used the DNA-editing system, CRISPR to alter the genomes of bacteria living in the guts of mammals, a development which stands to advance our understanding of the microbiome and could eventually pave the way…

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BioTechniques Explores the Ethics Surrounding CRISPR Gene Editing

Gene engineering is an umbrella term for several gene-editing systems, including CRISPR (clusters of regularly interspaced short palindromic repeats) techniques. CRISPR describes a region of DNA that holds short, repeated sequences that are sandwiched together with “spacers”. Developments in CRISPR gene editing techniques and technologies have accelerated over the past…

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Senior Data Scientist (Machine Learning) – Job Offer at Lonza AG

Senior Data Scientist (Machine Learning) Switzerland, BaselUnited Kingdom, Cambridge Today, Lonza is a global leader in life sciences operating across three continents. While we work in science, there’s no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses…

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AstraZeneca opens new advanced therapeutics R&D facility in Cambridge

The pharma giant said the new £1bn (US$1.3bn) research and development center will include advanced robotics, high-throughput screening and AI-driven technology. A spokesperson for AstraZeneca told BioPharma-Reporter that the facility aims to pioneer a faster and more agile approach to developing medicines, in order to fully deliver patient-centered precision medicine…

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CRISPR Reveals how Hox Genes Controls Appearance

New findings utilizing CRISPR-Cas9 gene editing in drosophila demonstrate the ‘scaffold’ role of Hox genes in the development of anatomical appearance.  Following on from the ‘McGinnis experiment’ 30-years ago, Ankush Auradkar, William McGinnis’ mentee, has led a study on Hox genes, alongside senior author Ethan Bier (both University of California San Diego; UCSD, CA, USA). The researchers used CRISPR-Cas9 gene-editing technology to investigate the role…

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ToolGen Files Motion to Exclude Evidence, CVC Opposes, and ToolGen Replies in Interference No. 106,127 | McDonnell Boehnen Hulbert & Berghoff LLP

In its turn, on September 17th, Senior Party ToolGen Inc. filed its Motion to Exclude certain evidence presented by Junior Party the University of California/Berkeley, the University of Vienna, and Emmanuelle Charpentier (collectively, “CVC”) in Interference No. 106,127.  CVC filed its Opposition to ToolGen’s motion on October 8th, and ToolGen filed…

Continue Reading ToolGen Files Motion to Exclude Evidence, CVC Opposes, and ToolGen Replies in Interference No. 106,127 | McDonnell Boehnen Hulbert & Berghoff LLP

In the battle to save beer, it’s CRISPR vs. climate change

A staple crop around the world, barley is grown for animal feed, breads and cereals, and, most crucially of all, as malt for making beer and whiskey.  But a warmer world is posing problems for this essential brew ingredient. Fortunately, CRISPR and clever scientists have found a way to keep…

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Intellia Therapeutics Announces Expansion of Ongoing Phase

CAMBRIDGE, Mass., Nov. 22, 2021 (GLOBE NEWSWIRE) —  Intellia Therapeutics, Inc. (NASDAQ:NTLA) announced today that the United Kingdom Medicines and Healthcare products Regulatory Agency (MHRA) has approved a protocol amendment for the Company’s ongoing Phase 1 study of NTLA-2001 to include patients with ATTR amyloidosis with cardiomyopathy (ATTR-CM). The study…

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Targeted integration of EpCAM-specific CAR in human induced pluripotent stem cells and their differentiation into NK cells | Stem Cell Research & Therapy

1. Shimasaki N, Jain A, Campana D. NK cells for cancer immunotherapy. Nat Rev Drug Discov. 2020;19(3):200–18. CAS  PubMed  Google Scholar  2. Myers JA, Miller JS. Exploring the NK cell platform for cancer immunotherapy. Nat Rev Clin Oncol. 2021;18(2):85–100. PubMed  Google Scholar  3. Cantoni C, Wurzer H, Thomas C, Vitale…

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the race to make antiviral drugs

It took just days for Pfizer and Moderna to design an effective mRNA vaccine against COVID-19 – a breathtaking display of the power of this state-of-the-art mRNA technology. By contrast it took years to design the first effective antiviral drugs against COVID-19, paxlovid and molnupiravir – a dismal display of…

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the race to make antiviral drugs

It took just days for Pfizer and Moderna to design an effective mRNA vaccine against COVID-19 – a breathtaking display of the power of this state-of-the-art mRNA technology. By contrast it took years to design the first effective antiviral drugs against COVID-19, paxlovid and molnupiravir – a dismal display of…

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BIOINFORMATICIAN I PRATT SCHOOL OF ENGINEERING, Duke University Pratt School of Engineering, Durham, North Carolina

Summary We are looking for a talented and motivated individual to work with teams of Researchers and Scientists providing bioinformatics training, consulting, application development and support as part of the Center for Advanced Genomic Technologies (CAGT). Work performed • Contribute to the design, development, implementation, and testing of bioinformatic tools…

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Continuous-flow, electrically triggered, single cell-level electroporation

Credit: Technology Journal Graduate students Mingde ‘Jack’ Zheng and Joseph Sherba have developed a novel, microfluidic platform for monitoring electroporation and molecular delivery at the single cell-level as part of a collaborative re-search team led by Professors Jeffrey Zahn and David Shreiber in the Department of Biomedical Engineer-ing and Professors…

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Continuous-flow, electrically triggered, single cell-level electroporation

Credit: Technology Journal Graduate students Mingde ‘Jack’ Zheng and Joseph Sherba have developed a novel, microfluidic platform for monitoring electroporation and molecular delivery at the single cell-level as part of a collaborative re-search team led by Professors Jeffrey Zahn and David Shreiber in the Department of Biomedical Engineer-ing and Professors…

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Most Genetic Counselors Encounter Discrepant Variant Classifications, Must Work Out Interpretations

NEW YORK — What a certain genetic variant means to one testing lab might not be the same as what it means to another, leaving genetic counselors to work the interpretation out. At the National Society of Genetic Counselors annual meeting this year, Brian Reys, a genetic counselor at the…

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Syngene International Limited Senior Research Investigator-Cell Biology

Designation: Senior Research Investigator- Cell BiologyJob Location: BangaloreDepartment: Discovery BiologyAbout SyngeneIncorporated in 1993, Syngene International Ltd. is an innovation-focused global discovery, development and manufacturing organization providing integrated scientific services to the pharmaceutical, biotechnology, nutrition, animal health, consumer goods and specialty chemical industries around the world. Syngene s clientele includes world…

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Uncontrollable Species Collapse Too High A Price For GE Predator Control

Saturday, 20 November 2021, 3:07 pmPress Release: GE Free NZ Using Genetic Engineering (GE) technologies such as gene editing for predator control to drive population collapse or extinction, pose unknown dangers and much suffering. [1] Scientists have openly expressed concerns about the ability to control gene trait transfer to other…

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CVC Files Motion to Exclude Evidence, ToolGen Opposes, and CVC Replies in Interference No. 106,126 | McDonnell Boehnen Hulbert & Berghoff LLP

On September 17th, Junior Party the University of California/Berkeley, the University of Vienna, and Emmanuelle Charpentier (collectively, “CVC”) filed its Motion to Exclude certain evidence presented by Senior Party ToolGen Inc. in Interference No. 106,126.  ToolGen filed its Opposition to CVC’s motion on October 8th, and CVC filed its Reply…

Continue Reading CVC Files Motion to Exclude Evidence, ToolGen Opposes, and CVC Replies in Interference No. 106,126 | McDonnell Boehnen Hulbert & Berghoff LLP

Epigenetic Editing Startup Chroma Medicine Launches With $125M Funding

Chroma Medicine, a new Cambridge, Massachusetts startup, came out of stealth mode and officially launched this week with $125M in Series A financing to develop the therapeutic potential of epigenetic editing. The company has a team of well-known and experienced scientific founders including Beam Therapeutics founder and Broad Institute professor…

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Intellia (NTLA) gains 0.37% for November 18

Last Price $ Last Trade Change $ Change Percent % Open $ Prev Close $ High $ low $ 52 Week High $ 52 Week Low $ Market Cap PE Ratio Volume Exchange NTLA – Market Data & News Trade Today, Intellia Therapeutics Inc Inc’s (NASDAQ: NTLA) stock gained…

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p53 Is Activated During CRISPR-Cas9 Genome Editing

A protein that protects cells from DNA damage, p53, is activated during gene editing using the CRISPR technique. Consequently, cells with mutated p53 have a survival advantage, which can cause cancer. Researchers at Karolinska Institutet in Sweden have found new links between CRISPR, p53 and other cancer genes that could…

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p53 Is Activated During CRISPR-Cas9 Genome Editing

A protein that protects cells from DNA damage, p53, is activated during gene editing using the CRISPR technique. Consequently, cells with mutated p53 have a survival advantage, which can cause cancer. Researchers at Karolinska Institutet in Sweden have found new links between CRISPR, p53 and other cancer genes that could…

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New findings on the link between CRISPR gene-

A protein that protects cells from DNA damage, p53, is activated during gene editing using the CRISPR technique. Consequently, cells with mutated p53 have a survival advantage, which can cause cancer. Researchers at Karolinska Institutet in Sweden have found new links between CRISPR, p53 and other cancer genes that could…

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New insights into the link between CRISPR and mutant cells

When a gene is edited with CRISPR, a protein that protects cells from DNA damage p53 is activated. Therefore, cells that have mutations in p53 have a survival advantage, which could cause cancer. Researchers from Sweden’s Karolinska Institutet discovered new links between CRISPR and p53. This could help prevent the…

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‘Growing a chair is easy’ and other wisdom from George Church

George Church, the larger-than-life Harvard biologist who pioneered both DNA sequencing and gene editing, is known for making bold bets. He’s founded more than three dozen companies, including ones promising to curb climate change with cold-tolerant elephants, end inherited disease with a dating app, and keep your DNA out of…

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CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity

1. Chapman, N. M., Boothby, M. R. & Chi, H. Metabolic coordination of T cell quiescence and activation. Nat. Rev. Immunol. 20, 55–70 (2020). CAS  PubMed  Google Scholar  2. Kim, J. & Guan, K. L. mTOR as a central hub of nutrient signalling and cell growth. Nat. Cell Biol. 21,…

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Nature Papers Present Arctic Ocean Metagenomes, Gene Knock-Up in Rice, More

A collection of hundreds of metagenome-assembled bacterial and archaeal genomes from the Arctic Ocean is presented in Nature Microbiology this week. Given the growing pressure of climate change on the Arctic and the importance of microorganisms to the marine food web, a team led by scientists from the Institut de…

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Life | Free Full-Text | An Episomal CRISPR/Cas12a System for Mediating Efficient Gene Editing

(1) Background: Gene editing technology, as represented by CRISPR is a powerful tool used in biomedical science. However, the editing efficiency of such technologies, especially in induced pluripotent stem cells (iPSCs) and other types of stem cells, is low which hinders its application in regenerative medicine; (2) Methods: A gene-editing…

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Bioinformatics Scientist job with Arcus Biosciences, Inc.

Locations: Hayward, California | Remote, United States Summary Scientists at Arcus work in a highly embedded and highly collaborative model with colleagues across the organization. We seek a highly motivated Bioinformatics Scientist to work closely with translational and biology research scientists in the development of novel therapeutics and biomarkers in…

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CRISPR-Cas9: A weapon against antibiotic-resistant superbugs?

Antibiotic-resistant bacteria are on the rise, causing hundreds of thousands of deaths each year. A technology to edit genes, called CRISPR-Cas9, could help us eliminate these superbugs, a new study has found. Before the discovery of penicillin in 1928, even common infections such as strep throat could be a terminal…

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Tweaked barley may keep beer flowing as climate change hits crops

Climate change is shifting growing seasons and introducing other weather phenomena that may have a major impact on crop yields in the coming years. In addition to farmers making adjustments to their practices to account for these changes, scientists have been developing modified versions of crops using gene-editing tools to…

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Roswell Biotechnologies Launches Molecular Electronics Chip, Pulls Focus to Binding Assays

SAN DIEGO – Roswell Biotechnologies has unveiled the capabilities of its core electronic sensing technology and in doing so established itself as more than just a DNA sequencing firm. “We always had in the back of our minds that you could do diagnostics this way,” said Barry Merriman, the company’s…

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CRISPR (CRSP) to Begin Clinical Study on Diabetes Therapy Drug

CRISPR Therapeutics CRSP, along with partner ViaCyte, announced that Health Canada has approved the clinical trial application for its investigational allogeneic stem cell-derived therapy, VCTX210. The candidate will be evaluated as a potential treatment for type 1 diabetes (T1D). CRISPR plans to begin a phase I study to evaluate the…

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Genome Research Papers on Cryptosporidium, Mobile Element Insertions, Hirschsprung Disease

A team from the US and Australia presents findings from a sequencing and comparative genomics study of Cryptosporidium, which can infect waterways and lead to a diarrheal disease called cryptosporidiosis. With two long-read sequencing technologies, the researchers put together a new reference genome assembly for C. parvum, comparing it with…

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Profiling Key Players to Witness

CRISPR Technology Market CRISPR Technology Market research report is a detailed analysis of the latest developments, market size, status, future technologies, industry drivers, challenges, regulatory guidelines, key company profiles, and player strategies. According to the research study, this overview of the CRISPR Technology market is a valuable guide and guidance…

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New gene-editing tools delete long stretches of DNA | Spectrum

Restoring function: Unlike a conventional CRISPR system (left), a new method (right) can delete a stretch of DNA and replace a missing portion of a gene, restoring the gene’s expression in the liver of mice (arrows). Two new methods make it possible to delete long sections of the genome,…

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Gene-edited barley to bolster beer production in face of climate change

Climate change is expected to have a big impact on crop yields and food security over the coming decades, as farmers contend with rising temperatures and increasingly abnormal conditions. Scientists working on solutions to this problem continue to demonstrate how gene-editing tools like CRISPR could have a role to play,…

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Metagenomi to Present at CRISPR 2.0 Conference Highlighting the Company’s Novel Base Editor, Novel CRISPR Systems, and Metagenomics Discovery Engine

—Presentations share the discoveries of a novel compact adenine base editor and novel CRISPR-associated gene editing systems optimized for cell therapy development— EMERYVILLE, Calif., November 16, 2021–(BUSINESS WIRE)–Metagenomi, a genetic medicines company with a versatile portfolio of next-generation gene editing tools, today announced that the company will give three presentations…

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Blackhawk Genomics Announces Launch of HerediSeq and PanSeq Genomic Analysis Kits

SAN FRANCISCO (PRWEB) November 16, 2021 Blackhawk Genomics LLC, a molecular diagnostics technology company, today announced the launch of the HerediSeq and PanSeq genomic analysis kits designed to detect structural variants and elucidate difficult-to-characterize genomic regions using long-read sequencing. HerediSeq chemistry resolves deletions and duplications, repetitive regions and pseudogenes,…

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How CRISPR, Nasal Septum Cells, and Gut Bacteria Can Help Treat Arthritis

Over 100 types of arthritis exist, but most people are affected by rheumatoid arthritis and osteoarthritis. The symptoms of these two common forms can be similar, but their causes are different and, therefore, treatments also differ. Rheumatoid arthritis is a chronic disease resulting in joint swelling, pain, and inflammation. It’s…

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How CRISPR, Nasal Septum Cells, and Gut Bacteria Can Help Treat Arthritis

Over 100 types of arthritis exist, but most people are affected by rheumatoid arthritis and osteoarthritis. The symptoms of these two common forms can be similar, but their causes are different and, therefore, treatments also differ. Rheumatoid arthritis is a chronic disease resulting in joint swelling, pain, and inflammation. It’s…

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Research Associate, Cell Engineering – Philadelphia

Position Title: Research Associate, Cell Engineering Position Level: Research Associate/Sr. Research Associate Reports to: Shelby Keating, Scientific Associate Company Background: Century Therapeutics is developing novel allogeneic living cell products for oncology that overcome the limitations of current cell therapies. Century’s genetically-engineered, universal iPSC-derived immune effector cell products are designed to…

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ElevateBio Announces Issuance of U.S. Patent Providing Protection for RNA-Guided Nucleases Identified through its Life Edit Gene Editing Platform

– Powerful suite of gene editing technologies with the potential to target any genomic sequence of interest CAMBRIDGE, Mass., November 15, 2021–(BUSINESS WIRE)–ElevateBio, LLC (ElevateBio), a cell and gene therapy technology company focused on powering transformative cell and gene therapies, today announced that the United States Patent and Trademark Office…

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Cheers! Scientists have developed gene-edited barley that could better your beer

Newswise — After a spell of unexpected rain, before the harvest season, a farmer may be faced with the unpredictable problem of untimely sprouting of barley. Sprouted barley fetches considerably low market prices and poses an economic burden on farmers and corporations that are at the mercy of nature to…

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Scientists Develop Gene-Edited Barley That Could Better Your Beer

After a spell of unexpected rain, before the harvest season, a farmer may be faced with the unpredictable problem of untimely sprouting of barley. Sprouted barley fetches considerably low market prices and poses an economic burden on farmers and corporations that are at the mercy of nature to survive in…

Continue Reading Scientists Develop Gene-Edited Barley That Could Better Your Beer

E7-Targeted Nanotherapeutics for Key HPV Afflicted Cervical Lesions by

Introduction Cervical cancer remains the leading cause of gynecological tumor-related mortality worldwide and the second most common malignancy in women, with 570,000 women diagnosed with cervical cancer and 311,000 dying from the disease each year.1–3 Persistent HR-HPV infection is the main cause of cervical cancer,4 with HPV16 and HPV18 causing…

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Multiple stages of evolutionary change in anthrax toxin receptor expression in humans

Human research participants We have complied with all relevant ethical regulations and informed consent was obtained from all participants. This work was approved by the Cornell University IRB under protocol 1506005662. Animal research This work was approved by the Cornell University IACUC under protocol 2009-0044. Welfare and handling of all…

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Multiple stages of evolutionary change in anthrax toxin receptor expression in humans

Human research participants We have complied with all relevant ethical regulations and informed consent was obtained from all participants. This work was approved by the Cornell University IRB under protocol 1506005662. Animal research This work was approved by the Cornell University IACUC under protocol 2009-0044. Welfare and handling of all…

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CRISPR/Cas9 – Human Repair Genomic Surgery

Until recently, it seemed like that CRISPR/CAS 9 It is a useful tool only for biologists. One of the first researchers in the field of genetic scissors was Dr. Samuel Sternberg, who worked on the team Dr. Jennifer Dondy (The winners of the 2020 Nobel Prize in Chemistry for their…

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Cheers! Better Beer From CRISPR Gene-Edited Barley

Germination in the non-mutated barley was almost complete, while the gene-edited barley did not germinate at all. This shows that the gene-edited barley had been dormant for longer (images taken 7 days after imbibition). Credit: Hiroshi Hisano from Okayama University Using CRISPR/Cas9 technology, scientists develop and study gene-edited barley that…

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CRISPR Strategy Zeroes in on Drug Target for Multiple Inflammatory Diseases

Using a new and unbiased CRISPR-Cas9-based screen, scientists at Vanderbilt University Medical Center and their collaborators have zeroed in on a metabolic checkpoint enzyme called MTHFD2 as a potential target for anti-inflammatory immunotherapy in multiple inflammatory diseases. MTHFD2 is consistently upregulated in individuals with a variety of inflammatory diseases, including…

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GenScript Launches Closed-End Double-Stranded DNA Service for CRISPR

PISCATAWAY, N.J., Nov. 12, 2021 /PRNewswire/ — GenScript USA Inc.   the world’s leading life science research tools and services provider, announced today that it has launched the GenWand™ Double-Stranded DNA (dsDNA) Service for the manufacture of CRISPR knock-in homology- directed repair (HDR) templates in T cell engineering. Closed-end dsDNA enables researchers to perform…

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GenScript Launches Closed-End Double-Stranded DNA Service for CRISPR

PISCATAWAY, N.J., Nov. 12, 2021 /PRNewswire/ — GenScript USA Inc.   the world’s leading life science research tools and services provider, announced today that it has launched the GenWand™ Double-Stranded DNA (dsDNA) Service for the manufacture of CRISPR knock-in homology- directed repair (HDR) templates in T cell engineering. Closed-end dsDNA enables researchers to perform…

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Cheers! Scientists have developed gene-edited

image: Germination in the non-mutated barley was almost complete, while the gene-edited barley did not germinate at all. This shows that the gene-edited barley had been dormant for longer (images taken 7 days after imbibition). view more  Credit: Image credit: Hiroshi Hisano from Okayama University After a spell of unexpected rain,…

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Editas Medicine Presents Preclinical Data on Novel

CAMBRIDGE, Mass., Nov. 12, 2021 (GLOBE NEWSWIRE) — Editas Medicine, Inc. (Nasdaq: EDIT), a leading genome editing company, today announced preclinical data on its progress in the development of novel engineered induced pluripotent stem cell (iPSC)-derived natural killer (NK) cells (or iNKs) for the treatment of cancer. In the presentation,…

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ICH GCP – CRA jobs – Senior Scientist Bioinformatics

Parexel International Corporation USA – Any Region – Home Based The Senior Scientist operationally delivers client projects for Biomarker and Genomic Medicine (BGM) services. S/he demonstrates deep knowledge of scientific principles and concepts related to one or more capabilities and is experienced in industry standards. S/he will provide support for…

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Zombie apocalypse? How gene editing could be used as a weapo…

(MENAFN– The Conversation) It has been over a year since the World Health Organisation (WHO) declared COVID-19 a pandemic. And perhaps the most important lesson is that we were completely unprepared to face the debilitating virus. This raises some scary thoughts. What if the threat wasn’t COVID-19, but a gene-edited…

Continue Reading Zombie apocalypse? How gene editing could be used as a weapo…

Zombie apocalypse? How gene editing could be used as a weapo…

(MENAFN– The Conversation) It has been over a year since the World Health Organisation (WHO) declared COVID-19 a pandemic. And perhaps the most important lesson is that we were completely unprepared to face the debilitating virus. This raises some scary thoughts. What if the threat wasn’t COVID-19, but a gene-edited…

Continue Reading Zombie apocalypse? How gene editing could be used as a weapo…

Scientists Developed Gene-Edited Barley that Could Better Your Beer

Germination in the non-mutated barley was almost complete, while the gene-edited barley did not germinate at all. This shows that the gene-edited barley had been dormant for longer (images taken 7 days after imbibition). Source: Hiroshi Hisano from Okayama University After a spell of unexpected rain, before the harvest season,…

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Cheers! Scientists develop gene-edited barley to produce better beer

OKAYAMA, Japan — Can science help make a better beer? Researchers in Japan believe they’ve found a way to make one of the beverage’s key ingredients more resistant to the impact of poor weather and climate change. Using genetic manipulation, a team from Okayama University, have created the “perfect” barley which…

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Constant BDNF Supply by Stem Cells May Hold Rett Therapeutic Promise

Stem cells engineered to produce a constant level of a downstream target of the MECP2 protein, called brain-derived neurotrophic factor (BDNF), increased the development of new neurons and prevented body weight loss in a mouse model of Rett syndrome. The study with that finding, “Brain-Derived Neurotrophic Factor Secreting Human Mesenchymal…

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New Products Posted to GenomeWeb: Fluidigm, GenScript, Biognosys, More

Fluidigm Biomark X Fluidigm has launched BioMark X, the latest generation of its Biomark microfluidic real-time PCR platform. Biomark X integrates the company’s Juno microfluidic sample preparation platform with the company’s current BioMark HD instrument into a single sample-to-answer platform, the company said. The integrated system can be used for…

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New genetically edited barley that has the potential to improve beer

The germination of unmutated barley was almost complete, but the genetically edited barley did not germinate at all. This indicates that the genetically edited barley was dormant for a longer period of time (image taken 7 days after absorption).Credit: Hiroshi Kuno, Okayama University After unexpected rains and before the harvest…

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New Strategy for Fine-Tuning CRISPR Editing

Want to keep the riffraff out of the gene pool party? Sneak in and slam the gate before they arrive. That’s the central idea of a new strategy by Rice University scientists who seek to avoid gene-editing errors by fine-tuning specific CRISPR-base editing strategies in advance. Rice chemical and biomolecular…

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New gene-edited barley that could improve beer

Germination in the non-mutated barley was almost complete, while the gene-edited barley did not germinate at all. This shows that the gene-edited barley had been dormant for longer (images taken 7 days after imbibition). Credit: Hiroshi Hisano, Okayama University After a spell of unexpected rain, before the harvest season, a…

Continue Reading New gene-edited barley that could improve beer

Nkarta Presents New Preclinical Data from Engineered NK Cell Platform at SITC 36th Annual Meeting

SOUTH SAN FRANCISCO, Calif., Nov. 12, 2021 (GLOBE NEWSWIRE) — Nkarta, Inc. (Nasdaq: NKTX), a biopharmaceutical company developing engineered natural killer (NK) cell therapies to treat cancer, today announced the presentation of four preclinical data abstracts focused on its natural killer cell platform and pipeline at the Society for Immunotherapy…

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Using CRISPR to find a new drug target for multiple sclerosis, inflammatory bowel disease

CRISPR gene editing is a popular tool among scientists searching for new targets in treating inflammatory diseases. A team at Vanderbilt University Medical Center used the technology to study the role of metabolism in the functioning of immune cells, and they ended up uncovering a target they believe could be…

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Researchers have developed gene-edited barley that could better your beer

Researchers have developed gene-edited barley that could better your beer After a spell of unexpected rain, before the harvest season, a farmer may be faced with the unpredictable problem of untimely sprouting of barley. Sprouted barley fetches considerably low market prices and poses an economic burden on farmers and corporations…

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Intl Conference-cum-workshop On Gene Editing In Pakistan Held At UAD

A day long international conference-cum-workshop on insight to the nature and scope of gene editing in Pakistan was held at University of Agriculture Dera Ismail Khan wherein local and foreign experts delivered lectures PESHAWAR, (UrduPoint / Pakistan Point News – 12th Nov, 2021 ) :A day long international conference-cum-workshop on…

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International Science Week: Exciting Recent Advances in Medicine Science

Advances in future medical technology will not just restore function but used to augment the limits of human ability. By Dr (Lt Gen) CS Narayanan, In 1928, a chance event at the St Mary’s hospital changed the face of medical practice forever. The discovery of Penicillin by Dr Alexander Fleming…

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Study highlights the need for caution while using CRISPR-based gene therapies

A comprehensive study-;conducted by researchers at Sanford Burnham Prebys, the National Cancer Institute (NCI) and other groups-;has shown that gene editing, specifically gene knockout (KO), with CRISPR -Cas9 can favor cells with mutated forms of genes linked to cancer. The findings highlight the need to monitor patients undergoing CRISPR-Cas9-based gene…

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New study offers genetic insight into why we look the way we do

Which genes control the defining features that make us look as we do? And how do they make it happen? In 1990, University of California San Diego biologist William McGinnis conducted a seminal experiment that helped scientists unravel how high-level control genes called Hox genes shape our appearance features. The…

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Study encourages cautious approach to CRISPR

LA JOLLA, CALIF. – Nov 11, 2021 – A comprehensive study—conducted by researchers at Sanford Burnham Prebys, the National Cancer Institute (NCI) and other groups—has shown that gene editing, specifically gene knockout (KO), with CRISPR -Cas9 can favor cells with mutated forms of genes linked to cancer. The findings highlight…

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Study encourages cautious approach to CRISPR

LA JOLLA, CALIF. – Nov 11, 2021 – A comprehensive study—conducted by researchers at Sanford Burnham Prebys, the National Cancer Institute (NCI) and other groups—has shown that gene editing, specifically gene knockout (KO), with CRISPR -Cas9 can favor cells with mutated forms of genes linked to cancer. The findings highlight…

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Over a third of strawberries harvested are discarded due to their short shelf life. Here’s how CRISPR could help them last longer

The GLP Needs Your Help It is easier than ever for advocacy groups to spread disinformation on pressing science issues, such as the ongoing coronavirus pandemic. No, vaccines are not harmful. Yes, the use of biotechnology, GMOs or gene editing to develop antigens for treatments including vaccines are part of…

Continue Reading Over a third of strawberries harvested are discarded due to their short shelf life. Here’s how CRISPR could help them last longer

RUBY Trial of SCD Gene Editing Cell Therapy EDIT-301 Now Enrolling

Enrollment is underway for a Phase 1/2 trial evaluating the safety and efficacy of EDIT-301, an experimental gene editing cell therapy for people with sickle cell disease (SCD). The trial, called RUBY (NCT04853576), had been cleared for launch by the U.S. Food and Drug Administration earlier this year, and will…

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Approach improves avoidance of ‘bystander’ edits in CRISPR-base editor treatments — ScienceDaily

Want to keep the riffraff out of the gene pool party? Sneak in and slam the gate before they arrive. That’s the central idea of a new strategy by Rice University scientists who seek to avoid gene-editing errors by fine-tuning specific CRISPR-base editing strategies in advance. Rice chemical and biomolecular…

Continue Reading Approach improves avoidance of ‘bystander’ edits in CRISPR-base editor treatments — ScienceDaily

Exavir Aims CRISPR Program at HIV, Sees Powerful Preclinical Results

Since HIV first reared its deadly head 40 years ago, multiple medications have been developed, and drug makers continue to search for the Holy Grail in HIV treatment and create a potential cure for the disease. Exavir Therapeutics believes it has a chance to hit that mark with its gene editing…

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Ark Invest’s genomic revolution analyst Ali Urman on DNA sequencing

Ali Urman has been fascinated by medicine since an early age. She focused on epidemiology and biostatistics at university before taking up research positions at the Memorial Sloan Kettering Cancer Centre and Montefiore Health System. Driven to explore the intersection between medicine and technology, Urman worked at IBM’s artificial intelligence…

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Ark Invest’s genomic revolution analyst Ali Urman on DNA sequencing

Ali Urman has been fascinated by medicine since an early age. She focused on epidemiology and biostatistics at university before taking up research positions at the Memorial Sloan Kettering Cancer Centre and Montefiore Health System. Driven to explore the intersection between medicine and technology, Urman worked at IBM’s artificial intelligence…

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Studies encourage a cautious approach to CRISPR treatment

Credit: CC0 public domain In a comprehensive study conducted by Sanford Burnham Prebys, the National Cancer Institute (NCI), and other groups of researchers, gene editing using CRISPR-Cas9, especially gene knockout (KO), is cancerous. The findings highlight the need to monitor cancer-related mutations in patients receiving CRISPR-Cas9-based gene therapy.The study was…

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A strategy to refine genetic base editors

A new strategy by Rice University scientists seeks to avoid gene-editing errors by fine-tuning specific CRISPR-base editing strategies in advance. Their theoretical framework is intended to eliminate trial and error in the design of a library of editors. Credit: Qian Wang/Rice University Want to keep the riffraff out of the…

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Senior Scientist Bioinformatics at Parexel

The Senior Scientist operationally delivers client projects for Biomarker and Genomic Medicine (BGM) services. S/he demonstrates deep knowledge of scientific principles and concepts related to one or more capabilities and is experienced in industry standards. S/he will provide support for the BGM strategy and interpretation to other SBUs and clients….

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Annotation tools (prokaryotes): prokka vs eggnog

Annotation tools (prokaryotes): prokka vs eggnog 1 Are there any obvious advantages/disadvantages to using one over the other? Both use HMM (I think), both are hierarchical (starting with EggNOG 4.5). Are they simply competitors? Perhaps there is a trade-off between database size (Prokka is smaller) and the quality of curation?…

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Turning Genes “On” and “Off” With New Epigenetic Editing Technique

All the cells in an individual’s body bear the same genetic code. It is the reading and writing of this code – the “turning on” and “turning off” of specific genes in specific cells – that gives the cells their identities. Imagine, for example, the disastrous situation wherein the genes…

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Editas Medicine (EDIT) falls 0.03% to Close at $40.56 on November 9

Last Price $ Last Trade Change $ Change Percent % Open $ Prev Close $ High $ low $ 52 Week High $ 52 Week Low $ Market Cap PE Ratio Volume Exchange EDIT – Market Data & News Trade Editas Medicine Inc (NASDAQ: EDIT) shares fell 0.03%, or…

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CRISPR-Cas9 Mediated Exonic Disruption for HIV-1 Elimination

Abstract Background A barrier to HIV-1 cure rests in the persistence of proviral DNA in infected CD4+ leukocytes. The high HIV-1 mutation rate leads to viral diversity, immune evasion, and consequent antiretroviral drug resistance. While CRISPR-spCas9 can eliminate latent proviral DNA, its efficacy is limited by HIV strain diversity and…

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