Tag: crispr

Solved 1. S. mait (SO2) – 165 rRNA 2. PC228 – 16 s rRNA 3.

Transcribed image text: 1. S. mait (SO2) – 165 rRNA 2. PC228 – 16 s rRNA 3. PC237 – 16s rRNA 4. PC1091 – 16s rRNA 5. Control-16s rRNA 6. 1 kb Ladder 7. S. malt ( SO22 – mer 8. PC1091 mer 9. Control-mer 10. S. molt ( SO22 –…

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Combination of CRISPR-Cas9-RNP and Single-Cell RNAseq to Identify Cell State-Specific FOXJ1 Functions in the Human Airway Epithelium

doi: 10.1007/978-1-0716-3507-0_1. Laure-Emmanuelle Zaragosi  1 , Alizé Gouleau  2 , Margot Delin  2 , Kevin Lebrigand  2 , Marie-Jeanne Arguel  2 , Cedric Girard-Riboulleau  2 , Geraldine Rios  2 , Elisa Redman  2 , Magali Plaisant  2 , Rainer Waldmann  2 , Virginie Magnone  2 , Brice Marcet  2 , Pascal Barbry  2 , Gilles Ponzio  2 Affiliations Expand Affiliations 1 Université Côte…

Continue Reading Combination of CRISPR-Cas9-RNP and Single-Cell RNAseq to Identify Cell State-Specific FOXJ1 Functions in the Human Airway Epithelium

Safer CRISPR-Cas Alternative? Retroelement-Based Genome Tools

In a Perspective, Stephen Tang and Samuel Sternberg discuss retroelement-based gene editing as a safer alternative to CRISPR-Cas approaches. Precision genome editing technologies have transformed modern biology. Capabilities for programable DNA targeting have improved rapidly, largely due to the development of bacterial RNA-guided CRISPR-Cas systems, which allow precise cleavage of…

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Chinese scientists use custom genome assembly

image:  A. An image of sheepgrass showing its robust rhizome; B. Overview of the assembled genome; C, D. Karyotype and principal component analysis; E Resequencing data from Psathyrostachys juncea were mapped on the sheepgrass genome such that Ns and Xm could be distinguished by the coverage of each chromosome. view…

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Author Spotlight: A Battery of Highly Reproducible Behavioral Tests to Validate an Angelman Syndrome Murine Model

Our goal is to elucidate the physiological roles of genes using mice as an experimental model. We also focus on developing mouse models of specific diseases that scientists can use to investigate disease causation and develop effective treatments. An example of such activity is the mouse model of Angelman syndrome….

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Mouse mm10 chr4:22,481,383-22,489,763 UCSC Genome Browser v455

     Custom Tracks Adiposehidedensesquishpackfull Cerebellumhidedensesquishpackfull Cortexhidedensesquishpackfull Liverhidedensesquishpackfull Lunghidedensesquishpackfull Sintesthidedensesquishpackfull Spleenhidedensesquishpackfull    mouse_7_core ATAC Adipose Rep1hidedensefull ATAC Adipose Rep2hidedensefull ATAC Cerebellum Rep1hidedensefull ATAC Cerebellum Rep2hidedensefull ATAC Colon Rep1hidedensefull ATAC Colon Rep2hidedensefull ATAC Cortex Rep1hidedensefull ATAC Cortex Rep2hidedensefull ATAC Heart Rep1hidedensefull ATAC Heart Rep2hidedensefull ATAC Liver Rep1hidedensefull ATAC Liver Rep2hidedensefull ATAC…

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[Latest] Global DNA Repair Drugs Market to be Worth USD 10.4 billion by 2031 | Transparency Market Research Inc.

DNA Repair Drugs Market Rise in incidence of cancer and advancements in DNA sequencing technologies WILMINGTON, DELAWARE, UNITED STATES, October 26, 2023 /EINPresswire.com/ — The global DNA repair drugs market offers a unique insight into key trends shaping the industry world-wide and in the largest markets. Written by some…

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Animals | Free Full-Text | RPA-CRISPR/Cas12a-Based Detection of Haemophilus parasuis

H. parasuis is a common pathogenic bacterium in the respiratory tract of pigs, which can cause widespread cellulose inflammation (also called Glässer’s disease) when the immunity of pigs is decreased. H. parasuis has fifteen serovars, and some clinical strains remain indistinguishable from serotypes. The vaccine’s cross-protection is poor among different…

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New CRISPR/Cas9 Licensing Agreement for ERS Genomics & CHUM Research Centre, Montreal

New licence provides CHUM access to the ERS CRISPR/Cas9 patent portfolio. DUBLIN and MONTREAL, Oct. 26, 2023 /PRNewswire/ — ERS Genomics Limited (‘ERS’) is pleased to announce a new license agreement with the CHUM Research Centre (‘(CRCHUM),’). This is a non-exclusive licensing agreement granting the CRCHUM research rights to the…

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Identification of CCZ1 as an essential lysosomal trafficking regulator in Marburg and Ebola virus infections

Cells and viruses Haploid mSCs AN3–12 are a feeder independent clonal derivative of HMSc2 isolated from mice oocyte and maintained at IMBA52. The AN3–12 library and knocked out cells used for the haploid screening was obtained from IMBA (Austria)14,52. AN3–12 cells were validated by STR analysis. Haploid mES cells were…

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New “anti-CRISPR” discovered in viruses

A newly discovered “anti-CRISPR” system in viruses could help us control CRISPR gene-editing technologies and lead to better weapons against antibiotic-resistant superbugs. The background: Your immune system has ways to remember viruses you’ve encountered before and help defend you if they appear again — and, amazingly, some single-celled bacteria do,…

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Novel Gene Therapy Approach Delivers Large Genes

A breakthrough by University of Zurich (UZH) researchers introduces a versatile technique for efficiently and safely delivering substantial genes, holding significant promise for therapeutic applications. The new method REVeRT (reconstitution via mRNA trans-splicing) is more efficient and flexible in application. Image Credit: istock.com/DrAfter123. While gene therapy stands as the most…

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Unveiling Fascinating Schizophrenia Discoveries: Brain Organoids, Genes, and Revolutionary Insights

Researchers have utilized advanced technology to gain insights into the neurodevelopmental origins of schizophrenia, a severe neuropsychiatric disease. In one study, scientists grew brain organoids derived from patients’ skin cells and discovered persistent axonal dysregulation in individuals with schizophrenia. In a separate study, researchers focused on a schizophrenia risk gene…

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Excision BioTherapeutics Presents Positive Interim Clinical Data from Ongoing Phase 1/2 Trial of EBT-101 for the Treatment of HIV at ESGCT 30th Annual Congress

Excision BioTherapeutics Excision reported positive safety and biodistribution data to 48 weeks in the first-in-human Phase 1/2 clinical evaluation of EBT-101 No serious adverse events or dose-limiting toxicities were seen in any trial participant EBT-101 was detected in blood in all participants SAN FRANCISCO, Oct. 25, 2023 (GLOBE NEWSWIRE) —…

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Research Associate in the Division of Science Biology, Dr. Dan Ohtan Wang job with NEW YORK UNIVERSITY ABU DHABI

Description The Wang RNA-MIND Laboratory in the Division of Science, New York University Abu Dhabi, seeks to recruit a Research Associate to work on projects focused on understanding RNA modification signaling pathways in the nervous system and their function in synaptic, neuronal and behavioral plasticity. Research in the Wang RNA-MIND laboratory focuses…

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Scientists use custom genome assembly and editing method to improve sheepgrass

Morphological view and genomic profile of forage Sheepgrass. A. An image of sheepgrass showing its robust rhizome; B. Overview of the assembled genome; C, D. Karyotype and principal component analysis; E Resequencing data from Psathyrostachys juncea were mapped on the sheepgrass genome such that Ns and Xm could be distinguished…

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Excision BioTherapeutics Presents Positive Interim Clinical

Excision reported positive safety and biodistribution data to 48 weeks in the first-in-human Phase 1/2 clinical evaluation of EBT-101 No serious adverse events or dose-limiting toxicities were seen in any trial participant EBT-101 was detected in blood in all participants SAN FRANCISCO, Oct. 25, 2023 (GLOBE NEWSWIRE) — Excision BioTherapeutics,…

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Companies that had their IPO in 2016

Hostess Brands, the iconic American company behind beloved snacks like Twinkies and Ding Dongs, made a significant comeback with its entry into the public markets in November 2016. This move was particularly notable given the company’s tumultuous history, including its bankruptcy in 2012 and subsequent acquisition by Apollo Global Management…

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New Notification out, Check Post, Age, Salary, and Interview Details

National Centre For Cell Science Recruitment 2023: New Notification out, Check Post, Age, Salary, and Interview Details National Centre for Cell Science Recruitment 2023: The National Centre for Cell Science (NCCS), an autonomous institution of the Department of Biotechnology, Ministry of Science and Technology, Government of India, is inviting applications…

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Chinese Scientists Enhance Sheepgrass via Custom Genome Editing

A research team led by Dr. CAO Xiaofeng at the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences has improved biomass-related traits in sheepgrass using its own custom genome editing system while increasing understanding of sheepgrass genomics. The team’s excellent genome assembly and innovative gene editing…

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Is Crispr Therapeutics AG (CRSP) Stock About to Get Hot Tuesday?

News Home Tuesday, October 24, 2023 11:24 AM | InvestorsObserver Analysts Mentioned in this article Overall market sentiment has been down on Crispr Therapeutics AG (CRSP) stock lately. CRSP receives a Bearish rating from InvestorsObserver Stock Sentiment Indicator. Crispr Therapeutics AG has a Bearish sentiment reading. Find out what this…

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Safely Navigating the Future of Genome Editing

Advancements in gene editing technologies have revolutionized the field of genomics, offering researchers the ability to modify an organism’s DNA. Among these technologies, CRISPR-Cas9 has gained immense popularity due to its speed, accuracy, and cost-effectiveness. However, the CRISPR technology presents its own set of challenges. Now, a team of researchers…

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Background mutations: Why CRISPR-edited genes have to work together with thousands of naturally-evolved genes

For tens of thousands of years, evolution shaped tomatoes through natural mutations. Then, humans came along. For centuries, we’ve bred and cherry-picked tomatoes with our preferred traits. Today, CRISPR genome editing allows us to make new crop mutations that improve traits even further. However, individual mutations, whether natural or engineered,…

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New software tool provides a way for safer design of genome editing

A team of researchers has developed a software tool called DANGER (Deleterious and ANticipatable Guides Evaluated by RNA-sequencing) analysis that provides a way for the safer design of genome editing in all organisms with a transcriptome. For about a decade, researchers have used the CRISPR technology for genome editing. However,…

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Dual AAV Method Delivers DNA That’s Reassembled into Large Genes

University of Zurich scientists demonstrated that they could reassemble and express large genes using a new dual adeno-associated viral (AAV) vector technology that depends on mRNA trans-splicing. This technology, known as REVeRT (reconstitution via mRNA trans-splicing), enables versatile split site selection as well as the efficient reconstitution of various split…

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Novel Schizophrenia Insights from Brain Organoids and Genes

Summary: Researchers leveraged cutting-edge technology to gain insights into schizophrenia’s neurodevelopmental origins. The researchers grew brain organoids from patients’ skin cells, finding persistent axonal disruptions in those with schizophrenia. In another study, researchers zeroed in on a schizophrenia risk gene, CYFIP1, revealing its potential role in brain immune cells called…

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DepMap Portal

DepMap Portal 1 Hi, everyone, When I searched a gene in DepMap portal, in the “Top Co-dependencies CRISPR (DepMap Public 23Q2+Score, Chronos)” section, there is a 100-gene list with a correlation score. Do you know what that score means? And how we interpret the results of this section? Thank you…

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Planet Microbe

The pioneering cartographer of the human genome, Craig Venter, discusses synthetic biology and his new book, “Sorcerer II: The Expedition That Unlocked The Secrets of The Ocean’s Biome” with Noema Editor-in-Chief Nathan Gardels. Nathan Gardels: Generative AI has been heralded lately as one of the great game-changing innovations of our…

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World-Leading Gene Editing Technology Unveiled in United Kingdom

Dublin, Oct. 23, 2023 (GLOBE NEWSWIRE) — In a momentous stride toward the future of agriculture, scientists have recently achieved a remarkable breakthrough in the realm of gene editing. The creation of the world’s first flu-resistant chickens, signals a turning point in biotechnology, offering promising prospects for gene-edited poultry in…

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How CRISPR Companies Target Sickle Cell Anemia

A Crippling And Painful Disease Sickle Cell Disease (SCD) is a blood disease caused by a genetic mutation. This mutation creates abnormal hemoglobin, the protein carrying oxygen in the blood’s red cells. As a result, red cells are shaped like sickles and tend to get stuck in blood vessels, causing…

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Study unveils a cortico-amygdala neural substrate supporting fear extinction via endocannabinoids

Zooming into fear and endocannabinoids in the brain. Credit: Ozge Gunduz-Cinar and Biorender. Endogenous cannabinoids, or endocannabinoids for short, are lipid-based neurotransmitters known to support various physiological processes. Recent studies have hinted at the role of these neurotransmitters in so-called fear extinction, the process through which fear towards a particular…

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Intrinsic Targeting of Host RNA by Cas13: Implications and Challenges

A recent study published in Nature Biomedical Engineering sheds light on the previously unknown ability of Cas13 to intrinsically target host RNA in mammalian cells. Cas13 is a member of the type-VI CRISPR-Cas13 systems, which have been widely utilized for various RNA-targeting applications. Cas13 is known to require a single…

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The Age of Aquarius – RNA, the Epicenter of Genetic Information

The veil on genetic information was lifted by the advent of gene cloning and sequencing technologies in the 1970s. The discovery and purification of bacterial nucleases capable of cutting DNA at specific sequences and ligases capable of joining them enabled DNA from any species – or mRNAs converted to complementary…

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Amerigo Scientific Unveils CRISPR/Cas Enzymes to Expand

Amerigo Scientific, as a distributor focused on providing critical products and services to biomedical and life science communities, announced the release of a groundbreaking selection of CRISPR/Cas enzymes to its extensive life science portfolio, aimed at further expanding the vast potential of the CRISPR toolbox. This addition brings cutting-edge genetic…

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Cas13’s Intrinsic Targeting of Host RNA Limits Its Utility

Cas13 is capable of intrinsically targeting host RNA in mammalian cells through mechanisms that were not previously understood. Through transcript-specific mechanisms that are independent of the CRISPR RNA sequence and dynamically dependent on the conformational state of Cas13, Cas13 can also cleave host RNA. This effect is demonstrated by a…

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Phase 3 trial of NTLA-2001 for ATTR-CM to launch by year’s end

Intellia Therapeutics is launching a pivotal Phase 3 clinical trial in the U.S. to evaluate the safety and effectiveness of its investigational gene-editing therapy NTLA-2001 in people with ATTR amyloidosis with cardiomyopathy (ATTR-CM). The study, which is expected to start by the end of the year, follows the recent approval…

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Gene Editing Market to Be Valued USD 36.4 Billion by 2032, North America in the Lead

Marketresearch.biz highlights that the growth of gene editing market is driven by increased genetically modified crop production and rising demand for synthetic genes in emerging markets, particularly for crop enhancement. CRISPR/Cas9 technology is often researchers’ top choice for crop development and modification. New York, Oct. 23, 2023 (GLOBE NEWSWIRE) —…

Continue Reading Gene Editing Market to Be Valued USD 36.4 Billion by 2032, North America in the Lead

Cancer-associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7

doi: 10.1002/1878-0261.13537. Online ahead of print. Joseph S Baxter  1   2 , Rachel Brough  1   2 , Dragomir B Krastev  1   2 , Feifei Song  1   2 , Sandhya Sridhar  1   2 , Aditi Gulati  2 , John Alexander  2 , Theodoros I Roumeliotis  3 , Zuza Kozik  3 , Jyoti S Choudhary  3…

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CRISPR and CAS Gene Market Size US$ 1.54 Billion in 2023 and is expected to exhibit a CAGR of 22.8 % by 2030

The Crispr and Cas Gene Market is estimated to be valued at US$ 1.54 Billion in 2023 and is expected to exhibit a CAGR of 22.8 % by 2030. BURLINGAME, WASHINGTON, UNITED STATES, October 23, 2023 /EINPresswire.com/ — The new report titled ‘Global CRISPR and CAS Gene Market Size, Share,…

Continue Reading CRISPR and CAS Gene Market Size US$ 1.54 Billion in 2023 and is expected to exhibit a CAGR of 22.8 % by 2030

World-Leading Gene Editing Technology Unveiled in United

Dublin, Oct. 23, 2023 (GLOBE NEWSWIRE) — In a momentous stride toward the future of agriculture, scientists have recently achieved a remarkable breakthrough in the realm of gene editing. The creation of the world’s first flu-resistant chickens, signals a turning point in biotechnology, offering promising prospects for gene-edited poultry in…

Continue Reading World-Leading Gene Editing Technology Unveiled in United

Intrinsic targeting of host RNA by Cas13 constrains its utility

Abudayyeh, O. O. et al. C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector. Science 353, aaf5573 (2016). Article  PubMed  PubMed Central  Google Scholar  Terns, M. P. CRISPR-based technologies: impact of RNA-targeting systems. Mol. Cell 72, 404–412 (2018). Article  CAS  PubMed  PubMed Central  Google Scholar  Abudayyeh, O. O. et al….

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Intellia (NTLA) Focuses on Developing Gene-Editing Therapies

Intellia Therapeutics, Inc. NTLA is a clinical-stage genome editing company focused on developing CRISPR/Cas9-based therapeutics. The company is evaluating its leading in vivo genome-editing candidates — NTLA-2001 for the treatment of transthyretin (ATTR) amyloidosis and NTLA-2002 for the treatment of hereditary angioedema (HAE). Earlier this week, the FDA cleared an…

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Researchers Develop Novel Genome Editing Software That Is Safer Than CRISPR

Register for free to listen to this article Thank you. Listen to this article using the player above. ✖ Want to listen to this article for FREE? Complete the form below to unlock access to ALL audio articles. A team of researchers has developed a software tool…

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Gene analysis tool that overcomes challenges with CRISPR editing developed

Tokyo : In a significant discovery, a team of researchers has developed a software tool called DANGER (Deleterious and ANticipatable Guides Evaluated by RNA-sequencing) analysis that provides a way for the safer design of genome editing in all organisms. For about a decade, researchers have used the CRISPR technology for…

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Researchers develop DANGER analysis tool for the safer design of gene editing

Oct 23, 2023 (Nanowerk News) A team of researchers has developed a software tool called DANGER (Deleterious and ANticipatable Guides Evaluated by RNA-sequencing) analysis that provides a way for the safer design of genome editing in all organisms with a transcriptome. For about a decade, researchers have used the CRISPR…

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Intellia (NTLA) Focuses on Developing Gene-Editing Therapies – October 23, 2023

Intellia Therapeutics, Inc. (NTLA Quick QuoteNTLA – Free Report) is a clinical-stage genome editing company focused on developing CRISPR/Cas9-based therapeutics. The company is evaluating its leading in vivo genome-editing candidates — NTLA-2001 for the treatment of transthyretin (ATTR) amyloidosis and NTLA-2002 for the treatment of hereditary angioedema (HAE). Earlier this…

Continue Reading Intellia (NTLA) Focuses on Developing Gene-Editing Therapies – October 23, 2023

New DANGER Tool Enhances Safety in Gene Editing Design

A team of researchers has developed a software tool called DANGER (Deleterious and ANticipatable Guides Evaluated by RNA-sequencing) analysis that provides a way for the safer design of genome editing in all organisms with a transcriptome. For about a decade, researchers have used the CRISPR technology for genome editing. However,…

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CRISPR pioneer Doudna envisions ending asthma, aiding climate

The technology known as CRISPR is considered one of modern biology’s biggest breakthroughs. It allows scientists to edit genes, similarly to how you cut and paste text in a word processor. More than a decade after pioneering CRISPR, Nobel laureate Jennifer Doudna of the University of California, Berkeley, is applying…

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7 Biotech Stocks to Get In Now Before Investors Catch On

Biotechnology is the source of some of our strongest and growing revolutions. Gene technology allows us to cure incurable diseases and make miracles happen with living organisms. Immunotherapies promise targeted treatment without harmful side effects. And more and more, we are understanding the deep structure of cancers, allowing us to…

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Conformational control of Cas9 by CRISPR hybrid RNA-DNA guides mitigates off-target activity in T cells

CRISPR-based genome editing of primary human T cells has the potential to revolutionize disease-modifying therapies. However, substantial improvements in CRISPR-Cas9 specificity are needed to minimize its off-target activity in cells. A number of “high-fidelity” Cas9 variants have been engineered in an attempt to address specificity improvements, but these proteins often…

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CRISPR/Cas12a and primer-assisted rolling circle amplification integrated ultra-sensitive dual-signal sensing platform for EGFR 19 detection

. 2023 Oct 23:1279:341755. doi: 10.1016/j.aca.2023.341755. Epub 2023 Sep 6. Affiliations Expand Affiliations 1 Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering, College of Chongqing University, Chongqing, 400044, PR China. 2 Key Laboratory of Bio-Resource and Eco-environment…

Continue Reading CRISPR/Cas12a and primer-assisted rolling circle amplification integrated ultra-sensitive dual-signal sensing platform for EGFR 19 detection

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9 – Fingerprint — University of Texas Southwestern Medical Center Sort by Weight Alphabetically Medicine & Life Sciences Guide RNA 100% Clustered Regularly Interspaced Short Palindromic Repeats 82% Genome 32% Genomic Library 30% Human Genome 25% Libraries 21% Engineering…

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MODX assignment – DNA Sequencing Method – Enumerate and compare the different DNA sequencing

1. Enumerate and compare the different DNA sequencing methods. (Manual and Automated) Whole genome sequencing (WGS) – is used to determine an organism’s genome sequence for the first time. WGS can also be used to determine variant (mutation) frequencies within organism populations and to link genetic variants to disease via…

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Oklahoma Medical Research Foundation – Bioinformatics Specialists – Oklahoma City, OK

Job Title Data Analyst / Bioinformatics Specialist Job Location Oklahoma Medical Research Foundation, Oklahoma City, OK Job Overview Independent, not-for-profit biomedical research institute adjacent to University of Oklahoma Health Sciences Center campus Dynamic and flourishing downtown area with low cost of living and short commute times Diversified economy Compensation Competitive…

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The Promise of Genetic Engineering in Pest Control

Insects play a vital role in ecosystems, but some can pose a significant threat as disease vectors or agricultural pests. Traditional insecticides, while effective, can have detrimental effects on the environment and non-targeted beneficial insects. To address this issue, scientists are exploring new methods of targeted pest control. One strategy…

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CRISPR sgRNA Cloning & Control Vectors

  The CRISPR/Cas9 system can be used for knocking out gene expression in vivo or in vitro by using the combination of a sgRNA (single guide RNA) along with Cas9 (dCas9) nuclease. Achieve permanent 100% knockout in your cell line by using Cellecta´s lentivirus-based CRISPR system. Expression of the sgRNA and Cas9…

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How can we fight insects that can infect humans with diseases without harming the ones that do not? | Science

Insects are part of the ecosystem and have beneficial effects. But there are some that can be very dangerous because of their nasty habit of acting as vectors of diseases like malaria or as agricultural pests like Xylella fastidiosa. Therefore, fighting certain types of insects can save lives directly or…

Continue Reading How can we fight insects that can infect humans with diseases without harming the ones that do not? | Science

Monkey lives with CRISPR’d pig kidney for over two years

A monkey survived for more than two years with a kidney from a gene-edited pig, according to a new study.  It’s a dramatic example of a new technology that could help save countless lives, but the two-year survivor had the best outcome of the 15 monkeys in the study —…

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The Gene Editing Market Soars

The global gene editing market in terms of revenue was estimated to be worth $5.3 billion in 2023 and is poised to reach $10.6 billion by 2028 The gene editing market is on an upward trajectory, poised to double in value from USD 5.3 billion in 2023 to a staggering…

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DNA Virus Detection System Based on RPA-CRISPR/Cas12a-SPM and Deep Learning

Abstract We report a fast, easy-to-implement, highly sensitive, sequence-specific, and point-of-care (POC) DNA virus detection system, which combines recombinase polymerase amplification (RPA) and CRISPR/Cas12a system for trace detection of DNA viruses. Target DNA is amplified and recognized by RPA and CRISPR/Cas12a separately, which triggers the collateral cleavage activity of Cas12a…

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Pathway-driven analysis of synthetic lethal interactions in cancer using perturbation screens

Introduction Cancer cells are characterized by unrestrained proliferation and dysregulated growth, which lead to the formation of malignant neoplasms (Hanahan & Weinberg, 2023). The development and progression of cancer have been linked to the dysregulation of multiple signaling pathways, including MAPK/ERK, Wnt/β-catenin, PI3K/AKT/mTOR, and NF-kB, which are among crucial pathways…

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Volume 72 Issue 11 | Diabetes

Cover Image On the cover: Immunofluorescence image of the pancreatic islet from Pdx1 βKO mice detected with anti-insulin antibody (blue). The EGFP- and RFP-positive cells show the effective knockout of Pdx1 without insulin staining. Image courtesy of Kyosei Ueki, Yuya Nishida, and Hirotaka Watada, Department of Metabolism and Endocrinology, Juntendo…

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Genomics Market size to grow by USD 18.24 billion from 2022 to 2027, North America is estimated to account for 37% of the growth- Technavio

NEW YORK, Oct. 19, 2023 /PRNewswire/ — The genomics market size is expected to grow by USD 18.24 billion from 2022 to 2027. In addition, the momentum of the market will progress at a CAGR of 10.53%  during the forecast period, according to Technavio Research. The market has been segmented by solution (products…

Continue Reading Genomics Market size to grow by USD 18.24 billion from 2022 to 2027, North America is estimated to account for 37% of the growth- Technavio

Yale Receives NIH Grant to Research Gene Editing Delivery System

The National Institutes of Health has awarded a $40 million grant to Yale School of Medicine to develop a new CRISPR-based gene therapy platform that will target genetic brain diseases such as Angelman syndrome and H1-4, also known as Rahman syndrome. Angelman syndrome is a rare genetic disorder that causes…

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Global Genomics Market Research Report 2027: In-Depth Analysis

Genomics is a branch of biology that investigates an organism’s complete gene set or genome, focusing on DNA analysis. This comprehensive study involves understanding the gene structure, function, and their interactions within an organism. Genomic research often entails sequencing an organism’s DNA to identify and categorize all its genes. This…

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Inflammatory cell death, PANoptosis, screen identifies host factors in coronavirus innate immune response as therapeutic targets

Dong, E., Du, H. & Gardner, L. An interactive web-based dashboard to track COVID-19 in real time. Lancet Infect. Dis. 20, 533–534 (2020). Article  CAS  PubMed  PubMed Central  Google Scholar  Tan, W. et al. A novel coronavirus genome identified in a cluster of pneumonia cases – Wuhan, China 2019–2020. China…

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Dates, FAQs, Activities, History, and Facts About CRISPR

World CRISPR Day 2023: Annually, World CRISPR Day is observed on October 20. It is a day dedicated to discussing the practical applications and technological implications of the genetic disorder treatment revolution. Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) is an innovative technology that modifies genes by locating particular segments of…

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How To Fight Insects That Transmit Diseases To People Without Harming Those Who Cannot?

Insects are part of the ecosystem and have a beneficial effect. But there are some that can be very dangerous because of their nasty habit of being carriers of diseases like malaria or agricultural pests like Xylella fastidiosa. Therefore, fighting certain types of insects can save lives directly, or indirectly…

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Clock.bio’s Mission to Extend Health Span

Clock.bio, a sister company of bit.bio, is dedicated to extending and improving the quality of life by reversing the harmful effects of time on our cells. Founded by Mark Kotter, who also serves as the CEO of bit.bio, Clock.bio harnesses the regenerative capabilities of human pluripotent stem cells (hiPSCs) to…

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How Genome Sequencing is Improving Human Health

Contributed Commentary by Ephrem Chin, Revvity Omics  October 20, 2023 | There has perhaps never been a more exciting time to work in genetics. Thanks to technological advances and information sharing through various industry and academic collaborations, we know more today about the human genome and how it influences human…

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Solved Which of the following processes would result in a

Transcribed image text: Which of the following processes would result in a mutation in the DNA upon repair of a double strand break? SSDR NHE HDR CRISPR Question 5 1 pts Inclusion of a template during CRISPR editing can lead to which of the following? an indel Always leads to…

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Systematic differences in discovery of genetic effects on gene expression and complex traits

Claussnitzer, M. et al. A brief history of human disease genetics. Nature 577, 179–189 (2020). Article  CAS  PubMed  PubMed Central  Google Scholar  Maurano, M. T. et al. Systematic localization of common disease-associated variation in regulatory DNA. Science 337, 1190–1195 (2012). Article  CAS  PubMed  PubMed Central  Google Scholar  Gusev, A. et…

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Inactive S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in human stem cell model of Parkinson’s disease

. 2023 Oct 18;13(1):17796. doi: 10.1038/s41598-023-45078-3. Affiliations Expand Affiliations 1 Department of Pathology, Stanford University School of Medicine, 300 Pasteur Dr., R271/217, Stanford, CA, 94305, USA. 2 Department of Biological Sciences, San Jose State University, San Jose, CA, 95192, USA. 3 Department of Experimental Medical Science, Lund University, Lund, Sweden….

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Transcriptional regulation and overexpression of GST cluster enhances pesticide resistance in the cotton bollworm, Helicoverpa armigera (Lepidoptera: Noctuidae)

Bras, A., Roy, A., Heckel, D. G., Anderson, P. & Green, K. K. Pesticide resistance in arthropods: ecology matters too. Ecol. Lett. 25, 1746–1759 (2022). Article  PubMed  PubMed Central  Google Scholar  Chen, Y. H. & Schoville, S. D. Editorial overview: ecology: ecological adaptation in agroecosystems: novel opportunities to integrate evolutionary…

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‘Quantum shift’: UK regulators replacing science-strangling ultra-precautionary crop biotech regulations to accelerate adoption of CRISPR and other precise breeding technologies

A ‘quantum shift’ by the Food Standards Agency in its planned approach to regulating gene edited food and feed products puts England on course to adopt one of the most progressive and enabling regulatory systems in the world. This could unlock significant new investment and economic activity by plant breeders…

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RNA Targeting Small Molecule Drug Discovery Market Size, Share And Growth Analysis For 2023-2032

(MENAFN– EIN Presswire) RNA Targeting Small Molecule Drug Discovery Global Market Report 2023 – Market Size, Trends, And Market Forecast 2023-2032 The Business Research Company’s RNA Targeting Small Molecule Drug Discovery Global Market Report 2023 – Market Size, Trends, And Market Forecast 2023-2032 The Business Research Company’s global market reports…

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Molecule Linking Cancer Driver and Cell Death Genes May Be Effective Against DLBCL | ASH Clinical News

Molecules that link cancer driver genes and promoters of cell death genes produce potent killing of diffuse large B-cell lymphoma (DLBCL) cells, according to findings published in Nature.1 The effectiveness of the molecules, called transcriptional/epigenetic chemical inducers of proximity (TCIPs), in killing cancer cells could have wider implications, potentially co-opting…

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Regulatory-first for gene editing therapy

The world’s first investigational in vivo CRISPR-based gene editing therapy cleared for late-stage clinical development is expected to enter Phase III in late 2023. The Investigational New Drug (IND) application for Intellia Therapeutics’ in vivo CRISPR-based candidate NTLA-2001, has been cleared as a gene editing therapy for transthyretin (ATTR) amyloidosis…

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Excision BioTherapeutics Announces Presentation of Interim

SAN FRANCISCO, Oct. 19, 2023 (GLOBE NEWSWIRE) — Excision BioTherapeutics, Inc., a clinical-stage biotechnology company developing CRISPR-based therapies to cure viral infectious diseases, today announced that interim clinical safety and biodistribution data will be presented at the 30th European Society of Gene and Cell Therapy (ESGCT) 2023 Annual Congress, which will…

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Microbial Gene Editing Services Market is poised for a remarkable US$ 30.5 Billion valuation by 2032, according to FMI’s study

Demand for microbial gene editing services market is projected to be worth US$ 5.35 billion globally in 2022 and to increase at a CAGR of 19% to US$ 30.5 billion globally from 2022 to 2032. A technique called microbial gene editing allows for the modification of an organism’s DNA. The…

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Broken String Biosciences’ INDUCE-seq Platform Demonstrates Impact of Structural DNA Changes on Specificity of CRISPR-Cas9 Gene Editing

Research published in Molecular Cell used INDUCE-seq to identify DNA topology as an important regulator of CRISPR targeting specificity Peer-reviewed data demonstrates the sensitivity of INDUCE-seq DNA break mapping platform, in identifying topology-related off-target events across the genome in cells CAMBRIDGE, England–(BUSINESS WIRE)– Broken String Biosciences (“Broken…

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Syngene gains access to ERS Genomics’ foundational CRISPR/Cas9 patent portfolio

ERS Genomics has completed licensing agreement with Syngene International, following which Syngene gains access to ERS Genomics’ foundational CRISPR/Cas9 patent portfolio, ushering in a new era of technical innovation in India for its global partners.  Syngene International, an integrated research, development and manufacturing services company, is poised to leverage the immense potential of CRISPR/Cas9…

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New Discovery Reveals How Viruses Can Suppress CRISPR-Cas Systems

A recent study published in the journal Nature by an international team of researchers has uncovered a new way in which viruses can suppress the CRISPR-Cas immune systems of bacteria. Led by Professor Peter Fineran from the University of Otago and Dr Rafael Pinilla-Redondo from the University of Copenhagen, the…

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ERS Genomics Limited (‘ERS’) completes licensing agreement with Syngene International

ERS Genomics Limited (‘ERS’) completes licensing agreement with Syngene International, India’s leading Contract Research, Development and Manufacturing Organization Syngene gains access to ERS Genomics’ foundational CRISPR/Cas9 patent portfolio, ushering in a new era of technical innovation in India for its global partners.  DUBLIN, Oct. 18, 2023 /PRNewswire/ — ERS Genomics, co-founded by…

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Scientists uncover new way viruses fight back against bacteria

A microscopic discovery will not only enable scientists to understand the microbial world around us but could also provide a new way to control CRISPR-Cas biotechnologies. An international team of researchers led by Professor Peter Fineran from the University of Otago and Dr Rafael Pinilla-Redondo from the University of Copenhagen…

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Antiviral type III CRISPR signalling via conjugation of ATP and SAM

Cloning Supplementary Table 1 shows the synthetic gene, DNA and RNA oligonucleotide sequences used in this study. The synthetic genes encoding B.fragilis Cas6, CorA, NrN and C. botulinum SAM lyase purchased as g-blocks (IDT) were codon-optimized for expression in E. coli C43 (DE3) via the vector pEhisV5TEV, which encodes eight…

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Inactive S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in human stem cell model of Parkinson’s disease

Cloning of CRISPR/sgRNA lentiviral constructs with fluorescent selection markers A tetracycline-inducible promoter (TRE3G) was used to control the expression of S. aureus dCas9 in a lentiviral vector. To facilitate selection of cells by FACS, pHR:TRE3G-SadCas9-2xKRAB-p2a-tdTomato (Addgene ID #209298) was subcloned from a pHR:TRE3G-SadCas9-2xKRAB-p2a-zeo (A gift from Professor Stanley Qi), where zeocin…

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Neuron Navigator 1 (Nav1) regulates the response to cocaine in mice

Mouse strains All mouse procedures were approved by the Institutional Animal Care and Use Committees at Binghamton or Stanford University; and were conducted in accordance with the National Institute of Health Guide for Care and Use of Laboratory Animals, Eighth Edition. All mice were originally obtained from Jackson Laboratories, and…

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Intellia Therapeutics: FDA Allows To Begin Phase 3 Trial Of NTLA-2001 – Quick Facts

(RTTNews) – Intellia Therapeutics, Inc. (NTLA) announced the FDA has cleared the company’s Investigational New Drug application for NTLA-2001 for the treatment of transthyretin amyloidosis with cardiomyopathy. The global Phase 3 study of NTLA-2001, an in vivo CRISPR-based gene editing candidate, is anticipated to initiate by year-end 2023. “The FDA…

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Delineating the dynamic transcriptional and epigenetic landscape regulating hematopoiesis

Credit: iScience (2023). DOI: 10.1016/j.isci.2023.107893 A research team led by Professor Megumu K. Saito (Department of Clinical Application) examined the dynamic transcriptional and epigenetic landscape during definitive hematopoiesis and revealed the non-redundant roles of ZEB2 and MEIS1 vital to producing hematopoietic stem cells from the hemogenic endothelium. The study is…

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Intellia Therapeutics (NTLA) Receives FDA Clearance of IND to Initiate a Phase 3 Trial of NTLA-2001

Intellia Therapeutics, Inc. (NASDAQ: NTLA), a leading clinical-stage genome editing company focused on developing potentially curative therapies leveraging CRISPR-based technologies, today announced that the U.S. Food and Drug Administration (FDA) has cleared the company’s Investigational New Drug (IND) application for NTLA-2001 for the treatment of transthyretin (ATTR) amyloidosis with cardiomyopathy….

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IJMS | Free Full-Text | CRISPR/Cas9 Editing Sites Identification and Multi-Elements Association Analysis in Camellia sinensis

1. Introduction Camellia sinensis is an important perennial cash crop and one of the most widely consumed non-alcoholic beverages in the world, with health benefits [1]. Camellia sinensis enriched with secondary metabolites that provide aroma, freshness, and astringent flavour are key determination factors contributing to its quality hence, it is…

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Viruses use RNA decoys to thwart CRISPR defences

Bernheim, A. & Sorek, R. Nature Rev. Microbiol. 18, 113–119 (2020). Article  PubMed  Google Scholar  Camara-Wilpert, S. et al. Nature doi.org/10.1038/s41586-023-06612-5 (2023). Article  Google Scholar  Barrangou, R., Sontheimer, E. J. & Marraffini, L. A. (eds) CRISPR: Biology and Applications (American Society for Microbiology Press, 2022). Google Scholar  Li, Y. &…

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Global CRISPR/CAS 9 Technology Market Size to Reach USD

Vancouver, Oct. 18, 2023 (GLOBE NEWSWIRE) — The global CRISPR/CAS 9 technology market size is expected to reach USD 13,072.73 Million at a steady revenue CAGR of 20.4% in 2032, according to latest analysis by Emergen Research. Steady CRISPR/CAS 9 market revenue growth is due to ability for researchers and…

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Core of the Month | Drug Discovery Core | University of Utah Health

The Drug Discovery Core at the University of Utah provides university researchers access to small molecule libraries/CRISPR libraries for screening, equipment for automation, and synthetic chemistry support for the characterization and validation of compounds for potential use as therapeutics, diagnostics, and biological tools. The Core currently offers the following services:…

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Intellia Therapeutics Announces FDA Clearance of Investigational New Drug Application to Initiate a Pivotal Phase 3 Trial of NTLA-2001 for the Treatment of Transthyretin Amyloidosis with Cardiomyopathy -October 18, 2023 at 07:00 am EDT

Intellia Therapeutics, Inc. announced that the U.S. Food and Drug Administration (FDA) has cleared the company?s Investigational New Drug (IND) application for NTLA-2001 for the treatment of transthyretin (ATTR) amyloidosis with cardiomyopathy. The global Phase 3 study of NTLA-2001, an in vivo CRISPR-based gene editing candidate, is expected to initiate…

Continue Reading Intellia Therapeutics Announces FDA Clearance of Investigational New Drug Application to Initiate a Pivotal Phase 3 Trial of NTLA-2001 for the Treatment of Transthyretin Amyloidosis with Cardiomyopathy -October 18, 2023 at 07:00 am EDT

Sensitive, rapid detection of NCOA4-m6A towards precisely quantifying radiation dosage on a Cas13a-Microdroplet platform

. 2023 Oct 11:242:115753. doi: 10.1016/j.bios.2023.115753. Online ahead of print. Zhiyuan Jin  1 , Zaizai Dong  2 , Xi Zhao  3 , Xinxin Hang  1 , Yiming Lu  4 , Qi Zhang  5 , Hongxia Chen  3 , Zhaocun Huang  1 , Yusen Wang  1 , Gangqiao Zhou  6 , Lingqian Chang  7 Affiliations Expand Affiliations 1 Beijing Advanced Innovation…

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Unlocking the Potential of CRISPR-Cas9: Gene Editing and Its Transformative Applications | by Remya ramani | Oct, 2023

The world of genetics has witnessed a revolution with the advent of CRISPR-Cas9 technology. This groundbreaking gene-editing tool has simplified the process of modifying DNA and opened up new frontiers in science and medicine. This article will delve into the fascinating world of CRISPR-Cas9 and explore its transformative applications. Background:CRISPR,…

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Broad Institute of MIT and Harvard hiring Principal Bioinformatics Engineer in Cambridge, Massachusetts, United States

Job DescriptionThe Cancer Data Science (CDS) team at the Broad (www.cancerdatascience.org/) is an interdisciplinary group dedicated to accelerating cancer research. We help design and analyze large-scale experiments, develop new statistical tools and machine learning methods, write papers, produce datasets used by tens of thousands of researchers around the world, and…

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Genetically Modified Silkworms Can Produce Spider Silk That’s Stronger Than Kevlar | Smart News

Gene-editing silkworms produced this spider silk. Junpeng Mi Spider silk is an unparalleled material: It’s strong and tough, yet also lightweight and flexible. But getting spiders to mass-produce their silk for commercial purposes has proven nearly impossible. For one, they’re cannibals, so raising them in large numbers is a challenge….

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